SG11201701122XA - Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods - Google Patents

Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods

Info

Publication number
SG11201701122XA
SG11201701122XA SG11201701122XA SG11201701122XA SG11201701122XA SG 11201701122X A SG11201701122X A SG 11201701122XA SG 11201701122X A SG11201701122X A SG 11201701122XA SG 11201701122X A SG11201701122X A SG 11201701122XA SG 11201701122X A SG11201701122X A SG 11201701122XA
Authority
SG
Singapore
Prior art keywords
timp
variants
compositions
methods
tissue inhibitor
Prior art date
Application number
SG11201701122XA
Inventor
Jason C O'neill
Randal R Ketchem
Taeweon Lee
Vishnu Chintalgattu
Jennitte Leann Stevens
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54035361&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG11201701122X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG11201701122XA publication Critical patent/SG11201701122XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81Protease inhibitors
    • C07K14/8107Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
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    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
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    • A61P11/06Antiasthmatics
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    • A61P15/14Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00Drugs for dermatological disorders
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    • AHUMAN NECESSITIES
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    • A61P17/04Antipruritics
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P19/00Drugs for skeletal disorders
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/10Antimycotics
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    • A61P31/12Antivirals
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    • AHUMAN NECESSITIES
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    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
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    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
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    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • AHUMAN NECESSITIES
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    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Otolaryngology (AREA)
  • Emergency Medicine (AREA)
SG11201701122XA 2014-08-27 2015-08-26 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods SG11201701122XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462042574P 2014-08-27 2014-08-27
PCT/US2015/046992 WO2016033212A1 (en) 2014-08-27 2015-08-26 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods

Publications (1)

Publication Number Publication Date
SG11201701122XA true SG11201701122XA (en) 2017-03-30

Family

ID=54035361

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201701122XA SG11201701122XA (en) 2014-08-27 2015-08-26 Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods

Country Status (18)

Country Link
US (2) US11149078B2 (en)
EP (2) EP3575316A1 (en)
JP (3) JP6672257B2 (en)
KR (1) KR20170042301A (en)
CN (1) CN107001445B (en)
AR (1) AR101942A1 (en)
AU (2) AU2015306608B2 (en)
BR (1) BR112017003889A2 (en)
CA (1) CA2956726C (en)
CL (1) CL2017000440A1 (en)
EA (1) EA201790470A1 (en)
ES (1) ES2746264T3 (en)
IL (1) IL249947B (en)
MX (1) MX2017002466A (en)
SG (1) SG11201701122XA (en)
TW (1) TW201613961A (en)
UY (1) UY36280A (en)
WO (1) WO2016033212A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022548627A (en) * 2019-09-16 2022-11-21 ノバルティス アーゲー Use of high-affinity ligand-blocking humanized anti-T cell immunoglobulin domain and mucin domain 3 (TIM-3) IGG4 antibodies for the treatment of myelofibrosis

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US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
JPS6023084B2 (en) 1979-07-11 1985-06-05 味の素株式会社 blood substitute
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4640835A (en) 1981-10-30 1987-02-03 Nippon Chemiphar Company, Ltd. Plasminogen activator derivatives
US4496689A (en) 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
US4740461A (en) 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
DE3675588D1 (en) 1985-06-19 1990-12-20 Ajinomoto Kk HAEMOGLOBIN TIED TO A POLY (ALKENYLENE OXIDE).
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
US4791192A (en) 1986-06-26 1988-12-13 Takeda Chemical Industries, Ltd. Chemically modified protein with polyethyleneglycol
US4959455A (en) 1986-07-14 1990-09-25 Genetics Institute, Inc. Primate hematopoietic growth factors IL-3 and pharmaceutical compositions
US4912040A (en) 1986-11-14 1990-03-27 Genetics Institute, Inc. Eucaryotic expression system
US5011912A (en) 1986-12-19 1991-04-30 Immunex Corporation Hybridoma and monoclonal antibody for use in an immunoaffinity purification system
WO1995005478A1 (en) * 1993-08-12 1995-02-23 The Regents Of The University Of California Human timp-3
US6562596B1 (en) * 1993-10-06 2003-05-13 Amgen Inc. Tissue inhibitor of metalloproteinase type three (TIMP-3) composition and methods
JPH09235300A (en) * 1996-02-29 1997-09-09 Fuji Yakuhin Kogyo Kk Human timp-3 and anti-human timp-3 monoclonal antibody and use thereof
US20030191056A1 (en) 2002-04-04 2003-10-09 Kenneth Walker Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins
WO2004085617A2 (en) 2003-03-21 2004-10-07 The Cleveland Clinic Foundation Timp3 as vegf inhibitor
CN1660433B (en) * 2005-01-10 2011-09-07 王振军 Combination of treating and/or preventing hemorrhoid
CN1660429B (en) * 2005-01-10 2011-09-07 王振军 New application of inhibitor of matrix metal metal protease (MMP) in use for treating hemorrhoid
US20090318342A1 (en) * 2005-07-29 2009-12-24 Imperial Innovations Limited Compounds
DK1764372T3 (en) * 2005-09-20 2009-11-30 Peter Jon Nelson Tissue inhibitor of metalloproteinases (TIMP) bound to glycosylphosphatidylinositol (GPI) anchors for cancer treatment
US7592009B2 (en) 2006-10-10 2009-09-22 Ecole Polytechnique Federale De Lausanne (Epfl) Polypeptide ligands for targeting cartilage and methods of use thereof
US20130143693A1 (en) 2011-12-02 2013-06-06 Charles P. Forrest, Sr. Pop-up tackling practice machine
US20140274874A1 (en) * 2013-03-14 2014-09-18 Amgen Inc. Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
SG11201507524TA (en) * 2013-03-14 2015-10-29 Amgen Inc Variants of tissue inhibitor of metalloproteinase type three (timp-3), compositions and methods
CA2934472A1 (en) * 2014-01-09 2015-07-16 Alpha-O Peptides Ag Flagellin-containing protein nanoparticles as a vaccine platform

Also Published As

Publication number Publication date
IL249947A0 (en) 2017-03-30
EP3186276A1 (en) 2017-07-05
JP6672257B2 (en) 2020-03-25
AU2020203749A1 (en) 2020-06-25
JP7075426B2 (en) 2022-05-25
IL249947B (en) 2021-04-29
CN107001445B (en) 2022-06-24
CN107001445A (en) 2017-08-01
AU2020203749B2 (en) 2021-11-18
MX2017002466A (en) 2017-05-15
AR101942A1 (en) 2017-01-25
UY36280A (en) 2016-04-01
JP2020108383A (en) 2020-07-16
EA201790470A1 (en) 2017-07-31
JP2017532004A (en) 2017-11-02
TW201613961A (en) 2016-04-16
AU2015306608B2 (en) 2020-03-05
KR20170042301A (en) 2017-04-18
CA2956726C (en) 2023-06-06
CL2017000440A1 (en) 2017-10-13
EP3575316A1 (en) 2019-12-04
BR112017003889A2 (en) 2018-02-27
US20220089689A1 (en) 2022-03-24
EP3186276B1 (en) 2019-07-10
WO2016033212A1 (en) 2016-03-03
US11149078B2 (en) 2021-10-19
CA2956726A1 (en) 2016-03-03
AU2015306608A1 (en) 2017-02-02
US20180030116A1 (en) 2018-02-01
JP2022058365A (en) 2022-04-12
ES2746264T3 (en) 2020-03-05

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