SG11201909581PA - An improved process for the preparation of n-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride - Google Patents

An improved process for the preparation of n-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride

Info

Publication number
SG11201909581PA
SG11201909581PA SG11201909581PA SG11201909581PA SG 11201909581P A SG11201909581P A SG 11201909581PA SG 11201909581P A SG11201909581P A SG 11201909581PA SG 11201909581P A SG11201909581P A SG 11201909581PA
Authority
SG
Singapore
Prior art keywords
natco
house
road
international
hyderabad
Prior art date
Application number
Inventor
Pulla Reddy Muddasani
Shankar Reddy Budideti
Srinivasa Krishna Murthy Konduri
Nagalingam Samatham
Venkaiah Chowdary Nannapaneni
Original Assignee
Natco Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Natco Pharma Ltd filed Critical Natco Pharma Ltd
Publication of SG11201909581PA publication Critical patent/SG11201909581PA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

NHC1 (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PCT ill 1111u°11111DIVIIl °nolo mol Elmo mo Ho mrnom oimIE (10) International Publication Number WO 2018/189747 Al (51) International Patent Classification: CO7D 239/94 (2006.01) (21) International Application Number: PCT/IN2017/050245 EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (22) International Filing Date: 19 June 2017 (19.06.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 201741013419 15 April 2017 (15.04.2017) IN (71) Applicant: NATCO PHARMA LIMITED [IN/IN]; Nat- co House, Road No.2, Banjara Hills, Hyderabad 500034 (IN). (72) Inventors: MUDDASANI, Pulla Reddy; Natco Pharma Limited, Natco House, Road No.2, Banjara Hills, Hyder- abad 500034 (IN). BUDIDETI, Shankar Reddy; Natco Pharma Limited, Natco House, Road No.2, Banjara Hills, Hyderabad 500034 (IN). KONDURI, Srinivasa Krish- na Murthy; Natco Pharma Limited, Natco House, Road No.2, Banjara Hills, Hyderabad 500034 (IN). SAMATH- AM, Nagalingam; Natco Pharma Limited, Natco House, Road No.2, Banjara Hills, Hyderabad 500034 (IN). NAN- NAPANENI, Venkaiah Chowdary; Natco Pharma Lim- ited, Natco House, Road No.2, Banjara Hills, Hyderabad 500034 (IN). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: — with international search report (Art. 21(3)) (54) Title: AN IMPROVED PROCESS FOR THE PREPARATION OF N-(3-ETHYNYLPHENYL)-7-METHOXY-6-(3-MOR- PHOLINOPROPDXY) QUINAZOLIN -4-AMINE DIHYDROCHLORIDE 71' (57) : Present invention relates to an improved process for the preparation 00 of N-(3- ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin-4-amine di- 0\" - * - * . ) H N hydrochloride of formula-I. ° 1-1 Me() C
SG11201909581P 2017-04-15 2017-06-19 An improved process for the preparation of n-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride SG11201909581PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN201741013419 2017-04-15
PCT/IN2017/050245 WO2018189747A1 (en) 2017-04-15 2017-06-19 An improved process for the preparation of n-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride

Publications (1)

Publication Number Publication Date
SG11201909581PA true SG11201909581PA (en) 2019-11-28

Family

ID=59558439

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201909581P SG11201909581PA (en) 2017-04-15 2017-06-19 An improved process for the preparation of n-(3-ethynylphenyl)-7-methoxy-6-(3-morpholinopropoxy) quinazolin -4-amine dihydrochloride

Country Status (8)

Country Link
US (1) US11091470B2 (en)
EP (1) EP3609875B1 (en)
AU (1) AU2017409559B2 (en)
BR (1) BR112019021645A2 (en)
CA (1) CA3059670A1 (en)
ES (1) ES2899145T3 (en)
SG (1) SG11201909581PA (en)
WO (1) WO2018189747A1 (en)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070909A1 (en) 2004-01-22 2005-08-04 Natco Pharma Limited An improved process for the preparation of gefitinib
CA2711737C (en) 2008-01-18 2015-03-31 Natco Pharma Limited 6,7-dialkoxy quinazoline derivatives useful for treatment of cancer related disorders
US9050341B2 (en) * 2009-07-14 2015-06-09 Natco Pharma Limited Methods of treating drug resistant and other tumors by administering 6,7-dialkoxy quinazoline derivatives
CN106432202B (en) * 2016-09-22 2019-04-02 郑州大学第一附属医院 Quinazoline derivative and its application

Also Published As

Publication number Publication date
CA3059670A1 (en) 2018-10-18
AU2017409559B2 (en) 2021-08-19
ES2899145T3 (en) 2022-03-10
AU2017409559A1 (en) 2019-10-31
US20200331899A1 (en) 2020-10-22
BR112019021645A2 (en) 2020-05-12
EP3609875A1 (en) 2020-02-19
WO2018189747A1 (en) 2018-10-18
US11091470B2 (en) 2021-08-17
EP3609875B1 (en) 2021-10-20

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