SG11201708556SA - Combination therapy for non-small cell lung cancer positive for egfr mutation - Google Patents

Combination therapy for non-small cell lung cancer positive for egfr mutation

Info

Publication number
SG11201708556SA
SG11201708556SA SG11201708556SA SG11201708556SA SG11201708556SA SG 11201708556S A SG11201708556S A SG 11201708556SA SG 11201708556S A SG11201708556S A SG 11201708556SA SG 11201708556S A SG11201708556S A SG 11201708556SA SG 11201708556S A SG11201708556S A SG 11201708556SA
Authority
SG
Singapore
Prior art keywords
lung cancer
small cell
cell lung
combination therapy
egfr mutation
Prior art date
Application number
SG11201708556SA
Other languages
English (en)
Inventor
Mohammed M Dar
Joyson J Karakunnel
Haiyi Jiang
Maxwell J Kirkby
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Publication of SG11201708556SA publication Critical patent/SG11201708556SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
SG11201708556SA 2015-04-23 2016-04-22 Combination therapy for non-small cell lung cancer positive for egfr mutation SG11201708556SA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562151739P 2015-04-23 2015-04-23
PCT/EP2016/059083 WO2016170157A1 (fr) 2015-04-23 2016-04-22 Polythérapie pour cancer du poumon non à petites cellules positif pour mutation de l'egfr

Publications (1)

Publication Number Publication Date
SG11201708556SA true SG11201708556SA (en) 2017-11-29

Family

ID=55910937

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201708556SA SG11201708556SA (en) 2015-04-23 2016-04-22 Combination therapy for non-small cell lung cancer positive for egfr mutation

Country Status (13)

Country Link
US (2) US20180147279A1 (fr)
EP (1) EP3285804A1 (fr)
JP (1) JP2018513178A (fr)
KR (1) KR20170139071A (fr)
CN (1) CN107530434A (fr)
AU (1) AU2016251971A1 (fr)
CA (1) CA2983067A1 (fr)
HK (1) HK1247577A1 (fr)
IL (1) IL255058A0 (fr)
RU (1) RU2017136709A (fr)
SG (1) SG11201708556SA (fr)
TW (1) TW201705979A (fr)
WO (1) WO2016170157A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR110038A1 (es) 2016-05-26 2019-02-20 Kalyra Pharmaceuticals Inc Compuestos inhibidores de egfr; composición farmacéutica que lo comprende; métodos para mejorar o tratar un cáncer; método para inhibir la replicación de un crecimiento maligno o un tumor; métodos para inhibir la actividad del egfr; y usos de los compuestos
US20180282417A1 (en) * 2017-03-31 2018-10-04 Medimmune, Llc Tumor burden as measured by cell free dna
BR112020021271A2 (pt) 2018-04-17 2021-01-26 Celldex Therapeutics, Inc. construtos bispecíficos e anticorpos anti- cd27 e anti-pd-l1
WO2020091066A1 (fr) * 2018-11-01 2020-05-07 Momotaro-Gene Inc. Polythérapie pour le traitement du cancer thoracique faisant appel à ad-reic/dkk-3 et à un inhibiteur de point de contrôle
CA3127388A1 (fr) * 2019-01-25 2020-07-30 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Composition pharmaceutique combinee pour le traitement de tumeurs
CN111617243B (zh) * 2019-02-28 2023-12-19 正大天晴药业集团股份有限公司 喹啉衍生物与抗体的药物组合
MX2021011810A (es) * 2019-03-29 2021-10-26 Astrazeneca Ab Osimertinib para su uso en el tratamiento de cancer de pulmon de celulas no peque?as.
KR20220003546A (ko) * 2019-04-17 2022-01-10 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 티로신 키나제 억제제 저항성 egfr 돌연변이를 지니는 암 세포에 대한 항종양 활성을 갖는 화합물
CN112168961A (zh) * 2019-07-03 2021-01-05 正大天晴药业集团南京顺欣制药有限公司 治疗结直肠癌的联用药物组合物
CN114728000A (zh) * 2019-10-21 2022-07-08 荷兰癌症研究所-安东尼·范·雷文虎克医院基金会 治疗癌症的新型药物组合
EP4190362A1 (fr) * 2020-07-31 2023-06-07 Momotaro-Gene Inc. Agent comprenant un gène reic/dkk-3 pour le traitement du cancer du poumon positif pour les mutations du gène egfr

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101070538B (zh) * 2005-03-28 2011-02-09 中国科学院广州生物医药与健康研究院 人表皮生长因子受体突变基因及其用途
RU2701327C2 (ru) * 2013-09-11 2019-09-25 Медиммьюн Лимитед Антитела к b7-h1 для лечения опухолей

Also Published As

Publication number Publication date
JP2018513178A (ja) 2018-05-24
RU2017136709A (ru) 2019-05-23
HK1247577A1 (zh) 2018-09-28
EP3285804A1 (fr) 2018-02-28
IL255058A0 (en) 2017-12-31
US20200171149A1 (en) 2020-06-04
CN107530434A (zh) 2018-01-02
WO2016170157A1 (fr) 2016-10-27
KR20170139071A (ko) 2017-12-18
AU2016251971A1 (en) 2017-12-07
US20180147279A1 (en) 2018-05-31
TW201705979A (zh) 2017-02-16
RU2017136709A3 (fr) 2019-12-11
CA2983067A1 (fr) 2016-10-27

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