SG11202109958SA - Determining biomarkers from histopathology slide images - Google Patents

Determining biomarkers from histopathology slide images

Info

Publication number
SG11202109958SA
SG11202109958SA SG11202109958SA SG11202109958SA SG 11202109958S A SG11202109958S A SG 11202109958SA SG 11202109958S A SG11202109958S A SG 11202109958SA SG 11202109958S A SG11202109958S A SG 11202109958SA
Authority
SG
Singapore
Prior art keywords
slide images
histopathology slide
determining biomarkers
biomarkers
determining
Prior art date
Application number
Other languages
English (en)
Inventor
Stephen Yip
Irvin Ho
Lingdao Sha
Boleslaw Osinski
Aly Khan
Andrew Kruger
Michael Carlson
Abel Greenwald
Caleb Willis
Original Assignee
Tempus Labs Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US16/412,362 external-priority patent/US11741365B2/en
Priority claimed from US16/732,242 external-priority patent/US10991097B2/en
Application filed by Tempus Labs Inc filed Critical Tempus Labs Inc
Publication of SG11202109958SA publication Critical patent/SG11202109958SA/en

Links

Classifications

    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B45/00ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06FELECTRIC DIGITAL DATA PROCESSING
    • G06F18/00Pattern recognition
    • G06F18/20Analysing
    • G06F18/24Classification techniques
    • G06F18/241Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches
    • G06F18/2413Classification techniques relating to the classification model, e.g. parametric or non-parametric approaches based on distances to training or reference patterns
    • G06F18/24133Distances to prototypes
    • G06F18/24143Distances to neighbourhood prototypes, e.g. restricted Coulomb energy networks [RCEN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/04Architecture, e.g. interconnection topology
    • G06N3/045Combinations of networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • G06N3/084Backpropagation, e.g. using gradient descent
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T3/00Geometric image transformations in the plane of the image
    • G06T3/40Scaling of whole images or parts thereof, e.g. expanding or contracting
    • G06T3/4046Scaling of whole images or parts thereof, e.g. expanding or contracting using neural networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/12Edge-based segmentation
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/187Segmentation; Edge detection involving region growing; involving region merging; involving connected component labelling
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/40Extraction of image or video features
    • G06V10/44Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components
    • G06V10/443Local feature extraction by analysis of parts of the pattern, e.g. by detecting edges, contours, loops, corners, strokes or intersections; Connectivity analysis, e.g. of connected components by matching or filtering
    • G06V10/449Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters
    • G06V10/451Biologically inspired filters, e.g. difference of Gaussians [DoG] or Gabor filters with interaction between the filter responses, e.g. cortical complex cells
    • G06V10/454Integrating the filters into a hierarchical structure, e.g. convolutional neural networks [CNN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V10/00Arrangements for image or video recognition or understanding
    • G06V10/70Arrangements for image or video recognition or understanding using pattern recognition or machine learning
    • G06V10/82Arrangements for image or video recognition or understanding using pattern recognition or machine learning using neural networks
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06VIMAGE OR VIDEO RECOGNITION OR UNDERSTANDING
    • G06V20/00Scenes; Scene-specific elements
    • G06V20/60Type of objects
    • G06V20/69Microscopic objects, e.g. biological cells or cellular parts
    • G06V20/698Matching; Classification
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B15/00ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
    • G16B15/30Drug targeting using structural data; Docking or binding prediction
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16HHEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H30/00ICT specially adapted for the handling or processing of medical images
    • G16H30/40ICT specially adapted for the handling or processing of medical images for processing medical images, e.g. editing
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06NCOMPUTING ARRANGEMENTS BASED ON SPECIFIC COMPUTATIONAL MODELS
    • G06N3/00Computing arrangements based on biological models
    • G06N3/02Neural networks
    • G06N3/08Learning methods
    • G06N3/088Non-supervised learning, e.g. competitive learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10024Color image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10056Microscopic image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/10Image acquisition modality
    • G06T2207/10064Fluorescence image
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20016Hierarchical, coarse-to-fine, multiscale or multiresolution image processing; Pyramid transform
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20021Dividing image into blocks, subimages or windows
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20072Graph-based image processing
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20076Probabilistic image processing
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20081Training; Learning
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/20Special algorithmic details
    • G06T2207/20084Artificial neural networks [ANN]
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30024Cell structures in vitro; Tissue sections in vitro
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30096Tumor; Lesion
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30101Blood vessel; Artery; Vein; Vascular
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2219/00Indexing scheme for manipulating 3D models or images for computer graphics
    • G06T2219/004Annotating, labelling

