SG11201803794YA - Method for preventing or treating nosocomial pneumonia - Google Patents
Method for preventing or treating nosocomial pneumoniaInfo
- Publication number
- SG11201803794YA SG11201803794YA SG11201803794YA SG11201803794YA SG11201803794YA SG 11201803794Y A SG11201803794Y A SG 11201803794YA SG 11201803794Y A SG11201803794Y A SG 11201803794YA SG 11201803794Y A SG11201803794Y A SG 11201803794YA SG 11201803794Y A SG11201803794Y A SG 11201803794YA
- Authority
- SG
- Singapore
- Prior art keywords
- gaithersburg
- llc
- way
- medlmmune
- medimmune
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1214—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Pseudomonadaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/40—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum bacterial
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property -' Organization International Bureau ires.. 00) (43) International Publication Date ..... ..sr ,„,„. 8 June 2017 (08.06.2017) W I P0 1 PCT (10) WO International 111111111111311111111111111111111111111111111111111111111111111111111111111111111111111111 2017/095744 Publication Al Number (51) International Patent Classification: (74) Agents: MARTIN, Cynthia, Lan et al.; Medlmmune, CO7H 21/04 (2006.01) A61K 39/104 (2006.01) LLC, One MedImmune Way, Gaithersburg, MD 20878 C12P 21/08 (2006.01) C07K 16/00 (2006.01) (US). A61K 39/00 (2006.01) (81) Designated States (unless otherwise indicated, for every (21) International Application Number: kind of national protection available): AE, AG, AL, AM, PCT/US2016/063865 AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (22) International Filing Date: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, 28 November 2016 (28.11.2016) HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (25) Filing Language: English KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (26) Publication Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (30) Priority Data: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, 62/260,935 30 November 2015 (30.11.2015) US TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant: MEDIMMUNE, LLC [US/US]; One Medlm- mune Way, Gaithersburg, MD 20878 (US). (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (72) Inventors: JAFRI, Hasan; MedImmune, LLC, One GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, Medlmmune Way, Gaithersburg, MD 20878 (US). DIGI- TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, ANDOMENICO, Anthony; Medlmmune, LLC, One TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, Medlmmune Way, Gaithersburg, MD 20878 (US). MC- DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, CARTHY, Michael; MedImmune, LLC, One MedImmune LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, MD 20878 YU, Xiang-Qing; Way, Gaithersburg, (US). SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, Medlmmune, LLC, One Medlmmune Way, Gaithersburg, GW, KM, ML, MR, NE, SN, TD, TG). MD 20878 (US). STOVER, Charles, K.; MedImmune, Declarations under Rule 4.17: LLC, One Medlmmune Way, Gaithersburg, MD 20878 (US). BISHOP, Brian; MedImmune, LLC, One Medlm- — as to applicant's entitlement to apply for and be a granted mune Way, Gaithersburg, MD 20878 (US). patent (Rule 4.170) — as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) [Continued on next page] Title: METHOD FOR PREVENTING OR TREATING NOSOCOMIAL PNEUMONIA (54) FIG.1 Study Day 12 4 8 15 22 29 50 4 )9 )9 )9 4^ - 19 Predose N -= 143 Day -7 to Day -1 Da 1 Treatment Arm 2: single IV dose of 1500 mg or 3000 mg MEIN3902 H Z LEI (/) Z Z 0 9-) N = 286 D ----49 LEP 0 0 (.t co ,.l LE_ 7 1 2 4 8 15 22 29 50 1\" i 1 1\" 1 N = 143 .4t — — * Treatment Arm single IV dose of placebo ll• Legend ll• ], It\"-- MED13902/piacebo administration in ii 01 Post-dose follow-up C:: , IN Il (57) : A method for preventing or treating nosocomial diseases, e.g., diseases caused by Pseudomonas aeruginosa, is O provided. The method includes administering to a susceptible human a specified dose of a bispecific antibody that that specifically \" binds Pseudomonas aeruginosa Psl and PcrV. WO 2017/095744 Al MIDEDIMOMMIDIIMMEHMOMINEMOIMINVOIMIE • \"\"\"°\"\"`' — with sequence listing part of description (Rule 5.2(a)) — with international search report (Art. 21(3))
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562260935P | 2015-11-30 | 2015-11-30 | |
PCT/US2016/063865 WO2017095744A1 (en) | 2015-11-30 | 2016-11-28 | Method for preventing or treating nosocomial pneumonia |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201803794YA true SG11201803794YA (en) | 2018-06-28 |
Family
ID=58798034
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913100WA SG10201913100WA (en) | 2015-11-30 | 2016-11-28 | Method for preventing or treating nosocomial pneumonia |
