SG11202004310YA - A novel one-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazoles - Google Patents
A novel one-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazolesInfo
- Publication number
- SG11202004310YA SG11202004310YA SG11202004310YA SG11202004310YA SG11202004310YA SG 11202004310Y A SG11202004310Y A SG 11202004310YA SG 11202004310Y A SG11202004310Y A SG 11202004310YA SG 11202004310Y A SG11202004310Y A SG 11202004310YA SG 11202004310Y A SG11202004310Y A SG 11202004310YA
- Authority
- SG
- Singapore
- Prior art keywords
- novel
- large scale
- scale manufacture
- homogeneous process
- substituted benzimidazoles
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/08—Radicals containing only hydrogen and carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F11/00—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
- C23F11/08—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids
- C23F11/10—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using organic inhibitors
- C23F11/14—Nitrogen-containing compounds
- C23F11/149—Heterocyclic compounds containing nitrogen as hetero atom
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762585278P | 2017-11-13 | 2017-11-13 | |
| PCT/US2018/059947 WO2019094672A1 (en) | 2017-11-13 | 2018-11-09 | A novel one-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11202004310YA true SG11202004310YA (en) | 2020-06-29 |
Family
ID=64572508
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11202004310YA SG11202004310YA (en) | 2017-11-13 | 2018-11-09 | A novel one-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazoles |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US11053203B2 (en) |
| EP (1) | EP3710436A1 (en) |
| JP (1) | JP2021502401A (en) |
| KR (1) | KR102653426B1 (en) |
| CN (1) | CN111372924B (en) |
| AU (1) | AU2018366253B2 (en) |
| BR (1) | BR112020009285A2 (en) |
| CA (1) | CA3082375A1 (en) |
| MX (1) | MX2020004901A (en) |
| SG (1) | SG11202004310YA (en) |
| TW (1) | TWI823873B (en) |
| WO (1) | WO2019094672A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110776467A (en) * | 2019-10-30 | 2020-02-11 | 西南石油大学 | Corrosion inhibitor based on benzimidazole derivative and preparation method and application thereof |
| EP4127268A1 (en) * | 2020-03-27 | 2023-02-08 | Ecolab Usa Inc. | Galvanized metal corrosion inhibitor compositions and methods of use |
| US20230053321A1 (en) * | 2021-08-02 | 2023-02-16 | Ecolab Usa Inc. | One-pot homogeneous process for the large scale manufacture of 2-substituted benzimidazoles |
| US20230416128A1 (en) | 2022-06-23 | 2023-12-28 | Ecolab Usa Inc. | Method of Inhibiting Corrosion of a Metal in an Industrial Water System |
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| DE1176659B (en) | 1960-12-27 | 1964-08-27 | Beiersdorf & Co A G P | Process for the preparation of 1- (ª ‰ -Diaethyl-amino-ethyl) -2- (ª ‡ -hydroxy-p-methoxy-benzyl) -5-nitro-benzimidazole and its hydrochloride |
| US3784517A (en) * | 1972-06-27 | 1974-01-08 | Us Air Force | Preparation of polybenzimidazoles in the presence of a sulfone solvent |
| US4001268A (en) | 1974-08-07 | 1977-01-04 | The United States Of America As Represented By The Secretary Of The Air Force | Substituted phenyl-benzimidazo compounds |
