SG11202011592SA - Hsp70 protein levels in pbmc samples as biomarker for disease - Google Patents

Hsp70 protein levels in pbmc samples as biomarker for disease

Info

Publication number
SG11202011592SA
SG11202011592SA SG11202011592SA SG11202011592SA SG11202011592SA SG 11202011592S A SG11202011592S A SG 11202011592SA SG 11202011592S A SG11202011592S A SG 11202011592SA SG 11202011592S A SG11202011592S A SG 11202011592SA SG 11202011592S A SG11202011592S A SG 11202011592SA
Authority
SG
Singapore
Prior art keywords
biomarker
disease
protein levels
pbmc samples
hsp70 protein
Prior art date
Application number
SG11202011592SA
Other languages
English (en)
Inventor
Linda Ingemann
Jensen Thomas Kirkegaard
Original Assignee
Orphazyme As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orphazyme As filed Critical Orphazyme As
Publication of SG11202011592SA publication Critical patent/SG11202011592SA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/133—Amines having hydroxy groups, e.g. sphingosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/50—Determining the risk of developing a disease
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/56—Staging of a disease; Further complications associated with the disease

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Cell Biology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG11202011592SA 2018-05-28 2019-05-28 Hsp70 protein levels in pbmc samples as biomarker for disease SG11202011592SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP18174576 2018-05-28
PCT/EP2019/063854 WO2019229078A1 (fr) 2018-05-28 2019-05-28 Taux de protéine hsp70 dans des échantillons de pbmc en tant que biomarqueur d'une maladie

Publications (1)

Publication Number Publication Date
SG11202011592SA true SG11202011592SA (en) 2020-12-30

Family

ID=62455375

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011592SA SG11202011592SA (en) 2018-05-28 2019-05-28 Hsp70 protein levels in pbmc samples as biomarker for disease

Country Status (12)

Country Link
US (1) US20210164997A1 (fr)
EP (1) EP3803406A1 (fr)
JP (1) JP2021525864A (fr)
KR (1) KR20210015790A (fr)
CN (1) CN112166326A (fr)
AU (1) AU2019276048A1 (fr)
BR (1) BR112020024182A2 (fr)
CA (1) CA3101241A1 (fr)
IL (1) IL278937A (fr)
MX (1) MX2020012480A (fr)
SG (1) SG11202011592SA (fr)
WO (1) WO2019229078A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4124861A1 (fr) 2021-07-31 2023-02-01 Deutsches Zentrum für Neurodegenerative Erkrankungen e.V. (DZNE) Phénotypes des cellules mononucléaires du sang périphérique (pbmc) en tant que biomarqueurs pour des patients atteints de la maladie d'alzheimer et/ou de troubles cognitifs légers (mci)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222994B1 (hu) 1995-11-02 2004-01-28 BIOREX Kutató és Fejlesztő Rt. Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HU226617B1 (en) 1998-12-14 2009-04-28 Cytrx Corp Optically active pyridyl-4h-1,2,4-oxadiazine derivatives, and pharmaceutical composition containing the compound as active ingredient
HUP9900475D0 (en) 1999-02-26 1999-04-28 Biorex Kutato Fejlesztoe Kft O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
PL2318032T3 (pl) * 2008-06-26 2012-08-31 Orphazyme Aps Zastosowanie hsp70 jako regulatora aktywności enzymatycznej
US9662375B2 (en) * 2010-11-30 2017-05-30 Orphazyme Aps Methods for increasing intracellular activity of Hsp70
CA2847839A1 (fr) * 2011-09-07 2013-03-14 Genway Biotech, Inc. Dosage de diagnostic pour la prediction d'un risque cardiovasculaire

Also Published As

Publication number Publication date
CA3101241A1 (fr) 2019-12-05
BR112020024182A2 (pt) 2021-03-30
IL278937A (en) 2021-01-31
CN112166326A (zh) 2021-01-01
AU2019276048A1 (en) 2021-01-21
WO2019229078A1 (fr) 2019-12-05
MX2020012480A (es) 2021-03-25
JP2021525864A (ja) 2021-09-27
KR20210015790A (ko) 2021-02-10
EP3803406A1 (fr) 2021-04-14
US20210164997A1 (en) 2021-06-03

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