SG11201608064WA - Compositions and methods for treating neurodegenerative diseases - Google Patents

Compositions and methods for treating neurodegenerative diseases

Info

Publication number
SG11201608064WA
SG11201608064WA SG11201608064WA SG11201608064WA SG11201608064WA SG 11201608064W A SG11201608064W A SG 11201608064WA SG 11201608064W A SG11201608064W A SG 11201608064WA SG 11201608064W A SG11201608064W A SG 11201608064WA SG 11201608064W A SG11201608064W A SG 11201608064WA
Authority
SG
Singapore
Prior art keywords
compositions
methods
neurodegenerative diseases
treating neurodegenerative
treating
Prior art date
Application number
SG11201608064WA
Inventor
Michael J Brownstein
Original Assignee
Azevan Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Azevan Pharmaceuticals Inc filed Critical Azevan Pharmaceuticals Inc
Publication of SG11201608064WA publication Critical patent/SG11201608064WA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41781,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42Oxazoles
    • A61K31/422Oxazoles not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4453Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
SG11201608064WA 2014-03-28 2015-03-27 Compositions and methods for treating neurodegenerative diseases SG11201608064WA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461971862P 2014-03-28 2014-03-28
PCT/US2015/023060 WO2015148962A1 (en) 2014-03-28 2015-03-27 Compositions and methods for treating neurodegenerative diseases

Publications (1)

Publication Number Publication Date
SG11201608064WA true SG11201608064WA (en) 2016-10-28

Family

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Family Applications (2)

Application Number Title Priority Date Filing Date
SG10202001065SA SG10202001065SA (en) 2014-03-28 2015-03-27 Compositions and methods for treating neurodegenerative diseases
SG11201608064WA SG11201608064WA (en) 2014-03-28 2015-03-27 Compositions and methods for treating neurodegenerative diseases

Family Applications Before (1)

Application Number Title Priority Date Filing Date
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Country Status (22)

Country Link
US (4) US9802925B2 (en)
EP (1) EP3122743B1 (en)
JP (2) JP7255967B2 (en)
KR (2) KR20160130853A (en)
CN (3) CN116139282A (en)
AU (2) AU2015237253B2 (en)
BR (1) BR112016022575A2 (en)
CA (1) CA2944211C (en)
DK (1) DK3122743T3 (en)
ES (1) ES2939959T3 (en)
FI (1) FI3122743T3 (en)
IL (1) IL248074B (en)
MX (2) MX2016012645A (en)
MY (1) MY184878A (en)
NZ (1) NZ724718A (en)
PL (1) PL3122743T3 (en)
RU (1) RU2742773C2 (en)
SG (2) SG10202001065SA (en)
SI (1) SI3122743T1 (en)
TW (1) TWI736519B (en)
WO (1) WO2015148962A1 (en)
ZA (1) ZA201606673B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
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WO2012003436A1 (en) 2010-07-01 2012-01-05 Azevan Pharmaceuticals, Inc. Methods for treating post traumatic stress disorder
BR112016022575A2 (en) 2014-03-28 2017-08-15 Azevan Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES
TWI622380B (en) * 2017-01-17 2018-05-01 正崴精密工業股份有限公司 Physiological Signal Measuring Device and Blood Oxygen Calculation Method
JP2020534274A (en) 2017-09-15 2020-11-26 アゼヴァン ファーマシューティカルズ,インコーポレイテッド Compositions and Methods for Treating Brain Injury
CN116685313A (en) * 2020-12-23 2023-09-01 细胞基因公司 Indanyl-containing carboxylic acid compounds for the treatment of neurodegenerative diseases
WO2023164710A1 (en) * 2022-02-28 2023-08-31 The Trustees Of Columbia University In The City Of New York Avpr1a blockade to reduce social isolation-induced anxiety in females

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Publication number Publication date
MX2021005502A (en) 2023-01-16
AU2015237253B2 (en) 2019-11-14
CA2944211C (en) 2022-10-04
DK3122743T3 (en) 2023-02-20
CN116327950A (en) 2023-06-27
US11319306B2 (en) 2022-05-03
BR112016022575A2 (en) 2017-08-15
MY184878A (en) 2021-04-29
CN106459021A (en) 2017-02-22
KR20220151037A (en) 2022-11-11
US20180201608A1 (en) 2018-07-19
TW202216702A (en) 2022-05-01
AU2019253831A1 (en) 2019-11-14
IL248074B (en) 2020-07-30
CA2944211A1 (en) 2015-10-01
EP3122743A1 (en) 2017-02-01
RU2016138349A3 (en) 2018-10-26
US20200102294A1 (en) 2020-04-02
JP2022116001A (en) 2022-08-09
CN116139282A (en) 2023-05-23
NZ724718A (en) 2023-04-28
EP3122743A4 (en) 2017-11-29
ZA201606673B (en) 2019-06-26
FI3122743T3 (en) 2023-03-02
SG10202001065SA (en) 2020-04-29
CN106459021B (en) 2023-04-07
SI3122743T1 (en) 2023-07-31
IL248074A0 (en) 2016-11-30
US20230123729A1 (en) 2023-04-20
WO2015148962A1 (en) 2015-10-01
MX2016012645A (en) 2017-01-11
PL3122743T3 (en) 2023-05-02
JP2017510645A (en) 2017-04-13
RU2016138349A (en) 2018-05-04
ES2939959T3 (en) 2023-04-28
US9802925B2 (en) 2017-10-31
TW201620902A (en) 2016-06-16
TWI736519B (en) 2021-08-21
RU2742773C2 (en) 2021-02-10
AU2015237253A1 (en) 2016-10-20
US20170174670A1 (en) 2017-06-22
EP3122743B1 (en) 2022-11-09
US10364236B2 (en) 2019-07-30
KR20160130853A (en) 2016-11-14
AU2019253831B2 (en) 2021-10-28
JP7255967B2 (en) 2023-04-11

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