SG11201900799XA - Pyridopyrimdinone cdk2/4/6 inhibitors - Google Patents
Pyridopyrimdinone cdk2/4/6 inhibitorsInfo
- Publication number
- SG11201900799XA SG11201900799XA SG11201900799XA SG11201900799XA SG11201900799XA SG 11201900799X A SG11201900799X A SG 11201900799XA SG 11201900799X A SG11201900799X A SG 11201900799XA SG 11201900799X A SG11201900799X A SG 11201900799XA SG 11201900799X A SG11201900799X A SG 11201900799XA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- rule
- san diego
- pct
- applicant
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Abstract
INTERNATIONAL APPLICATION PUBLISHE D UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 22 February 2018 (22.02.2018) WIPO I PCT Iiiimmomitia °nolo olimin °mu onno oimIE (10) International Publication Number WO 2018/033815 Al (51) International Patent Classification: C07D 471/04 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/IB2017/054655 (22) International Filing Date: 31 July 2017 (31.07.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/371,602 15 August 2016 (15.08.2016) US 62/533,347 17 July 2017 (17.07.2017) US (71) Applicant: PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US). (72) Inventors: BEHENNA, Douglas Carl; 31302 Calle Del Campo, San Juan Capistrano, CA 92675 (US). CHEN, Ping; 7666 Pipit Place, San Diego, CA 92129 (US). FREEMAN-COOK, Kevin Daniel; 7946 Sitio Nispero, Carlsbad, CA 92009 (US). HOFFMAN, Robert Louis; 2390 Rising Glen Way, #201, Carlsbad, CA 92008 (US). JALAIE, Mehran; 11373 Saddle Cove Lane, San Diego, CA 92130 (US). NAGATA, Asako; 7335 Rock Canyon Drive, San Diego, CA 92126 (US). NAIR, Sajiv Krish- nan; 1923 White Birch Drive, Vista, CA 92081 (US). NINKOVIC, Sacha; 8902 Nottingham Place, La Jolla, CA 92037 (US). ORNELAS, Martha Alicia; 15062 Aveni- da Montuose, Apartment C, San Diego, CA 92129 (US). PALMER, Cynthia Louise; 9847 Ogram Drive, La Mesa, CA 91941 (US). RUE Eugene Yuanjin; 11254 Caminito Corriente, San Diego, CA 92128 (US). (74) Agent: WALDRON, Roy F.; Pfizer INC., 235 East 42nd Street, MS 235/9/S20, New York, NY 10017 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the identity of the inventor (Rule 4.170) as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: PYRIDOPYRIMDINONE CDK2/4/6 INHIBITORS (57) : This invention relates to compounds of general Formula (I), and pharmaceutically acceptable salts thereof, in which R i R2 R SA , RIB, R 3 R4 RSA, R 5B R6 R7, R R 9 , R pq and r are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, C..) including cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662371602P | 2016-08-15 | 2016-08-15 | |
| US201762533347P | 2017-07-17 | 2017-07-17 | |
| PCT/IB2017/054655 WO2018033815A1 (en) | 2016-08-15 | 2017-07-31 | Pyridopyrimdinone cdk2/4/6 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201900799XA true SG11201900799XA (en) | 2019-02-27 |
Family
ID=59631834
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201900799XA SG11201900799XA (en) | 2016-08-15 | 2017-07-31 | Pyridopyrimdinone cdk2/4/6 inhibitors |
Country Status (41)
Families Citing this family (39)
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| GEP20217234B (en) * | 2016-08-15 | 2021-03-25 | Pfizer | Pyridopyrimdinone cdk2/4/6 inhibitors |
| JP6952747B2 (en) * | 2018-09-18 | 2021-10-20 | ファイザー・インク | Combination of TGFβ inhibitor and CDK inhibitor for cancer treatment |
| JP2020097562A (en) * | 2018-09-25 | 2020-06-25 | ファイザー・インク | Synthesis of pyrido[2,3-d]pyrimidine-7(8h)-one |
| US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
| BR112021011894A2 (en) | 2018-12-21 | 2021-09-08 | Daiichi Sankyo Company, Limited | PHARMACEUTICAL COMPOSITION |
| CA3126788A1 (en) * | 2019-01-17 | 2020-07-23 | Pfizer Inc. | Crystalline form of a cdk inhibitor |
| KR20210139269A (en) * | 2019-02-15 | 2021-11-22 | 인사이트 코포레이션 | Cyclin-dependent kinase 2 biomarkers and uses thereof |
| WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
| WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
| US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
| WO2020212865A1 (en) * | 2019-04-19 | 2020-10-22 | Pfizer Inc. | Anti-proliferative agents for treating pah |
| WO2020223469A1 (en) | 2019-05-01 | 2020-11-05 | Incyte Corporation | N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer |
| US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
| CA3141452A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| EP3976090A1 (en) | 2019-05-24 | 2022-04-06 | Pfizer Inc. | Combination therapies using cdk inhibitors |
| WO2021014360A1 (en) | 2019-07-23 | 2021-01-28 | Pfizer Inc. | Oral modified release dosage forms |
| CN116348458A (en) | 2019-08-14 | 2023-06-27 | 因赛特公司 | Imidazolylpyrimidinylamine compounds as CDK2 inhibitors |
| US11851426B2 (en) * | 2019-10-11 | 2023-12-26 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
