SG11201604622XA - Biosensors for biological or chemical analysis and methods of manufacturing the same - Google Patents

Biosensors for biological or chemical analysis and methods of manufacturing the same

Info

Publication number
SG11201604622XA
SG11201604622XA SG11201604622XA SG11201604622XA SG11201604622XA SG 11201604622X A SG11201604622X A SG 11201604622XA SG 11201604622X A SG11201604622X A SG 11201604622XA SG 11201604622X A SG11201604622X A SG 11201604622XA SG 11201604622X A SG11201604622X A SG 11201604622XA
Authority
SG
Singapore
Prior art keywords
biosensors
biological
manufacturing
methods
same
Prior art date
Application number
SG11201604622XA
Inventor
Cheng Frank Zhong
Hod Finkelstein
Boyan Boyanov
Dietrich Dehlinger
Darren Segale
Original Assignee
Illumina Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Illumina Inc filed Critical Illumina Inc
Publication of SG11201604622XA publication Critical patent/SG11201604622XA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G01N21/6454—Individual samples arranged in a regular 2D-array, e.g. multiwell plates using an integrated detector array
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4145—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/02—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier
    • H01L27/04—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body
    • H01L27/08—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind
    • H01L27/085—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only
    • H01L27/088—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components specially adapted for rectifying, oscillating, amplifying or switching and having at least one potential-jump barrier or surface barrier; including integrated passive circuit elements with at least one potential-jump barrier or surface barrier the substrate being a semiconductor body including only semiconductor components of a single kind including field-effect components only the components being field-effect transistors with insulated gate
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01L—SEMICONDUCTOR DEVICES NOT COVERED BY CLASS H10
    • H01L27/00—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate
    • H01L27/14—Devices consisting of a plurality of semiconductor or other solid-state components formed in or on a common substrate including semiconductor components sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation and specially adapted either for the conversion of the energy of such radiation into electrical energy or for the control of electrical energy by such radiation
    • H01L27/144—Devices controlled by radiation
    • H01L27/146—Imager structures
    • H01L27/14601—Structural or functional details thereof
    • H01L27/1462—Coatings
    • H01L27/14623—Optical shielding
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
    • G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N2021/6482—Sample cells, cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/061—Sources
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2201/00—Features of devices classified in G01N21/00
    • G01N2201/06—Illumination; Optics
    • G01N2201/064—Stray light conditioning
    • G01N2201/0642—Light traps; baffles
SG11201604622XA 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same SG11201604622XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361914275P 2013-12-10 2013-12-10
PCT/US2014/069373 WO2015089092A1 (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same

Publications (1)

Publication Number Publication Date
SG11201604622XA true SG11201604622XA (en) 2016-07-28

Family

ID=53371771

Family Applications (3)

Application Number Title Priority Date Filing Date
SG10201804913YA SG10201804913YA (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same
SG10202010045QA SG10202010045QA (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same
SG11201604622XA SG11201604622XA (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same

Family Applications Before (2)

Application Number Title Priority Date Filing Date
SG10201804913YA SG10201804913YA (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same
SG10202010045QA SG10202010045QA (en) 2013-12-10 2014-12-09 Biosensors for biological or chemical analysis and methods of manufacturing the same

Country Status (18)

