SG11202011394WA - Device, system and method for direct electrical measurement of enzyme activity - Google Patents

Device, system and method for direct electrical measurement of enzyme activity

Info

Publication number
SG11202011394WA
SG11202011394WA SG11202011394WA SG11202011394WA SG11202011394WA SG 11202011394W A SG11202011394W A SG 11202011394WA SG 11202011394W A SG11202011394W A SG 11202011394WA SG 11202011394W A SG11202011394W A SG 11202011394WA SG 11202011394W A SG11202011394W A SG 11202011394WA
Authority
SG
Singapore
Prior art keywords
enzyme activity
direct electrical
electrical measurement
measurement
direct
Prior art date
Application number
SG11202011394WA
Inventor
Stuart Lindsay
Peiming Zhang
Original Assignee
Stuart Lindsay
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stuart Lindsay filed Critical Stuart Lindsay
Publication of SG11202011394WA publication Critical patent/SG11202011394WA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/48707Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48721Investigating individual macromolecules, e.g. by translocation through nanopores
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001Enzyme electrodes
    • C12Q1/005Enzyme electrodes involving specific analytes or enzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869Methods for sequencing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403Cells and electrode assemblies
    • G01N27/414Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438Electrodes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00Reactions demanding special reaction conditions
    • C12Q2527/146Concentration of target or template

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Cell Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
SG11202011394WA 2018-05-17 2019-05-16 Device, system and method for direct electrical measurement of enzyme activity SG11202011394WA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201862673080P 2018-05-17 2018-05-17
US201862682991P 2018-06-10 2018-06-10
US201962812312P 2019-03-01 2019-03-01
PCT/US2019/032707 WO2019222527A1 (en) 2018-05-17 2019-05-16 Device, system and method for direct electrical measurement of enzyme activity

Publications (1)

Publication Number Publication Date
SG11202011394WA true SG11202011394WA (en) 2020-12-30

Family

ID=68540979

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202011394WA SG11202011394WA (en) 2018-05-17 2019-05-16 Device, system and method for direct electrical measurement of enzyme activity

Country Status (12)

Country Link
US (1) US11808755B2 (en)
EP (1) EP3793721A4 (en)
JP (1) JP7433300B2 (en)
KR (1) KR20210045361A (en)
CN (1) CN112384296B (en)
AU (1) AU2019269615B2 (en)
BR (1) BR112020023494A2 (en)
CA (1) CA3100693A1 (en)
IL (1) IL278769A (en)
MX (1) MX2020012329A (en)
SG (1) SG11202011394WA (en)
WO (1) WO2019222527A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3793721A4 (en) 2018-05-17 2022-07-20 Recognition Analytix, Inc. Device, system and method for direct electrical measurement of enzyme activity
MX2021009150A (en) * 2019-01-30 2021-12-10 Univ Arizona State Bioelectronic circuits, systems and methods for preparing and using them.
KR20220147602A (en) 2020-02-28 2022-11-03 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 How to sequence biopolymers
CN115605612A (en) * 2020-03-25 2023-01-13 通用测序技术公司(Us) Enzyme mutants directly connected to nanogap devices
EP4136256A1 (en) * 2020-04-17 2023-02-22 Arizona Board of Regents on behalf of Arizona State University Single-molecule electronic sequence detector and methods of use
JP2023524079A (en) * 2020-04-30 2023-06-08 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティー Method for sequencing biopolymers
WO2022139886A1 (en) * 2020-12-21 2022-06-30 Roswell Biotechnologies, Inc. Crispr enzyme circuits for molecular electronic sensors
WO2022260963A1 (en) * 2021-06-07 2022-12-15 Arizona Board Of Regents On Behalf Of Arizona State University Methods for sequencing biopolymers

