SG11201909361SA - Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2 sulfatase (ids) produced by human neural or glial cells - Google Patents
Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2 sulfatase (ids) produced by human neural or glial cellsInfo
- Publication number
- SG11201909361SA SG11201909361SA SG11201909361SA SG11201909361SA SG 11201909361S A SG11201909361S A SG 11201909361SA SG 11201909361S A SG11201909361S A SG 11201909361SA SG 11201909361S A SG11201909361S A SG 11201909361SA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- october
- mucopolysaccharidosis
- sulfatase
- ids
- Prior art date
Links
- 208000022018 mucopolysaccharidosis type 2 Diseases 0.000 title abstract 4
- 101000840540 Homo sapiens Iduronate 2-sulfatase Proteins 0.000 title abstract 3
- 201000002273 mucopolysaccharidosis II Diseases 0.000 title abstract 3
- 230000001537 neural effect Effects 0.000 title abstract 3
- 210000004498 neuroglial cell Anatomy 0.000 title abstract 3
- 210000003061 neural cell Anatomy 0.000 title 1
- 101710096421 Iduronate 2-sulfatase Proteins 0.000 abstract 2
- 102100029199 Iduronate 2-sulfatase Human genes 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 241000701022 Cytomegalovirus Species 0.000 abstract 1
- 241000287828 Gallus gallus Species 0.000 abstract 1
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 abstract 1
- 210000001175 cerebrospinal fluid Anatomy 0.000 abstract 1
- 239000003623 enhancer Substances 0.000 abstract 1
- 102000018146 globin Human genes 0.000 abstract 1
- 108060003196 globin Proteins 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000002569 neuron Anatomy 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
- 229910052709 silver Inorganic materials 0.000 abstract 1
- 239000004332 silver Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y301/00—Hydrolases acting on ester bonds (3.1)
- C12Y301/06—Sulfuric ester hydrolases (3.1.6)
- C12Y301/06013—Iduronate-2-sulfatase (3.1.6.13)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14132—Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Abstract
ITR Chicken -actin intron tintglifiditionat&. Cytomegalovirus Immediate-early enhancer Chicken p-actin promoter Rabbit p- globin poly A signal FIG. 5 ITR (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 18 October 2018 (18.10.2018) W I PO I PCT 0111111010 0111 °nolo mu Oil IIIII Kuno oimIE (10) International Publication Number WO 2018/191666 Al (51) International Patent Classification: A61K 38/43 (2006.01) A61P 25/00 (2006.01) A61K 47/26 (2006.01) Cl 2N 15/86 (2006.01) A61K 48/00 (2006.01) (21) International Application Number: PCT/US2018/027568 (22) International Filing Date: 13 April 2018 (13.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/485,659 14 April 2017 (14.04.2017) US 62/573,921 18 October 2017 (18.10.2017) US 62/574,355 19 October 2017 (19.10.2017) US 62/579,686 31 October 2017 (31.10.2017) US (71) Applicant: REGENXBIO INC. [US/US]; 9712 Medical Center Drive, Suite 100, Rockville, MD 20850 (US). (72) Inventors: YOO, Stephen; 5521 Southwick Street, Bethes- da, MD 20817 (US). REINHARDT, Rickey, Robert; 108 Apple Grove Road, Silver Spring, MD 20904 (US). SIM- PSON, Curran, Matthew; 2149 Thurston Road, Frederick, MD 21704 (US). WU, Zhuchun; 14716 Soft Wind Drive, North Potomac, MD 20878 (US). (74) Agent: ELBERT, Maya et al.; Jones Day, 250 Vesey Street, New York, NY 10281-1047 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: TREATMENT OF MUCOPOLYSACCHARIDOSIS II WITH RECOMBINANT HUMAN IDURONATE-2 SULFATASE (IDS) PRODUCED BY HUMAN NEURAL OR GLIAL CELLS CB7 promoter (57) : Compositions and methods are described for the delivery of recombinant human iduronate-2-sulfatase (IDS) produced by human neuronal or glial cells to the cerebrospinal fluid of the central nervous system (CNS) of a human subject diagnosed with mucopolysaccharidosis II (MPS II).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762485659P | 2017-04-14 | 2017-04-14 | |
US201762573921P | 2017-10-18 | 2017-10-18 | |
US201762574355P | 2017-10-19 | 2017-10-19 | |
US201762579686P | 2017-10-31 | 2017-10-31 | |
PCT/US2018/027568 WO2018191666A1 (en) | 2017-04-14 | 2018-04-13 | Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2 sulfatase (ids) produced by human neural or glial cells |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201909361SA true SG11201909361SA (en) | 2019-11-28 |
Family
ID=63793615
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201909361S SG11201909361SA (en) | 2017-04-14 | 2018-04-13 | Treatment of mucopolysaccharidosis ii with recombinant human iduronate-2 sulfatase (ids) produced by human neural or glial cells |
Country Status (12)
Country | Link |
---|---|
US (1) | US11613739B2 (en) |
EP (1) | EP3609526A4 (en) |
JP (2) | JP2020516291A (en) |
