SG11201809899RA - Method of treating hyperglycemia - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 1111111111111 0 1101 010 11111 010 11111 0 11 011 11111 11111 0101110111111101111 0111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\"\") WO 2017/198177 Al 23 November 2017 (23.11.2017) WIPO I P C T (51) International Patent Classification: Taipei City, Taiwan 115 (CN). LEE, Meng-Ju; 7F., No.3-2, A61K 31/277 (2006.01) A61K 9/20 (2006.01) Yuanqu St., Nangang Dist., Taipei City, Taiwan 115 (CN). A61K 9/08 (2006.01) A61K 9/48 (2006.01) LIAO, Yi-Ping; 7F., No.3-2, Yuanqu St., Nangang Dist., A61K 9/14 (2006.01) A61P 3/10 (2006.01) Taipei City, Taiwan 115 (CN). YEH, Yu-Yin; 7F., No.3-2, (21) International Application Number: Yuanqu St., Nangang Dist., Taipei City, Taiwan 115 (CN). PCT/CN2017/084746 (74) Agent: CHINA ZHENGHE INTELLECTUAL PROP- (22) International Filing Date: ERTY AGENCY; Unit C7, Floor 17, Block 2, Xihuan 17 May 2017 (17.05.2017) Plaza No.1, Xizhimenwai Street, Xicheng District, Beijing 100044 (CN). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, (30) Priority Data: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 62/339,131 20 May 2016 (20.05.2016) US CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicant: CENTER LABORATORIES, INC. HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, [CN/CN]; 7F., No.3-2, Yuanqu St., Nangang Dist., Taipei KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, City, Taiwan 115 (CN). MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, (72) Inventors: HSU, Jui-Pao; 7F., No.3-2, Yuanqu St., Nan- SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, — gang Dist., Taipei City, Taiwan 115 (CN). SHANE, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. — Guang-Tzuu; 7F., No.3-2, Yuanqu St., Nangang Dist., = (54) Title: METHOD = _ FIG 3 = = _ = \"o —I ISM = CZ 800 - — E = ii) = t 600 - 0 = U) = = 400 - = ii) 0 200 - E 1=1 Vehicle, 1111111 Vehicle, OF .x. Metformin \ ‘,, ,, k' ' , \ K‘ \ s \ TREATING HYPERGLYCEMIA db/m+, 10mUkg ,;• . 24' . /, ': 2 .., ; •<' .'.-- ;' ,.?' ,:;,, , , 7 I '= — = — Imo 10mUkg - ZS CM =I + .i. N t 7 / : 7 R-VPM, R-VPM, R-VPM, .• so :\". — 15mg/kg, 30mg/kg, 50mg/kg, r---1 + bid bid bid P<0.05 \\'' s ks ks E3 MI =I ... R-VPM, R-VPM, R-VPM, ....._ * 15mg/kg, 30mg/kg, 50mg/kg, P<0.05 r—i + ' 'N bid bid bid ',` ,:• , ,,, ,, / + + + *** i l - 7 - — _ Metformin Metformin Metformin u- C) isCI IN Day ,-1 co C :N (57) : Disclosed herein are methods for treating conditions and/or disorders related to hyperglycemia. Such conditions and/or 1-1 ----- disorders related to hyperglycemia include, but are not limited to, type I, II diabetes mellitus, gestational diabetes, other forms diabetes, IN and disorders related thereto. In particular, the present invention relates to methods of using (R) - (+) -verapamil or a pharmaceutically © acceptable salt thereof in the treatment of conditions and/or disorders related to hyperglycemia. ei O [Continued on next page] WO 2017/198177 Al MIDEDIMOMOIDEIRMEMOMOHHHOEBERVOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3))