SG11201906803WA - N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases - Google Patents

N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases

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Publication number
SG11201906803WA
SG11201906803WA SG11201906803WA SG11201906803WA SG11201906803WA SG 11201906803W A SG11201906803W A SG 11201906803WA SG 11201906803W A SG11201906803W A SG 11201906803WA SG 11201906803W A SG11201906803W A SG 11201906803WA SG 11201906803W A SG11201906803W A SG 11201906803WA
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Singapore
Prior art keywords
co7d
phenyl
diseases
international
ror
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SG11201906803WA
Inventor
Jean-François Delhomel
Enrico Perspicace
Zouher Majd
Peggy Parroche
Robert Walczak
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Genfit
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61054412&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201906803W(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genfit filed Critical Genfit
Publication of SG11201906803WA publication Critical patent/SG11201906803WA/en

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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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Abstract

International Publication Date (19) World Intellectual Property Organization International Bureau (10) International Publication Number WO 2018/138362 Al 0111111010 0111 °nolo 01110ll mil moiniou oimIE (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) 02 August 2018 (02.08.2018) WIPO I PCT (51) International Patent Classification: (84) Designated States (unless otherwise indicated, for every CO7D 265/36 (2006.01) A61K 31/4725 (2006.01) kind of regional protection available): ARIPO (BW, GH, CO7D 215/48 (2006.01) A61K 31/498 (2006.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, CO7D 241/52 (2006.01) A61K 31/454 (2006.01) UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, CO7D 209/34 (2006.01) A61K 31/425 (2006.01) TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, CO7D 209/38 (2006.01) A61P 37/00 (2006.01) EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, CO7D 231/56 (2006.01) A61P 37/06 (2006.01) MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, CO7D 405/12 (2006.01) A61P 37/08 (2006.01) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, CO7D 413/12 (2006.01) A61P 31/00 (2006.01) KM, ML, MR, NE, SN, TD, TG). CO7D 417/12 (2006.01) A61P 19/02 (2006.01) A61K 31/536 (2006.01) A61P 11/06 (2006.01) Published: — with international search report (Art. 21(3)) (21) International Application Number: PCT/EP2018/052172 (22) International Filing Date: 29 January 2018 (29.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 17305093.1 27 January 2017 (27.01.2017) EP 17178888.8 29 June 2017 (29.06.2017) EP (71) Applicant: GENFIT [FR/FR]; 885 avenue Eugene Avinee, 59120 Loos (FR). = (72) Inventors: DELHOMEL, Jean-Francois; 79 avenue du President JF Kennedy, 62000 ARRAS (FR). PERSPI- CACE, Enrico; 1 me Maurice SCHUMANN, 59133 PHALEMPIN (FR). MAJD, Zouher; 29 rue Nationale, 59320 ENNETIERES-EN-WEPPES (FR). PARROCHE, Peggy; 9 rue des Brigittines, 59800 LILLE (FR). WAL- CZAK, Robert; Residence Parc d'Isly, 13B rue Delezenne, 59000 LILLE (FR). (74) Agent: CABINET BECKER ET ASSOCIES; 25, me Louis le Grand, 75002 Paris (FR). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. co (54) Title: N- f [2-(PIPERIDIN-1-YL)PHENYL](PHENYL)METHYLI -2-(3-0X0-3,4-DIHYDRO-2H-1,4-BENZOXA ZIN-7- YL)ACETAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ROR-GAMMA MODULATORS FOR TREATING AU- 00 TOIMMUNE DISEASES O (57) : The present invention provides e.g. N-f [2-(piperidin-l-yl)phenyl] (phenyl)methyll-2-(3-oxo-3,4-dihydro-2H-1,4-ben- zoxazin-7-yl)acetamide derivatives and related compounds as ROR-gamma modulators for treating e.g. autoimmune diseases, autoim- C mune-related diseases, inflammatory diseases, metabolic diseases, fibrotic diseases or cholestatic diseases, such as e.g. arthitis and asthma.
SG11201906803WA 2017-01-27 2018-01-29 N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases SG11201906803WA (en)

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PCT/EP2018/052172 WO2018138362A1 (en) 2017-01-27 2018-01-29 N-{[2-(piperidin-1-yl)phenyl](phenyl)methyl}-2-(3-oxo-3,4-dihydro-2h-1,4-benzoxa zin-7-yl)acetamide derivatives and related compounds as ror-gamma modulators for treating autoimmune diseases

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