SG11202103741RA - Single domain antibodies that bind human serum albumin - Google Patents

Single domain antibodies that bind human serum albumin

Info

Publication number
SG11202103741RA
SG11202103741RA SG11202103741RA SG11202103741RA SG11202103741RA SG 11202103741R A SG11202103741R A SG 11202103741RA SG 11202103741R A SG11202103741R A SG 11202103741RA SG 11202103741R A SG11202103741R A SG 11202103741RA SG 11202103741R A SG11202103741R A SG 11202103741RA
Authority
SG
Singapore
Prior art keywords
serum albumin
human serum
single domain
domain antibodies
bind human
Prior art date
Application number
SG11202103741RA
Inventor
Bryan Edwards
Debora Pinto
Original Assignee
Crescendo Biologics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Crescendo Biologics Ltd filed Critical Crescendo Biologics Ltd
Publication of SG11202103741RA publication Critical patent/SG11202103741RA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11202103741RA 2018-11-13 2019-11-13 Single domain antibodies that bind human serum albumin SG11202103741RA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1818460.6A GB201818460D0 (en) 2018-11-13 2018-11-13 Single domain antibodies that bind human serum albumin
PCT/GB2019/053220 WO2020099871A1 (en) 2018-11-13 2019-11-13 Single domain antibodies that bind human serum albumin

Publications (1)

Publication Number Publication Date
SG11202103741RA true SG11202103741RA (en) 2021-05-28

Family

ID=64739541

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202103741RA SG11202103741RA (en) 2018-11-13 2019-11-13 Single domain antibodies that bind human serum albumin

Country Status (11)

Country Link
US (1) US20210340233A1 (en)
EP (1) EP3880703A1 (en)
JP (1) JP2022507307A (en)
KR (1) KR20210091254A (en)
CN (1) CN113412278A (en)
AU (1) AU2019378154A1 (en)
CA (1) CA3118640A1 (en)
GB (1) GB201818460D0 (en)
IL (1) IL282641A (en)
SG (1) SG11202103741RA (en)
WO (1) WO2020099871A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018127710A1 (en) 2017-01-06 2018-07-12 Crescendo Biologics Limited Single domain antibodies to programmed cell death (pd-1)
GB201802573D0 (en) 2018-02-16 2018-04-04 Crescendo Biologics Ltd Therapeutic molecules that bind to LAG3
CN109942704B (en) * 2019-04-12 2023-01-20 深圳普瑞金生物药业股份有限公司 HSA single domain antibodies, nucleic acids and kits
WO2022206900A1 (en) * 2021-04-01 2022-10-06 江苏先声药业有限公司 Anti-human serum albumin (hsa) nanobodies and applications thereof
WO2022257868A1 (en) * 2021-06-07 2022-12-15 上海济煜医药科技有限公司 Antigen binding protein against human serum albumin
GB202205589D0 (en) 2022-04-14 2022-06-01 Crescendo Biologics Ltd Mesothelin binders
CN117088975A (en) * 2022-05-11 2023-11-21 东莞市朋志生物科技有限公司 Anti-albumin antibody, reagent and kit for detecting albumin

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0115256D0 (en) 2001-06-21 2001-08-15 Babraham Inst Mouse light chain locus
US20050271663A1 (en) * 2001-06-28 2005-12-08 Domantis Limited Compositions and methods for treating inflammatory disorders
US20060073141A1 (en) * 2001-06-28 2006-04-06 Domantis Limited Compositions and methods for treating inflammatory disorders
US9321832B2 (en) * 2002-06-28 2016-04-26 Domantis Limited Ligand
GB2398784B (en) 2003-02-26 2005-07-27 Babraham Inst Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal
MX363423B (en) * 2005-05-18 2019-03-22 Ablynx Nv Improved nanobodies against tumor necrosis factor-alpha.
US20080267949A1 (en) * 2006-12-05 2008-10-30 Ablynx N.V. Peptides capable of binding to serum proteins
CN103282381A (en) * 2010-08-20 2013-09-04 葛兰素史克知识产权开发有限公司 Improved anti-erum albumin binding variants
EP2723772A1 (en) * 2011-06-23 2014-04-30 Ablynx N.V. Immunoglobulin single variable domains directed against ige
CA2845029A1 (en) * 2011-08-17 2013-02-21 Glaxo Group Limited Modified proteins and peptides
WO2014111550A1 (en) * 2013-01-17 2014-07-24 Glaxosmithkline Intellectual Property Development Limited Modified anti-serum albumin binding proteins
PT3209698T (en) 2014-10-22 2018-12-14 Crescendo Biologics Ltd Transgenic mice
GB201500464D0 (en) * 2015-01-12 2015-02-25 Crescendo Biolog Ltd Method of producing optimised therapeutic molecules
CN108473589B (en) * 2016-01-12 2023-05-02 克雷森多生物制剂有限公司 Molecules that bind Prostate Specific Membrane Antigen (PSMA)
US10100106B2 (en) * 2016-05-20 2018-10-16 Harpoon Therapeutics, Inc. Single domain serum albumin binding protein
WO2018224439A1 (en) * 2017-06-05 2018-12-13 Numab Innovation Ag Novel anti-hsa antibodies

Also Published As

Publication number Publication date
IL282641A (en) 2021-06-30
CA3118640A1 (en) 2020-05-22
CN113412278A (en) 2021-09-17
JP2022507307A (en) 2022-01-18
US20210340233A1 (en) 2021-11-04
GB201818460D0 (en) 2018-12-26
WO2020099871A1 (en) 2020-05-22
EP3880703A1 (en) 2021-09-22
AU2019378154A1 (en) 2021-05-20
KR20210091254A (en) 2021-07-21

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