SG11201608499XA - Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus - Google Patents

Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus

Info

Publication number
SG11201608499XA
SG11201608499XA SG11201608499XA SG11201608499XA SG11201608499XA SG 11201608499X A SG11201608499X A SG 11201608499XA SG 11201608499X A SG11201608499X A SG 11201608499XA SG 11201608499X A SG11201608499X A SG 11201608499XA SG 11201608499X A SG11201608499X A SG 11201608499XA
Authority
SG
Singapore
Prior art keywords
devices
providing
microfluidic apparatus
same microfluidic
dep manipulation
Prior art date
Application number
SG11201608499XA
Inventor
Igor Y Khandros
Daniele Malleo
J Tanner Nevill
Steven W Short
Ming C Wu
Original Assignee
Berkeley Lights Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US14/262,200 external-priority patent/US20150306599A1/en
Priority claimed from US14/262,140 external-priority patent/US20150306598A1/en
Application filed by Berkeley Lights Inc filed Critical Berkeley Lights Inc
Publication of SG11201608499XA publication Critical patent/SG11201608499XA/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/005Dielectrophoresis, i.e. dielectric particles migrating towards the region of highest field strength
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C5/00Separating dispersed particles from liquids by electrostatic effect
    • B03C5/02Separators
    • B03C5/022Non-uniform field separators
    • B03C5/026Non-uniform field separators using open-gradient differential dielectric separation, i.e. using electrodes of special shapes for non-uniform field creation, e.g. Fluid Integrated Circuit [FIC]
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0647Handling flowable solids, e.g. microscopic beads, cells, particles
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00Additional constructional details
    • B01L2300/08Geometry, shape and general structure
    • B01L2300/0809Geometry, shape and general structure rectangular shaped
    • B01L2300/0819Microarrays; Biochips
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0424Dielectrophoretic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0427Electrowetting
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B03SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03CMAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
    • B03C2201/00Details of magnetic or electrostatic separation
    • B03C2201/26Details of magnetic or electrostatic separation for use in medical applications
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume, or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
SG11201608499XA 2014-04-25 2015-04-25 Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus SG11201608499XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/262,200 US20150306599A1 (en) 2014-04-25 2014-04-25 Providing DEP Manipulation Devices And Controllable Electrowetting Devices In The Same Microfluidic Apparatus
US14/262,140 US20150306598A1 (en) 2014-04-25 2014-04-25 DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
PCT/US2015/027680 WO2015164847A1 (en) 2014-04-25 2015-04-25 Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus

Publications (1)

Publication Number Publication Date
SG11201608499XA true SG11201608499XA (en) 2016-11-29

Family

ID=54333341

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201608499XA SG11201608499XA (en) 2014-04-25 2015-04-25 Providing dep manipulation devices and controllable electrowetting devices in the same microfluidic apparatus

Country Status (9)

Country Link
EP (1) EP3134739B1 (en)
JP (1) JP6802709B2 (en)
KR (1) KR102232094B1 (en)
CN (1) CN106461696B (en)
AU (1) AU2015249294B2 (en)
CA (1) CA2945177C (en)
IL (1) IL248365B (en)
SG (1) SG11201608499XA (en)
WO (1) WO2015164847A1 (en)