Family Cites Families (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5198543A (en) * 1989-03-24 1993-03-30 Consejo Superior Investigaciones Cientificas PHI29 DNA polymerase
EP1040349B2 (en) * 1997-12-17 2012-12-19 Ecole Polytechnique Federale De Lausanne (Epfl) Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers
US7015047B2 (en) 2001-01-26 2006-03-21 Aviva Biosciences Corporation Microdevices having a preferential axis of magnetization and uses thereof
US6824974B2 (en) 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
JP4355214B2 (en) * 2001-07-30 2009-10-28 メソ スケイル テクノロジーズ,エルエルシー Electrode for assay having immobilized lipid / protein layer for measurement of luminescence test, preparation method thereof, and use thereof
DK1417222T3 (en) 2001-08-07 2010-12-13 Medestea Res & Production S P A Isolated polypeptides based on the neutralizing epitope of the p17 protein from HIV suitable for vaccines as well as neutralizing anti-p17 antibodies that specifically recognize said neutralizing epitope
US7632671B2 (en) 2001-11-29 2009-12-15 Sun-Wing Tong Molecular detection and assay by electrobiochip micro-array
US8078408B2 (en) 2003-08-06 2011-12-13 The Procter & Gamble Company Bridged element for detection of a target substance
US7462452B2 (en) 2004-04-30 2008-12-09 Pacific Biosciences Of California, Inc. Field-switch sequencing
US20070292855A1 (en) * 2005-08-19 2007-12-20 Intel Corporation Method and CMOS-based device to analyze molecules and nanomaterials based on the electrical readout of specific binding events on functionalized electrodes
US20070231794A1 (en) * 2005-09-21 2007-10-04 Combimatrix Corporation Process to detect binding events on an electrode microarray using enzymes
US8855955B2 (en) * 2005-09-29 2014-10-07 Custom Array, Inc. Process and apparatus for measuring binding events on a microarray of electrodes
KR100849384B1 (en) 2005-10-21 2008-07-31 한국생명공학연구원 A method for fabricating nanogap and nanogap sensor
EP1951742A4 (en) 2005-10-27 2011-06-01 Life Technologies Corp Optoelectronic separation of biomolecules
WO2008124706A2 (en) 2007-04-06 2008-10-16 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Devices and methods for target molecule characterization
AT505495A1 (en) 2007-07-04 2009-01-15 Arc Austrian Res Centers Gmbh METHOD FOR IDENTIFYING AND QUANTIFYING ORGANIC AND BIOCHEMICAL SUBSTANCES
US8865179B2 (en) 2008-01-26 2014-10-21 Swey-Shen Alexchen Aptameric IgE peptides in a protein scaffold as an allergy vaccine
US8961757B2 (en) 2008-03-18 2015-02-24 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Nanopore and carbon nanotube based DNA sequencer
WO2009117522A2 (en) 2008-03-18 2009-09-24 Reinhart, Kevin Nanopore and carbon nanotube based dna sequencer and a serial recognition sequencer
CN102066945A (en) 2008-06-19 2011-05-18 科技研究局 Modulators of STAT3 signalling
WO2010042514A1 (en) 2008-10-06 2010-04-15 Arizona Board Of Regents Nanopore and carbon nanotube based dna sequencer and a serial recognition elements
US8669079B2 (en) 2008-11-12 2014-03-11 Cara Therapeutics, Inc. Methods for genetic analysis of textiles made of Gossypium barbadense and Gossypium hirsutum cotton
US8715981B2 (en) 2009-01-27 2014-05-06 Purdue Research Foundation Electrochemical biosensor
US20100219085A1 (en) * 2009-02-27 2010-09-02 Edwards Lifesciences Corporation Analyte Sensor Offset Normalization
US9376713B2 (en) 2009-09-23 2016-06-28 The Board Of Trustees Of The University Of Illinois Label free detection of nucleic acid amplification
CA2773101C (en) 2010-02-02 2018-08-21 Arizona Board Of Regents Controlled tunnel gap device for sequencing polymers
JP4963000B2 (en) * 2010-06-15 2012-06-27 株式会社第一興商 Rapid and sensitive molecular detection and quantification method using power-generating enzyme by charge measurement, and detection unit and apparatus for use in the method
WO2011159942A1 (en) 2010-06-18 2011-12-22 Illumina, Inc. Conformational probes and methods for sequencing nucleic acids
WO2013038272A2 (en) 2011-09-13 2013-03-21 Uti Limited Partnership Streptavidin mutein exhibiting reversible binding for biotin and streptavidin binding peptide tagged proteins
WO2013056241A2 (en) 2011-10-14 2013-04-18 Pacific Biosciences Of California, Inc. Real-time redox sequencing
US20140231274A1 (en) * 2011-11-22 2014-08-21 Panasonic Corporation Single molecule detection method and single molecule detection apparatus for biological molecule, and disease marker testing apparatus
US10093975B2 (en) * 2011-12-01 2018-10-09 Genapsys, Inc. Systems and methods for high efficiency electronic sequencing and detection
WO2013116509A1 (en) 2012-02-01 2013-08-08 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Systems, apparatuses and methods for reading an amino acid sequence
US20150142327A1 (en) 2012-03-28 2015-05-21 Arizona Board Of Regents On Behalf Of Arizona State University Method for improving the accuracy of chemical identification in a recognition-tunneling junction
EP2834374A4 (en) 2012-04-04 2016-04-06 Univ Arizona Electrodes for sensing chemical composition
EP2836604B1 (en) 2012-04-09 2021-09-15 The Trustees of Columbia University in the City of New York Method of preparation of nanopore and uses thereof
WO2013180819A1 (en) 2012-06-01 2013-12-05 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University System, method and device for analysis of carbohydrates
EP2864502B1 (en) 2012-06-20 2019-10-23 The Trustees of Columbia University in the City of New York Nucleic acid sequencing by nanopore detection of tag molecules
TWI492384B (en) * 2012-08-17 2015-07-11 Univ Nat Chiao Tung Protein transistor devic
WO2014049142A1 (en) 2012-09-27 2014-04-03 Technische Universiteit Eindhoven Switchable reporter enzymes for homogenous antibody detection
EP2906720A4 (en) 2012-10-10 2016-06-01 Univ Arizona Systems and devices for molecule sensing and method of manufacturing thereof
US9605309B2 (en) * 2012-11-09 2017-03-28 Genia Technologies, Inc. Nucleic acid sequencing using tags
