SG11201908267XA - Anticancer compounds - Google Patents
Anticancer compoundsInfo
- Publication number
- SG11201908267XA SG11201908267XA SG11201908267XA SG11201908267XA SG 11201908267X A SG11201908267X A SG 11201908267XA SG 11201908267X A SG11201908267X A SG 11201908267XA SG 11201908267X A SG11201908267X A SG 11201908267XA
- Authority
- SG
- Singapore
- Prior art keywords
- madrid
- avenida
- viejo
- international
- colmenar
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 230000001093 anti-cancer Effects 0.000 title abstract 3
- 241000234282 Allium Species 0.000 abstract 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 239000012620 biological material Substances 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 101150017124 lab gene Proteins 0.000 abstract 1
- 230000008520 organization Effects 0.000 abstract 1
- 102220240796 rs553605556 Human genes 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/07—Bacillus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/38—Pseudomonas
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pyrane Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 20 September 2018 (20.09.2018) WIPO I PCT onion °nolo momioomi olomoilowo oimIE (10) International Publication Number WO 2018/167270 Al (51) International Patent Classification: C07D 407/12 (2006.01) A61P 35/00 (2006.01) A61K 31/351 (2006.01) (21) International Application Number: PCT/EP2018/056665 (22) International Filing Date: 16 March 2018 (16.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17382140.6 17 March 2017 (17.03.2017) EP (71) Applicant: PHARMA MAR, S.A. [ES/ES]; Avenida de los Reyes, 1, E-28770 Colmenar Viejo-Madrid (ES). (72) Inventors: CASEDO HERNANDEZ, Librada Maria; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). DE LA CALLE VERDU, Fernando; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industri- al La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). RODRIGUEZ RAMOS, Maria Pilar; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mi- na-Norte, E-28770 Colmenar Viejo-Madrid (ES). SCH- LEISSNER SANCHEZ, Maria del Carmen; PHARMA MAR, S.A., Avenida de los Reyes, 1, Poligono Industrial La Mina-Norte, E-28770 Colmenar Viejo-Madrid (ES). ZUNI- GA GIRON, Paz; PHARMA MAR, S.A., Avenida de los Reyes, 1 Poligono Industrial La Mina-Norte, E-28770 Col- menar Viejo-Madrid (ES). (74) Agent: BERNARDO NORIEGA, Francisco; ABG PATENTES, S.L., Avda. de Burgos, 16D , Edificio EURO- MOR, E-28036 Madrid (ES). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) (54) Title: ANTICANCER COMPOUNDS 1-1 O N OR 1 OR2 Me0 OR 4 H Me (3?) Me 0 OR 3 CZ CZ 0 Me0 C (57) : Anticancer compounds of general formula (I), wherein R1 to R4 take various meanings, for use in the treatment of cancer. A novel Labrenziasp. strain named PHM005 with Accession Deposit Number CECT-9225, a method of producing compounds of the invention and analogues thereof by using the PHM005 strain and the Lab gene cluster codifying the biosynthesis of pederin-like and onnamide-like compounds are also provided.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17382140 | 2017-03-17 | ||
| PCT/EP2018/056665 WO2018167270A1 (en) | 2017-03-17 | 2018-03-16 | Anticancer compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201908267XA true SG11201908267XA (en) | 2019-10-30 |
Family
ID=58398130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201908267X SG11201908267XA (en) | 2017-03-17 | 2018-03-16 | Anticancer compounds |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US20210317490A1 (en) |
| EP (1) | EP3596068A1 (en) |
| JP (1) | JP7209633B2 (en) |
| KR (1) | KR102547649B1 (en) |
| CN (1) | CN110650954B (en) |
| AU (2) | AU2018235140B2 (en) |
| BR (1) | BR112019019301A2 (en) |
| CA (1) | CA3056725A1 (en) |
| CL (2) | CL2019002661A1 (en) |
