SG11201605498VA - Combination of a 6-oxo- 1,6-dihydro-pyridazine derivate having anti-cancer activity with gefitinib - Google Patents

Combination of a 6-oxo- 1,6-dihydro-pyridazine derivate having anti-cancer activity with gefitinib

Info

Publication number
SG11201605498VA
SG11201605498VA SG11201605498VA SG11201605498VA SG11201605498VA SG 11201605498V A SG11201605498V A SG 11201605498VA SG 11201605498V A SG11201605498V A SG 11201605498VA SG 11201605498V A SG11201605498V A SG 11201605498VA SG 11201605498V A SG11201605498V A SG 11201605498VA
Authority
SG
Singapore
Prior art keywords
derivate
gefitinib
pyridazine
dihydro
oxo
Prior art date
Application number
SG11201605498VA
Inventor
Friedhelm Bladt
Manja Friese-Hamim
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of SG11201605498VA publication Critical patent/SG11201605498VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SG11201605498VA 2014-01-07 2014-12-16 Combination of a 6-oxo- 1,6-dihydro-pyridazine derivate having anti-cancer activity with gefitinib SG11201605498VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14000035 2014-01-07
PCT/EP2014/003366 WO2015104043A1 (en) 2014-01-07 2014-12-16 Combination of a 6-oxo- 1,6-dihydro-pyridazine derivate having anti-cancer activity with gefitinib

Publications (1)

Publication Number Publication Date
SG11201605498VA true SG11201605498VA (en) 2016-08-30

Family

ID=49916968

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201605498VA SG11201605498VA (en) 2014-01-07 2014-12-16 Combination of a 6-oxo- 1,6-dihydro-pyridazine derivate having anti-cancer activity with gefitinib

Country Status (16)

Country Link
US (1) US20160324855A1 (en)
EP (1) EP3091979A1 (en)
JP (1) JP2017502055A (en)
KR (1) KR20160106147A (en)
CN (1) CN105848658A (en)
AR (1) AR099036A1 (en)
AU (1) AU2014377080A1 (en)
CA (1) CA2935892C (en)
CL (1) CL2016001727A1 (en)
IL (1) IL246629A0 (en)
MX (1) MX2016008816A (en)
PH (1) PH12016500948A1 (en)
RU (1) RU2016132400A (en)
SG (1) SG11201605498VA (en)
TW (1) TW201609102A (en)
WO (1) WO2015104043A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3039401B1 (en) * 2015-07-31 2018-07-13 Les Laboratoires Servier NOVEL ASSOCIATION BETWEEN 3 - [(3 - {[4- (4-MORPHOLINYLMETHYL) -1H-PYRROL-2-YL] METHYLENE} -2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL) METHYL ] -1,3-THIAZOLIDINE-2,4-DIONE AND AN EGFR TYR KINASE INHIBITOR
KR20200077193A (en) 2018-12-20 2020-06-30 노수민 Enforcement of violation of agricultural land law using drones aerial photographing

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007032507A1 (en) * 2007-07-12 2009-04-02 Merck Patent Gmbh pyridazinone derivatives
MX2014010982A (en) * 2012-03-19 2014-10-13 Merck Patent Gmbh Combination of a 6-oxo-1,6-dihydro-pyridazine derivative having anti-cancer activity with other anti-tumor compounds.
CN110507654A (en) * 2012-04-03 2019-11-29 诺华有限公司 Combination with tyrosine kinase inhibitors and use thereof

Also Published As

Publication number Publication date
PH12016500948A1 (en) 2016-06-27
TW201609102A (en) 2016-03-16
AR099036A1 (en) 2016-06-22
CN105848658A (en) 2016-08-10
CA2935892C (en) 2022-08-02
EP3091979A1 (en) 2016-11-16
RU2016132400A3 (en) 2018-07-04
IL246629A0 (en) 2016-08-31
JP2017502055A (en) 2017-01-19
US20160324855A1 (en) 2016-11-10
WO2015104043A1 (en) 2015-07-16
RU2016132400A (en) 2018-02-13
CA2935892A1 (en) 2015-07-16
CL2016001727A1 (en) 2016-12-16
MX2016008816A (en) 2016-09-08
AU2014377080A1 (en) 2016-08-18
KR20160106147A (en) 2016-09-09

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