SG11201809783RA - Dna monoclonal antibodies targeting influenza virus - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property 11111111111111111111111111111111111111111111111111111111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/192946 Al 09 November 2017 (09.11.2017) W I P0 I P C T (51) International Patent Classification: (74) Agent: NGUYEN, Quang, D. et al.; Riverside Law, LLP, C07K 16/08 (2006.01) A61K 48/00 (2006.01) Glenhardie Corporation Center, 1285 Drummers Lane, C07K 16/00 (2006.01) Suite 202, Wayne, PA 19087 (US). (21) International Application Number: (81) Designated States (unless otherwise indicated, for every PCT/US2017/031213 kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, 05 May 2017 (05.05.2017) CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (25) Filing Language: English HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, (26) Publication Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, (30) Priority Data: PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/332,381 05 May 2016 (05.05.2016) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, 62/376,162 17 August 2016 (17.08.2016) US TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: WEINER, David [US/US]; 717 Beacon Lane, (84) Designated States (unless otherwise indicated, for every Merion, PA 19066 (US). kind of regional protection available): ARIPO (BW, GH, (72) Inventors; and GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (71) Applicants: ELLOTT, Sarah [US/US]; P.O.Box 301, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, — Pullman, WA 99163 (US). PATEL, Ami [US/US]; 1 EE, ES, FL FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, Rainey Court, Philadelphia, PA 19103 (US). YAN, Man — MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, = [US/US]; 503 Sheffild Drive, Wallingford, PA 19086 (US). = (54) Title: DNA MONOCLONAL ANTIBODIES TARGETING INFLUENZA VIRUS DMAb 5J8 construct = = = Influenza DMAb contain variable regions i- . 5J8 from anti-influenza monoclonal = published =fi a antibodies = = = 5 J8 (Krause et al, J Virol, 2011) = • Binds to receptor binding pocket on = variable globular head • Cross-reactive to multiple influenza-A H1 viruses 1-1 7r tz. Influenza Hemacialutinin ei tz Figure 1 • —I Ir -- - 1 -1 (57) : Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an anti-influenza-hemag- N glutinin synthetic antibody. The disclosure also provides a method of preventing and/or treating influenza in a subject using said com- _ position and method of generation. [Continued on next page] WO 2017/192946 Al MIDEDIMOMMIDIRMEMOMOICHOMMODEVOIMIE TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — before the expiration of the time limit for amending the claims and to be republished in the event of receipt amendments (Rule 48.2(h)) of — with sequence listing part of description (Rule 5.2(a))