| DE2900506A1 (en) | 1979-01-08 | 1980-07-17 | Basf Ag | 2-cyanomethyl-benzimidazole prepn. - from 0-phenylenediamine and cyano-acetic acid deriv. without solvent |
| SU819098A1 (en) | 1979-01-17 | 1981-04-07 | Предприятие П/Я Р-6875 | Method of preparing 2-methylbenzimidazole |
| SU1164232A1 (en) | 1983-05-11 | 1985-06-30 | Ферганский политехнический институт | Method of obtaining 2-acetylaminobenzimidazole |
| DE4305714A1 (en) | 1993-02-25 | 1994-09-01 | Hoechst Ag | Process for the preparation of substituted and unsubstituted 2- (cyanomethyl) benzimidazole |
| DE19539114C1 (en) | 1995-10-20 | 1997-04-17 | Hoechst Ag | Process for working up reaction mixtures containing benzimidazolones |
| DE10201725A1 (en) | 2002-01-18 | 2003-08-14 | Boehringer Ingelheim Pharma | Process for the preparation and purification of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole |
| WO2006034418A2 (en) | 2004-09-21 | 2006-03-30 | Athersys, Inc. | Benzimidazole acetic acids exhibiting crth2 receptor antagonism and uses thereof |
| WO2006132625A1 (en) * | 2005-06-03 | 2006-12-14 | Ppg Industries Ohio, Inc. | Composition for the vapor phase dehydrohalogenation of 1,1,2-trihaloethane to 1,1-dihaloethylene and methods for preparing and using such compositions |
| DE102005034279A1 (en) | 2005-07-22 | 2007-01-25 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Preparation of 1,7'-dimethyl-2'-propyl-2,5'-bi-1H-benzimidazole |
| US7834130B2 (en) * | 2007-02-22 | 2010-11-16 | Pbi Performance Products, Inc. | Process for the production of polybenzimidazole from a tetraminobiphenyl and an isophthalic acid |
| WO2009116089A2 (en) | 2008-03-14 | 2009-09-24 | Ipca Laboratories Limited | Novel intermediates and method for synthesis of 4'-[(1,4'-dimethyl-2'-propyl-[2,6'- bi-1hbenzimidazol]-l-yl)methyl]-1,1-biphenyl]-2-carboxylic acid. |
| US8362269B2 (en) | 2008-05-02 | 2013-01-29 | Boehringer Ingelheim International Gmbh | Preparation of 1,7′-dimethyl-2′-propyl-2,5′-bi-1H-benzimidazole |
| CN101891689B (en) | 2010-07-23 | 2012-04-18 | 江苏先声药物研究有限公司 | Preparation method of hydrochloric acid gamma-hydroxy bendamustine |
| WO2012028925A2 (en) | 2010-09-03 | 2012-03-08 | Ogene Systems (I) Pvt Ltd | An improved process for the preparation of telmisartan |
| CN101979383B (en) * | 2010-09-27 | 2012-09-05 | 昆明振华制药厂有限公司 | Method for synthesizing hydrobenzole hydrochloride |
| US20130303781A1 (en) | 2010-11-24 | 2013-11-14 | Sequent Scientific Limited | Process for preparation of triclabendazole |
| CN102050791B (en) | 2010-12-10 | 2012-12-26 | 江苏江神药物化学有限公司 | Key intermediate of telmisartan, synthesis method thereof and method for synthesizing telmisartan by intermediate |
| US8710082B2 (en) * | 2011-02-18 | 2014-04-29 | Board Of Trustees Of Michigan State University | Benzimidazole inhibition of biofilm formation |
| EP3009427B1 (en) * | 2011-03-03 | 2019-12-18 | Zalicus Pharmaceuticals Ltd. | Benzimidazole inhibitors of the sodium channel |
| CN102250021B (en) | 2011-04-27 | 2013-06-05 | 浙江工业大学 | Method for preparing quinoxaline compounds and benzimidazole compounds |
| CN102659686B (en) | 2012-04-11 | 2014-11-26 | 宁波九胜创新医药科技有限公司 | Preparation method of 2-n-propyl-4-methyl-6-(1'-methylbenzimidazolyl-2-yl)benzimidazole |