KR (1) | KR20190139951A (en) |
AU (1) | AU2018253303A1 (en) |
BR (1) | BR112019021569A2 (en) |
CA (1) | CA3059441A1 (en) |
IL (2) | IL269892B2 (en) |
SG (1) | SG11201909361SA (en) |
TW (1) | TW201903146A (en) |
UY (1) | UY37679A (en) |
WO (1) | WO2018191666A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR112019021569A2 (en) | 2017-04-14 | 2020-05-12 | Regenxbio Inc. | PRECURSOR OF GLUCOSYLATED RECOMBINANT HUMAN IDURONATE-2-SULPHATASE (IDS), METHOD FOR TREATING A HUMAN SUBJECT DIAGNOSED WITH TYPE II MUCOPOLYSACARIDOSIS (MPS II) |
CN110960671A (en) * | 2019-12-25 | 2020-04-07 | 广州中医药大学(广州中医药研究院) | New application of Elabela polypeptide and medicine thereof |
KR20220148162A (en) * | 2020-01-29 | 2022-11-04 | 리젠엑스바이오 인크. | Treatment of Mucopolysaccharidosis II with Recombinant Human Iduronate-2-sulfatase (IDS) Produced by Human Neuronal or Glia Cells |
AU2022214429A1 (en) | 2021-02-01 | 2023-09-14 | Regenxbio Inc. | Gene therapy for neuronal ceroid lipofuscinoses |
KR20230145386A (en) * | 2021-02-10 | 2023-10-17 | 리젠엑스바이오 인크. | Treatment of mucopolysaccharidosis II using recombinant human iduronate-2-sulfatase (IDS) |
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EP2369002A1 (en) | 1999-08-09 | 2011-09-28 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
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EP1453547B1 (en) | 2001-12-17 | 2016-09-21 | The Trustees Of The University Of Pennsylvania | Adeno-associated virus (aav) serotype 8 sequences, vectors containing same, and uses therefor |
CN1856576B (en) | 2003-09-30 | 2011-05-04 | 宾夕法尼亚州立大学托管会 | Adeno-associated virus (aav) clades, sequences, vectors containing same, and uses therefor |
CN104293835B (en) | 2005-04-07 | 2017-07-04 | 宾夕法尼亚大学托管会 | The method for strengthening function of gland related viral vector |
EP1777906A1 (en) | 2005-06-09 | 2007-04-25 | Matsushita Electric Industrial Co., Ltd. | Amplitude error compensating apparatus and orthogonality error compensating apparatus |
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ES2754234T3 (en) * | 2010-06-25 | 2020-04-16 | Shire Human Genetic Therapies | Methods and compositions for CNS administration of iduronate-2-sulfatase |
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HRP20220050T1 (en) * | 2015-05-15 | 2022-10-14 | Regents Of The University Of Minnesota | Adeno-associated for therapeutic delivery to central nervous system |
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EP3452104A1 (en) * | 2016-04-15 | 2019-03-13 | The Trustees of The University of Pennsylvania | Gene therapy for treating mucopolysaccharidosis type ii |
BR112019021569A2 (en) | 2017-04-14 | 2020-05-12 | Regenxbio Inc. | PRECURSOR OF GLUCOSYLATED RECOMBINANT HUMAN IDURONATE-2-SULPHATASE (IDS), METHOD FOR TREATING A HUMAN SUBJECT DIAGNOSED WITH TYPE II MUCOPOLYSACARIDOSIS (MPS II) |
KR20220148162A (en) | 2020-01-29 | 2022-11-04 | 리젠엑스바이오 인크. | Treatment of Mucopolysaccharidosis II with Recombinant Human Iduronate-2-sulfatase (IDS) Produced by Human Neuronal or Glia Cells |
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2018
- 2018-04-13 BR BR112019021569-7A patent/BR112019021569A2/en unknown
- 2018-04-13 CA CA3059441A patent/CA3059441A1/en active Pending
- 2018-04-13 EP EP18783760.4A patent/EP3609526A4/en active Pending
- 2018-04-13 JP JP2019555865A patent/JP2020516291A/en active Pending
- 2018-04-13 TW TW107112724A patent/TW201903146A/en unknown
- 2018-04-13 AU AU2018253303A patent/AU2018253303A1/en active Pending
- 2018-04-13 US US16/604,427 patent/US11613739B2/en active Active
- 2018-04-13 IL IL269892A patent/IL269892B2/en unknown
- 2018-04-13 IL IL307936A patent/IL307936A/en unknown
- 2018-04-13 WO PCT/US2018/027568 patent/WO2018191666A1/en active Application Filing
- 2018-04-13 SG SG11201909361S patent/SG11201909361SA/en unknown
- 2018-04-13 KR KR1020197033526A patent/KR20190139951A/en not_active IP Right Cessation
- 2018-04-13 UY UY0001037679A patent/UY37679A/en unknown
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2022
- 2022-12-27 JP JP2022209169A patent/JP2023052096A/en active Pending
Also Published As
Publication number | Publication date |
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US20200149019A1 (en) | 2020-05-14 |
UY37679A (en) | 2018-11-30 |
US11613739B2 (en) | 2023-03-28 |
IL269892A (en) | 2019-12-31 |
IL307936A (en) | 2023-12-01 |
JP2023052096A (en) | 2023-04-11 |
BR112019021569A2 (en) | 2020-05-12 |
WO2018191666A1 (en) | 2018-10-18 |
AU2018253303A1 (en) | 2019-10-31 |
IL269892B1 (en) | 2023-12-01 |
JP2020516291A (en) | 2020-06-11 |
CA3059441A1 (en) | 2018-10-18 |
EP3609526A1 (en) | 2020-02-19 |
KR20190139951A (en) | 2019-12-18 |
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IL269892B2 (en) | 2024-04-01 |
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