Country Link
US (4) US10254225B2 (en)
EP (2) EP4220137A1 (en)
JP (3) JP6672149B2 (en)
KR (3) KR102374536B1 (en)
CN (2) CN110411998B (en)
AU (2) AU2014364006B2 (en)
BR (2) BR112016013353B1 (en)
CA (2) CA3133543C (en)
CL (1) CL2016001389A1 (en)
DK (1) DK3080585T3 (en)
IL (1) IL246060B (en)
MX (1) MX360883B (en)
NZ (1) NZ720871A (en)
RU (1) RU2675775C1 (en)
SA (1) SA516371289B1 (en)
SG (3) SG10201804913YA (en)
WO (1) WO2015089092A1 (en)
ZA (3) ZA201603872B (en)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
WO2014133625A2 (en) 2012-12-11 2014-09-04 University Of Southern California Passive leakage cancellation networks for duplexers and coexisting wireless communication systems
WO2015089091A1 (en) 2013-12-10 2015-06-18 University Of Southern California Enhancing isolation and impedance matching in hybrid-based cancellation networks and duplexers
SG10201804913YA (en) 2013-12-10 2018-07-30 Illumina Inc Biosensors for biological or chemical analysis and methods of manufacturing the same
WO2015123586A1 (en) 2014-02-14 2015-08-20 University Of Southern California Reflection and hybrid reflection filters
US10615949B2 (en) 2014-02-14 2020-04-07 University Of Southern California Hybrid-based cancellation in presence of antenna mismatch
US9871543B2 (en) 2014-02-19 2018-01-16 University Of Southern California Miniature acoustic resonator-based filters and duplexers with cancellation methodology
PL3669985T3 (en) * 2014-06-05 2022-07-18 Illumina, Inc. Systems including a rotary valve for at least one of sample preparation or sample analysis
US10900030B2 (en) 2015-04-14 2021-01-26 Illumina, Inc. Structured substrates for improving detection of light emissions and methods relating to the same
EP3854884A1 (en) 2015-08-14 2021-07-28 Illumina, Inc. Systems and methods using magnetically-responsive sensors for determining a genetic characteristic
CN107923869B (en) * 2015-08-25 2021-10-08 生命技术公司 Deep micro-well design and method of making same
EP3371575A4 (en) * 2015-09-14 2019-06-26 Shenzhen Genorivision Technology Co. Ltd. Biosensor
IL290157B2 (en) 2016-10-14 2023-09-01 Illumina Inc Cartridge assembly
JP6775223B2 (en) * 2016-10-27 2020-10-28 シャープ株式会社 Fluorescence test system, molecular test method and fluorescence test method
TWI777989B (en) * 2016-11-03 2022-09-21 大陸商深圳華大智造科技有限公司 Biosensors for biological or chemical analysis and methods of manufacturing the same
US20200080142A1 (en) * 2017-03-07 2020-03-12 Illumina, Inc. Single light source, two-optical channel sequencing
SG11201908509TA (en) 2017-03-20 2019-10-30 Mgi Tech Co Ltd Biosensors for biological or chemical analysis and methods of manufacturing the same
NL2019043B1 (en) * 2017-04-25 2018-11-05 Illumina Inc Sensors having integrated protection circuitry
WO2019035897A1 (en) 2017-08-15 2019-02-21 Omniome, Inc. Scanning apparatus and methods useful for detection of chemical and biological analytes
WO2019060177A1 (en) * 2017-09-19 2019-03-28 Complete Genomics, Inc. Wafer level sequencing flow cell fabrication
NL2020612B1 (en) * 2017-12-22 2019-07-02 Illumina Inc Light detection devices with protective liner and methods of manufacturing same
EP3707294B1 (en) 2017-12-22 2022-10-12 Illumina, Inc. Passivating fissures in substrates
NL2020625B1 (en) * 2017-12-22 2019-07-02 Illumina Inc Two-filter light detection devices and methods of manufacturing same
NL2020615B1 (en) * 2017-12-26 2019-07-02 Illumina Inc Image sensor structure
CR20190592A (en) * 2017-12-26 2020-02-26 Illumina Inc Sensor system
TWI698638B (en) * 2017-12-28 2020-07-11 美商伊路米納有限公司 Detector with reduced fluorescence range noise and method for reducing fluorescence range noise
NL2020636B1 (en) * 2017-12-28 2019-07-08 Illumina Inc Light energy fluorescence excitation
NL2020621B1 (en) * 2018-01-08 2019-07-15 Illumina Inc Multiplexing of an active sensor detector using structured illumination
AU2019205797A1 (en) * 2018-01-08 2019-12-19 Illumina, Inc. Systems and devices for high-throughput sequencing with semiconductor-based detection
WO2019136376A1 (en) 2018-01-08 2019-07-11 Illumina, Inc. High-throughput sequencing with semiconductor-based detection
