SG11201911031TA - Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells - Google Patents
Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cellsInfo
- Publication number
- SG11201911031TA SG11201911031TA SG11201911031TA SG11201911031TA SG11201911031TA SG 11201911031T A SG11201911031T A SG 11201911031TA SG 11201911031T A SG11201911031T A SG 11201911031TA SG 11201911031T A SG11201911031T A SG 11201911031TA SG 11201911031T A SG11201911031T A SG 11201911031TA
- Authority
- SG
- Singapore
- Prior art keywords
- microorganisms
- programmed
- tumor cells
- cancer therapeutics
- immune modulators
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 244000005700 microbiome Species 0.000 title 1
- 210000004881 tumor cell Anatomy 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001136—Cytokines
- A61K39/001141—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2497—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing N- glycosyl compounds (3.2.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/485—Exopeptidases (3.4.11-3.4.19)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/04—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amidines (3.5.4)
- C12Y305/04001—Cytosine deaminase (3.5.4.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762531784P | 2017-07-12 | 2017-07-12 | |
US201762543322P | 2017-08-09 | 2017-08-09 | |
US201762552319P | 2017-08-30 | 2017-08-30 | |
US201762592317P | 2017-11-29 | 2017-11-29 | |
US201762607210P | 2017-12-18 | 2017-12-18 | |
PCT/US2018/012698 WO2018129404A1 (en) | 2017-01-06 | 2018-01-05 | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
US201862628786P | 2018-02-09 | 2018-02-09 | |
US201862642535P | 2018-03-13 | 2018-03-13 | |
US201862657487P | 2018-04-13 | 2018-04-13 | |
US201862688852P | 2018-06-22 | 2018-06-22 | |
PCT/US2018/041705 WO2019014391A1 (en) | 2017-07-12 | 2018-07-11 | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201911031TA true SG11201911031TA (en) | 2020-01-30 |
Family
ID=65002257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201911031TA SG11201911031TA (en) | 2017-07-12 | 2018-07-11 | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
Country Status (10)
Country | Link |
---|---|
US (1) | US20200149053A1 (en) |
EP (1) | EP3651782A1 (en) |
JP (1) | JP2020527025A (en) |
KR (1) | KR20200064980A (en) |
CN (1) | CN111246865A (en) |
AU (1) | AU2018301668A1 (en) |
CA (1) | CA3066109A1 (en) |
IL (1) | IL270892A (en) |
SG (1) | SG11201911031TA (en) |
WO (1) | WO2019014391A1 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3402498A1 (en) | 2016-01-11 | 2018-11-21 | Synlogic, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
BR112019013863A2 (en) | 2017-01-06 | 2020-03-03 | Synlogic Operating Company, Inc. | MICRO-ORGANISMS PROGRAMMED TO PRODUCE IMMUNE AND ANTICANCER THERAPEUTIC MODULATORS IN TUMOR CELLS |
BR112019018915A2 (en) | 2017-03-15 | 2020-04-14 | Pandion Therapeutics Inc | targeted immunotolerance |
MX2019013517A (en) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Targeted immunotolerance. |
CA3069523A1 (en) | 2017-07-11 | 2019-01-17 | Actym Therapeutics, Inc. | Engineered immunostimulatory bacterial strains and uses thereof |
US11458172B2 (en) | 2017-09-08 | 2022-10-04 | New Portal Limited | Nucleic acid systems that enable bacteria to specifically target solid tumors via glucose-dependent viability |
US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
CN109536444B (en) * | 2018-12-11 | 2022-06-28 | 吉林省拓华生物科技有限公司 | Separation induction method suitable for malignant solid tumor infiltrating T lymphocytes |