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US11192107B2 (en) 2014-04-25 2021-12-07 Berkeley Lights, Inc. DEP force control and electrowetting control in different sections of the same microfluidic apparatus
US20150306598A1 (en) * 2014-04-25 2015-10-29 Berkeley Lights, Inc. DEP Force Control And Electrowetting Control In Different Sections Of The Same Microfluidic Apparatus
EP3227025B1 (en) 2014-12-05 2019-03-27 The Regents of The University of California Single-sided light-actuated microfluidic device with integrated mesh ground
CN107249742B (en) 2014-12-08 2019-12-06 伯克利之光生命科技公司 Directional flow actuated microfluidic structures in microfluidic devices and methods of using the same
SG10201900567QA (en) * 2014-12-08 2019-02-27 Berkeley Lights Inc Microfluidic device comprising lateral/vertical transistor structures and process of making and using same
US9996920B2 (en) 2014-12-09 2018-06-12 Berkeley Lights, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
US10384204B2 (en) 2014-12-10 2019-08-20 Berkeley Lights, Inc. Systems for operating electrokinetic devices
US9744533B2 (en) 2014-12-10 2017-08-29 Berkeley Lights, Inc. Movement and selection of micro-objects in a microfluidic apparatus
US10101250B2 (en) 2015-04-22 2018-10-16 Berkeley Lights, Inc. Manipulation of cell nuclei in a micro-fluidic device
US10723988B2 (en) 2015-04-22 2020-07-28 Berkeley Lights, Inc. Microfluidic cell culture
US10799865B2 (en) 2015-10-27 2020-10-13 Berkeley Lights, Inc. Microfluidic apparatus having an optimized electrowetting surface and related systems and methods
JP6891169B2 (en) * 2015-10-27 2021-06-18 バークレー ライツ,インコーポレイテッド Microfluidic electrowetting device device with covalently bonded hydrophobic surface
US11666913B2 (en) 2015-11-23 2023-06-06 Berkeley Lights, Inc In situ-generated microfluidic isolation structures, kits and methods of use thereof
CA3005077C (en) 2015-12-08 2023-02-28 Berkeley Lights, Inc. In situ-generated microfluidic assay structures, related kits, and methods of use thereof
WO2017117567A1 (en) 2015-12-30 2017-07-06 Berkeley Lights, Inc. Droplet generation in a microfluidic device having an optoelectrowetting configuration
US10712344B2 (en) 2016-01-15 2020-07-14 Berkeley Lights, Inc. Methods of producing patient-specific anti-cancer therapeutics and methods of treatment therefor
EP3429753A4 (en) 2016-03-16 2019-11-06 Berkeley Lights, Inc. Methods, systems and devices for selection and generation of genome edited clones
CN115354025A (en) 2016-03-17 2022-11-18 伯克利之光生命科技公司 Selection and cloning of T lymphocytes in microfluidic devices
AU2017239666B2 (en) 2016-03-31 2021-07-29 Berkeley Lights, Inc. Nucleic acid stabilization reagent, kits, and methods of use thereof
IL295600A (en) 2016-04-15 2022-10-01 Wolff Bregman And Goller Methods, systems and kits for sequestration pen-based assays
CN109689213B (en) 2016-05-26 2022-10-14 伯克利之光生命科技公司 Covalently modified surface, kit, preparation method and application
WO2018018017A1 (en) 2016-07-21 2018-01-25 Berkeley Lights, Inc. Sorting of t lymphocytes in a microfluidic device
CN110114520B (en) 2016-10-01 2023-08-08 伯克利之光生命科技公司 DNA barcode compositions and methods of in situ identification in microfluidic devices
DK3529611T3 (en) 2016-10-23 2023-02-06 Berkeley Lights Inc METHODS FOR SCREENING B CELL LYMPHOCYTES
EP3549099A4 (en) 2016-12-01 2020-07-29 Berkeley Lights, Inc. Automated detection and repositioning of micro-objects in microfluidic devices
WO2018111765A1 (en) 2016-12-12 2018-06-21 xCella Biosciences, Inc. Methods and systems for screening using microcapillary arrays
WO2018200872A1 (en) * 2017-04-26 2018-11-01 Berkeley Lights, Inc. Biological process systems and methods using microfluidic apparatus having an optimized electrowetting surface
CN107527595B (en) * 2017-09-27 2019-06-07 京东方科技集团股份有限公司 A kind of microfluidic system and its driving method
EP3721209B1 (en) 2017-10-15 2024-02-07 Berkeley Lights, Inc. Methods for in-pen assays
CN108387488B (en) * 2018-02-28 2023-08-01 上海欣戈赛生物科技有限公司 Particulate matter detection device and detection method
CN108344678B (en) 2018-04-25 2021-03-26 北京怡天佳瑞科技有限公司 Particulate matter detection device and detection method
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Also Published As

Publication number Publication date
EP3134739A4 (en) 2017-11-22
EP3134739A1 (en) 2017-03-01
CN106461696B (en) 2019-06-07
CA2945177A1 (en) 2015-10-29
KR20160147925A (en) 2016-12-23
JP6802709B2 (en) 2020-12-16
AU2015249294B2 (en) 2020-02-27
EP3134739B1 (en) 2019-07-10
AU2015249294A1 (en) 2016-11-17
KR102232094B1 (en) 2021-03-25
WO2015164847A1 (en) 2015-10-29
CA2945177C (en) 2021-12-21
IL248365A0 (en) 2016-11-30
IL248365B (en) 2021-08-31
CN106461696A (en) 2017-02-22
JP2017519618A (en) 2017-07-20

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