WO2019143564A1 (en) * 2018-01-16 2019-07-25 Illumina, Inc. Pattern angle spatial selection structured illumination imaging
CN112740016A (en) * 2018-09-14 2021-04-30 亿明达股份有限公司 Flow cell and methods related thereto
KR20210095797A (en) * 2018-11-26 2021-08-03 일루미나, 인코포레이티드 Flow cell systems and methods related thereto
US11573109B2 (en) * 2018-12-26 2023-02-07 Houghton Technical Corp. Measurement of fluid parameters
WO2020172444A1 (en) 2019-02-20 2020-08-27 Omniome, Inc. Scanning apparatus and methods for detecting chemical and biological analytes
US11210554B2 (en) 2019-03-21 2021-12-28 Illumina, Inc. Artificial intelligence-based generation of sequencing metadata
US11783917B2 (en) 2019-03-21 2023-10-10 Illumina, Inc. Artificial intelligence-based base calling
CN110066723A (en) * 2019-05-05 2019-07-30 京东方科技集团股份有限公司 Gene sequencing chip, equipment, manufacturing method
US11593649B2 (en) 2019-05-16 2023-02-28 Illumina, Inc. Base calling using convolutions
US11828709B2 (en) 2019-05-17 2023-11-28 GeneSense Technology Inc. Analytical system for molecule detection and sensing
EP3977456A4 (en) 2019-05-31 2023-05-31 Illumina Inc Storage device, system, and method
EP3976826A4 (en) 2019-05-31 2023-08-23 Illumina, Inc. Systems and methods for information storage and retrieval using flow cells
EP3977455A4 (en) * 2019-05-31 2023-07-12 Illumina, Inc. System and method for storage
WO2020243074A1 (en) 2019-05-31 2020-12-03 Illumina, Inc. Obtaining information from a biological sample in a flow cell
US11143638B2 (en) 2019-05-31 2021-10-12 Illumina, Inc. Flow cell with one or more barrier features
SG11202012812PA (en) 2019-05-31 2021-01-28 Illumina Inc Flow cell with selective deposition or activation of nucleotides
CN110229747A (en) * 2019-06-18 2019-09-13 京东方科技集团股份有限公司 Gene sequencing chip, equipment and preparation method
TWI709773B (en) * 2019-09-20 2020-11-11 銘傳大學 Electrical polarity adjustable biosensor based on lossy mode resonance, sensing system, and method of using the same
EP4042481A4 (en) * 2019-10-09 2023-10-18 Illumina, Inc. Image sensor structure
US11630062B2 (en) 2019-10-10 2023-04-18 Visera Technologies Company Limited Biosensor and method of forming the same
US11105745B2 (en) 2019-10-10 2021-08-31 Visera Technologies Company Limited Biosensor
US11705472B2 (en) * 2019-10-10 2023-07-18 Visera Technologies Company Limited Biosensor and method of distinguishing a light
US20220395828A1 (en) * 2019-11-13 2022-12-15 Beijing Boe Technology Development Co., Ltd. Detection chip, method for manufacturing detection chip, method for operating detection chip, and reaction system
WO2021150212A1 (en) 2020-01-21 2021-07-29 Hewlett-Packard Development Company, L.P. Microfluidic reaction chamber with a reaction chamber circuit
EP4107735A2 (en) 2020-02-20 2022-12-28 Illumina, Inc. Artificial intelligence-based many-to-many base calling
CN113711368A (en) 2020-03-20 2021-11-26 上海芯像生物科技有限公司 High throughput analysis system for molecular detection and sensing
US20210379578A1 (en) * 2020-06-04 2021-12-09 Illumina, Inc. Apparatus with a sensor having an active surface
RU2749698C1 (en) * 2020-11-17 2021-06-16 федеральное государственное автономное образовательное учреждение высшего образования "Санкт-Петербургский политехнический университет Петра Великого" (ФГАОУ ВО "СПбПУ") Biomolecular sensor with a microelectronic generator of an electromagnetic wave
US20220336054A1 (en) 2021-04-15 2022-10-20 Illumina, Inc. Deep Convolutional Neural Networks to Predict Variant Pathogenicity using Three-Dimensional (3D) Protein Structures
RU2764964C1 (en) * 2021-04-16 2022-01-24 Татьяна Анатольевна Кучменко Mobile device based on an array of sensors for the analysis of small volume bioassays
KR102497632B1 (en) * 2021-05-31 2023-02-08 호산테크 주식회사 Apparatus for eliminating nano bubble
WO2023122137A1 (en) * 2021-12-23 2023-06-29 Illumina, Inc. Systems and related temperature calibration methods
WO2023170695A1 (en) * 2022-03-10 2023-09-14 Watersight Ltd System and apparatus for fluid monitoring

