SG11202009680XA - Use of fubp1 inhibitors for treating hepatitis b virus infection - Google Patents
Use of fubp1 inhibitors for treating hepatitis b virus infectionInfo
- Publication number
- SG11202009680XA SG11202009680XA SG11202009680XA SG11202009680XA SG11202009680XA SG 11202009680X A SG11202009680X A SG 11202009680XA SG 11202009680X A SG11202009680X A SG 11202009680XA SG 11202009680X A SG11202009680X A SG 11202009680XA SG 11202009680X A SG11202009680X A SG 11202009680XA
- Authority
- SG
- Singapore
- Prior art keywords
- virus infection
- treating hepatitis
- fubp1
- inhibitors
- fubp1 inhibitors
- Prior art date
Links
- 208000002672 hepatitis B Diseases 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/549—Sugars, nucleosides, nucleotides or nucleic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP18165897 | 2018-04-05 | ||
| PCT/EP2019/058664 WO2019193165A1 (en) | 2018-04-05 | 2019-04-05 | Use of fubp1 inhibitors for treating hepatitis b virus infection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202009680XA true SG11202009680XA (en) | 2020-10-29 |
Family
ID=61911421
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202009680XA SG11202009680XA (en) | 2018-04-05 | 2019-04-05 | Use of fubp1 inhibitors for treating hepatitis b virus infection |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US11732262B2 (de) |
| EP (1) | EP3775208A1 (de) |
| JP (1) | JP2021520387A (de) |
| KR (1) | KR20200140853A (de) |
| CN (1) | CN112055749A (de) |
| AU (1) | AU2019247645A1 (de) |
| BR (1) | BR112020020220A8 (de) |
| CA (1) | CA3097544A1 (de) |
| CL (1) | CL2020002563A1 (de) |
| CR (1) | CR20200453A (de) |
| IL (1) | IL277745A (de) |
| MA (1) | MA52661A (de) |
| MX (1) | MX2020010383A (de) |
| PE (1) | PE20211912A1 (de) |
| RU (1) | RU2020135289A (de) |
| SG (1) | SG11202009680XA (de) |
| TW (1) | TW202006138A (de) |
| WO (1) | WO2019193165A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112055749A (zh) | 2018-04-05 | 2020-12-08 | 豪夫迈·罗氏有限公司 | Fubp1抑制剂用于治疗乙型肝炎病毒感染的用途 |
| EP4077668A1 (de) * | 2019-12-19 | 2022-10-26 | F. Hoffmann-La Roche AG | Verwendung von scamp3-inhibitoren zum behandeln von hepatitis-b-virus-infektionen |
| AR122731A1 (es) | 2020-06-26 | 2022-10-05 | Hoffmann La Roche | Oligonucleótidos mejorados para modular la expresión de fubp1 |
| EP4200419A2 (de) * | 2020-08-21 | 2023-06-28 | F. Hoffmann-La Roche AG | Verwendung von a1cf-inhibitoren zur behandlung von hepatitis-b-virusinfektionen |
| WO2023111210A1 (en) | 2021-12-17 | 2023-06-22 | F. Hoffmann-La Roche Ag | Combination of oligonucleotides for modulating rtel1 and fubp1 |
| CN115851725A (zh) * | 2022-10-28 | 2023-03-28 | 珠海市人民医院 | 一种抑制解螺旋酶Ⅴ基因表达的siRNA及其应用 |
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| DE69829760T3 (de) | 1997-09-12 | 2016-04-14 | Exiqon A/S | Bi- und tri-zyklische - nukleosid, nukleotid und oligonukleotid-analoga |
| NZ513402A (en) | 1999-02-12 | 2003-06-30 | Sankyo Co | Novel nucleosides and oligonucleotide analogues |
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| MA45496A (fr) | 2016-06-17 | 2019-04-24 | Hoffmann La Roche | Molécules d'acide nucléique pour la réduction de l'arnm de padd5 ou pad7 pour le traitement d'une infection par l'hépatite b |
| CN112055749A (zh) | 2018-04-05 | 2020-12-08 | 豪夫迈·罗氏有限公司 | Fubp1抑制剂用于治疗乙型肝炎病毒感染的用途 |
-
2019
- 2019-04-05 CN CN201980023565.2A patent/CN112055749A/zh active Pending
- 2019-04-05 WO PCT/EP2019/058664 patent/WO2019193165A1/en active Application Filing
- 2019-04-05 RU RU2020135289A patent/RU2020135289A/ru unknown
- 2019-04-05 AU AU2019247645A patent/AU2019247645A1/en active Pending
- 2019-04-05 EP EP19714455.3A patent/EP3775208A1/de active Pending
- 2019-04-05 CA CA3097544A patent/CA3097544A1/en active Pending
- 2019-04-05 KR KR1020207031603A patent/KR20200140853A/ko active Search and Examination
- 2019-04-05 PE PE2020001470A patent/PE20211912A1/es unknown
- 2019-04-05 SG SG11202009680XA patent/SG11202009680XA/en unknown
- 2019-04-05 JP JP2020554482A patent/JP2021520387A/ja active Pending
- 2019-04-05 BR BR112020020220A patent/BR112020020220A8/pt unknown
- 2019-04-05 CR CR20200453A patent/CR20200453A/es unknown
- 2019-04-05 MA MA052661A patent/MA52661A/fr unknown
- 2019-04-05 MX MX2020010383A patent/MX2020010383A/es unknown
- 2019-04-08 TW TW108112210A patent/TW202006138A/zh unknown
-
2020
- 2020-10-01 IL IL277745A patent/IL277745A/en unknown
- 2020-10-02 CL CL2020002563A patent/CL2020002563A1/es unknown
- 2020-10-05 US US17/063,610 patent/US11732262B2/en active Active
-
2023
- 2023-06-23 US US18/340,054 patent/US20240150758A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2021520387A (ja) | 2021-08-19 |
| MA52661A (fr) | 2021-02-17 |
| CA3097544A1 (en) | 2019-10-10 |
| IL277745A (en) | 2020-11-30 |
| CL2020002563A1 (es) | 2021-05-07 |
| US20240150758A1 (en) | 2024-05-09 |
| CR20200453A (es) | 2021-03-02 |
| CN112055749A (zh) | 2020-12-08 |
| US11732262B2 (en) | 2023-08-22 |
| KR20200140853A (ko) | 2020-12-16 |
| AU2019247645A1 (en) | 2020-10-15 |
| WO2019193165A1 (en) | 2019-10-10 |
| BR112020020220A2 (pt) | 2021-01-19 |
| RU2020135289A (ru) | 2022-05-05 |
| US20210024934A1 (en) | 2021-01-28 |
| EP3775208A1 (de) | 2021-02-17 |
| MX2020010383A (es) | 2020-12-10 |
| BR112020020220A8 (pt) | 2021-02-17 |
| PE20211912A1 (es) | 2021-09-28 |
| TW202006138A (zh) | 2020-02-01 |
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