SG11201809962SA - Particle size and distribution of polymer for melt extrusion application - Google Patents

Particle size and distribution of polymer for melt extrusion application

Info

Publication number
SG11201809962SA
SG11201809962SA SG11201809962SA SG11201809962SA SG11201809962SA SG 11201809962S A SG11201809962S A SG 11201809962SA SG 11201809962S A SG11201809962S A SG 11201809962SA SG 11201809962S A SG11201809962S A SG 11201809962SA SG 11201809962S A SG11201809962S A SG 11201809962SA
Authority
SG
Singapore
Prior art keywords
international
pct
group
polymer
particle size
Prior art date
Application number
SG11201809962SA
Inventor
Dieter Lubda
Mengyao Zheng
Gallo Nicole Di
Anja-Nadine Knuettel
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201809962SA publication Critical patent/SG11201809962SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
    • B29C48/022—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor characterised by the choice of material
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/0016—Plasticisers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/005—Stabilisers against oxidation, heat, light, ozone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L29/00—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers
    • C08L29/02—Homopolymers or copolymers of unsaturated alcohols
    • C08L29/04—Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29K—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES B29B, B29C OR B29D, RELATING TO MOULDING MATERIALS OR TO MATERIALS FOR MOULDS, REINFORCEMENTS, FILLERS OR PREFORMED PARTS, e.g. INSERTS
    • B29K2029/00—Use of polyvinylalcohols, polyvinylethers, polyvinylaldehydes, polyvinylketones or polyvinylketals or derivatives thereof as moulding material
    • B29K2029/04—PVOH, i.e. polyvinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111101011111111111 0111011111111111111001H1111011101111111111 Organization International Bureau (10) International Publication Number 0 (43) International Publication Date .....0\"\" WO 2017/194578 Al 16 November 2017 (16.11.2017) WIPO I PCT (51) International Patent Classification: A61K 47/32 (2006.01) (21) International Application (22) International Filing Date: (25) Filing Language: (26) Publication Language: (30) Priority Data: 16169690.1 13 May 2016 (13.05.2016) (71) Applicant: MERCK PATENT furter Strasse 250, 64293 Darmstadt (72) Inventors: LUBDA, Dieter; sheim (DE). ZHENG, Mengyao; DARMSTADT (DE). DI GALLO, tor 4, 64625 BENSHEIM dine; Stieglitzgasse 3, 68307 CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, A61K 9/14 (2006.01) DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, Number: HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, PCT/EP2017/061130 KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 10 May 2017 (10.05.2017) SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. English English (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, EP UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, GMBH [DE/DE]; Frank- EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (DE). MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, Im Bangert 21C, 64625 Ben- TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, Havelstrasse 20, 64295 KM, ML, MR, NE, SN, TD, TG). Nicole; Am Ziegelfall- (DE). KNUETTEL, Anja-Na- Published: MANNHEIM (DE). — with international search report (Art. 21(3)) otherwise indicated, for every available): AE, AG, AL, AM, BG, BH, BN, BR, BW, BY, BZ, (81) Designated States (unless _ — kind of national protection = AO, AT, AU, AZ, BA, BB, = Title: PARTICLE SIZE AND DISTRIBUTION OF POLYMER FOR MELT EXTRUSION APPLICATION Flowability of PVA particle without API I (54) = = Fig. 3 = = 45 = 40 = 35— = = 30 = — 8 0 25 = _ e = is 20 7 ,-, .i 15 1-1 10 GC 5 IC - - kin 0 O\ Group 1-1 IC - - C (57) : The present invention \" products, and that due to its improved „., to pharmaceutical formulations comprising I I I A Group B Group C relates to an improved powdered polyvinyl alcohol (PVA), which can be used for pharmaceutical properties can be better dosed during formulation processes. Furthermore, this invention refers polyvinyl alcohol as carrier matrix and their use.
SG11201809962SA 2016-05-13 2017-05-10 Particle size and distribution of polymer for melt extrusion application SG11201809962SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP16169690 2016-05-13
PCT/EP2017/061130 WO2017194578A1 (en) 2016-05-13 2017-05-10 Particle size and distribution of polymer for melt extrusion application

Publications (1)