Family Cites Families (171)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762413A (en) * 1984-09-07 1988-08-09 Olympus Optical Co., Ltd. Method and apparatus for measuring immunological reaction with the aid of fluctuation in intensity of scattered light
AT390677B (en) 1986-10-10 1990-06-11 Avl Verbrennungskraft Messtech SENSOR ELEMENT FOR DETERMINING SUBSTANCE CONCENTRATIONS
WO1991006678A1 (en) 1989-10-26 1991-05-16 Sri International Dna sequencing
US5605662A (en) 1993-11-01 1997-02-25 Nanogen, Inc. Active programmable electronic devices for molecular biological analysis and diagnostics
US5846708A (en) 1991-11-19 1998-12-08 Massachusetts Institiute Of Technology Optical and electrical methods and apparatus for molecule detection
JPH069818A (en) * 1992-06-22 1994-01-18 Tokyo Seihin Kaihatsu Kenkyusho:Kk Organic optical material
US5298741A (en) 1993-01-13 1994-03-29 Trustees Of Tufts College Thin film fiber optic sensor array and apparatus for concurrent viewing and chemical sensing of a sample
JPH0745805A (en) 1993-07-29 1995-02-14 Olympus Optical Co Ltd Solid-stage image pickup device
EP1157743B1 (en) 1993-10-28 2009-03-11 Houston Advanced Research Center Microfabricated, flowthrough porous apparatus for discrete detection of binding reactions
US5965452A (en) 1996-07-09 1999-10-12 Nanogen, Inc. Multiplexed active biologic array
US5485277A (en) * 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US6090592A (en) 1994-08-03 2000-07-18 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid on supports
US5641658A (en) 1994-08-03 1997-06-24 Mosaic Technologies, Inc. Method for performing amplification of nucleic acid with two primers bound to a single solid support
US5672881A (en) 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
DE59703919D1 (en) 1996-08-16 2001-08-02 Zeptosens Ag Witterswil OPTICAL DETECTION DEVICE
US5872623A (en) 1996-09-26 1999-02-16 Sarnoff Corporation Massively parallel detection
US5854684A (en) 1996-09-26 1998-12-29 Sarnoff Corporation Massively parallel detection
US6111248A (en) 1996-10-01 2000-08-29 Texas Instruments Incorporated Self-contained optical sensor system
CA2271717A1 (en) 1996-12-12 1998-06-18 Prolume, Ltd. Apparatus and method for detecting and identifying infectious agents
CA2276462C (en) 1996-12-31 2007-06-12 Genometrix Incorporated Multiplexed molecular analysis system apparatus and method
US6122042A (en) 1997-02-07 2000-09-19 Wunderman; Irwin Devices and methods for optically identifying characteristics of material objects
ATE269908T1 (en) 1997-04-01 2004-07-15 Manteia S A METHOD FOR SEQUENCING NUCLEIC ACIDS
EP3034626A1 (en) 1997-04-01 2016-06-22 Illumina Cambridge Limited Method of nucleic acid sequencing
US6235471B1 (en) 1997-04-04 2001-05-22 Caliper Technologies Corp. Closed-loop biochemical analyzers
US5942775A (en) 1997-04-30 1999-08-24 Lucent Technologies Inc. Photosensing device with improved spectral response and low thermal leakage
US5894351A (en) 1997-05-13 1999-04-13 Colvin, Jr.; Arthur E. Fluorescence sensing device
US6222619B1 (en) 1997-09-18 2001-04-24 University Of Utah Research Foundation Diagnostic device and method
WO2000050877A1 (en) 1999-02-23 2000-08-31 Ljl Biosystems, Inc. Frequency-domain light detection device
US6117643A (en) 1997-11-25 2000-09-12 Ut Battelle, Llc Bioluminescent bioreporter integrated circuit
US6197503B1 (en) 1997-11-26 2001-03-06 Ut-Battelle, Llc Integrated circuit biochip microsystem containing lens
US6686150B1 (en) 1998-01-27 2004-02-03 Clinical Micro Sensors, Inc. Amplification of nucleic acids with electronic detection