| IL (2) | IL292572A (en) |
| MA (1) | MA49880A (en) |
| MX (2) | MX2019010890A (en) |
| MY (1) | MY195435A (en) |
| SG (1) | SG11201908267XA (en) |
| UA (1) | UA126338C2 (en) |
| WO (1) | WO2018167270A1 (en) |
| ZA (2) | ZA201906518B (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4025253B1 (en) * | 2019-09-05 | 2024-03-20 | Pharma Mar, S.A. | Drug antibody conjugates |
| CN112661808B (en) * | 2020-12-23 | 2022-05-27 | 浙江大学 | Depsipeptide compound and preparation method and application thereof |
| EP4326869A1 (en) * | 2021-04-20 | 2024-02-28 | University of Louisville | Recombinant miropin |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2040338T3 (en) | 1987-04-29 | 1993-10-16 | Harbor Branch Oceanographic Institution, Inc. | ANTITUMORAL AND ANTIVIRIC COMPOUNDS OF MARINE ORIGIN. |
| US4801606A (en) | 1987-07-17 | 1989-01-31 | Harbor Branch Oceanographic Institution Inc. | Antiviral compositions |
| EP1448767B1 (en) | 2001-11-22 | 2010-10-13 | Rheinische Friedrich-Wilhelms-Universität Bonn | Novel gene cluster of pederin biosynthesis genes |
| WO2013016120A1 (en) | 2011-07-22 | 2013-01-31 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Pederin and psymberin agents |
-
2018
- 2018-03-16 CA CA3056725A patent/CA3056725A1/en active Pending
- 2018-03-16 KR KR1020197030504A patent/KR102547649B1/en active IP Right Grant
- 2018-03-16 SG SG11201908267X patent/SG11201908267XA/en unknown
- 2018-03-16 WO PCT/EP2018/056665 patent/WO2018167270A1/en active Application Filing
- 2018-03-16 MX MX2019010890A patent/MX2019010890A/en unknown
- 2018-03-16 JP JP2019550649A patent/JP7209633B2/en active Active
- 2018-03-16 AU AU2018235140A patent/AU2018235140B2/en active Active
- 2018-03-16 MY MYPI2019005105A patent/MY195435A/en unknown
- 2018-03-16 MA MA049880A patent/MA49880A/en unknown
- 2018-03-16 IL IL292572A patent/IL292572A/en unknown
- 2018-03-16 BR BR112019019301A patent/BR112019019301A2/en unknown
- 2018-03-16 EP EP18711108.3A patent/EP3596068A1/en active Pending
- 2018-03-16 CN CN201880018986.1A patent/CN110650954B/en active Active
- 2018-03-16 US US16/494,720 patent/US20210317490A1/en active Pending
- 2018-03-16 UA UAA201910399A patent/UA126338C2/en unknown
-
2019
- 2019-09-12 MX MX2021011385A patent/MX2021011385A/en unknown
- 2019-09-15 IL IL269353A patent/IL269353B/en unknown
- 2019-09-16 CL CL2019002661A patent/CL2019002661A1/en unknown
- 2019-10-03 ZA ZA2019/06518A patent/ZA201906518B/en unknown
-
2020
- 2020-10-05 ZA ZA2020/06147A patent/ZA202006147B/en unknown
-
2021
- 2021-01-14 CL CL2021000117A patent/CL2021000117A1/en unknown
- 2021-12-01 AU AU2021277683A patent/AU2021277683B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| CL2021000117A1 (en) | 2021-07-30 |
| BR112019019301A2 (en) | 2020-04-28 |
| ZA202006147B (en) | 2023-03-29 |
| WO2018167270A1 (en) | 2018-09-20 |
| KR102547649B1 (en) | 2023-06-23 |
| JP7209633B2 (en) | 2023-01-20 |
| IL292572A (en) | 2022-06-01 |
| CA3056725A1 (en) | 2018-09-20 |
| IL269353B (en) | 2022-06-01 |
| RU2019132808A (en) | 2021-04-19 |
| CN110650954A (en) | 2020-01-03 |
| CN110650954B (en) | 2023-11-03 |
| MX2021011385A (en) | 2021-10-13 |
| MA49880A (en) | 2020-06-24 |
| MX2019010890A (en) | 2019-12-19 |
| US20210317490A1 (en) | 2021-10-14 |
| CL2019002661A1 (en) | 2019-12-27 |
| AU2021277683A1 (en) | 2021-12-23 |
| AU2018235140A1 (en) | 2019-10-03 |
| AU2021277683B2 (en) | 2023-03-09 |
| AU2018235140B2 (en) | 2021-11-11 |
| MY195435A (en) | 2023-01-20 |
| UA126338C2 (en) | 2022-09-21 |
| KR20190129950A (en) | 2019-11-20 |
| JP2020510065A (en) | 2020-04-02 |
| EP3596068A1 (en) | 2020-01-22 |
| IL269353A (en) | 2019-11-28 |
| RU2019132808A3 (en) | 2021-10-04 |
| ZA201906518B (en) | 2021-01-27 |
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