SG11202106348QA - Human alpha-galactosidase variants - Google Patents
Human alpha-galactosidase variantsInfo
- Publication number
- SG11202106348QA SG11202106348QA SG11202106348QA SG11202106348QA SG11202106348QA SG 11202106348Q A SG11202106348Q A SG 11202106348QA SG 11202106348Q A SG11202106348Q A SG 11202106348QA SG 11202106348Q A SG11202106348Q A SG 11202106348QA SG 11202106348Q A SG11202106348Q A SG 11202106348QA
- Authority
- SG
- Singapore
- Prior art keywords
- human alpha
- galactosidase
- variants
- galactosidase variants
- alpha
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2465—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1) acting on alpha-galactose-glycoside bonds, e.g. alpha-galactosidase (3.2.1.22)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01022—Alpha-galactosidase (3.2.1.22)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/22—Vectors comprising a coding region that has been codon optimised for expression in a respective host
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862782553P | 2018-12-20 | 2018-12-20 | |
PCT/US2019/067493 WO2020132252A2 (en) | 2018-12-20 | 2019-12-19 | Human alpha-galactosidase variants |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202106348QA true SG11202106348QA (en) | 2021-07-29 |
Family
ID=71099305
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202106348QA SG11202106348QA (en) | 2018-12-20 | 2019-12-19 | Human alpha-galactosidase variants |
Country Status (15)
Country | Link |
---|---|
US (2) | US11427813B2 (zh) |
EP (1) | EP3898960A4 (zh) |
JP (1) | JP2022515742A (zh) |
KR (1) | KR20210106537A (zh) |
CN (1) | CN113544268A (zh) |
AU (1) | AU2019403323A1 (zh) |
BR (1) | BR112021011750A2 (zh) |
CA (1) | CA3123598A1 (zh) |
CO (1) | CO2021009297A2 (zh) |
EA (1) | EA202191735A1 (zh) |
IL (1) | IL284133A (zh) |
MX (1) | MX2021007552A (zh) |
PH (1) | PH12021551372A1 (zh) |
SG (1) | SG11202106348QA (zh) |
WO (1) | WO2020132252A2 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112017013300A2 (pt) | 2014-12-22 | 2018-02-27 | Codexis Inc | alfa galactosidase a recombinante e/ou fragmento de alfa galactosidase a recombinante biologicamente ativo, composição, sequência de polinucleotídeos recombinantes, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições. |
MX2021007552A (es) | 2018-12-20 | 2021-08-11 | Codexis Inc | Variantes de alfa-galactosidasa humana. |
WO2022183052A1 (en) * | 2021-02-26 | 2022-09-01 | Takeda Pharmaceutical Company Limited | Composition and methods for the treatment of fabry disease |
Family Cites Families (67)
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US5356804A (en) | 1990-10-24 | 1994-10-18 | Mount Sinai School Of Medicine Of The City Of New York | Cloning and expression of biologically active human α-galactosidase A |
US6395547B1 (en) | 1994-02-17 | 2002-05-28 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6309883B1 (en) | 1994-02-17 | 2001-10-30 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US6165793A (en) | 1996-03-25 | 2000-12-26 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
US6406855B1 (en) | 1994-02-17 | 2002-06-18 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
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US5834252A (en) | 1995-04-18 | 1998-11-10 | Glaxo Group Limited | End-complementary polymerase reaction |
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US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
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US6458574B1 (en) | 1996-09-12 | 2002-10-01 | Transkaryotic Therapies, Inc. | Treatment of a α-galactosidase a deficiency |
ES2581828T3 (es) | 1996-09-13 | 2016-09-07 | Shire Human Genetic Therapies, Inc. | Proceso de purificación de alfa-galactosidasa A |
US7148054B2 (en) | 1997-01-17 | 2006-12-12 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
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US6326204B1 (en) | 1997-01-17 | 2001-12-04 | Maxygen, Inc. | Evolution of whole cells and organisms by recursive sequence recombination |
