SG11201806455PA - Human antibodies and binding fragments thereof to tenascin - Google Patents

Human antibodies and binding fragments thereof to tenascin

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Publication number
SG11201806455PA
SG11201806455PA SG11201806455PA SG11201806455PA SG11201806455PA SG 11201806455P A SG11201806455P A SG 11201806455PA SG 11201806455P A SG11201806455P A SG 11201806455PA SG 11201806455P A SG11201806455P A SG 11201806455PA SG 11201806455P A SG11201806455P A SG 11201806455PA
Authority
SG
Singapore
Prior art keywords
international
tenascin
princes
london
pct
Prior art date
Application number
SG11201806455PA
Inventor
Patrick Hextall
Kim Suzanne Midwood
Eric Culbert
Original Assignee
Nascient Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nascient Ltd filed Critical Nascient Ltd
Publication of SG11201806455PA publication Critical patent/SG11201806455PA/en

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    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C—CHEMISTRY; METALLURGY
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Abstract

aTA EGF-L TNIII FBG W O 17 / 1375 42 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/137542 Al 17 August 2017 (17.08.2017) WIPO I PCT (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/18 (2006.01) C07K 14/78 (2006.01) GO1N 33/68 (2006.01) (21) International Application Number: PCT/EP2017/052974 (22) International Filing Date: 10 February 2017 (10.02.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1602414.3 10 February 2016 (10.02.2016) GB (71) Applicant: NASCIENT LIMITED [GB/GB]; Imperial In- novations Ltd, 52 Princes Gate, Exhibition Road, London SW7 2PG (GB). (72) Inventors: HEXTALL, Patrick; c/oNascient Limited, Im- perial Innovations, 52 Princes Gate, London SW7 2PG (GB). MIDWOOD, Kim Suzanne; Kennedy Institute of Rheumatology, Roosevelt Drive Headington, Headington, Oxford OX3 7FY (GB). CULBERT, Eric; c/oNascient Limited, Imperial Innovations, 52 Princes Gate, London SW7 2PG (GB). (74) Agents: STERLING IP et al.; Orion House, Bessemer Road, Welwyn Garden City Hertfordshire AL7 1HH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a)) (54) Title: HUMAN ANTIBODIES AND BINDING FRAGMENTS THEREOF TO TENASCIN FIGURE 9 (57) : The present disclosure relates fully antibodies and binding fragments, to a Tenascin, in particular the FBG domain of a Tenascin, which are potentially less immunogenic than the parent antibody. The disclosure also relates to composition comprising the antibody or binding fragment and use of any one of the same for diagnosis, prognosis and/or treatment of disorders such as those associated with chronic inflammation. The disclosure further provides methods of making said antibodies. 111111111111110111011111111111010111110111011101111111110011111011111111111110111111
SG11201806455PA 2016-02-10 2017-02-10 Human antibodies and binding fragments thereof to tenascin SG11201806455PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1602414.3A GB201602414D0 (en) 2016-02-10 2016-02-10 Biological materials and uses thereof
PCT/EP2017/052974 WO2017137542A1 (en) 2016-02-10 2017-02-10 Human antibodies and binding fragments thereof to tenascin

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SG11201806455PA true SG11201806455PA (en) 2018-08-30

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