SG11201804899YA - Indane derivatives as mglur7 modulators - Google Patents

Indane derivatives as mglur7 modulators

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Publication number
SG11201804899YA
SG11201804899YA SG11201804899YA SG11201804899YA SG11201804899YA SG 11201804899Y A SG11201804899Y A SG 11201804899YA SG 11201804899Y A SG11201804899Y A SG 11201804899YA SG 11201804899Y A SG11201804899Y A SG 11201804899YA SG 11201804899Y A SG11201804899Y A SG 11201804899YA
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Singapore
Prior art keywords
cambridge
co7d
takeda
international
opa
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SG11201804899YA
Inventor
Anne Goldby
Gemma Liwicki
Stephen Mack
Martin Teall
Katy White
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Takeda Pharmaceuticals Co
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Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of SG11201804899YA publication Critical patent/SG11201804899YA/en

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    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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  • Indole Compounds (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property , Organization MD 1111101110101011111 HO 1111101110111011 OH MOH 1111110 IIE III International Bureau .. ..... ..Yi j (10) International Publication Number (43) International Publication Date ..... ...r .....1 WO 2017/131221 Al 3 August 2017 (03.08.2017) W I P0 I P CT (51) International Patent Classification: WHITE, Katy; c/o Takeda Cambridge Limited, 418 Cam- C07C 233/23 (2006.01) C07C 317/30 (2006.01) bridge Science Park, Milton Road, Cambridge CB4 OPA C07D 309/08 (2006.01) CO7D 239/42 (2006.01) (GB). CO7D 309/14 (2006.01) CO7D 413/12 (2006.01) C07C 271/24 (2006.01) CO7C 233/41 (2006.01) (74) Agent: TAKASHIMA, Hajime; Meiji Yasuda Seimei Osaka Midosuji Bldg., 1-1, Fushimimachi 4-chome, Chuo- CO7D 231/12 (2006.01) CO7D 261/10 (2006.01) hi., Osaka-shi, Osaka, 5410044 (JP). CO7D 231/14 (2006.01) CO7C 235/36 (2006.01) CO7C 311/06 (2006.01) CO7D 205/04 (2006.01) (81) Designated States (unless otherwise indicated, for every CO7D 237/14 (2006.01) kind of national protection available): AE, AG, AL, AM, (21) International Application Number: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, PCT/JP2017/003078 BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, 24 January 2017 (24.01.2017) KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, (25) Filing Language: English NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (26) Publication Language: English RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, (30) Priority Data: ZA, ZM, ZW. 1601301.3 25 January 2016 (25.01.2016) GB (84) Designated States (unless otherwise indicated, for every (71) Applicant: TAKEDA PHARMACEUTICAL COM- kind of regional protection available): ARIPO (BW, GH, PANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Chuo-ku, Osaka-shi, Osaka, 5410045 (JP). TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, (72) Inventors: GOLDBY, Anne; c/o Takeda Cambridge Lim- TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, ited, 418 Cambridge Science Park, Milton Road, Cam- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, = bridge CB4 OPA (GB). LIWICKI, Gemma; c/o Takeda LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, Cambridge Limited, 418 Cambridge Science Park, Milton SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, = Road, Cambridge CB4 OPA (GB). MACK, Stephen; c/o GW, KM, ML, MR, NE, SN, TD, TG). = Takeda Cambridge Limited, 418 Cambridge Science Park, Published: = Milton Road, Cambridge CB4 OPA (GB). TEALL, Mar- - with tin; c/o Takeda Cambridge Limited, 418 Cambridge Sci- international search report (Art. 21(3)) = ence Park, Milton Road, Cambridge CB4 OPA (GB). = (54) Title: INDANE DERIVATIVES AS MGLUR7 MODULATORS R 2 = = = = Rt 1101 R 3 = R4' — N Il R4a .4 11 N N illa Il en (I) Il IN 1-1 (57) : The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1, 0 R2, R3, R4a and R4 b are as defined in the specification, processes for their preparation, pharmaceutical compositions containing \" them and their use in therapy. The compounds of formula (I) are mGluR7 modulators.
SG11201804899YA 2016-01-25 2017-01-24 Indane derivatives as mglur7 modulators SG11201804899YA (en)

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GBGB1601301.3A GB201601301D0 (en) 2016-01-25 2016-01-25 Novel compounds
PCT/JP2017/003078 WO2017131221A1 (en) 2016-01-25 2017-01-24 Indane derivatives as mglur7 modulators