JP2022524951A (en) * | 2019-02-27 | 2022-05-11 | アクティム・セラピューティクス・インコーポレイテッド | Tumors, tumor-resident immune cells and immunostimulatory bacteria engineered to colonize the tumor microenvironment |
US20200270613A1 (en) * | 2019-02-27 | 2020-08-27 | Actym Therapeutics, Inc. | Immunostimulatory bacteria engineered to colonize tumors, tumor-resident immune cells, and the tumor microenvironment |
US20220257732A1 (en) | 2019-04-29 | 2022-08-18 | Synlogic Operating Company, Inc. | Enumeration of genetically engineered microorganisms by live cell counting techniques |
US11739146B2 (en) | 2019-05-20 | 2023-08-29 | Pandion Operations, Inc. | MAdCAM targeted immunotolerance |
CN110747154A (en) * | 2019-09-17 | 2020-02-04 | 广州维生君生物科技有限公司 | PD-1 humanized single-chain antibody fusion gene transformed lactic acid bacteria and application thereof |
CN110904002B (en) * | 2019-11-25 | 2022-04-29 | 天津大学 | Method for biologically removing tetracycline antibiotics |
CN111088197B (en) * | 2020-01-20 | 2021-07-23 | 华南农业大学 | Provevelis alcaligenes and application thereof in degrading tetracycline and producing auxin |
AU2021220986A1 (en) * | 2020-02-13 | 2022-09-01 | The Johns Hopkins University | Recombinant therapeutic interventions for cancer |
CN111849805B (en) * | 2020-06-17 | 2022-04-22 | 天津科技大学 | Pediococcus acidilactici with cervical cancer resistance effect and application thereof |
WO2022006748A1 (en) * | 2020-07-07 | 2022-01-13 | New Portal Limited | Genetically engineered live bacteria and methods of constructing the same |
CN116113425A (en) * | 2020-07-07 | 2023-05-12 | 丹麦科技大学 | Bacterial vectors for engineering non-phagocytic immune cells |
CN111893074B (en) * | 2020-08-14 | 2022-05-20 | 贵州大学 | Bacillus fusiformis strain and application thereof |
CN112410365B (en) * | 2020-10-21 | 2022-08-26 | 山东大学 | Burkholderia homologous recombination system and application thereof |
WO2022094865A1 (en) * | 2020-11-05 | 2022-05-12 | 中国科学院深圳先进技术研究院 | "autolytic" salmonella strain, preparation method therefor and application thereof in tumor treatment |
US20240041945A1 (en) * | 2020-11-05 | 2024-02-08 | Shenzhen Institutes Of Advanced Technology Chinese Academy Of Sciences | Method for constructing strictly anaerobic salmonella, constructed strictly anaerobic salmonella and application thereof |
CN112342233B (en) * | 2020-11-10 | 2022-08-26 | 上海陶宇晟生物技术有限责任公司 | Polynucleotide for increasing c-di-AMP production when bacteria express DacA |
CA3200887A1 (en) | 2020-12-02 | 2022-06-09 | Michael James | Engineered microorganisms |
CN114196564B (en) * | 2021-10-08 | 2023-02-14 | 沈阳农业大学 | Tetragenococcus halophilus and application thereof in production of anti-cancer extracellular polysaccharide |
WO2023076988A1 (en) * | 2021-10-27 | 2023-05-04 | University Of Cincinnati | Engineered bacteria and methods of use in tumor remodeling |
CN114317347B (en) * | 2021-12-28 | 2023-11-07 | 武汉科缘生物发展有限责任公司 | Bacillus coagulans and application thereof, composition and fermentation culture method of bacillus coagulans |
CN115895989A (en) * | 2022-08-05 | 2023-04-04 | 湖北工业大学 | Escherichia coli with high succinic acid yield as well as preparation method and application thereof |
US20240091351A1 (en) * | 2022-09-21 | 2024-03-21 | Gilead Sciences, Inc. | FOCAL IONIZING RADIATION AND CD47/SIRPa DISRUPTION ANTICANCER COMBINATION THERAPY |
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US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
ATE192037T1 (en) * | 1989-12-29 | 2000-05-15 | Braun Medical Inc | USE OF ARGININE AS AN IMMUNE STIMULATOR |
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US6203797B1 (en) | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