US6485905B2 (en) 1998-02-02 2002-11-26 Signature Bioscience, Inc. Bio-assay device
GB9810350D0 (en) * 1998-05-14 1998-07-15 Ciba Geigy Ag Organic compounds
US6908770B1 (en) 1998-07-16 2005-06-21 Board Of Regents, The University Of Texas System Fluid based analysis of multiple analytes by a sensor array
AR021833A1 (en) 1998-09-30 2002-08-07 Applied Research Systems METHODS OF AMPLIFICATION AND SEQUENCING OF NUCLEIC ACID
EP1151139A2 (en) 1999-01-25 2001-11-07 UT-Battelle, LLC Multifunctional and multispectral biosensor devices and methods of use
AU771594B2 (en) * 1999-02-01 2004-03-25 Vir A/S A surface plasmon resonance sensor
US20050244870A1 (en) 1999-04-20 2005-11-03 Illumina, Inc. Nucleic acid sequencing using microsphere arrays
US6899137B2 (en) 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
CA2346032C (en) * 1999-08-02 2004-03-23 Casio Computer Co., Ltd. Photosensor and photosensor system
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
US6784982B1 (en) 1999-11-04 2004-08-31 Regents Of The University Of Minnesota Direct mapping of DNA chips to detector arrays
JP2003515129A (en) 1999-11-19 2003-04-22 ジョビン イヴォン、インコーポレーテッド Compact spectrofluorometer
US6323944B1 (en) 1999-11-19 2001-11-27 Jobin Yvon, Inc. Compact spectrofluorometer
TW463525B (en) 2000-06-01 2001-11-11 Ind Tech Res Inst Organic electroluminescent device and the manufacturing method of the same
IT1317969B1 (en) 2000-06-09 2003-07-21 Nora Elettrodi De ELECTRODE CHARACTERIZED BY A HIGH ADHESION OF A SURFACE CATALYTIC LAYER.
CN101525660A (en) 2000-07-07 2009-09-09 维西根生物技术公司 An instant sequencing methodology
JP4030710B2 (en) 2000-08-07 2008-01-09 富士フイルム株式会社 Image reading device
DE60034562T2 (en) 2000-08-25 2008-01-17 Stmicroelectronics S.R.L., Agrate Brianza A system for automatic image analysis of DNA microarrays
AU2001289914A1 (en) 2000-09-25 2002-04-02 Sensovation Ag Image sensor device, apparatus and method for optical measurements
JP3672085B2 (en) 2000-10-11 2005-07-13 シャープ株式会社 Solid-state imaging device and manufacturing method thereof
WO2002044425A2 (en) 2000-12-01 2002-06-06 Visigen Biotechnologies, Inc. Enzymatic nucleic acid synthesis: compositions and methods for altering monomer incorporation fidelity
US6403970B1 (en) 2000-12-05 2002-06-11 Industrial Technology Research Institute Matrix biochip sensing system
AR031640A1 (en) 2000-12-08 2003-09-24 Applied Research Systems ISOTHERMAL AMPLIFICATION OF NUCLEIC ACIDS IN A SOLID SUPPORT
US7214295B2 (en) * 2001-04-09 2007-05-08 Vishay Dale Electronics, Inc. Method for tantalum pentoxide moisture barrier in film resistors
US6844563B2 (en) 2001-05-22 2005-01-18 Matsushita Electric Industrial Co., Ltd. Fluorescence detecting device with integrated circuit and photodiode, and detection method
US6653083B2 (en) 2001-05-22 2003-11-25 Matsushita Electric Industrial Co., Ltd. Fluorescence detecting device, method for producing the same, and fluorescence detecting method employing the same
US7075104B2 (en) 2001-09-12 2006-07-11 Reveo, Inc. Microchannel plates and biochip arrays, and methods of making same
US6982519B2 (en) 2001-09-18 2006-01-03 Ut-Battelle Llc Individually electrically addressable vertically aligned carbon nanofibers on insulating substrates
US7057026B2 (en) 2001-12-04 2006-06-06 Solexa Limited Labelled nucleotides
TWI293363B (en) 2001-12-11 2008-02-11 Sensors For Med & Science Inc High performance fluorescent optical sensor