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JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
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EP2250595B1 (en) | 2008-02-12 | 2017-06-14 | Codexis, Inc. | Method of selecting an optimized diverse population of variants |
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SG10201502609QA (en) | 2010-03-02 | 2015-05-28 | Protalix Ltd | Stabilized alpha-galactosidase and uses thereof |
PT2717893T (pt) | 2011-06-08 | 2019-08-20 | Translate Bio Inc | Composições de nanopartículas lipídicas e métodos para transferência de arnm |
DK2726651T3 (en) | 2011-06-28 | 2019-01-28 | Codexis Inc | PROTEIN INVARIANT GENERATION BY REGION SHUFFLING |
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EP2839001B1 (en) | 2012-04-18 | 2017-09-06 | VIB vzw | Means and methods for generating improved proteins |
CN105074463B (zh) | 2013-01-31 | 2018-09-25 | 科德克希思公司 | 使用相乘形式的模型鉴定生物分子的方法、系统和软件 |
HUE053049T2 (hu) | 2013-09-27 | 2021-06-28 | Codexis Inc | Enzimvariánsok automatizált szûrése |
WO2015048573A1 (en) | 2013-09-27 | 2015-04-02 | Codexis, Inc. | Structure based predictive modeling |
BR112017013300A2 (pt) | 2014-12-22 | 2018-02-27 | Codexis Inc | alfa galactosidase a recombinante e/ou fragmento de alfa galactosidase a recombinante biologicamente ativo, composição, sequência de polinucleotídeos recombinantes, vetor de expressão, célula hospedeira, métodos para produzir uma variante de alfa galactosidase a e para tratar e/ou prevenir os sintomas da doença de fabry, composição farmacêutica, e, uso das composições. |
US20170051267A1 (en) * | 2015-08-20 | 2017-02-23 | Research Foundation Of The City University Of New York | Novel alpha-galactosidase a derivatives |
MX2021007552A (es) | 2018-12-20 | 2021-08-11 | Codexis Inc | Variantes de alfa-galactosidasa humana. |
EP3895708A3 (en) * | 2019-08-07 | 2022-01-19 | Amicus Therapeutics, Inc. | Methods of treating fabry disease in patients having a mutation in the gla gene |
WO2021173928A2 (en) | 2020-02-28 | 2021-09-02 | Codexis, Inc. | Human alpha-galactosidase variants |
-
2019
- 2019-12-19 MX MX2021007552A patent/MX2021007552A/es unknown
- 2019-12-19 EP EP19897710.0A patent/EP3898960A4/en active Pending
- 2019-12-19 WO PCT/US2019/067493 patent/WO2020132252A2/en active Application Filing
- 2019-12-19 AU AU2019403323A patent/AU2019403323A1/en active Pending
- 2019-12-19 BR BR112021011750-4A patent/BR112021011750A2/pt unknown
- 2019-12-19 CN CN201980092718.9A patent/CN113544268A/zh active Pending
- 2019-12-19 US US16/721,102 patent/US11427813B2/en active Active
- 2019-12-19 JP JP2021535658A patent/JP2022515742A/ja active Pending
- 2019-12-19 EA EA202191735A patent/EA202191735A1/ru unknown
- 2019-12-19 CA CA3123598A patent/CA3123598A1/en active Pending
- 2019-12-19 SG SG11202106348QA patent/SG11202106348QA/en unknown
- 2019-12-19 KR KR1020217023026A patent/KR20210106537A/ko unknown
-
2021
- 2021-06-10 PH PH12021551372A patent/PH12021551372A1/en unknown
- 2021-06-17 IL IL284133A patent/IL284133A/en unknown
- 2021-07-15 CO CONC2021/0009297A patent/CO2021009297A2/es unknown
-
2022
- 2022-07-22 US US17/814,371 patent/US20220356458A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US11427813B2 (en) | 2022-08-30 |
MX2021007552A (es) | 2021-08-11 |
CN113544268A (zh) | 2021-10-22 |
EA202191735A1 (ru) | 2021-11-24 |
WO2020132252A2 (en) | 2020-06-25 |
US20200199563A1 (en) | 2020-06-25 |
JP2022515742A (ja) | 2022-02-22 |
WO2020132252A3 (en) | 2020-07-23 |
AU2019403323A1 (en) | 2021-07-01 |
CO2021009297A2 (es) | 2021-07-30 |
KR20210106537A (ko) | 2021-08-30 |
BR112021011750A2 (pt) | 2021-08-31 |
EP3898960A4 (en) | 2022-11-30 |
IL284133A (en) | 2021-08-31 |
US20220356458A1 (en) | 2022-11-10 |
CA3123598A1 (en) | 2020-06-25 |
PH12021551372A1 (en) | 2021-11-29 |
EP3898960A2 (en) | 2021-10-27 |
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