SG11201807661WA - A closed system for labelling and selecting live cells - Google Patents

A closed system for labelling and selecting live cells

Info

Publication number
SG11201807661WA
SG11201807661WA SG11201807661WA SG11201807661WA SG11201807661WA SG 11201807661W A SG11201807661W A SG 11201807661WA SG 11201807661W A SG11201807661W A SG 11201807661WA SG 11201807661W A SG11201807661W A SG 11201807661WA SG 11201807661W A SG11201807661W A SG 11201807661WA
Authority
SG
Singapore
Prior art keywords
international
new jersey
avenue
closed system
english
Prior art date
Application number
SG11201807661WA
Inventor
David Smith
Wai Shun Chan
Brian Hampson
Robert Preti
Yajuan Jiang
Courtney Leblon
Original Assignee
Hitachi Chemical Advanced Therapeutics Solutions Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Chemical Advanced Therapeutics Solutions Llc filed Critical Hitachi Chemical Advanced Therapeutics Solutions Llc
Publication of SG11201807661WA publication Critical patent/SG11201807661WA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0081—Purging biological preparations of unwanted cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/362—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits changing physical properties of target cells by binding them to added particles to facilitate their subsequent separation from other cells, e.g. immunoaffinity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A61M1/029—Separating blood components present in distinct layers in a container, not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3618—Magnetic separation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3693—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits using separation based on different densities of components, e.g. centrifuging
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/40—Details relating to driving

Abstract

110 PRODUCT BAG & LABELING BAG (WASTE) IR LABELING WASTE) 140 170 CLOSED SYSTEM- LOOP 0 • o MICRO DEXTRAN BEADS COATED WITH ALGINATE (OPTION 2) ALGINATE BEADS OPTION 1 120 130 FINAL PRODUCT BAG 100 W O 20 17 / 15 397 4 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/153974 Al 14 September 2017 (14.09.2017) WIPO I PCT 111111111111110111011111111111010111110111011110110111111011101111111111111110111111 (51) International Patent Classification: GO1N 33/48 (2006.01) C12N 15/00 (2006.01) GO1N 33/487 (2006.01) A61K 35/00 (2006.01) C12N 5/00 (2006.01) (21) International Application Number: PCT/IB2017/051736 (22) International Filing Date: 27 March 2017 (27.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/304,781 7 March 2016 (07.03.2016) US 62/305,779 9 March 2016 (09.03.2016) US (71) Applicant: CALADRIUS BIOSCIENCES, INC. [US/US]; 420 Lexington Avenue, Suite 350, New York, New York 10170 (US). (72) Inventors: SMITH, David; 357 South Maple Avenue, Ridgewood, New Jersey 07450 (US). CHAN, Wai Shun; 150 Overlook Avenue, 14C, Hackensack, New Jersey 07601 (US). HAMPSON, Brian; 215 Bamford Avenue, Hawthorne, New Jersey 07506 (US). PRETI, Robert; 80 Nursery Road, Ridgefield, Connecticut 06877 (US). JI- ANG, Yajuan; 260 Franklin Avenue, Apartment 518, Mahwah, New Jersey 07430 (US). LEBLON, Courtney; 84 Rutgers Lane, Parsippany, New Jersey 07054 (US). (74) Agent: LUBIT, Beverly; McCarter & English LLP, 100 Mulberry Street, Newark, New Jersey 07052 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, [Continued on next page] (54) Title: A CLOSED SYSTEM FOR LABELLING AND SELECTING LIVE CELLS (57) : The described invention provides an auto- FIG. 1 mated, closed system and method for separating/isolating a target cell type from a heterogeneous cell population. WO 2017/153974 Al MIDEDIMOMOIDEIR0101311011001MOBIMMEMOIMIE RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with information concerning request for restoration of the right of priority in respect of one or more priority claims (Rules 26bis.3 and 48.2(b)(vii))
SG11201807661WA 2016-03-07 2017-03-27 A closed system for labelling and selecting live cells SG11201807661WA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662304781P 2016-03-07 2016-03-07
US201662305779P 2016-03-09 2016-03-09
PCT/IB2017/051736 WO2017153974A1 (en) 2016-03-07 2017-03-27 A closed system for labelling and selecting live cells

Publications (1)

Publication Number Publication Date
SG11201807661WA true SG11201807661WA (en) 2018-10-30

Family

ID=59789042

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201807661WA SG11201807661WA (en) 2016-03-07 2017-03-27 A closed system for labelling and selecting live cells

Country Status (8)

Country Link
US (1) US20190099540A1 (en)
JP (1) JP2019509763A (en)
CN (1) CN109196357A (en)
AU (1) AU2017229635A1 (en)
CA (1) CA3016871A1 (en)
GB (1) GB2565664A (en)
SG (1) SG11201807661WA (en)
WO (1) WO2017153974A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11118163B2 (en) * 2017-02-02 2021-09-14 Sartorius Stedim Biotech Gmbh Separation of cell populations by marker identification and sedimentation velocity
WO2019104637A1 (en) * 2017-11-30 2019-06-06 Yantai Ausbio Laboratories Co., Ltd. Method, system and filtration unit for the isolation of particles from biological samples
WO2019178314A1 (en) * 2018-03-14 2019-09-19 Thermogenesis Corporation Buoyancy-activated cell sorting (bacs)-compatible activation/transduction systems and methods
WO2019204645A1 (en) * 2018-04-18 2019-10-24 Cedars-Sinai Medical Center Nanoparticles for boron neutron capture therapy and for diagnosing, detecting, and treating cancer
WO2020055455A1 (en) * 2018-09-14 2020-03-19 Cedars-Sinai Medical Center Targeted nanoparticles for diagnosing, detecting, and treating cancer
EP3907276A4 (en) 2020-03-11 2022-03-30 Showa Denko Materials Co., Ltd. Cell recovery device, cell recovery method, cell separation system, and cell separation method
CN115885036A (en) * 2020-04-03 2023-03-31 米伦纽姆医药公司 Increased efficiency of viral transduction
WO2023147515A1 (en) * 2022-01-28 2023-08-03 Juno Therapeutics, Inc. Methods of manufacturing cellular compositions

