SG11202009581TA - Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds - Google Patents

Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds

Info

Publication number
SG11202009581TA
SG11202009581TA SG11202009581TA SG11202009581TA SG11202009581TA SG 11202009581T A SG11202009581T A SG 11202009581TA SG 11202009581T A SG11202009581T A SG 11202009581TA SG 11202009581T A SG11202009581T A SG 11202009581TA SG 11202009581T A SG11202009581T A SG 11202009581TA
Authority
SG
Singapore
Prior art keywords
biopharmaceutical
feeds
target proteins
low salt
chromatography media
Prior art date
Application number
SG11202009581TA
Inventor
Matthew T Stone
Romas Skudas
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11202009581TA publication Critical patent/SG11202009581TA/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SG11202009581TA 2018-04-03 2019-03-26 Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds SG11202009581TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862651878P 2018-04-03 2018-04-03
PCT/EP2019/057497 WO2019192877A1 (en) 2018-04-03 2019-03-26 Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds

Publications (1)

Publication Number Publication Date
SG11202009581TA true SG11202009581TA (en) 2020-10-29

Family

ID=65955215

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009581TA SG11202009581TA (en) 2018-04-03 2019-03-26 Cex chromatography media and low salt elution of target proteins from biopharmaceutical feeds

Country Status (8)

Country Link
US (1) US20210024573A1 (en)
EP (1) EP3773969A1 (en)
JP (1) JP2021519339A (en)
KR (1) KR20200138346A (en)
CN (1) CN112105430A (en)
CA (1) CA3095850A1 (en)
SG (1) SG11202009581TA (en)
WO (1) WO2019192877A1 (en)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ547315A (en) 2003-10-27 2008-07-31 Wyeth Corp
TWI391399B (en) * 2005-05-25 2013-04-01 Hoffmann La Roche Method for determining the concentration of a salt for eluting a polypeptide
CA2687930C (en) * 2007-05-25 2016-05-17 Merck Patent Gesellschaft Mit Beschraenkter Haftung Graft copolymers for cation exchange chromatography
KR101226353B1 (en) * 2007-06-01 2013-01-24 에프. 호프만-라 로슈 아게 Immunoglobulin purification
EP2285485B1 (en) * 2008-05-30 2014-04-23 Merck Patent GmbH Ce(iv)-initiated graft polymerization on polymers not containing hydroxyl groups
EP2153877A1 (en) * 2008-07-30 2010-02-17 MERCK PATENT GmbH Mixed graft polymers for ion exchange chromatography
CN104801204B (en) * 2009-02-27 2019-01-01 Emd密理博公司 For removing the film with sulfonic acid group of protein aggregate
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
EP2598223B1 (en) * 2010-07-30 2022-04-06 EMD Millipore Corporation Chromatography media and method
SG10201701224UA (en) * 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode
WO2013180647A1 (en) * 2012-05-31 2013-12-05 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
US20150266919A1 (en) * 2012-10-18 2015-09-24 Jnc Corporation Cation exchange chromatography carrier for refining of antibodies, and method for separation of antibody monomers from polymers thereof produced in antibody drug manufacturing process
EP3160611A4 (en) * 2014-06-25 2018-02-28 JHL Biotech, Inc. Methods and reagents for purification of proteins

Also Published As

Publication number Publication date
US20210024573A1 (en) 2021-01-28
WO2019192877A1 (en) 2019-10-10
EP3773969A1 (en) 2021-02-17
CN112105430A (en) 2020-12-18
CA3095850A1 (en) 2019-10-10
KR20200138346A (en) 2020-12-09
JP2021519339A (en) 2021-08-10

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