US20030136921A1 (en) 2002-01-23 2003-07-24 Reel Richard T Methods for fluorescence detection that minimizes undesirable background fluorescence
US20030178641A1 (en) * 2002-01-23 2003-09-25 Blair Steven M. Microfluidic platforms for use with specific binding assays, specific binding assays that employ microfluidics, and methods
US7524459B2 (en) 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
US7371564B2 (en) 2002-02-27 2008-05-13 Celltek Co., Ltd. Apparatus for automatically analyzing genetic and protein materials using photodiodes
US20040002090A1 (en) 2002-03-05 2004-01-01 Pascal Mayer Methods for detecting genome-wide sequence variations associated with a phenotype
US7604981B1 (en) 2002-03-08 2009-10-20 The Board Of Trustees Of The Leland Stanford Junior University Excitable target marker detection
US7179654B2 (en) 2002-03-18 2007-02-20 Agilent Technologies, Inc. Biochemical assay with programmable array detection
US6946286B2 (en) 2002-05-09 2005-09-20 Matsushita Electric Industrial Co., Ltd. Method and apparatus for detecting DNA hybridization
JP3641619B2 (en) 2002-05-14 2005-04-27 株式会社日立製作所 Biological sample inspection equipment
US7005264B2 (en) 2002-05-20 2006-02-28 Intel Corporation Method and apparatus for nucleic acid sequencing and identification
US6867420B2 (en) 2002-06-03 2005-03-15 The Regents Of The University Of California Solid-state detector and optical system for microchip analyzers
US6975251B2 (en) 2002-06-20 2005-12-13 Dakota Technologies, Inc. System for digitizing transient signals with waveform accumulator
EP3002289B1 (en) 2002-08-23 2018-02-28 Illumina Cambridge Limited Modified nucleotides for polynucleotide sequencing
US7414116B2 (en) 2002-08-23 2008-08-19 Illumina Cambridge Limited Labelled nucleotides
US7595883B1 (en) 2002-09-16 2009-09-29 The Board Of Trustees Of The Leland Stanford Junior University Biological analysis arrangement and approach therefor
TW594006B (en) 2003-07-04 2004-06-21 Veutron Corp Biosensor with multi-channel A/D conversion and a method thereof
US7170605B2 (en) 2003-08-25 2007-01-30 Evan Francis Cromwell Active sensor and method for optical illumination and detection
CN1875370B (en) * 2003-09-05 2010-04-14 奥森泰克公司 Multi-biometric finger sensor using different biometrics having different selectivities and associated methods
GB0321306D0 (en) 2003-09-11 2003-10-15 Solexa Ltd Modified polymerases for improved incorporation of nucleotide analogues
ATE517329T1 (en) * 2003-12-10 2011-08-15 Ge Healthcare Bio Sciences Ab SAMPLE FLOW POSITIONING METHOD
WO2005065814A1 (en) 2004-01-07 2005-07-21 Solexa Limited Modified molecular arrays
US7221455B2 (en) 2004-01-20 2007-05-22 The Regents Of The Unversity Of California Integrated, fluorescence-detecting microanalytical system
US20070281288A1 (en) 2004-01-27 2007-12-06 Shimshon Belkin Method and System for Detecting Analytes
DE102004009012A1 (en) * 2004-02-25 2005-09-15 Roche Diagnostics Gmbh Test element with a capillary for transporting a liquid sample
US7489401B2 (en) 2004-03-01 2009-02-10 National Institute Of Advanced Industrial Science And Technology Device for detecting emission light of micro-object
US20060068412A1 (en) * 2004-03-05 2006-03-30 Cha-Mei Tang Integrated multistep bioprocessor and sensor
US7258731B2 (en) 2004-07-27 2007-08-21 Ut Battelle, Llc Composite, nanostructured, super-hydrophobic material
CN101010806A (en) * 2004-08-20 2007-08-01 皇家飞利浦电子股份有限公司 Microelectronic system with a passivation layer
JP2008513782A (en) 2004-09-17 2008-05-01 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド Apparatus and method for molecular analysis
