SG11202100829SA - Method for producing cd3-positive cell - Google Patents

Method for producing cd3-positive cell

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Publication number
SG11202100829SA
SG11202100829SA SG11202100829SA SG11202100829SA SG11202100829SA SG 11202100829S A SG11202100829S A SG 11202100829SA SG 11202100829S A SG11202100829S A SG 11202100829SA SG 11202100829S A SG11202100829S A SG 11202100829SA SG 11202100829S A SG11202100829S A SG 11202100829SA
Authority
SG
Singapore
Prior art keywords
producing
positive cell
positive
cell
Prior art date
Application number
SG11202100829SA
Inventor
Shin Kaneko
Yohei Kawai
Suguru Arima
Maiko Takiguchi
Kazuhide Nakayama
Yoshiaki Kassai
Akira Hayashi
Original Assignee
Univ Kyoto
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Kyoto, Takeda Pharmaceuticals Co filed Critical Univ Kyoto
Publication of SG11202100829SA publication Critical patent/SG11202100829SA/en

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WO2024020365A1 (en) * 2022-07-18 2024-01-25 The Children's Medical Center Corporation Methods of t cell differentiation and compositions thereof
WO2024071411A1 (en) * 2022-09-30 2024-04-04 国立大学法人京都大学 IMMUNE CELL INDUCED FROM iPS CELL
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Family Cites Families (26)

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EA016168B1 (en) 2005-09-30 2012-02-28 Такара Био Инк. Method for production of t cell population and use thereof
EP2208786B1 (en) 2005-12-13 2018-08-01 Kyoto University Nuclear reprogramming factor
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
US7661738B2 (en) 2006-11-28 2010-02-16 Veritainer Corporation Radiation detection unit for mounting a radiation sensor to a container crane
CN101743306A (en) 2007-03-23 2010-06-16 威斯康星校友研究基金会 Somatic cell reprogramming
WO2008124133A1 (en) 2007-04-07 2008-10-16 Whitehead Institute For Biomedical Research Reprogramming of somatic cells
CN101802172A (en) 2007-05-30 2010-08-11 通用医疗公司 methods of generating pluripotent cells from somatic cells
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
JP6043934B2 (en) * 2008-10-31 2016-12-14 国立大学法人名古屋大学 Antigen-specific cytotoxic T cell preparation kit
JP6344821B2 (en) 2011-11-21 2018-06-20 ユニバーシティ・ヘルス・ネットワーク A population of hematopoietic progenitors and a method of enriching stem cells for hematopoietic progenitors
US9944898B2 (en) 2013-03-11 2018-04-17 Case Western Reserve University Method of generating tumor-specific T cells
EP3186284B1 (en) * 2014-08-28 2022-04-06 BioAtla, Inc. Conditionally active chimeric antigen receptors for modified t-cells
EP3219791A4 (en) 2014-11-13 2018-07-18 Kyoto University Method for induction of t cells from pluripotent stem cells
AU2015350103A1 (en) 2014-11-17 2017-06-29 Adicet Bio, Inc. Engineered gamma delta T-cells
AU2016225012B2 (en) * 2015-02-27 2020-09-03 Kevin Chen Chimeric antigen receptors (CARS) targeting hematologic malignancies, compositions and methods of use thereof
GB201503500D0 (en) * 2015-03-02 2015-04-15 Ucl Business Plc Cell
GB201507368D0 (en) * 2015-04-30 2015-06-17 Ucl Business Plc Cell
US11578310B2 (en) * 2016-06-23 2023-02-14 Kyoto University Method for producing CD4/CD8 double-positive T cells
EP3572502B1 (en) * 2017-01-20 2023-01-11 Kyoto University Method for producing cd8alpha +beta + cytotoxic t cells
JP6885122B2 (en) 2017-03-14 2021-06-09 富士フイルムビジネスイノベーション株式会社 Fixing device and image forming device
JP6919426B2 (en) 2017-08-31 2021-08-18 日立造船株式会社 How to operate the sludge concentrator and sludge concentrator system
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