SG11202004691WA - Complex for genome editing having stability and few side-effects, and nucleic acid coding same - Google Patents
Complex for genome editing having stability and few side-effects, and nucleic acid coding sameInfo
- Publication number
- SG11202004691WA SG11202004691WA SG11202004691WA SG11202004691WA SG11202004691WA SG 11202004691W A SG11202004691W A SG 11202004691WA SG 11202004691W A SG11202004691W A SG 11202004691WA SG 11202004691W A SG11202004691W A SG 11202004691WA SG 11202004691W A SG11202004691W A SG 11202004691WA
- Authority
- SG
- Singapore
- Prior art keywords
- complex
- stability
- effects
- nucleic acid
- genome editing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/102—Mutagenizing nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases RNAses, DNAses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/02—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2) hydrolysing N-glycosyl compounds (3.2.2)
- C12Y302/02027—Uracil-DNA glycosylase (3.2.2.27)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04005—Cytidine deaminase (3.5.4.5)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/95—Fusion polypeptide containing a motif/fusion for degradation (ubiquitin fusions, PEST sequence)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2017225221 | 2017-11-22 | ||
PCT/JP2018/042915 WO2019103020A1 (en) | 2017-11-22 | 2018-11-21 | Complex for genome editing having stability and few side-effects, and nucleic acid coding same |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202004691WA true SG11202004691WA (en) | 2020-06-29 |
Family
ID=66632001
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202004691WA SG11202004691WA (en) | 2017-11-22 | 2018-11-21 | Complex for genome editing having stability and few side-effects, and nucleic acid coding same |
Country Status (9)
Country | Link |
---|---|
US (1) | US20210024906A1 (en) |
EP (1) | EP3715454A4 (en) |
JP (2) | JP7328695B2 (en) |
KR (1) | KR102387830B1 (en) |
CN (1) | CN111615557A (en) |
BR (1) | BR112020010036A2 (en) |
CA (1) | CA3082922C (en) |
SG (1) | SG11202004691WA (en) |
WO (1) | WO2019103020A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110446782B (en) * | 2017-03-22 | 2024-03-01 | 国立大学法人神户大学 | Method for changing target site of DNA of cell and complex for the method |
US20230407339A1 (en) * | 2020-11-06 | 2023-12-21 | The University Of Hong Kong | Transferable type i-f crispr-cas genome editing system |
CN114292831B (en) * | 2021-02-03 | 2023-04-07 | 山东舜丰生物科技有限公司 | Novel Cas enzyme and application |
CN113862274B (en) * | 2021-09-29 | 2023-10-03 | 燕山大学 | Oligonucleotide aptamer APT-D1 for high-specificity recognition of APE1 and preparation method and application thereof |
CN116064429B (en) * | 2022-08-04 | 2023-11-03 | 四川省畜牧科学研究院 | Method for efficiently expressing laccase by recombinant escherichia coli |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8106255B2 (en) | 2002-01-23 | 2012-01-31 | Dana Carroll | Targeted chromosomal mutagenasis using zinc finger nucleases |
JP2013128413A (en) | 2010-03-11 | 2013-07-04 | Kyushu Univ | Method for modifying rna-binding protein using ppr motif |
US9468621B2 (en) | 2011-10-04 | 2016-10-18 | Ihi Corporation | Metal-salen complex compound responsive drug and intra-corporeal behavior control system for metal-salen complex compound |
EP3115457B1 (en) | 2014-03-05 | 2019-10-02 | National University Corporation Kobe University | Genomic sequence modification method for specifically converting nucleic acid bases of targeted dna sequence, and molecular complex for use in same |
US11021718B2 (en) * | 2014-10-01 | 2021-06-01 | The General Hospital Corporation | Methods for increasing efficiency of nuclease-induced homology-directed repair |
WO2016072399A1 (en) | 2014-11-04 | 2016-05-12 | 国立大学法人神戸大学 | Method for modifying genome sequence to introduce specific mutation to targeted dna sequence by base-removal reaction, and molecular complex used therein |
CN104531632A (en) | 2014-11-18 | 2015-04-22 | 李云英 | Rapidly-degraded Cas9-ODC422-461 fusion protein and application thereof |
US20160362667A1 (en) * | 2015-06-10 | 2016-12-15 | Caribou Biosciences, Inc. | CRISPR-Cas Compositions and Methods |
CN108290933A (en) | 2015-06-18 | 2018-07-17 | 布罗德研究所有限公司 | Reduce the CRISPR enzyme mutants of undershooting-effect |
JP6909475B2 (en) | 2016-06-14 | 2021-07-28 | 有限会社メカノトランスフォーマ | How to draw lead wires for actuators and telescopic elements |
WO2018145068A1 (en) * | 2017-02-06 | 2018-08-09 | Trustees Of Boston University | An integrated system for programmable dna methylation |
WO2018226880A1 (en) * | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving escherichia coli |
-
2018
- 2018-11-21 CN CN201880075854.2A patent/CN111615557A/en active Pending
- 2018-11-21 SG SG11202004691WA patent/SG11202004691WA/en unknown
- 2018-11-21 CA CA3082922A patent/CA3082922C/en active Active
- 2018-11-21 JP JP2019555327A patent/JP7328695B2/en active Active
- 2018-11-21 EP EP18882051.8A patent/EP3715454A4/en active Pending
- 2018-11-21 US US16/764,799 patent/US20210024906A1/en active Pending
- 2018-11-21 BR BR112020010036-6A patent/BR112020010036A2/en unknown
- 2018-11-21 KR KR1020207017695A patent/KR102387830B1/en active IP Right Grant
- 2018-11-21 WO PCT/JP2018/042915 patent/WO2019103020A1/en unknown
-
2023
- 2023-07-28 JP JP2023123850A patent/JP2023129709A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
BR112020010036A2 (en) | 2020-10-20 |
KR102387830B1 (en) | 2022-04-18 |
WO2019103020A1 (en) | 2019-05-31 |
JPWO2019103020A1 (en) | 2021-01-21 |
US20210024906A1 (en) | 2021-01-28 |
CA3082922A1 (en) | 2019-05-31 |
EP3715454A1 (en) | 2020-09-30 |
JP7328695B2 (en) | 2023-08-17 |
CA3082922C (en) | 2024-02-13 |
EP3715454A4 (en) | 2021-08-18 |
JP2023129709A (en) | 2023-09-14 |
KR20200091884A (en) | 2020-07-31 |
CN111615557A (en) | 2020-09-01 |
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