EP1034787A1 (en) | 1999-03-11 | 2000-09-13 | Société des Produits Nestlé S.A. | Lactobacillus strains preventing diarrhea caused by pathogenic bacteria |
NZ518354A (en) * | 1999-10-04 | 2005-02-25 | Vion Pharmaceuticals Inc | Compositions and methods for tumor-targeted delivery of effector molecules |
US6962696B1 (en) * | 1999-10-04 | 2005-11-08 | Vion Pharmaceuticals Inc. | Compositions and methods for tumor-targeted delivery of effector molecules |
AU2002257420A1 (en) | 2001-05-01 | 2002-11-11 | National Research Council Of Canada | A system for inducible expression in eukaryotic cells |
AU2002356962C1 (en) * | 2001-12-12 | 2008-05-01 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Methods for using extracellular adenosine inhibitors and adenosine receptor inhibitors to enhance immune response and inflammation |
US7731976B2 (en) | 2003-08-29 | 2010-06-08 | Cobb And Company, Llp | Treatment of irritable bowel syndrome using probiotic composition |
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CN104136037B (en) | 2012-01-17 | 2018-02-23 | 小利兰·斯坦福大学托管委员会 | High-affinity SIRP α reagents |
EP2894985A4 (en) | 2012-09-13 | 2016-09-28 | Massachusetts Inst Technology | Programmable drug delivery profiles of tumor-targeted bacteria |
BR112016004095A2 (en) | 2013-08-30 | 2017-10-17 | Univ Texas | administration of quinurenine depletion enzymes for tumor therapy |
WO2016183532A1 (en) * | 2015-05-13 | 2016-11-17 | Synlogic, Inc. | Bacteria engineered to treat a disease or disorder |
US9688967B2 (en) | 2014-12-05 | 2017-06-27 | Synlogic, Inc. | Bacteria engineered to treat diseases associated with hyperammonemia |
BR112017011923A2 (en) * | 2014-12-05 | 2018-02-27 | Synlogic Inc | bacteria modified to treat diseases associated with hyperammonemia |
WO2016106178A1 (en) * | 2014-12-24 | 2016-06-30 | The Uab Research Foundation, Inc. | Multitargeting onocolytic adenovirus, methods of use, and methods of making |
CA3013713A1 (en) * | 2015-02-11 | 2016-08-18 | The Johns Hopkins University | Bacteria over-expressing c-di-amp and therapeutic methods |
EP3402498A1 (en) | 2016-01-11 | 2018-11-21 | Synlogic, Inc. | Microorganisms programmed to produce immune modulators and anti-cancer therapeutics in tumor cells |
BR112019013863A2 (en) * | 2017-01-06 | 2020-03-03 | Synlogic Operating Company, Inc. | MICRO-ORGANISMS PROGRAMMED TO PRODUCE IMMUNE AND ANTICANCER THERAPEUTIC MODULATORS IN TUMOR CELLS |
-
2018
- 2018-07-11 CN CN201880046649.3A patent/CN111246865A/en active Pending
- 2018-07-11 WO PCT/US2018/041705 patent/WO2019014391A1/en unknown
- 2018-07-11 EP EP18747085.1A patent/EP3651782A1/en active Pending
- 2018-07-11 JP JP2019564936A patent/JP2020527025A/en active Pending
- 2018-07-11 KR KR1020207004070A patent/KR20200064980A/en not_active Application Discontinuation
- 2018-07-11 CA CA3066109A patent/CA3066109A1/en active Pending
- 2018-07-11 SG SG11201911031TA patent/SG11201911031TA/en unknown
- 2018-07-11 AU AU2018301668A patent/AU2018301668A1/en not_active Abandoned
- 2018-07-11 US US16/619,010 patent/US20200149053A1/en active Pending
-
2019
- 2019-11-25 IL IL270892A patent/IL270892A/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2018301668A1 (en) | 2019-12-19 |
JP2020527025A (en) | 2020-09-03 |
IL270892A (en) | 2020-01-30 |
KR20200064980A (en) | 2020-06-08 |
CA3066109A1 (en) | 2019-01-17 |
CN111246865A (en) | 2020-06-05 |
US20200149053A1 (en) | 2020-05-14 |
WO2019014391A1 (en) | 2019-01-17 |
EP3651782A1 (en) | 2020-05-20 |
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