SG11202109514VA - Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy - Google Patents

Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

Info

Publication number
SG11202109514VA
SG11202109514VA SG11202109514VA SG11202109514VA SG11202109514VA SG 11202109514V A SG11202109514V A SG 11202109514VA SG 11202109514V A SG11202109514V A SG 11202109514VA SG 11202109514V A SG11202109514V A SG 11202109514VA SG 11202109514V A SG11202109514V A SG 11202109514VA
Authority
SG
Singapore
Prior art keywords
lnp
cancer immunotherapy
replicon rna
synthetic oncolytic
oncolytic
Prior art date
Application number
SG11202109514VA
Other languages
English (en)
Inventor
Darrell Irvine
Karl Wittrup
Ron Weiss
Yingzhong Li
Noor Momin
Yizhou Dong
Original Assignee
Massachusetts Inst Technology
Univ Ohio State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Massachusetts Inst Technology, Univ Ohio State filed Critical Massachusetts Inst Technology
Publication of SG11202109514VA publication Critical patent/SG11202109514VA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5434—IL-12
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
SG11202109514VA 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy SG11202109514VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962815611P 2019-03-08 2019-03-08
PCT/US2020/013069 WO2020185293A1 (en) 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

Publications (1)

Publication Number Publication Date
SG11202109514VA true SG11202109514VA (en) 2021-09-29

Family

ID=69526302

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202109514VA SG11202109514VA (en) 2019-03-08 2020-01-10 Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy

Country Status (14)

Country Link
US (2) US11717548B2 (enrdf_load_html_response)
EP (1) EP3934673A1 (enrdf_load_html_response)
JP (2) JP7561134B2 (enrdf_load_html_response)
KR (1) KR20220006041A (enrdf_load_html_response)
CN (1) CN113966221A (enrdf_load_html_response)
AU (1) AU2020233788A1 (enrdf_load_html_response)
BR (1) BR112021017637A8 (enrdf_load_html_response)
CA (1) CA3132714A1 (enrdf_load_html_response)
CO (1) CO2021013417A2 (enrdf_load_html_response)
IL (1) IL285963A (enrdf_load_html_response)
MX (1) MX2021010808A (enrdf_load_html_response)
PH (1) PH12021552145A1 (enrdf_load_html_response)
SG (1) SG11202109514VA (enrdf_load_html_response)
WO (1) WO2020185293A1 (enrdf_load_html_response)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7561134B2 (ja) * 2019-03-08 2024-10-03 マサチューセッツ インスティテュート オブ テクノロジー 合成腫瘍溶解性ｌｎｐレプリコンｒｎａおよびがん免疫治療のための使用
CN113509542A (zh) * 2021-04-20 2021-10-19 嘉晨西海(杭州)生物技术有限公司 一种基于mRNA的表达白介素12针对肿瘤的药物及其制备方法
CZ310443B6 (cs) * 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
KR20250004731A (ko) 2022-04-26 2025-01-08 스트랜드 세러퓨틱스 인코포레이티드 베네수엘라 말 뇌염 (vee) 레플리콘을 포함하는 지질 나노입자 및 이의 용도
CN115227674B (zh) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 包封的溶瘤病毒遗传物质及其应用
AU2024208643A1 (en) * 2023-01-12 2025-06-26 Bavarian Nordic A/S RECOMBINANT MODIFIED saRNA (VRP) FOR CANCER VACCINE
WO2024211865A2 (en) * 2023-04-07 2024-10-10 Omega Therapeutics, Inc. Lipids and lipid-like compounds for therapeutic lipid nanoparticle (lnp) delivery
CN118147171B (zh) * 2024-03-08 2024-12-06 上海复诺健生物科技有限公司 具有增强的外源基因表达水平的自扩增mRNA核酸序列
WO2025024704A1 (en) 2023-07-25 2025-01-30 Strand Therapeutics Inc. Polynucleotides comprising a micro rna detargeting sensor and uses thereof
CN119479778B (zh) * 2024-10-16 2025-04-25 北京悦康科创医药科技股份有限公司 一种lnp转染效率预测模型构建方法及装置

