SG11201804884PA - Method for modulating autophagy and applications thereof - Google Patents

Method for modulating autophagy and applications thereof

Info

Publication number
SG11201804884PA
SG11201804884PA SG11201804884PA SG11201804884PA SG11201804884PA SG 11201804884P A SG11201804884P A SG 11201804884PA SG 11201804884P A SG11201804884P A SG 11201804884PA SG 11201804884P A SG11201804884P A SG 11201804884PA SG 11201804884P A SG11201804884P A SG 11201804884PA
Authority
SG
Singapore
Prior art keywords
autophagy
jakkur
centre
bangalore
lab
Prior art date
Application number
SG11201804884PA
Inventor
Ravi Manjithaya
Piyush Mishra
Natesan Suresh Santhi
Somya Bats
Veena Ammanathan
Aravinda Chavalmane
Original Assignee
Jawaharlal Nehru Centre For Advanced Scient Research
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Jawaharlal Nehru Centre For Advanced Scient Research filed Critical Jawaharlal Nehru Centre For Advanced Scient Research
Publication of SG11201804884PA publication Critical patent/SG11201804884PA/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/325—Carbamic acids; Thiocarbamic acids; Anhydrides or salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -, Organization 11 M1111101110101011111 HO 11111 0101101HEIM1100 1111111110111011# International Bureau 0.. .... .. (10) International Publication Number (43) International Publication Date ..... .....!;,' WO 2017/098467 Al 15 June 2017(15.06.2017) WIPO I PCT (51) International Patent Classification: Aravinda; Autophagy lab, Molecular Biology and Genet- A61K 31/277 (2006.01) A61K 31/443 (2006.01) ics Unit, Jawaharlal Nehru Centre for Advanced Scientific A61K 31/325 (2006.01) A61P 25/00 (2006.01) Research, Jakkur, Bangalore 560064 (IN). A61K 31/352 (2006.01) A61P 25/28 (2006.01) A61K 31/4025 (2006.01) A61P 25/16 (2006.01) (74) Agents: MUKHARYA, Durgesh et al.; K&S Partners, 4121/B, 6th Cross, 19A Main, HAL II Stage (Extension), (21) International Application Number: Bangalore Karnataka 560 038 (IN). PCT/IB2016/057498 (81) Designated States (unless otherwise indicated, for every (22) International Filing Date: 9 December 2016 (09.12.2016) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (26) Publication Language: English HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, (30) Priority Data: 6596/CHE/2015 9 December 2015 (09.12.2015) IN MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, (71) Applicant: JAWAHARLAL NEHRU CENTRE FOR RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. ADVANCED SCIENTIFIC RESEARCH [IN/IN]; Jakkur, Karnataka, Bangalore 560064 (IN). (84) Designated States (unless otherwise indicated, for every (72) Inventors: MANJITHAYA, Ravi; Autophagy lab, Mo- _ lecular Biology and Genetics Unit, Jawaharlal Nehru kind of regional protection available): ARIPO (BW, GH, Centre for Advanced Scientific Research, Jakkur, Ban- galore 560064 (IN). MISHRA, Piyush; Autophagy lab, Molecular Biology and Genetics Unit, Jawaharlal Nehru GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, — _ _ Centre for Advanced Scientific Research, Jakkur, Ban- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: = galore 560064 (IN). SANTHI NATESAN, Suresh; Auto- phagy lab, Molecular Biology and Genetics Unit, Jawa- harlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064 (IN). BATS, Somya; Auto- = = lab, Molecular Biology and Genetics Unit, Jawa- phagy harlal Nehru Centre for Advanced Scientific Research, Jakkur, Bangalore 560064 (IN). AMMANATHAN, of inventorship (Rule 4.17(iv)) Published: Veena; Autophagy lab, Molecular Biology and Genetics = Unit, Jawaharlal Nehru Centre for Advanced Scientific Re- with international search report (Art. 21(3)) = search, Jakkur, Bangalore 560064 (IN). CHAVALMANE, = = = = = = 1-1 IN 7r GC t:t © IN 1-1 (54) Title: METHOD FOR MODULATING AUTOPHAGY AND APPLICATIONS THEREOF 0 ei (57) : The present disclosure relates to method of modulating autophagy by modulators of autophagy, wherein the auto - en. ) phagy includes but is not limited to macroautophagy, chaperone mediated autophagy and microautophagy. The present disclosure further relates to modulators of autophagy for increasing or decreasing the autophagic flux. The disclosure also relates to modulator per se in modulating autophagy including but not limiting to macroautophagy, chaperon mediated autophagy and microautophagy.
SG11201804884PA 2015-12-09 2016-12-09 Method for modulating autophagy and applications thereof SG11201804884PA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN6596CH2015 2015-12-09
PCT/IB2016/057498 WO2017098467A1 (en) 2015-12-09 2016-12-09 Method for modulating autophagy and applications thereof

Publications (1)

Publication Number Publication Date
SG11201804884PA true SG11201804884PA (en) 2018-07-30

Family

ID=57681685

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201804884PA SG11201804884PA (en) 2015-12-09 2016-12-09 Method for modulating autophagy and applications thereof

Country Status (5)

Country Link
US (1) US20180369186A1 (en)
EP (1) EP3386498A1 (en)
AU (2) AU2016366810A1 (en)
SG (1) SG11201804884PA (en)
WO (1) WO2017098467A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109384782A (en) * 2017-08-04 2019-02-26 厦门大学 Substituted five-membered and hexa-member heterocycle class compound, preparation method, pharmaceutical composition and application thereof
JOP20180094A1 (en) * 2017-10-18 2019-04-18 Hk Inno N Corp Heterocyclic compound as a protein kinase inhibito
WO2019118734A1 (en) 2017-12-13 2019-06-20 The Trustees Of Columbia University In The City Of New York Compositions and methods for treating motor neuron diseases
US11357780B2 (en) 2018-04-02 2022-06-14 The Children's Medical Center Corporation Methods and compositions relating to the inhibition of IP6K1
CN110812348A (en) * 2018-08-13 2020-02-21 天津科技大学 Novel application of quaternary ammonium compound
WO2022229985A1 (en) * 2021-04-29 2022-11-03 Jawaharlal Nehru Centre For Advanced Scientific Research Soluble analogues of 6bio thereof and implementation thereof
EP4183449A1 (en) * 2021-11-17 2023-05-24 Samsara Therapeutics Inc. Autophagy inducing compounds and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2799944A1 (en) * 2010-05-20 2011-11-24 University Of Rochester Methods and compositions related to modulating autophagy

Also Published As

Publication number Publication date
US20180369186A1 (en) 2018-12-27
WO2017098467A1 (en) 2017-06-15
AU2016366810A1 (en) 2018-06-28
EP3386498A1 (en) 2018-10-17
AU2019275604A1 (en) 2020-01-02

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