| CN103145623A (en) | 2012-06-14 | 2013-06-12 | 史慎德 | Method for preparing 2-(((1H-benzo[d]imidazolyl-2-yl)methyl)(1-phenmethyl-1H-benzo[d]imidazolyl-2-yl)amino)acetic acid |
| WO2013189847A1 (en) | 2012-06-19 | 2013-12-27 | Helmut Schickaneder | Bendamustine derivatives and related compounds, and medical use thereof cancer therapy |
| CN102827083A (en) | 2012-08-21 | 2012-12-19 | 江苏恒祥化工有限责任公司 | Preparation method of 2-methylbenzimidazole |
| US20140066629A1 (en) | 2012-08-29 | 2014-03-06 | E I Du Pont De Nemours And Company | Process for the preparation of aromatic azole compounds |
| CN103435551A (en) | 2013-06-28 | 2013-12-11 | 浙江工业大学 | 2-substituted benzimidazole compound preparation method |
| CN103910682B (en) | 2013-11-28 | 2016-03-02 | 大连理工大学 | A kind of benzimidazoles compound preparation method based on O-Phenylene Diamine cyclisation |
| EP2886536A1 (en) | 2013-12-19 | 2015-06-24 | Helmut Schickaneder | Bendamustine derivatives as anti-proliferative agents |
| JP6898255B2 (en) | 2015-05-28 | 2021-07-07 | エコラボ ユーエスエー インコーポレイティド | 2-Substituted imidazole and benzimidazole corrosion inhibitors |
| CN104974096B (en) | 2015-07-07 | 2019-02-01 | 威海迪素制药有限公司 | A kind of preparation method of telmisartan intermediate |
| CN105198819B (en) | 2015-09-23 | 2017-12-15 | 上海泰坦科技股份有限公司 | The synthesis technique of the formaldehyde of benzimidazole 2 |
| US20170152245A1 (en) | 2015-11-26 | 2017-06-01 | National Taiwan University | Benzimidazole compounds and their application in cardiovascular diseases |
| CA3007988A1 (en) | 2015-12-11 | 2017-06-15 | The Board Of Regents Of The University Of Texas System | Substituted benzimidazolium, pyrido-imidazolium, or pyrazino-imidazolium compounds as chemotherapeutics |
-
2018
- 2018-11-09 CA CA3082375A patent/CA3082375A1/en active Pending
- 2018-11-09 AU AU2018366253A patent/AU2018366253B2/en active Active
- 2018-11-09 US US16/185,304 patent/US11053203B2/en active Active
- 2018-11-09 WO PCT/US2018/059947 patent/WO2019094672A1/en active Application Filing
- 2018-11-09 EP EP18812476.2A patent/EP3710436A1/en active Pending
- 2018-11-09 MX MX2020004901A patent/MX2020004901A/en unknown
- 2018-11-09 CN CN201880075983.1A patent/CN111372924B/en active Active
- 2018-11-09 BR BR112020009285-1A patent/BR112020009285A2/en unknown
- 2018-11-09 SG SG11202004310YA patent/SG11202004310YA/en unknown
- 2018-11-09 JP JP2020526295A patent/JP2021502401A/en active Pending
- 2018-11-09 KR KR1020207014944A patent/KR102653426B1/en active IP Right Grant
- 2018-11-13 TW TW107140167A patent/TWI823873B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201922715A (en) | 2019-06-16 |
| JP2021502401A (en) | 2021-01-28 |
| CA3082375A1 (en) | 2019-05-16 |
| AU2018366253B2 (en) | 2024-05-02 |
| US11053203B2 (en) | 2021-07-06 |
| BR112020009285A2 (en) | 2020-10-27 |
| KR20200087779A (en) | 2020-07-21 |
| RU2020119396A (en) | 2021-12-15 |
| CN111372924B (en) | 2023-09-19 |
| EP3710436A1 (en) | 2020-09-23 |
| WO2019094672A1 (en) | 2019-05-16 |
| MX2020004901A (en) | 2020-09-09 |
| US20190144395A1 (en) | 2019-05-16 |
| AU2018366253A1 (en) | 2020-05-21 |
| CN111372924A (en) | 2020-07-03 |
| KR102653426B1 (en) | 2024-03-29 |
| TWI823873B (en) | 2023-12-01 |
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