SG11201808774RA - Treatment of renal cell carcinoma with lenvatinib and everolimus - Google Patents

Treatment of renal cell carcinoma with lenvatinib and everolimus

Info

Publication number
SG11201808774RA
SG11201808774RA SG11201808774RA SG11201808774RA SG11201808774RA SG 11201808774R A SG11201808774R A SG 11201808774RA SG 11201808774R A SG11201808774R A SG 11201808774RA SG 11201808774R A SG11201808774R A SG 11201808774RA SG 11201808774R A SG11201808774R A SG 11201808774RA
Authority
SG
Singapore
Prior art keywords
international
lenvatinib
everolimus
april
pct
Prior art date
Application number
SG11201808774RA
Inventor
Alton Kremer
Original Assignee
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai R&D Man Co Ltd filed Critical Eisai R&D Man Co Ltd
Publication of SG11201808774RA publication Critical patent/SG11201808774RA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11111111011110111010101111101011111011101011111111011111001101111101111011111 International Bureau .. .... ..Yejd (10) International Publication Number ..... .....1 (43) International Publication Date WO 2017/179739 Al 19 October 2017(19.10.2017) WIPO I PCT (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/47 (2006.01) A61K 31/436 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 9/20 (2006.01) A61P 35/00 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, A61K 9/48 (2006.01) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FL GB, GD, GE, GH, GM, GT, (21) International Application Number: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, PCT/JP2017/015461 KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (22) International Filing Date: MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, 17 April 2017 (17.04.2017) NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, (25) Filing Language: English TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (26) Publication Language: English ZA, ZM, ZW. (30) Priority Data: (84) Designated States (unless otherwise indicated, for every 2016-081787 15 April 2016 (15.04.2016) JP kind of regional protection available): ARIPO (BW, GH, 62/322916 15 April 2016 (15.04.2016) US GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (71) Applicant: EISAI R&D MANAGEMENT CO., LTD. TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, [JP/JP]; 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, 1128088 DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, (JP). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, — (72) Inventor: KREMER Alton; c/o Eisai Inc., 155 Tice Blvd, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Woodcliff Lake, NJ, 07677 (US). Agents: HASEGAWA Yoshiki et al.; SOEI PATENT Published: (74) = AND LAW FIRM, Marunouchi MY PLAZA (Meiji Yas- — with international search report (Art. 21(3)) uda Life Bldg.) 9th fl., 1-1, Marunouchi 2-chome, Chiyo - da-ku, Tokyo, 1000005 (JP). = = = = = = = = = = = = = 1-1 C:7 M IN C:7 IN 11 IN 11 © (54) Title: TREATMENT OF RENAL CELL CARCINOMA WITH LENVATINIB AND EVEROLIMUS ei O (57) : Methods and compositions for treating a renal cell carcinoma with the combination of lenvatinib or a pharmaceutic - ally acceptable salt thereof and everolimus are provided. Particularly useful dosages and dose modifications upon the occurrence of adverse events are also provided.
SG11201808774RA 2016-04-15 2017-04-17 Treatment of renal cell carcinoma with lenvatinib and everolimus SG11201808774RA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662322916P 2016-04-15 2016-04-15
JP2016081787 2016-04-15
PCT/JP2017/015461 WO2017179739A1 (en) 2016-04-15 2017-04-17 Treatment of renal cell carcinoma with lenvatinib and everolimus

Publications (1)

Publication Number Publication Date
SG11201808774RA true SG11201808774RA (en) 2018-11-29

Family

ID=60041779

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201808774RA SG11201808774RA (en) 2016-04-15 2017-04-17 Treatment of renal cell carcinoma with lenvatinib and everolimus

Country Status (7)

Country Link
EP (1) EP3442532A4 (en)
KR (1) KR20180129795A (en)
CN (1) CN108883106A (en)
AU (1) AU2017249459A1 (en)
CA (1) CA3019682A1 (en)
SG (1) SG11201808774RA (en)
WO (1) WO2017179739A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109793736A (en) * 2019-01-31 2019-05-24 徐州医科大学 A kind of pleasure cuts down the application for Buddhist nun in preparation natural killer cells agonist
CN116406288A (en) * 2020-06-17 2023-07-07 默沙东有限责任公司 Methods for treating cancer or von-hippel-lindau disease using a combination of a PD-1 antagonist, a HIF-2 alpha inhibitor, and lenvatinib or a pharmaceutically acceptable salt thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1698623T1 (en) * 2003-12-25 2015-07-31 Eisai R&D Management Co., Ltd. Crystal of salt of 4-(3-chloro-4-(cyclopropylaminocarbonyl)amino-phenoxy)-7-methoxy-6-quinolinecarboxamide or of solvate thereof and processes for producing these

Also Published As

Publication number Publication date
CN108883106A (en) 2018-11-23
EP3442532A1 (en) 2019-02-20
WO2017179739A1 (en) 2017-10-19
EP3442532A4 (en) 2019-12-11
AU2017249459A1 (en) 2018-10-25
CA3019682A1 (en) 2017-10-19
KR20180129795A (en) 2018-12-05

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