Landscapes

  • Engineering & Computer Science (AREA)
  • Theoretical Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Evolutionary Computation (AREA)
  • Artificial Intelligence (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Software Systems (AREA)
  • Multimedia (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Computing Systems (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Evolutionary Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Computational Linguistics (AREA)
  • Mathematical Physics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biotechnology (AREA)
  • Databases & Information Systems (AREA)
  • Public Health (AREA)
  • Quality & Reliability (AREA)
  • Epidemiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Primary Health Care (AREA)
  • Bioethics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physiology (AREA)
SG11202109958S 2019-03-26 2020-03-25 Determining biomarkers from histopathology slide images SG11202109958SA (en)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201962824039P 2019-03-26 2019-03-26
US16/412,362 US11741365B2 (en) 2018-05-14 2019-05-14 Generalizable and interpretable deep learning framework for predicting MSI from histopathology slide images
US201962889521P 2019-08-20 2019-08-20
US16/732,242 US10991097B2 (en) 2018-12-31 2019-12-31 Artificial intelligence segmentation of tissue images
US202062983524P 2020-02-28 2020-02-28
PCT/US2020/024748 WO2020198380A1 (en) 2019-03-26 2020-03-25 Determining biomarkers from histopathology slide images

Publications (1)

Publication Number Publication Date
SG11202109958SA true SG11202109958SA (en) 2021-10-28

Family

ID=72612095

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202109958S SG11202109958SA (en) 2019-03-26 2020-03-25 Determining biomarkers from histopathology slide images

Country Status (7)

Country Link
EP (1) EP3991171A4 (ko)
JP (2) JP7548932B2 (ko)
KR (1) KR20210145778A (ko)
AU (1) AU2020248416A1 (ko)
CA (1) CA3133826A1 (ko)
SG (1) SG11202109958SA (ko)
WO (1) WO2020198380A1 (ko)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115039126A (zh) 2020-01-28 2022-09-09 佩治人工智能公司 用于处理用于计算检测方法的电子图像的系统和方法
EP4097738A1 (en) * 2020-01-28 2022-12-07 PAIGE.AI, Inc. Systems and methods for processing electronic images for biomarker localization
WO2021158794A1 (en) * 2020-02-07 2021-08-12 Sanofi Systems and methods for predicting patient responses
US12204608B2 (en) * 2020-10-05 2025-01-21 Rakuten Group, Inc. Dual encoder attention U-net
US20220130542A1 (en) * 2020-10-22 2022-04-28 The Regents Of The University Of Michigan Using machine learning to assess medical information based on a spatial cell organization analysis
WO2022132917A1 (en) * 2020-12-15 2022-06-23 Carnegie Mellon University System, method, and computer program product for classification of diseases based on expansion microscopic images
CN112750106B (zh) * 2020-12-31 2022-11-04 山东大学 一种基于非完备标记的深度学习的核染色细胞计数方法、计算机设备、存储介质
CN112908414B (zh) * 2021-01-28 2023-08-22 中山大学 一种大规模单细胞分型方法、系统及存储介质
CN116888678A (zh) * 2021-02-26 2023-10-13 莱卡生物系统墨尔本私人有限公司 用于组织样本的混合虚拟和化学染色的系统和方法
KR102446638B1 (ko) * 2021-04-28 2022-09-26 주식회사 딥바이오 유방암 병변 영역을 판별하기 위한 인공 신경망을 학습하기 위한 학습 방법, 및 이를 수행하는 컴퓨팅 시스템
CN113762075B (zh) * 2021-07-29 2024-11-26 北京旷视科技有限公司 组分检测方法、装置、设备及介质
JP2024529420A (ja) * 2021-07-29 2024-08-06 テンプス エーアイ,インコーポレイティド がんにおけるヘテロタイプエフェクター細胞療法のインビトロ有効性を特徴付けるための共培養イメージングのためのプラットフォーム
WO2023022444A1 (ko) * 2021-08-18 2023-02-23 주식회사 루닛 병리 슬라이드 이미지로부터 예측된 종양 함량에 기초하여 검사와 관련된 가이드를 제공하는 방법 및 장치
CN113870280B (zh) * 2021-09-15 2024-08-09 中国科学院心理研究所 预测以细胞为基质的抗体核型类别的方法、设备和介质
US20250022139A1 (en) * 2021-12-09 2025-01-16 Daegu Gyeongbuk Institute Of Science And Technology Bottom-up instance segmentation method and device
CN114419366B (zh) * 2021-12-30 2024-07-26 福州大学 基于深度学习的花椒粉掺假快速识别方法及系统
CN114638292B (zh) * 2022-03-10 2023-05-05 中国医学科学院北京协和医院 一种基于多尺度分析的人工智能病理辅助诊断系统
CN114581429B (zh) * 2022-03-14 2024-04-19 中南大学 一种基于区域关系的宫颈细胞检测方法及成像方法
KR102671745B1 (ko) * 2022-05-24 2024-06-04 주식회사 루닛 병리 슬라이드 이미지의 품질을 평가하는 방법 및 장치
US12014502B2 (en) 2022-05-24 2024-06-18 Lunit Inc. Method and device for evaluating quality of pathological slide image
JP7557499B2 (ja) * 2022-05-31 2024-09-27 楽天グループ株式会社 画像からデータを予測する方法、コンピュータシステム、及びコンピュータ可読媒体
WO2023249552A1 (en) * 2022-06-24 2023-12-28 National Skin Centre (Singapore) Pte Ltd System and method for classification of basal cell carcinoma based on confocal microscopy
EP4300427A1 (en) * 2022-07-01 2024-01-03 Peek Health, S.A. Standardizing images of anatomical structures for analysis by machine learning systems
EP4318492A1 (en) * 2022-08-05 2024-02-07 Siemens Healthcare GmbH Computer-assisted medical diagnosis system and method
WO2024047608A1 (en) * 2022-09-02 2024-03-07 Janssen Research & Development, Llc Methods and systems for ai-based immune profiling for cancer patient stratification
CN115294191B (zh) * 2022-10-08 2022-12-27 武汉楚精灵医疗科技有限公司 基于电子内镜的标志物尺寸测量方法、装置、设备及介质
KR20240107296A (ko) * 2022-12-29 2024-07-09 서울대학교병원 폐암 stas 검출 장치 및 방법
KR20240129697A (ko) * 2023-02-21 2024-08-28 주식회사 위트젠바이오테크놀로지 인공지능을 이용하여 종양에 대한 단일세포 분석을 수행하는 분석 장치 및 이를 이용한 방법
CN116934742B (zh) * 2023-09-13 2024-02-27 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 一种淋巴结构图像识别方法及系统
CN117454762B (zh) * 2023-10-30 2024-05-24 昆明理工大学 Markov-神经网络的穿煤隧道掌子面瓦斯浓度预测方法
CN118688444B (zh) * 2024-07-05 2024-12-20 杭州茵菲多组学生物科技有限公司 一种用于检测髓系细胞的蛋白标记物组、应用、试剂盒及检测方法
CN118985332B (zh) * 2024-10-24 2025-01-28 中国电建集团昆明勘测设计研究院有限公司 一种生态舱的自动调控方法和装置