Publication Number Publication Date
SG11201809962SA true SG11201809962SA (en) 2018-12-28

Family

ID=56134084

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201809962SA SG11201809962SA (en) 2016-05-13 2017-05-10 Particle size and distribution of polymer for melt extrusion application

Country Status (12)

Country Link
US (1) US11246935B2 (en)
EP (1) EP3454906A1 (en)
JP (1) JP7082067B2 (en)
KR (3) KR20230151062A (en)
CN (1) CN109069652B (en)
BR (1) BR112018071740A2 (en)
CA (1) CA3023801A1 (en)
IL (1) IL262913A (en)
MX (1) MX2018013000A (en)
PH (1) PH12018502103A1 (en)
SG (1) SG11201809962SA (en)
WO (1) WO2017194578A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112559417B (en) * 2020-12-09 2023-04-25 广东美的暖通设备有限公司 Control method and device for air conditioner communication, communication system and readable storage medium

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2542346B2 (en) 1987-05-30 1996-10-09 日本合成化学工業株式会社 Method for producing high degree of polymerization polyvinyl alcohol
US4849256A (en) * 1988-03-11 1989-07-18 The Clorox Company Process for plasticizing polyvinyl alcohol resin
KR0182801B1 (en) 1991-04-16 1999-05-01 아만 히데아키 Method of manufacturing solid dispersion
JP4679822B2 (en) * 2002-03-13 2011-05-11 ノバルティス アーゲー Pharmaceutical fine particles
DE102004031835A1 (en) * 2004-06-30 2006-01-19 Basf Ag Fast-dispersible, finely divided, non-segregating powdery film coating composition based on polyvinyl alcohol-polyether graft copolymers characterized by particular physical stability and low roughness
EP2140883B1 (en) 2007-04-20 2012-10-31 Daido Chemical Corporation Novel base for dry solid dispersion, solid dispersion containing the base, and composition containing the dispersion
DE102007026166A1 (en) 2007-06-04 2008-12-11 Kuraray Europe Gmbh Thermoplastic shaping of polyvinyl alcohol for manufacturing granulates, foil, fibers or coating for use in pharmaceutical or cosmetic applications, involves accomplishing shaping in absence of extrusion additive
CA3076115C (en) 2007-08-21 2022-06-28 Board Of Regents, The University Of Texas System Thermo-kinetic mixing for pharmaceutical applications
US8946348B2 (en) * 2007-11-30 2015-02-03 Sekisui Specialty Chemicals America, Llc Method for dissolving polyvinyl alcohol particles into aqueous media using high shear
EP2105130A1 (en) 2008-03-25 2009-09-30 Ratiopharm GmbH Pharmaceutical formula and method for its production
CA2918570A1 (en) 2013-07-22 2015-01-29 Sandoz Ag Formulations containing amorphous dapagliflozin
CN105934241B (en) * 2013-11-26 2020-06-05 格吕伦塔尔有限公司 Preparation of powdered pharmaceutical composition by cryogenic grinding
US11040012B2 (en) 2014-07-30 2021-06-22 Merck Patent Gmbh Pulverulent, directly compressible polyvinyl alcohol grades
US20170209380A1 (en) 2014-07-30 2017-07-27 Merck Patent Gmbh Directly compressible composition comprising microcrystalline cellulose
CN107107463B (en) 2014-09-08 2019-10-25 中央兰开夏大学 Solid dosage forms production

Also Published As

Publication number Publication date
KR20190008334A (en) 2019-01-23
CN109069652B (en) 2023-03-24
BR112018071740A2 (en) 2019-02-19
CA3023801A1 (en) 2017-11-16
CN109069652A (en) 2018-12-21
US11246935B2 (en) 2022-02-15
KR20210145306A (en) 2021-12-01
JP7082067B2 (en) 2022-06-07
PH12018502103A1 (en) 2019-07-15
WO2017194578A1 (en) 2017-11-16
US20190111138A1 (en) 2019-04-18
MX2018013000A (en) 2019-01-28
IL262913A (en) 2018-12-31
KR20230151062A (en) 2023-10-31
JP2019520325A (en) 2019-07-18
EP3454906A1 (en) 2019-03-20

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