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EP3366683A1 (en) 2017-02-28 2018-08-29 Acousia Therapeutics GmbH Cyclic amides, acteamides and ureas useful as potassium channel openers
JP7453365B2 (en) 2020-05-29 2024-03-19 富士フイルム富山化学株式会社 High purity N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide and its production method

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK626889A (en) * 1988-12-16 1990-06-17 Roussel Uclaf INDANDER DERIVATIVES, THEIR PREPARATION AND MEDICINES WITH CONTENTS
EP0957092A1 (en) * 1992-06-22 1999-11-17 Boehringer Ingelheim Pharma KG Ring-closed dihydropyridines and their use in the preparation of pharmaceutical compositions
DE4220353A1 (en) * 1992-06-22 1993-12-23 Boehringer Ingelheim Kg Use of fused di:hydro-pyridinyl phenyl acetic acid derivs. - as anti-proliferative agents in treatment of tumours
EP1012166B1 (en) * 1997-08-29 2003-10-29 Tularik Limited 1-amino-7-isoquinoline derivatives as serine protease inhibitors
EP1192132B1 (en) * 1999-06-14 2005-09-07 Eli Lilly And Company Serine protease inhibitors
AU5667900A (en) * 1999-06-30 2001-01-22 Prescient Neuropharma Inc. 2-aminoindane analogs
EP1193248A1 (en) * 2000-09-30 2002-04-03 Aventis Pharma Deutschland GmbH Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use
WO2002051232A2 (en) * 2000-12-27 2002-07-04 Actelion Pharmaceuticals Ltd. Novel benzazepines and related heterocyclic derivatives
PE20020856A1 (en) * 2001-02-13 2002-11-11 Aventis Pharma Gmbh 1,2,3,4-TETRAHYDRONAFTIL ACILATED AMINES
TWI243164B (en) * 2001-02-13 2005-11-11 Aventis Pharma Gmbh Acylated indanyl amines and their use as pharmaceuticals
DE10108307A1 (en) * 2001-02-21 2002-08-29 Gruenenthal Gmbh Substituted propane-1,3-diamine derivatives
CA2451057A1 (en) * 2001-06-14 2002-12-27 Banyu Pharmaceutical Co., Ltd. Novel isoxazolopyridone derivatives and use thereof
TW200403058A (en) * 2002-04-19 2004-03-01 Bristol Myers Squibb Co Heterocyclo inhibitors of potassium channel function
EP1388342A1 (en) * 2002-08-07 2004-02-11 Aventis Pharma Deutschland GmbH Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals
EP1477167A1 (en) * 2003-05-15 2004-11-17 Pfizer Limited [(2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl)-ethylamino)-propyl] phenyl derivatives as beta2 agonists
EP1529525A1 (en) * 2003-11-06 2005-05-11 Aventis Pharma Deutschland GmbH ENOS transcription enhancers for use in the cell therapy of ischemic heart diseases
US7504400B2 (en) * 2004-03-10 2009-03-17 Janssen Pharmaceutica N.V. MTP inhibiting aryl piperydines or piperazines substituted with 5-membered heterocycles
RU2403242C2 (en) * 2004-08-09 2010-11-10 Глэксо Груп Лимитед Compounds, enhancing glutamate receptor, and their application in medicine
CN101248046A (en) * 2005-07-11 2008-08-20 德福根有限公司 Amide derivatives as kinase inhibitors
US8324250B2 (en) * 2009-03-19 2012-12-04 Hoffmann-La Roche Inc. Piperidine derivatives as NK3 receptor antagonists

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GB201601301D0 (en) 2016-03-09
PE20181333A1 (en) 2018-08-20
TW201733977A (en) 2017-10-01
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CN108602760A (en) 2018-09-28
CL2018002010A1 (en) 2019-03-15
MX2018009078A (en) 2018-11-09
CA3012443A1 (en) 2017-08-03
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AR107426A1 (en) 2018-04-25
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ECSP18056196A (en) 2018-08-31
WO2017131221A1 (en) 2017-08-03
KR20180108600A (en) 2018-10-04
MA43922A (en) 2018-12-05
UY37084A (en) 2017-08-31
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EP3408256A1 (en) 2018-12-05
HK1257091A1 (en) 2019-10-11

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