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011145264A (ja) 2010-01-18 2011-07-28 Olympus Corp 生体標本解析装置
JP5953035B2 (ja) 2011-11-28 2016-07-13 学校法人慶應義塾 病理診断支援装置、病理診断支援方法、及び病理診断支援プログラム
JP6629762B2 (ja) 2014-05-23 2020-01-15 ベンタナ メディカル システムズ, インコーポレイテッド 画像内の生物学的構造及び/又はパターンの検出のためのシステム及び方法
EP3262417B1 (en) * 2015-02-23 2021-11-03 Cellanyx Diagnostics, LLC Cell imaging and analysis to differentiate clinically relevant sub-populations of cells
AU2017205443A1 (en) 2016-01-06 2018-07-19 Epic Sciences, Inc. Single cell genomic profiling of circulating tumor cells (CTCs) in metastatic disease to characterize disease heterogeneity
EP3408410B1 (en) * 2016-01-26 2023-12-20 Ventana Medical Systems, Inc. Predictive diagnostic workflow for tumors using automated dissection, next generation sequencing, and automated slide stainers
EP3523779A1 (en) 2016-10-07 2019-08-14 Ventana Medical Systems, Inc. Digital pathology system and associated workflow for providing visualized whole-slide image analysis
US11835524B2 (en) 2017-03-06 2023-12-05 University Of Southern California Machine learning for digital pathology
WO2018200840A1 (en) 2017-04-27 2018-11-01 Retinopathy Answer Limited System and method for automated funduscopic image analysis
US10846367B2 (en) * 2017-09-15 2020-11-24 Case Western Reserve University University Predicting recurrence in early stage non-small cell lung cancer (NSCLC) with integrated radiomic and pathomic features

Also Published As

Publication number Publication date
AU2020248416A1 (en) 2021-10-07
CA3133826A1 (en) 2020-10-01
WO2020198380A1 (en) 2020-10-01
JP2024178195A (ja) 2024-12-24
KR20210145778A (ko) 2021-12-02
JP2022527264A (ja) 2022-06-01
EP3991171A1 (en) 2022-05-04
EP3991171A4 (en) 2022-12-14
JP7548932B2 (ja) 2024-09-10

Similar Documents

Publication Publication Date Title
SG11202109958SA (en) Determining biomarkers from histopathology slide images
IL291381A (en) Histological image analysis
EP3818496A4 (en) 3D RADIOMICS PLATFORM FOR IMAGING BIOMARKER DEVELOPMENT
GB2575153B (en) Determining image handle locations
GB201809345D0 (en) Image segmentation
IL285218A (en) Biomarkers for the diagnosis of ovarian cancer
GB201808476D0 (en) Biomarkers for colorectal cancer
GB201902077D0 (en) Biomarkers
GB201911947D0 (en) Miscarriage biomarkers
GB201900677D0 (en) Biomarkers
SG11202110589PA (en) Biomarkers for selinexor
GB201811093D0 (en) Biomarker
GB201907152D0 (en) Identifying at leasr one object within an image
GB2586601B (en) Determining object pose from image data
GB201915228D0 (en) Biomarkers
IL269733A (en) Biomarkers for cancer therapeutics
HK1254850A1 (zh) 用於診斷子宮內膜異位症的生物標誌物
GB201902070D0 (en) Biomarkers
GB201914183D0 (en) Biomarker
GB201913846D0 (en) Biomarker
GB201913612D0 (en) Biomarker
GB201912154D0 (en) Biomarker
GB201809875D0 (en) Biomarkers
GB201809885D0 (en) Biomarkers
GB201809868D0 (en) Biomarkers