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1335181C (en) * 1988-10-11 1995-04-11 R. Alan Hardwick System for selective cell separation from cell concentrate
JP3261456B2 (en) * 1999-10-29 2002-03-04 独立行政法人産業技術総合研究所 Cell culture carrier and method for culturing cells using the carrier
JP2004530436A (en) * 2001-06-22 2004-10-07 ユニべルシテ・カトリック・ドゥ・ルベン Hydrogel beads or capsules as artificial media for spawning insects and feeding endoparasitoids
US7595043B2 (en) * 2001-12-07 2009-09-29 Cytori Therapeutics, Inc. Method for processing and using adipose-derived stem cells
US8426126B2 (en) * 2004-03-18 2013-04-23 Applied Biosystems, Llc Modified surfaces as solid supports for nucleic acid purification
JP4044579B2 (en) * 2005-08-02 2008-02-06 株式会社Ｐｇリサーチ Artificial cartilage tissue
DK2433713T3 (en) * 2007-12-07 2017-09-25 Miltenyi Biotec Gmbh CELL PROCESSING SYSTEMS AND PROCEDURES
FR2931141B1 (en) * 2008-05-13 2011-07-01 Commissariat Energie Atomique MICROFLUIDIC SYSTEM AND METHOD FOR THE SORTING OF AMAS FROM CELLS AND PREFERENCE FOR CONTINUOUS ENCAPSULATION THROUGH THEIR SORTING
SG168174A1 (en) * 2008-07-16 2011-02-28 Kbi Biopharma Inc Methods and systems for manipulating particles using a fluidized bed
US20100210989A1 (en) * 2008-12-23 2010-08-19 Janet Lesley Macpherson Processing blood
WO2011069117A1 (en) * 2009-12-04 2011-06-09 Neostem, Inc. Method of isolation of stem cell populations from peripheral blood using sized-based separation (elutriation)
WO2013096778A1 (en) * 2011-12-21 2013-06-27 Lonza Walkersville Inc. Scalable process for therapeutic cell concentration and residual clearance
US20150093447A1 (en) * 2012-03-23 2015-04-02 Neostem, Inc. Stem cell identification and purification method
US9446105B2 (en) * 2013-03-15 2016-09-20 The Trustees Of The University Of Pennsylvania Chimeric antigen receptor specific for folate receptor β
AR095615A1 (en) * 2013-03-15 2015-10-28 Alder Biopharmaceuticals Inc PURIFICATION OF ANTIBODIES AND PURITY MONITORING
PL3215601T3 (en) * 2014-11-05 2020-11-02 Juno Therapeutics, Inc. Methods for transduction and cell processing

Also Published As

Publication number Publication date
GB2565664A (en) 2019-02-20
AU2017229635A1 (en) 2018-09-20
CA3016871A1 (en) 2017-09-14
WO2017153974A1 (en) 2017-09-14
CN109196357A (en) 2019-01-11
US20190099540A1 (en) 2019-04-04
JP2019509763A (en) 2019-04-11

Similar Documents

Publication Publication Date Title
SG11201807661WA (en) A closed system for labelling and selecting live cells
SG11201906794TA (en) Systems and methods for issuing and tracking digital tokens within distributed network nodes
SG11201904942YA (en) Blockchain-based service execution method and apparatus, and electronic device
SG11201807307VA (en) System and method for aerial system discrimination and action
SG11201804482UA (en) Search and retrieval data processing system for computing near real-time data aggregations
SG11201806650VA (en) Systems and methods for providing a personal distributed ledger
SG11201807334SA (en) Methods, compositions, and devices for information storage
SG11201808968WA (en) Time division multiplexing of synchronization channels
SG11201808014SA (en) Compositions, devices, and methods for cell separation
SG11201808474YA (en) Method and system for desychronization recovery for permissioned blockchains using bloom filters
SG11201806541RA (en) Image classification and labeling
SG11201804814YA (en) Materials and methods for delivering nucleic acids to cochlear and vestibular cells
SG11201806496SA (en) Antigen binding proteins that bind pd-l1
SG11201807784SA (en) 3-desoxy derivative and pharmaceutical compositions thereof
SG11201907476XA (en) Advanced signalling of regions of interest in omnidirectional visual media
SG11201809330TA (en) Item handling system, method and apparatus therefor
SG11201900554YA (en) Spiro-lactam nmda modulators and methods of using same
SG11201901517YA (en) Wireless telecommunications methods and apparatus using system information value tag
SG11201906853QA (en) Anti-rsv monoclonal antibody formulation
SG11201809395XA (en) Executable logic for processing keyed data in networks
SG11201808713YA (en) Ophthalmic compositions comprising levodopa, an antioxidant and an aqueous carrier
SG11201806825RA (en) A data source system agnostic fact category partitioned information repository and methods for the insertion and retrieval of data using the information repository
SG11201903076QA (en) Carbamoyl phenylalaninol compounds and uses therof
SG11201809497RA (en) Processes for preparing phosphorodiamidate morpholino oligomers
SG11201900192VA (en) Assembly line with integrated electronic visual inspection