SG11201604911VA - Novel msln targeting dna vaccine for cancer immunotherapy - Google Patents

Novel msln targeting dna vaccine for cancer immunotherapy

Info

Publication number
SG11201604911VA
SG11201604911VA SG11201604911VA SG11201604911VA SG11201604911VA SG 11201604911V A SG11201604911V A SG 11201604911VA SG 11201604911V A SG11201604911V A SG 11201604911VA SG 11201604911V A SG11201604911V A SG 11201604911VA SG 11201604911V A SG11201604911V A SG 11201604911VA
Authority
SG
Singapore
Prior art keywords
novel
dna vaccine
cancer immunotherapy
targeting dna
msln targeting
Prior art date
Application number
SG11201604911VA
Other languages
English (en)
Inventor
Marco Springer
Heinz Lubenau
Original Assignee
Vaximm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaximm Gmbh filed Critical Vaximm Gmbh
Publication of SG11201604911VA publication Critical patent/SG11201604911VA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/0005Vertebrate antigens
    • A61K39/0011Cancer antigens
    • A61K39/001166Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A61K39/001168Mesothelin [MSLN]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36Adaptation or attenuation of cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53DNA (RNA) vaccination
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541Mucosal route
    • A61K2039/542Mucosal route oral/gastrointestinal
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42Salmonella
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
SG11201604911VA 2013-12-18 2014-12-17 Novel msln targeting dna vaccine for cancer immunotherapy SG11201604911VA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13005896 2013-12-18
PCT/EP2014/003403 WO2015090584A1 (en) 2013-12-18 2014-12-17 Novel msln targeting dna vaccine for cancer immunotherapy

Publications (1)

Publication Number Publication Date
SG11201604911VA true SG11201604911VA (en) 2016-07-28

Family

ID=49876343

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201604911VA SG11201604911VA (en) 2013-12-18 2014-12-17 Novel msln targeting dna vaccine for cancer immunotherapy

Country Status (19)

Country Link
US (2) US20160317634A1 (ja)
EP (1) EP3082850B1 (ja)
JP (1) JP6662787B2 (ja)
KR (1) KR20160130979A (ja)
CN (1) CN106061500A (ja)
AU (1) AU2014365900B2 (ja)
BR (1) BR112016014405A2 (ja)
CA (1) CA2932388A1 (ja)
DK (1) DK3082850T3 (ja)
ES (1) ES2747772T3 (ja)
HU (1) HUE045567T2 (ja)
IL (1) IL246170B (ja)
LT (1) LT3082850T (ja)
MX (1) MX2016007939A (ja)
PL (1) PL3082850T3 (ja)
RU (1) RU2016129044A (ja)
SG (1) SG11201604911VA (ja)
SI (1) SI3082850T1 (ja)
WO (1) WO2015090584A1 (ja)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1951281B1 (en) 2005-10-17 2015-04-15 Sloan Kettering Institute For Cancer Research Wt1 hla class ii-binding peptides and compositions and methods comprising same
US9265816B2 (en) 2006-04-10 2016-02-23 Sloan Kettering Institute For Cancer Research Immunogenic WT-1 peptides and methods of use thereof
US20150104413A1 (en) 2012-01-13 2015-04-16 Memorial Sloan Kettering Cancer Center Immunogenic wt-1 peptides and methods of use thereof
HUE052541T2 (hu) 2013-01-15 2021-05-28 Memorial Sloan Kettering Cancer Center Immunogén WT-1 peptidek és eljárások azok alkalmazására
US10815273B2 (en) 2013-01-15 2020-10-27 Memorial Sloan Kettering Cancer Center Immunogenic WT-1 peptides and methods of use thereof
PL2988762T3 (pl) 2013-04-25 2019-01-31 Vaximm Ag Wektory na bazie Salmonella do immunoterapii przeciwnowotworowej ukierunkowanej na gen guza Wilmsa WT1
DK3082850T3 (da) 2013-12-18 2019-10-07 Vaximm Gmbh Msln-targeteret dna-vaccine til cancerimmunterapi
US10905752B2 (en) * 2015-06-18 2021-02-02 Vaximm Ag VEGFR-2 targeting DNA vaccine for combination therapy
EP3484503A1 (en) * 2016-07-13 2019-05-22 Vaximm AG Process for the production of a dna vaccine for cancer immunotherapy
RU2019112977A (ru) * 2016-11-04 2020-12-04 Факсимм Аг Днк-вакцина, нацеленная на wt1, для комбинированной терапии
SG11201907391SA (en) * 2017-02-17 2019-09-27 Vaximm Ag Novel vegfr-2 targeting immunotherapy approach
RU2019132253A (ru) * 2017-03-17 2021-04-19 Факсимм Аг Новая днк-вакцина, нацеленная на pd-l1, для иммунотерапии рака
JP7352547B2 (ja) * 2017-12-13 2023-09-28 イノビオ ファーマシューティカルズ,インコーポレイティド メソセリンを標的とするがんワクチンおよびその使用
CN112638408A (zh) * 2018-09-05 2021-04-09 万科斯蒙股份有限公司 用于联合疗法的靶向新抗原的dna疫苗
CA3162994A1 (en) 2020-01-13 2021-07-22 Vaximm Ag Salmonella-based dna vaccines in combination with an antibiotic