| CN114555600B (en) * | 2019-10-17 | 2024-03-01 | 辰欣药业股份有限公司 | Aminopyrimidines as CDK2/4/6 triple inhibitors |
| IL293926A (en) | 2019-12-17 | 2022-08-01 | Pfizer | Antibodies specific for cd47, pd-l1, and uses thereof |
| US20230135215A1 (en) * | 2020-02-28 | 2023-05-04 | Fochon Biosciences, Ltd. | Compounds as cdk2/4/6 inhibitors |
| WO2021176349A1 (en) | 2020-03-05 | 2021-09-10 | Pfizer Inc. | Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor |
| JP2021167301A (en) | 2020-04-08 | 2021-10-21 | ファイザー・インク | Co-treatment with cdk4/6 and cdk2 inhibitors to suppress tumor adaptation to cdk2 inhibitors |
| CN113773315A (en) * | 2020-06-10 | 2021-12-10 | 无锡佰翱得生物科学有限公司 | Highly selective deuterated inhibitors of cyclin dependent kinase 2(CDK2) |
| WO2021254384A1 (en) * | 2020-06-17 | 2021-12-23 | 微境生物医药科技(上海)有限公司 | Novel pyrido[2,3-d]pyrimidine-7(8h)-one derivative |
| WO2022015670A1 (en) * | 2020-07-14 | 2022-01-20 | Nikang Therapeutics, Inc. | Pyrido[2,3-d]pyrimidin-7(8h)-one derivatives as cyclin-dependent kinase 2 inhibitors |
| WO2022018667A1 (en) | 2020-07-24 | 2022-01-27 | Pfizer Inc. | Combination therapies using cdk2 and cdc25a inhibitors |
| JP7260606B2 (en) | 2020-09-15 | 2023-04-18 | ファイザー・インク | CDK4 inhibitors in solid form |
| TW202237585A (en) | 2020-11-27 | 2022-10-01 | 瑞士商瑞森製藥公司 | Cdk inhibitors |
| CA3202355A1 (en) * | 2020-12-22 | 2022-06-30 | Jiping Fu | Compounds for degrading cyclin-dependent kinase 2 via ubiquitin proteosome pathway |
| WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
| CN117858879A (en) * | 2021-01-15 | 2024-04-09 | 南京再明医药有限公司 | CDK2/4/6 inhibitor and preparation method and application thereof |
| WO2022258023A1 (en) * | 2021-06-09 | 2022-12-15 | 郑州同源康医药有限公司 | Compound as cdk kinase inhibitor and use thereof |
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2017
- 2017-07-31 GE GEAP201714998A patent/GEP20217234B/en unknown
- 2017-07-31 RS RS20210691A patent/RS61934B1/en unknown
- 2017-07-31 TN TNP/2019/000039A patent/TN2019000039A1/en unknown
- 2017-07-31 CN CN201780063655.5A patent/CN109803968A/en active Pending
- 2017-07-31 ES ES17752493T patent/ES2876411T3/en active Active
- 2017-07-31 RU RU2019104087A patent/RU2726115C1/en active
- 2017-07-31 PE PE2019000359A patent/PE20190475A1/en unknown
- 2017-07-31 EP EP17752493.1A patent/EP3497103B1/en active Active
- 2017-07-31 JP JP2019507917A patent/JP6563623B1/en active Active
- 2017-07-31 AU AU2017311645A patent/AU2017311645B2/en active Active
- 2017-07-31 DK DK17752493.1T patent/DK3497103T3/en active
- 2017-07-31 BR BR112019002610A patent/BR112019002610A2/en active Search and Examination
- 2017-07-31 PL PL17752493T patent/PL3497103T3/en unknown
- 2017-07-31 MD MDE20190682T patent/MD3497103T2/en unknown
- 2017-07-31 UA UAA201900905A patent/UA124804C2/en unknown
- 2017-07-31 MX MX2019001849A patent/MX2019001849A/en unknown
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- 2017-07-31 CA CA2975033A patent/CA2975033C/en active Active
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- 2017-07-31 US US15/664,265 patent/US10233188B2/en active Active
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- 2017-07-31 WO PCT/IB2017/054655 patent/WO2018033815A1/en active Application Filing
- 2017-07-31 KR KR1020197007466A patent/KR102236605B1/en active IP Right Grant
- 2017-07-31 MA MA45920A patent/MA45920B1/en unknown
- 2017-07-31 SG SG11201900799XA patent/SG11201900799XA/en unknown
- 2017-07-31 CU CU2019000010A patent/CU24522B1/en unknown
- 2017-07-31 LT LTEP17752493.1T patent/LT3497103T/en unknown
- 2017-07-31 HU HUE17752493A patent/HUE055978T2/en unknown
- 2017-07-31 SI SI201730793T patent/SI3497103T1/en unknown
- 2017-08-02 TW TW106126113A patent/TWI663169B/en active
- 2017-08-04 UY UY0001037352A patent/UY37352A/en not_active Application Discontinuation
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2019
- 2019-01-17 US US16/251,032 patent/US10800783B2/en active Active
- 2019-02-04 ZA ZA2019/00716A patent/ZA201900716B/en unknown
- 2019-02-06 IL IL264687A patent/IL264687B/en active IP Right Grant
- 2019-02-11 NI NI201900013A patent/NI201900013A/en unknown
- 2019-02-12 CL CL2019000368A patent/CL2019000368A1/en unknown
- 2019-02-12 CO CONC2019/0001240A patent/CO2019001240A2/en unknown
- 2019-02-14 EC ECSENADI201911216A patent/ECSP19011216A/en unknown
- 2019-02-14 DO DO2019000030A patent/DOP2019000030A/en unknown
- 2019-02-15 SV SV2019005836A patent/SV2019005836A/en unknown
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2020
- 2020-08-27 US US17/005,233 patent/US11396512B2/en active Active
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2021
- 2021-06-01 HR HRP20210871TT patent/HRP20210871T1/en unknown
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2022
- 2022-06-15 US US17/841,138 patent/US20220324872A1/en active Pending
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