SG11201907835YA - Anti-gitr antibodies and methods of use thereof - Google Patents

Anti-gitr antibodies and methods of use thereof

Info

Publication number
SG11201907835YA
SG11201907835YA SG11201907835YA SG11201907835YA SG11201907835YA SG 11201907835Y A SG11201907835Y A SG 11201907835YA SG 11201907835Y A SG11201907835Y A SG 11201907835YA SG 11201907835Y A SG11201907835Y A SG 11201907835YA SG 11201907835Y A SG11201907835Y A SG 11201907835YA
Authority
SG
Singapore
Prior art keywords
international
rule
california
pct
applicant
Prior art date
Application number
SG11201907835YA
Inventor
Samantha Lisa Bucktrout
Riggers Javier Fernando Chaparro
Edward Derrick Pascua
Bevin Marie Brady Smith
Original Assignee
Rinat Neuroscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rinat Neuroscience Corp filed Critical Rinat Neuroscience Corp
Publication of SG11201907835YA publication Critical patent/SG11201907835YA/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

80 - 60 - 0 40- o 20- o 0.00 0.01 0.1 00 -20 -40 00 -•-no ab -e-Control HulgG1 m 30 7 -A- m 10 H2 -0-target alone 100 Ab. [pg/mL] (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 07 September 2018 (07.09.2018) WIPO I PCT IiiimmoinionotiolomoluioluilioluovoimIE (10) International Publication Number WO 2018/158658 Al C (51) International Patent Classification: CO7K 16/28 (2006.01) (21) International Application Number: PCT/IB2018/051067 (22) International Filing Date: 21 February 2018 (21.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/466,918 03 March 2017 (03.03.2017) US (71) Applicant: RINAT NEUROSCIENCE CORP. [US/US]; 230 East Grand Avenue, South San Francisco, California 94080 (US). (72) Inventors: BUCKTROUT, Samantha Lisa; 2783 Gold- en Gate Avenue, San Francisco, California 94118 (US). CHAPARRO RIGGERS, Javier Fernando; 816 North Delaware Street, #411, San Mateo, California 94401 (US). PASCUA, Edward Derrick; 100 Grand Avenue, #1405, Oakland, California 94612 (US). SMITH, Bevin Marie Brady; 3134 Glen Canyon Road, Scotts Valley, California 95066 (US). (74) Agent: WALDRON, Roy F.; PFIZER INC., 235 East 42nd Street, MS 235/9/S20, New York, New York 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). (54) Title: ANTI-GITR ANTIBODIES AND METHODS OF USE THEREOF Figure 4A 1 -1 (57) : The present invention provides antibodies that bind Glucocorticoid Induced Tumor necrosis factor Receptor family 0 related protein (GITR) and methods of using same. The anti-GITR antibodies can be used therapeutically alone or in combination with \" other therapeutics to treat cancer and other diseases. [Continued on next page] WO 2018/158658 Al MIDEDIM1111011111111111111111111111111111111111111011111111101111111111111111111 Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(11)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(k) with (an) indication(s) in relation to deposited biological material furnished under Rule 13bis separately from the description (Rules 13bis.4(d)(i) and 48.2(a)(viii)) with sequence listing part of description (Rule 5.2(a)) in black and white; the international application as filed contained color or greyscale and is available for download from PATENTSCOPE
SG11201907835YA 2017-03-03 2018-02-21 Anti-gitr antibodies and methods of use thereof SG11201907835YA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762466918P 2017-03-03 2017-03-03
PCT/IB2018/051067 WO2018158658A1 (en) 2017-03-03 2018-02-21 Anti-gitr antibodies and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11201907835YA true SG11201907835YA (en) 2019-09-27

Family

ID=61599541

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201907835YA SG11201907835YA (en) 2017-03-03 2018-02-21 Anti-gitr antibodies and methods of use thereof

Country Status (16)

Country Link
US (1) US11198735B2 (en)
EP (1) EP3589657A1 (en)
JP (1) JP2020510435A (en)
KR (1) KR20190124753A (en)
CN (1) CN110431152A (en)
AU (2) AU2018226646A1 (en)
BR (1) BR112019017500A2 (en)
CA (1) CA3054885A1 (en)
CO (1) CO2019009586A2 (en)
IL (1) IL269077A (en)
MX (1) MX2019010458A (en)
PE (1) PE20191487A1 (en)
PH (1) PH12019502007A1 (en)
RU (1) RU2019127550A (en)
SG (1) SG11201907835YA (en)
WO (1) WO2018158658A1 (en)

Families Citing this family (10)

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RU2734432C1 (en) * 2019-04-23 2020-10-16 Закрытое Акционерное Общество "Биокад" Monoclonal antibody which specifically binds gitr
EP4085074A4 (en) * 2020-01-02 2024-05-15 Nanjing GenScript Biotech Co., Ltd. Anti-gitr antibodies and uses thereof
CN111732658B (en) * 2020-06-28 2022-04-26 英诺湖医药(杭州)有限公司 GITR monoclonal antibodies and medical application thereof
GB202011993D0 (en) * 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
TW202246334A (en) * 2021-02-02 2022-12-01 美商美國禮來大藥廠 Gitr antagonists and methods of using the same
CN117813327A (en) * 2021-05-10 2024-04-02 美帝马布生物公司 anti-GITR antibodies and uses thereof
CN118103399A (en) * 2021-09-30 2024-05-28 正大天晴药业集团南京顺欣制药有限公司 Pharmaceutical combinations of quinoline derivatives and anti-CD 47 antibodies
CN114316060B (en) * 2021-12-15 2023-06-13 北京市肿瘤防治研究所 Bispecific antibody against human CD19 and CD206, and preparation method and application thereof
CN114516918B (en) * 2022-03-04 2022-09-27 四川大学华西医院 Antibody and application thereof
CN116925206B (en) * 2023-07-18 2024-04-23 湖南中晟全肽生物科技股份有限公司 GITR related polypeptides and uses thereof

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PE20191487A1 (en) 2019-10-18
JP2020510435A (en) 2020-04-09
RU2019127550A3 (en) 2021-04-05
KR20190124753A (en) 2019-11-05
CO2019009586A2 (en) 2019-09-18
CA3054885A1 (en) 2018-09-07
BR112019017500A2 (en) 2020-04-14
IL269077A (en) 2019-11-28
US11198735B2 (en) 2021-12-14
CN110431152A (en) 2019-11-08
US20200031947A1 (en) 2020-01-30
WO2018158658A1 (en) 2018-09-07
MX2019010458A (en) 2020-01-20
RU2019127550A (en) 2021-04-05
EP3589657A1 (en) 2020-01-08
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AU2018226646A1 (en) 2019-09-19
AU2021203126A1 (en) 2021-06-10

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