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5726288A (en) 1989-11-13 1998-03-10 Massachusetts Institute Of Technology Localization and characterization of the Wilms' tumor gene
EP1575500A4 (en) * 2002-07-12 2007-01-03 Univ Johns Hopkins MESOTHELIN VACCINE AND MODEL SYSTEMS
US9200036B2 (en) * 2002-07-12 2015-12-01 The Johns Hopkins University Mesothelin vaccines and model systems
CN1859851A (zh) * 2002-07-12 2006-11-08 约翰斯霍普金斯大学 间皮素疫苗与模型系统
WO2006137836A2 (en) 2004-08-17 2006-12-28 Research Development Foundation Bacterial vector systems
RU2007137122A (ru) 2005-03-09 2009-04-20 Борд Оф Риджентс, Дзе Юниверсити Оф Техас Систем (Us) НОВЫЙ ПРОМОТОР hTMC И ВЕКТОРЫ ДЛЯ ОПУХОЛЕСЕЛЕКТИВНОЙ И ВЫСОКОЭФФЕКТИВНОЙ ЭКСПРЕССИИ ТЕРАПЕВТИЧЕСКИХ ПРОТИВОРАКОВЫХ ГЕНОВ
US7935804B2 (en) * 2006-03-01 2011-05-03 Aduro Biotech Engineered Listeria and methods of use thereof
WO2012149364A1 (en) 2011-04-28 2012-11-01 Diamond Don J Tumor associated vaccines and compositions for disrupting tumor-derived immunosuppression for use in combination cancer immunotherapy
LT2794849T (lt) * 2011-12-22 2017-12-11 Vaximm Ag Didelio produktyvumo susilpnintų salmonella padermių gamybos būdas
CN104812890A (zh) 2012-09-17 2015-07-29 美国健康及人类服务部 基于染色体重组工程的多功能口服疫苗
PL2988762T3 (pl) 2013-04-25 2019-01-31 Vaximm Ag Wektory na bazie Salmonella do immunoterapii przeciwnowotworowej ukierunkowanej na gen guza Wilmsa WT1
DK3082850T3 (da) 2013-12-18 2019-10-07 Vaximm Gmbh Msln-targeteret dna-vaccine til cancerimmunterapi

Also Published As

Publication number Publication date
CN106061500A (zh) 2016-10-26
PL3082850T3 (pl) 2020-01-31
SI3082850T1 (sl) 2020-01-31
US10441645B2 (en) 2019-10-15
JP2017502692A (ja) 2017-01-26
CA2932388A1 (en) 2015-06-25
BR112016014405A2 (pt) 2018-02-20
IL246170B (en) 2019-06-30
KR20160130979A (ko) 2016-11-15
WO2015090584A1 (en) 2015-06-25
RU2016129044A (ru) 2018-01-23
AU2014365900B2 (en) 2020-04-09
MX2016007939A (es) 2016-10-28
HUE045567T2 (hu) 2020-01-28
IL246170A0 (en) 2016-07-31
EP3082850A1 (en) 2016-10-26
EP3082850B1 (en) 2019-08-28
US20160317634A1 (en) 2016-11-03
AU2014365900A1 (en) 2016-07-14
LT3082850T (lt) 2019-11-11
JP6662787B2 (ja) 2020-03-11
DK3082850T3 (da) 2019-10-07
ES2747772T3 (es) 2020-03-11
US20180064794A1 (en) 2018-03-08

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