SG11202107434PA - Fxr (nr1h4) modulating compounds - Google Patents

Fxr (nr1h4) modulating compounds

Info

Publication number
SG11202107434PA
SG11202107434PA SG11202107434PA SG11202107434PA SG11202107434PA SG 11202107434P A SG11202107434P A SG 11202107434PA SG 11202107434P A SG11202107434P A SG 11202107434PA SG 11202107434P A SG11202107434P A SG 11202107434PA SG 11202107434P A SG11202107434P A SG 11202107434PA
Authority
SG
Singapore
Prior art keywords
nr1h4
fxr
modulating compounds
modulating
compounds
Prior art date
Application number
SG11202107434PA
Inventor
Peter A Blomgren
Kevin S Currie
Morin Mae Frick
Elizabeth M Horstman
Joshua A Kaplan
Jeffrey E Kropf
William J Watkins
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of SG11202107434PA publication Critical patent/SG11202107434PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
SG11202107434PA 2019-01-15 2020-01-13 Fxr (nr1h4) modulating compounds SG11202107434PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962792714P 2019-01-15 2019-01-15
PCT/US2020/013319 WO2020150136A1 (en) 2019-01-15 2020-01-13 Fxr (nr1h4) modulating compounds

Publications (1)

Publication Number Publication Date
SG11202107434PA true SG11202107434PA (en) 2021-08-30

Family

ID=69740522

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202107434PA SG11202107434PA (en) 2019-01-15 2020-01-13 Fxr (nr1h4) modulating compounds

Country Status (30)

Country Link
US (2) US11225473B2 (en)
EP (2) EP4360632A3 (en)
JP (2) JP7265635B2 (en)
KR (1) KR102692309B1 (en)
CN (1) CN113302190A (en)
AR (1) AR117814A1 (en)
AU (2) AU2020209564B2 (en)
BR (1) BR112021011762A2 (en)
CA (1) CA3124702A1 (en)
CL (1) CL2021001877A1 (en)
CO (1) CO2021009240A2 (en)
CR (1) CR20210385A (en)
DK (1) DK3911647T3 (en)
DO (2) DOP2021000148A (en)
EA (1) EA202191566A1 (en)
ES (1) ES2973500T3 (en)
FI (1) FI3911647T3 (en)
HR (1) HRP20240265T1 (en)
HU (1) HUE065889T2 (en)
IL (1) IL284591A (en)
LT (1) LT3911647T (en)
MX (1) MX2021008518A (en)
PE (1) PE20211907A1 (en)
PL (1) PL3911647T3 (en)
PT (1) PT3911647T (en)
SG (1) SG11202107434PA (en)
SI (1) SI3911647T1 (en)
TW (1) TWI733307B (en)
WO (1) WO2020150136A1 (en)
ZA (1) ZA202104705B (en)

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CA2968836A1 (en) 2016-06-13 2017-12-13 Gilead Sciences, Inc. Fxr (nr1h4) modulating compounds
CN110461328A (en) 2017-03-28 2019-11-15 吉利德科学公司 The therapeutic combination for treating liver disease
CN113226295A (en) * 2018-10-18 2021-08-06 阿沃林特有限公司 Use of SGLT2 inhibitor in treatment of primary sclerosing cholangitis
CN118388474A (en) 2019-02-19 2024-07-26 吉利德科学公司 Solid forms of FXR agonists
EP4090327A1 (en) 2020-01-15 2022-11-23 Institut National de la Santé et de la Recherche Médicale (INSERM) Use of fxr agonists for treating an infection by hepatitis d virus
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
AU2021359895A1 (en) * 2020-10-15 2023-06-15 Eli Lilly And Company Polymorphs of an fxr agonist
JP2024503861A (en) 2021-01-14 2024-01-29 ウエヌイグレックオ・ファーマ How to treat chronic kidney disease
CA3204800A1 (en) 2021-01-14 2022-07-21 Raphael Darteil Synergistic effect of a fxr agonist and ifn for the treatment of hbv infection
WO2022229302A1 (en) 2021-04-28 2022-11-03 Enyo Pharma Strong potentiation of tlr3 agonists effects using fxr agonists as a combined treatment
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