EP3462167A1 (en) 2013-03-05 2019-04-03 Arizona Board of Regents on behalf of Arizona State University Translocation of a polymer through a nanopore
EP2971180A4 (en) 2013-03-13 2016-11-23 Univ Arizona State Systems, devices and methods for translocation control
WO2014182630A1 (en) * 2013-05-06 2014-11-13 Pacific Biosciences Of California , Inc. Real-time electronic sequencing
WO2014190299A2 (en) 2013-05-23 2014-11-27 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Chemistry, systems and methods of translocation of a polymer through a nanopore
WO2014190322A2 (en) * 2013-05-24 2014-11-27 Quantapore, Inc. Nanopore-based nucleic acid analysis with mixed fret detection
WO2014194246A1 (en) 2013-05-30 2014-12-04 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Universal reader molecule for recognition tunneling
TW201502276A (en) 2013-07-09 2015-01-16 Univ Nat Chiao Tung Sequencing method for label-free single molecular nucleic acid
US9981997B2 (en) 2013-10-31 2018-05-29 Arizona Board Of Regents On Behalf Of Arizona State University Chemical reagents for attaching affinity molecules on surfaces
US10156572B2 (en) 2014-02-18 2018-12-18 Arizona Board Of Regents On Behalf Of Arizona State University Three arm Y-shaped bisbiotin ligand
WO2015130781A1 (en) 2014-02-25 2015-09-03 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Methods, apparatuses and systems for stabilizing nano-electronic devices in contact with solutions
WO2015131073A1 (en) 2014-02-27 2015-09-03 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Triazole-based reader molecules and methods for synthesizing and use thereof
US10145846B2 (en) * 2014-04-16 2018-12-04 Arizona Board Of Regents On Behalf Of Arizona State University Digital protein sensing chip and methods for detection of low concentrations of molecules
US10287257B2 (en) 2014-05-07 2019-05-14 Arizona Board Of Regents On Behalf Of Arizona State University Linker molecule for multiplex recognition by atomic force microscopy (AFM)
WO2015170784A1 (en) 2014-05-08 2015-11-12 Osaka University Nanogap electrodes with dissimilar materials
CN104359946B (en) * 2014-10-23 2017-05-31 北京大学 It is a kind of that device is sequenced to the monomolecular nucleic acid of electrode based on nanometer
US20160194698A1 (en) 2014-12-16 2016-07-07 Arizona Board Of Regents On Behalf Of Arizona State University Systems, apparatuses and methods for reading polymer sequence
US20160177383A1 (en) 2014-12-16 2016-06-23 Arizona Board Of Regents On Behalf Of Arizona State University Nanochannel with integrated tunnel gap
CN109517878A (en) * 2014-12-18 2019-03-26 加利福尼亚大学董事会 Use the detection of the nucleic acid polymerase conformation change of nanotube
CN107849738B (en) 2015-02-16 2021-03-16 密执安州立大学董事会 Systems and methods for performing immunoassays
TWI534426B (en) 2015-03-27 2016-05-21 國立清華大學 A method for biological detection
JP6487251B2 (en) 2015-03-30 2019-03-20 シーシーアイホールディングス株式会社 Biosensor
ES2870989T3 (en) * 2015-04-03 2021-10-28 Abbott Lab Devices and methods for sample analysis
CA2981512A1 (en) * 2015-04-03 2016-10-06 Abbott Laboratories Devices and methods for sample analysis
WO2016206593A1 (en) 2015-06-23 2016-12-29 深圳华大基因研究院 Micro-porous electrode and method for analysis of chemical substances
CN108027335B (en) * 2015-06-25 2021-05-04 罗斯韦尔生物技术股份有限公司 Biomolecule sensor and method
EP3332032B1 (en) 2015-08-06 2023-12-27 Pacific Biosciences Of California, Inc. Integrated circuits for selectively addressing sparsely arranged electronic measurement devices
WO2017084998A1 (en) 2015-11-16 2017-05-26 Qiagen Instruments Ag Calibration probe and method for calibrating an electronic device
US10379102B2 (en) 2015-12-11 2019-08-13 Arizona Board Of Regents On Behalf Of Arizona State University System and method for single molecule detection
US10422787B2 (en) * 2015-12-11 2019-09-24 Arizona Board Of Regents On Behalf Of Arizona State University System and method for single molecule detection
CN109416334B (en) * 2016-01-14 2021-11-16 罗斯韦尔生物技术股份有限公司 Molecular sensors and related methods
ES2877193T3 (en) * 2016-04-27 2021-11-16 Quantum Biosystems Inc Systems and methods for the measurement and sequencing of biomolecules
EP3491150A4 (en) 2016-08-01 2020-03-11 Roswell Biotechnologies, Inc Modified nucleotide triphosphates for molecular electronic sensors
CN106244712B (en) 2016-08-31 2019-11-19 北京大学 DNA sequencing method
US10508296B2 (en) 2017-04-25 2019-12-17 Roswell Biotechnologies, Inc. Enzymatic circuits for molecular sensors
US11905552B2 (en) 2017-08-04 2024-02-20 Keck Graduate Institute Of Applied Life Sciences Immobilized RNPs for sequence-specific nucleic acid capture and digital detection
US11131646B2 (en) 2017-11-03 2021-09-28 Robert Bosch Gmbh Electrochemical sequencing of DNA using an edge electrode
US20190234902A1 (en) 2018-01-26 2019-08-01 Ndsu Research Foundation Method for detecting analytes using dielectrophoresis related applications
GB2573323A (en) 2018-05-03 2019-11-06 Mursia Ltd Biosensor method and system
EP3791179A4 (en) 2018-05-09 2022-01-26 Arizona Board of Regents on behalf of Arizona State University Method for electronic detection and quantification of antibodies
EP3793721A4 (en) 2018-05-17 2022-07-20 Recognition Analytix, Inc. Device, system and method for direct electrical measurement of enzyme activity
MX2021009150A (en) 2019-01-30 2021-12-10 Univ Arizona State Bioelectronic circuits, systems and methods for preparing and using them.
WO2020257654A1 (en) 2019-06-20 2020-12-24 Arizona Board Of Regents On Behalf Of Arizona State University Direct electrical readout of nucleic acid sequences
KR20220137670A (en) 2020-02-12 2022-10-12 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 Electronic Conductivity in Bioelectronic Devices and Systems
KR20220147602A (en) 2020-02-28 2022-11-03 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 How to sequence biopolymers
JP2023524079A (en) 2020-04-30 2023-06-08 アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティー Method for sequencing biopolymers

