SG11201806422XA - Compositions comprising choline and their use - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/167895 Al 5 October 2017 (05.10.2017) WIPO I PCT 111111111111110111011111111111010111110 0111100111111101111111111111111110111111 (51) (21) International Patent Classification: A61K 31/14 (2006.01) A61P 25/00 (2006.01) International Application Number: PCT/EP2017/057571 (22) International Filing Date: 30 March 2017 (30.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/315,134 30 March 2016 (30.03.2016) US 62/315,142 30 March 2016 (30.03.2016) US 62/315,152 30 March 2016 (30.03.2016) US 62/315,158 30 March 2016 (30.03.2016) US 62/315,163 30 March 2016 (30.03.2016) US 62/328,105 27 April 2016 (27.04.2016) US PCT/EP2016/080790 13 December 2016 (13.12.2016) EP (71) Applicant: NESTEC S.A. [CH/CH]; Avenue Nestle 55, 1800 VEVEY (CH). (72) Inventors: SCHNEIDER, Nora; 31, Rte de la Croix- Blanche, 1066 Epalinges (CH). HAUSER, Jonas; 39, Rue de l'Ale, 1003 Lausanne (CH). SILVA ZOLEZZI, Irma; 5, Chemin de la Fontanettaz, 1084 Carrouge (CH). SAMUEL, Tinu, Mary; 98, Le Grand Chemin, 1066 Epalinges (CH). DEONI, Sean; Brown University, Divi- sion of Engineering, Providence, Rhode Island 02912 (US). BARTFAI, Tamas; 32, Upplandsgatan, 11328 Stockholm (SE). (74) Agent: NAUDE, Dawn; Nestle Research Center, Vers- chez-les-Blanc, 1000 Lausanne 26 (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) W O 20 17 / 167 895 Al (54) Title: COMPOSITIONS COMPRISING CHOLINE AND THEIR USE (57) : The present invention relates to a composition comprising choline for use in promoting, supporting or optimizing one or more of the following: (i) de novo myelination; (ii) brain structure; (iii) brain connectivity; (iv) intellectual potential; (v) cognitive potential; (vi) learning potential; and (vi) cognitive function; in an offspring of a female subject, wherein said composition is for ad- ministration to the female subject.