SG11202009213TA - Separation of vwf and vwf propeptide by chromatographic methods - Google Patents

Separation of vwf and vwf propeptide by chromatographic methods

Info

Publication number
SG11202009213TA
SG11202009213TA SG11202009213TA SG11202009213TA SG11202009213TA SG 11202009213T A SG11202009213T A SG 11202009213TA SG 11202009213T A SG11202009213T A SG 11202009213TA SG 11202009213T A SG11202009213T A SG 11202009213TA SG 11202009213T A SG11202009213T A SG 11202009213TA
Authority
SG
Singapore
Prior art keywords
vwf
separation
propeptide
chromatographic methods
chromatographic
Prior art date
Application number
SG11202009213TA
Inventor
Christian Fiedler
Meinhard Hasslacher
Christa Mayer
Original Assignee
Baxalta Inc
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Inc, Baxalta GmbH filed Critical Baxalta Inc
Publication of SG11202009213TA publication Critical patent/SG11202009213TA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/34—Size selective separation, e.g. size exclusion chromatography, gel filtration, permeation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G, L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
SG11202009213TA 2018-03-21 2019-03-20 Separation of vwf and vwf propeptide by chromatographic methods SG11202009213TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862646109P 2018-03-21 2018-03-21
PCT/US2019/023269 WO2019183290A1 (en) 2018-03-21 2019-03-20 Separation of vwf and vwf propeptide by chromatographic methods

Publications (1)

Publication Number Publication Date
SG11202009213TA true SG11202009213TA (en) 2020-10-29

Family

ID=66223800

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202009213TA SG11202009213TA (en) 2018-03-21 2019-03-20 Separation of vwf and vwf propeptide by chromatographic methods

Country Status (14)

Country Link
US (2) US10934340B2 (en)
EP (1) EP3768697A1 (en)
JP (2) JP2021519280A (en)
KR (1) KR20200144547A (en)
CN (1) CN112533940A (en)
AU (1) AU2019240135A1 (en)
BR (1) BR112020019057A2 (en)
CA (1) CA3094644A1 (en)
CO (1) CO2020013056A2 (en)
EA (1) EA202092223A1 (en)
IL (1) IL277464A (en)
MX (1) MX2020009788A (en)
SG (1) SG11202009213TA (en)
WO (1) WO2019183290A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110225757A (en) * 2017-01-31 2019-09-10 默沙东公司 By the method for S. pneumoniae serotypes 19F production capsular polysaccharide protein conjugate
CN115698245A (en) * 2020-01-27 2023-02-03 百时美施贵宝公司 Isoelectric focusing sample matrix

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US3941763A (en) 1975-03-28 1976-03-02 American Home Products Corporation PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4361509A (en) 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
WO1986006096A1 (en) 1985-04-11 1986-10-23 The Children's Medical Center Corporation Von willebrand factor
US8597910B1 (en) 1985-04-11 2013-12-03 Children's Medical Center Corporation DNA encoding Von Willebrand Factor (VWF) and methods and cells for producing VFW, and VFW produced by the DNA, methods and cells
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE).
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
JPH06502541A (en) * 1990-10-17 1994-03-24 ザ スクリップス リサーチ インスティテュート Von Willebrand factor therapeutic fragment
US6190609B1 (en) 1996-11-19 2001-02-20 Baxter International Inc. Methods and apparatus for inactivating contaminants in biological fluid
AT405403B (en) 1997-02-27 1999-08-25 Immuno Ag CLEANING OF WILLEBRAND FACTOR BY CATION EXCHANGER CHROMATOGRAPHY
AT406867B (en) 1997-02-27 2000-10-25 Immuno Ag METHOD FOR OBTAINING HIGH PURITY VWF OR FACTOR VIII / VWF COMPLEX
AT405485B (en) 1997-05-28 1999-08-25 Immuno Ag A PHARMACEUTICAL PREPARATION CONTAINING THE VWF PROPEPTIDE
AT407750B (en) * 1999-02-19 2001-05-25 Immuno Ag METHOD FOR PRODUCING A VWF PREPARATION
WO2004039337A2 (en) 2002-10-31 2004-05-13 Protein Design Labs, Inc. Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization
US20060094104A1 (en) 2004-10-29 2006-05-04 Leopold Grillberger Animal protein-free media for cultivation of cells
MX2007007877A (en) 2004-12-27 2007-08-21 Baxter Int Polymer-von willebrand factor-conjugates.
RU2486236C2 (en) 2006-01-04 2013-06-27 Бакстер Интернэшнл Инк. Method of protein expression
US7559509B1 (en) 2007-02-12 2009-07-14 Thomas C. Taylor Large cryogenic tank logistics for in-space vehicles
PT2152735E (en) * 2007-05-18 2015-07-21 Baxter Int Method for producing mature vwf from vwf pro-peptide
NZ586383A (en) * 2007-12-28 2012-11-30 Baxter Int Recombinant vwf formulations
BRPI0919693A2 (en) 2008-10-21 2020-08-11 Baxter Healthcare S.A lyophilized stable pharmaceutical formulation
CN106008697B (en) * 2009-08-20 2020-08-04 百深公司 Purification of vwf to increase removal of non-lipid encapsulated viruses
PL3715356T3 (en) * 2009-12-18 2024-03-11 Csl Limited Method of purifying polypeptides
PL2591094T3 (en) 2010-07-08 2019-02-28 Baxalta GmbH Method of producing recombinant adamts13 in cell culture
SG191184A1 (en) 2010-12-15 2013-07-31 Baxter Int Viral inactivation using improved solvent-detergent method
PT3412305T (en) * 2011-06-10 2021-01-29 Baxalta Inc Treatment of coagulation disease by administration of recombinant vwf
KR101908074B1 (en) * 2014-01-20 2018-10-15 옥타파마 아게 A process for manufacturing Factor VIII having an improved ratio of FVIII:C/FVIII:Ag
US10626164B2 (en) 2014-07-25 2020-04-21 Csl Limited Purification of VWF
WO2017031476A2 (en) * 2015-08-20 2017-02-23 Genentech, Inc. Purification of fkpa and uses thereof for producing recombinant polypeptides

Also Published As

Publication number Publication date
US20190382467A1 (en) 2019-12-19
WO2019183290A1 (en) 2019-09-26
KR20200144547A (en) 2020-12-29
IL277464A (en) 2020-11-30
AU2019240135A1 (en) 2020-10-22
CA3094644A1 (en) 2019-09-26
US10934340B2 (en) 2021-03-02
EA202092223A1 (en) 2021-02-10
BR112020019057A2 (en) 2020-12-29
JP2024001136A (en) 2024-01-09
MX2020009788A (en) 2020-12-09
CO2020013056A2 (en) 2020-10-30
JP2021519280A (en) 2021-08-10
US20220041693A1 (en) 2022-02-10
EP3768697A1 (en) 2021-01-27
CN112533940A (en) 2021-03-19

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