Also Published As

Publication number Publication date
CN112384296A (en) 2021-02-19
IL278769A (en) 2021-01-31
EP3793721A4 (en) 2022-07-20
AU2019269615B2 (en) 2023-04-06
WO2019222527A1 (en) 2019-11-21
AU2019269615A1 (en) 2021-01-14
JP2021524281A (en) 2021-09-13
EP3793721A1 (en) 2021-03-24
US20210208127A1 (en) 2021-07-08
KR20210045361A (en) 2021-04-26
CN112384296B (en) 2023-06-27
MX2020012329A (en) 2021-03-09
BR112020023494A2 (en) 2021-03-30
CA3100693A1 (en) 2019-11-21
US11808755B2 (en) 2023-11-07
JP7433300B2 (en) 2024-02-19

Similar Documents

Publication Publication Date Title
IL278769A (en) Device, system and method for direct electrical measurement of enzyme activity
IL278230A (en) System and method for using v2x and sensor data
SG11202005455YA (en) Active/inactive state detection method and apparatus
EP3796509A4 (en) Battery system, and method for detecting state of health of battery
EP3460431A4 (en) Stress measurement device, stress measurement system, and stress measurement method
EP3257013A4 (en) System and method for activity monitoring
EP3694615A4 (en) Method and apparatus for an activity environment generator
GB201807293D0 (en) Biosensor method and system
IL289079A (en) Method and system for measuring eeg signals
EP3574829A4 (en) Activity state analysis device and method
SG10201501052XA (en) Method And System For Monitoring Activity Of An Animal
EP3561468A4 (en) Stress measurement method, stress measurement device, and stress measurement system
GB2574697B (en) Method, system and device of obtaining 3D-information of objects
ZA202100620B (en) System and method for detecting and identifying power line carrier controlled devices within an irrigation system
IL284467A (en) Cell processing device, cell processing system and methods of use thereof
IL258470A (en) System and method for monitoring glucose level
GB201715910D0 (en) Neural probe interface system and method
EP3258404A4 (en) Method and system for health condition analysis on the basis of elasticity detection device
GB2570558B (en) Method and system for monitoring the mass of an object
EP3337381A4 (en) Method and system for cognitive function testing
ZA202100422B (en) System and method for moisture measurement
EP3254269A4 (en) Semi-automated system and method for assessment of responses
GB201901644D0 (en) Testing system and method
GB201821088D0 (en) Vaping monitor system and method
EP3709493A4 (en) Test system and test method for power conversion device