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4485045A (en) 1981-07-06 1984-11-27 Research Corporation Synthetic phosphatidyl cholines useful in forming liposomes
US4544545A (en) 1983-06-20 1985-10-01 Trustees University Of Massachusetts Liposomes containing modified cholesterol for organ targeting
US5013556A (en) 1989-10-20 1991-05-07 Liposome Technology, Inc. Liposomes with enhanced circulation time
WO2011005799A2 (en) * 2009-07-06 2011-01-13 Novartis Ag Self replicating rna molecules and uses thereof
PL4005592T3 (pl) 2010-07-06 2023-02-06 Glaxosmithkline Biologicals S.A. Podobne do wiriona cząstki do dostarczania samoreplikujących się molekuł rna
EP3508219A1 (en) * 2011-07-06 2019-07-10 GlaxoSmithKline Biologicals S.A. Self-replicating rna prime - protein boost vaccines
CA2893762A1 (en) * 2012-12-03 2014-06-12 Dipu Mohan-Kumar Ehrlichial invasin for immunization, diagnosis, and cell delivery
ES2969956T3 (es) 2014-09-05 2024-05-23 Novartis Ag Lípidos y composiciones lipídicas para el suministro de agentes activos
EP3212772A4 (en) * 2014-10-31 2018-10-03 Massachusetts Institute of Technology Delivery of biomolecules to immune cells
ES2880103T3 (es) * 2015-05-21 2021-11-23 Ohio State Innovation Foundation Derivados de benceno-1, 3, 5-tricarboxamida y usos de los mismos
JP7561134B2 (ja) * 2019-03-08 2024-10-03 マサチューセッツ インスティテュート オブ テクノロジー 合成腫瘍溶解性ｌｎｐレプリコンｒｎａおよびがん免疫治療のための使用
WO2022020811A1 (en) * 2020-07-24 2022-01-27 Strand Therapeutics, Inc. Lipidnanoparticle comprising modified nucleotides
US20240140960A1 (en) * 2021-02-12 2024-05-02 Ohio State Innovation Foundation Sugar derived lipid nanomaterials and uses thereof
US20240327865A1 (en) * 2021-07-09 2024-10-03 Replicate Bioscience, Inc. Modified eastern equine encephalitis viruses, self-replicating rna constructs, and uses thereof
CN117180454A (zh) * 2022-05-16 2023-12-08 上海行深生物科技有限公司 含有自复制rna分子和脂质纳米颗粒递送载体的组合物及其制备方法

Also Published As

Publication number Publication date
MX2021010808A (es) 2021-12-15
AU2020233788A1 (en) 2021-10-07
IL285963A (en) 2021-10-31
CO2021013417A2 (es) 2022-01-17
EP3934673A1 (en) 2022-01-12
PH12021552145A1 (en) 2022-08-31
US12383589B2 (en) 2025-08-12
US20200281994A1 (en) 2020-09-10
US11717548B2 (en) 2023-08-08
CN113966221A (zh) 2022-01-21
JP2022524391A (ja) 2022-05-02
JP2025011109A (ja) 2025-01-23
BR112021017637A8 (pt) 2022-08-16
JP7561134B2 (ja) 2024-10-03
BR112021017637A2 (enrdf_load_html_response) 2021-11-09
US20240024394A1 (en) 2024-01-25
KR20220006041A (ko) 2022-01-14
CA3132714A1 (en) 2020-09-17
WO2020185293A1 (en) 2020-09-17

Similar Documents

Publication Publication Date Title
SG11202109514VA (en) Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
IL288754A (en) Preparations and methods for cancer immunotherapy
TWI799411B (zh) 溶瘤病毒療法及免疫療法
EP3866813A4 (en) COMBINATORY CANCER IMMUNOTHERAPY
ZA202101368B (en) Rna particles comprising polysarcosine
EP3258967A4 (en) Bivalent antibody directed against nkg2d and tumor associated antigens
EP3500966A4 (en) IMMUNOTHERAPY MARKERS AND USES THEREFOR
IL289585A (en) DLL3-targeted antibodies and uses thereof
EP3247408A4 (en) Compositions and methods for cancer immunotherapy
IL291027A (en) Anti-steap1 antibodies and uses thereof
SG11202112112UA (en) Anti-galectin-9 antibodies and uses thereof
IL289205A (en) New cancer antigens and methods
IL289335A (en) New cancer antigens and methods
IL289334A (en) New cancer antigens and methods
IL290109A (en) Cells for enhanced immune healing and their uses
IL289200A (en) New cancer antigens and methods
IL291546A (en) Antibodies against kir3dl3 and their uses
IL286792A (en) Preparations and methods for cancer immunotherapy
IL291550A (en) Anti-il-27 antibodies and their uses
IL291343A (en) Compounds and Methods for Immunotherapy
IL291280A (en) Antibodies against cd371 and their uses
IL289006A (en) Combined immunotherapy for cancer
IL288807A (en) Anti-talen antibodies and their uses
HK40066607A (en) Synthetic oncolytic lnp-replicon rna and uses for cancer immunotherapy
EP4054612A4 (en) ONCOLYTIC VIROTHERAPY AND IMMUNOTHERAPY