SG11201902876TA - New antimicrobial agents against enterococcus bacteria - Google Patents

New antimicrobial agents against enterococcus bacteria

Info

Publication number
SG11201902876TA
SG11201902876TA SG11201902876TA SG11201902876TA SG11201902876TA SG 11201902876T A SG11201902876T A SG 11201902876TA SG 11201902876T A SG11201902876T A SG 11201902876TA SG 11201902876T A SG11201902876T A SG 11201902876TA SG 11201902876T A SG11201902876T A SG 11201902876TA
Authority
SG
Singapore
Prior art keywords
international
peptide
relates
present
seq
Prior art date
Application number
SG11201902876TA
Inventor
Manfred Biebl
Eva Schirmeier
Martin Griessl
Original Assignee
Lysando Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lysando Ag filed Critical Lysando Ag
Publication of SG11201902876TA publication Critical patent/SG11201902876TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2101/00—Chemical composition of materials used in disinfecting, sterilising or deodorising
    • A61L2101/32—Organic compounds
    • A61L2101/46—Macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/55—Fusion polypeptide containing a fusion with a toxin, e.g. diphteria toxin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111111111111111111001111110111101111111111110111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2018/073416 Al 26 April 2018 (26.04.2018) WIP0 I PCT (51) International Patent Classification: A61K 38/47 (2006.01) Cl 2N 9/36 (2006.01) Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) (21) International Application Number: PCT/EP2017/076861 Published: — with international search report (Art. 21(3)) (22) International Filing Date: — with sequence listing part of description (Rule 5.2(a)) 20 October 2017 (20.10.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16194788.2 20 October 2016 (20.10.2016) EP (71) Applicant: LYSANDO AG [LI/LI]; Wangerbergstr. 91, 9497 Triesenberg (LI). (72) Inventors: BIEBL, Manfred; Am Dietlmeierhof 10, 93083 Obertraubling (DE). SCHIRMEIER, Eva; Brun- huberstr. 8, 93053 Regensburg (DE). GRIESSL, Martin; Scambachring 7, 93155 Hohenschambach (DE). (74) Agent: RUCKERL, Florian; Dehmel & Bettenhausen — Patentanwalte PartmbB, HerzogspitalstraBe 11, 80331 = Miinchen (DE). = _ (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, _ DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, —= HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, = — KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, — = OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, = TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind ARIPO GH, = of regional protection available): (BW, _ GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, _ = UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, = TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, = EE, ES, FI, FR, HR, HU, IE, IS, IT, LT, LU, LV, GB, GR, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = — TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, = KM, ML, MR, NE, SN, TD, TG). 1-1 (54) Title: NEW ANTIMICROBIAL AGENTS AGAINST ENTEROCOCCUS BACTERIA 1-1 i v (57) : The present invention relates to the field of antimicrobial agents active against Enterococcus bacteria. In particular, the M present invention relates to a polypeptide comprising a first and a second amino acid sequence, wherein the first amino acid sequence C is a sequence selected from SEQ ID NO:2; SEQ ID NO:3; SEQ ID NO: 5; and derivatives thereof; and wherein the second amino acid ---- sequence is an antimicrobial peptide, amphipathic peptide, cationic peptide, hydrophobic peptide, sushi peptide or defensin. In addition, *1 : the present invention relates to nucleic acids encoding such polypeptides, vectors comprising such nucleic acids, and corresponding 1-1 © host cells. Finally, the present invention relates to applications of the inventive polypeptides, nucleic acids, vectors, and/or host cells, ei in particular in the pharmaceutical field. C
SG11201902876TA 2016-10-20 2017-10-20 New antimicrobial agents against enterococcus bacteria SG11201902876TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16194788 2016-10-20
PCT/EP2017/076861 WO2018073416A1 (en) 2016-10-20 2017-10-20 New antimicrobial agents against enterococcus bacteria

Publications (1)

Publication Number Publication Date
SG11201902876TA true SG11201902876TA (en) 2019-05-30

Family

ID=57184337

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201902876TA SG11201902876TA (en) 2016-10-20 2017-10-20 New antimicrobial agents against enterococcus bacteria

Country Status (12)

Country Link
US (1) US20190330608A1 (en)
EP (1) EP3528837A1 (en)
JP (1) JP7288851B2 (en)
KR (1) KR102560651B1 (en)
CN (1) CN110087675A (en)
AU (1) AU2017345217A1 (en)
BR (1) BR112019007979A2 (en)
CA (1) CA3041190A1 (en)
EA (1) EA201990856A1 (en)
MX (1) MX2019004439A (en)
SG (1) SG11201902876TA (en)
WO (1) WO2018073416A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019229184A1 (en) * 2018-05-30 2019-12-05 Lysando Ag Novel antimicrobial fusion proteins
EP3802814A1 (en) * 2018-05-30 2021-04-14 Lysando AG Novel antimicrobial proteins
EP3771463A1 (en) * 2019-07-29 2021-02-03 Ludwig-Maximilians-Universität München Stabilizing therapeutic proteins with piperazin- or morpholine-containing zwitterionic buffering substances
CN110950947B (en) * 2019-12-19 2022-04-29 温州大学 Rana temporaria chensinensis host defense peptide DMS-PS2, and gene and application thereof
WO2022154287A1 (en) * 2021-01-15 2022-07-21 주식회사 인트론바이오테크놀로지 Antibacterial protein efl200 having lytic activity to enterococcus faecium

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8816693D0 (en) 1988-07-13 1988-08-17 Agricultural & Food Res Viral enzyme & gene
WO1991019512A1 (en) * 1990-06-21 1991-12-26 University Of Georgia Research Foundation, Inc. Antimicrobial peptides
US7582291B2 (en) 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
JP6034188B2 (en) * 2009-06-26 2016-11-30 ライサンド アクツィエンゲゼルシャフト Antimicrobial agent
WO2014052438A1 (en) * 2012-09-25 2014-04-03 Regents Of The University Of Minnesota Methods for making and using antimicrobial peptides
GB201302042D0 (en) * 2013-02-05 2013-03-20 Plant Bioscience Ltd Novel polypeptides having endolysin activity and uses thereof

Also Published As

Publication number Publication date
CN110087675A (en) 2019-08-02
MX2019004439A (en) 2019-09-26
KR102560651B1 (en) 2023-07-26
KR20190067236A (en) 2019-06-14
AU2017345217A1 (en) 2019-04-18
US20190330608A1 (en) 2019-10-31
CA3041190A1 (en) 2018-04-26
JP7288851B2 (en) 2023-06-08
WO2018073416A1 (en) 2018-04-26
BR112019007979A2 (en) 2019-07-09
JP2020510404A (en) 2020-04-09
EA201990856A1 (en) 2019-10-31
EP3528837A1 (en) 2019-08-28

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