SG11201803794YA SG11201803794YA (en) | 2015-11-30 | 2016-11-28 | Method for preventing or treating nosocomial pneumonia |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913100WA SG10201913100WA (en) | 2015-11-30 | 2016-11-28 | Method for preventing or treating nosocomial pneumonia |
Country Status (11)
Country | Link |
---|---|
US (2) | US11066461B2 (en) |
EP (1) | EP3383884A4 (en) |
JP (2) | JP7110095B2 (en) |
KR (1) | KR20180088442A (en) |
CN (1) | CN108368149A (en) |
AU (1) | AU2016362202B2 (en) |
CA (1) | CA3005665A1 (en) |
HK (2) | HK1254854A1 (en) |
IL (1) | IL259509A (en) |
SG (2) | SG10201913100WA (en) |
WO (1) | WO2017095744A1 (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2014100111A (en) | 2011-06-10 | 2015-07-20 | МЕДИММЬЮН, ЭлЭлСи | MOLECULES RELATING TO Psl Pseudomonas, AND WAYS OF THEIR APPLICATION |
LT2776065T (en) * | 2011-11-07 | 2020-10-12 | Medimmune Limited | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
SG10201913100WA (en) | 2015-11-30 | 2020-03-30 | Medimmune Ltd | Method for preventing or treating nosocomial pneumonia |
BR112021023335A2 (en) * | 2019-06-11 | 2022-01-04 | Regeneron Pharma | Isolated recombinant or antigen-binding fragment thereof and isolated monoclonal or antigen-binding fragment thereof, pharmaceutical composition, isolated polynucleotide molecule, vector, cell, method of decreasing the risk of acquiring p. aeruginosa, and methods of decreasing the bacterial load in a subject with a p. aeruginosa, of increasing survival or the probability of survival of a subject suffering from p. aeruginosa or a subject at risk of infection with p. aeruginosa, to improve or reduce the severity, duration, or frequency of occurrence of at least one symptom of a p. aeruginosa, to increase survival or the likelihood of survival of a subject suffering from cystic fibrosis |
IL309559A (en) | 2021-07-09 | 2024-02-01 | Luxembourg Inst Of Health Lih | Dimeric protein complexes and uses thereof |
WO2024003103A1 (en) * | 2022-06-29 | 2024-01-04 | Astrazeneca Ab | Anti-pcrv and psl bispecific antibodies for treatment of bronchiectasis |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DK0710719T3 (en) | 1990-01-12 | 2007-07-09 | Amgen Fremont Inc | Generation of xenogenic antibodies |
RU2014100111A (en) | 2011-06-10 | 2015-07-20 | МЕДИММЬЮН, ЭлЭлСи | MOLECULES RELATING TO Psl Pseudomonas, AND WAYS OF THEIR APPLICATION |
LT2776065T (en) | 2011-11-07 | 2020-10-12 | Medimmune Limited | Combination therapies using anti- pseudomonas psl and pcrv binding molecules |
BR112015010240A2 (en) * | 2012-11-06 | 2017-08-22 | Medimmune Ltd | COMBINATION THERAPIES THROUGH THE USE OF PSL-BINDING MOLECULES AND ANTI-PSEUDOMONAL PCRV |
CA2911209A1 (en) | 2013-05-14 | 2014-11-20 | Medimmune, Llc | Synthetic oligosaccharide subunits of the psl exopolysaccharide of pseudomonas aeruginosa and uses thereof |
US20170183397A1 (en) * | 2014-05-05 | 2017-06-29 | Medimmune, Llc | Multi-specific anti-pseudomonas psl and pcrv binding molecules and uses thereof |
TWI719938B (en) | 2014-06-19 | 2021-03-01 | 美商麥迪紐有限責任公司 | Treatment of polybacterial infections |
SG10201913100WA (en) | 2015-11-30 | 2020-03-30 | Medimmune Ltd | Method for preventing or treating nosocomial pneumonia |
-
2016
- 2016-11-28 SG SG10201913100WA patent/SG10201913100WA/en unknown
- 2016-11-28 WO PCT/US2016/063865 patent/WO2017095744A1/en active Application Filing
- 2016-11-28 AU AU2016362202A patent/AU2016362202B2/en active Active
- 2016-11-28 KR KR1020187018422A patent/KR20180088442A/en unknown
- 2016-11-28 CA CA3005665A patent/CA3005665A1/en active Pending
- 2016-11-28 SG SG11201803794YA patent/SG11201803794YA/en unknown
- 2016-11-28 EP EP16871318.8A patent/EP3383884A4/en not_active Withdrawn
- 2016-11-28 US US15/779,189 patent/US11066461B2/en active Active
- 2016-11-28 JP JP2018526715A patent/JP7110095B2/en active Active
- 2016-11-28 CN CN201680068970.2A patent/CN108368149A/en active Pending
-
2018
- 2018-05-22 IL IL259509A patent/IL259509A/en unknown
- 2018-11-01 HK HK18113950.1A patent/HK1254854A1/en unknown
- 2018-12-18 HK HK18116170.8A patent/HK1257193A1/en unknown
-
2021
- 2021-06-22 US US17/354,161 patent/US20220041695A1/en not_active Abandoned
-
2022
- 2022-07-20 JP JP2022115219A patent/JP2022163050A/en not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
HK1257193A1 (en) | 2019-10-18 |
IL259509A (en) | 2018-07-31 |
JP7110095B2 (en) | 2022-08-01 |
HK1254854A1 (en) | 2019-07-26 |
CA3005665A1 (en) | 2017-06-08 |
WO2017095744A1 (en) | 2017-06-08 |
SG10201913100WA (en) | 2020-03-30 |
EP3383884A1 (en) | 2018-10-10 |
KR20180088442A (en) | 2018-08-03 |
AU2016362202A8 (en) | 2018-07-19 |
EP3383884A4 (en) | 2019-07-31 |
US11066461B2 (en) | 2021-07-20 |
JP2018535227A (en) | 2018-11-29 |
JP2022163050A (en) | 2022-10-25 |
AU2016362202A1 (en) | 2018-07-05 |
US20220041695A1 (en) | 2022-02-10 |
US20180355026A1 (en) | 2018-12-13 |
CN108368149A (en) | 2018-08-03 |
AU2016362202B2 (en) | 2020-02-27 |
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