SG11201809695TA - Modulators of the integrated stress pathway - Google Patents

Modulators of the integrated stress pathway

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Publication number
SG11201809695TA
SG11201809695TA SG11201809695TA SG11201809695TA SG11201809695TA SG 11201809695T A SG11201809695T A SG 11201809695TA SG 11201809695T A SG11201809695T A SG 11201809695TA SG 11201809695T A SG11201809695T A SG 11201809695TA SG 11201809695T A SG11201809695T A SG 11201809695TA
Authority
SG
Singapore
Prior art keywords
co7d
avenue
international
libertyville
pct
Prior art date
Application number
SG11201809695TA
Inventor
Carmela Sidrauski
Marina Pliushchev
Jennifer Frost
Lawrence BLACK
Xiangdong Xu
Ramzi Sweis
Lei Shi
Qinwei Zhang
Yunsong Tong
Charles Hutchins
Seungwon Chung
Michael DART
Original Assignee
Calico Life Sciences Llc
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calico Life Sciences Llc, Abbvie Inc filed Critical Calico Life Sciences Llc
Publication of SG11201809695TA publication Critical patent/SG11201809695TA/en

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C237/48—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring being part of a condensed ring system of the same carbon skeleton
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization 111111111111 0 1101010 11111 010 11111 0 11 01111111 0011111100111111110 1111 0111111 International Bureau (10) International Publication Number (43) International Publication Date .....0\"\" WO 2017/193034 Al 09 November 2017 (09.11.2017) WIP0 I PCT (51) International Patent Classification: C07D 213/73 (2006.01) C07D 261/08 (2006.01) C07D 317/64 (2006.01) C07D 261/20 (2006.01) PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. SC, TR, C07D 231/56 (2006.01) C07C 235/00 (2006.01) C07D 401/04 (2006.01) C07D 271/113 (2006.01) (84) Designated States (unless otherwise indicated, for every CO7D 237/14 (2006.01) CO7D 213/30 (2006.01) CO7D 237/16 (2006.01) CO7D 213/64 (2006.01) CO7D 405/08 (2006.01) CO7D 213/66 (2006.01) CO7D 241/18 (2006.01) A61K 31/44 (2006.01) CO7D 471/04 (2006.01) A61P 35/00 (2006.01) kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TZ, TJ, LV, (21) International Application Number: PCT/US2017/031360 TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, KM, ML, MR, NE, SN, TD, TG). GW, (22) International Filing Date: 05 May 2017 (05.05.2017) Published: — with international search report (Art. 21(3)) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: _ 62/332,278 05 May 2016 (05.05.2016) US (71) Applicants: CALICO LIFE SCIENCES [US/US]; 1170 = Veterans Blvd, South San Francisco, CA 94080 (US). AB- — BVIE, INC. [US/US]; 1 North Waukegan Road, North = Chicago, IL 60064 (US). Inventors: SIDRAUSKI, Carmelo; 20434 Walnut Ave, Saratoga, CA 95070 (US). PLIUSHCHEV, Marina; 1834 — (72) Ridge Avenue, Unit 108, Evanston, IL 60201 (US). FROST, Jennifer, M.; 635 Yorktown Lane, Gurnee, IL 60031 (US). BLACK, Lawrence, A.; 993 Green Meadow = = Avenue, Vernon Hills, IL 60061 (US). XU, Xiangdong; — _ 993 Green Meadow Avenue, Vernon Hills, IL 60061 (US). = SWEIS, Ramzi, Farath; 1012 Plaister Avenue, Lake Bluff, IL 60044 (US). SHI, Lei; 1908 Trevino Terrace, Vernon = Hills, IL 60061 (US). ZHANG, Qinwei, I.; 1820 S Falcon = Drive, Libertyville, IL 60048 (US). TONG, Yunsong; 1408 Braxton Road, Libertyville, IL 60048 (US). HUTCHINS, Charles, W.; 31005 Prairie Ridge Road, Green Oaks, IL = = 60048 (US). CHUNG, Seungwon; 1512 Virginia Avenue, = Libertyville, IL 60048 (US). DART, Michael, J.; 844 Yale = — Lane, Highland Park, IL 60035 (US). = — (74) Agent: LARKIN, Angelyn et al.; Goodwin Procter LLP, = 100 Northern Avenue, Boston, MA 02210 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, — 1-1 71' 0 en HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, M KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, 0\ MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 1-1 IN 1-1 (54) 0 Title: MODULATORS OF THE INTEGRATED STRESS PATHWAY N (57) : Provided herein are compounds, compositions, and methods useful for modulating the integrated stress response (ISR) 0 and for treating related diseases; disorders and conditions.
SG11201809695TA 2016-05-05 2017-05-05 Modulators of the integrated stress pathway SG11201809695TA (en)

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