FR2876185B1 (en) 2004-10-01 2008-01-11 Centre Nat Rech Scient Cnrse DETECTION OF LASER INDUCED FLUORESCENCE EMISSIONS
US7585664B2 (en) 2004-10-14 2009-09-08 The Hong Kong University Of Science And Technology Integrated circuit optical detector for biological detection
AU2005327903A1 (en) 2004-10-18 2006-08-31 Macquarie University Fluorescence detection
US7193289B2 (en) 2004-11-30 2007-03-20 International Business Machines Corporation Damascene copper wiring image sensor
US7483140B1 (en) * 2004-12-10 2009-01-27 University Of Central Florida Research Foundation, Inc. Micro integrated planar optical waveguide type SPR sensor
EP1828412B2 (en) 2004-12-13 2019-01-09 Illumina Cambridge Limited Improved method of nucleotide detection
US7483065B2 (en) * 2004-12-15 2009-01-27 Aptina Imaging Corporation Multi-lens imaging systems and methods using optical filters having mosaic patterns
US7280201B2 (en) 2004-12-17 2007-10-09 Avago Technologies General Ip Pte Ltd Sensor having integrated light detector and/or light source
JP4806197B2 (en) 2005-01-17 2011-11-02 パナソニック株式会社 Solid-state imaging device
JP4701739B2 (en) 2005-02-17 2011-06-15 パナソニック株式会社 Fluorescence measuring device
US7308292B2 (en) 2005-04-15 2007-12-11 Sensors For Medicine And Science, Inc. Optical-based sensing devices
US7738086B2 (en) 2005-05-09 2010-06-15 The Trustees Of Columbia University In The City Of New York Active CMOS biosensor chip for fluorescent-based detection
US8623628B2 (en) 2005-05-10 2014-01-07 Illumina, Inc. Polymerases
US7466409B2 (en) 2005-06-08 2008-12-16 California Institute Of Technology Method and apparatus for CMOS imagers and spectroscopy
SG162795A1 (en) 2005-06-15 2010-07-29 Callida Genomics Inc Single molecule arrays for genetic and chemical analysis
GB0514936D0 (en) 2005-07-20 2005-08-24 Solexa Ltd Preparation of templates for nucleic acid sequencing
US7683407B2 (en) * 2005-08-01 2010-03-23 Aptina Imaging Corporation Structure and method for building a light tunnel for use with imaging devices
GB0517097D0 (en) 2005-08-19 2005-09-28 Solexa Ltd Modified nucleosides and nucleotides and uses thereof
US7405281B2 (en) 2005-09-29 2008-07-29 Pacific Biosciences Of California, Inc. Fluorescent nucleotide analogs and uses therefor
FR2892196B1 (en) * 2005-10-18 2008-06-20 Genewave Soc Par Actions Simpl METHOD FOR MANUFACTURING INTEGRATED DETECTION BIOSENSOR
GB0522310D0 (en) 2005-11-01 2005-12-07 Solexa Ltd Methods of preparing libraries of template polynucleotides
US7547904B2 (en) 2005-12-22 2009-06-16 Palo Alto Research Center Incorporated Sensing photon energies emanating from channels or moving objects
US7433552B2 (en) 2005-12-22 2008-10-07 Palo Alto Research Center Incorporated Obtaining analyte information
EP1826554A1 (en) 2006-02-23 2007-08-29 STMicroelectronics (Research & Development) Limited Improved fluorescence biosensor
EP1999444A1 (en) 2006-03-02 2008-12-10 Chemimage Corporation System and method for structured illumination and collection for improved optical confocality of raman fiber array spectral translator imaging and interactive raman probing
US20080009420A1 (en) 2006-03-17 2008-01-10 Schroth Gary P Isothermal methods for creating clonal single molecule arrays
JP2009531704A (en) 2006-03-28 2009-09-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Integrated device comprising an array of photodetectors and an array of sample sites
WO2007123744A2 (en) 2006-03-31 2007-11-01 Solexa, Inc. Systems and devices for sequence by synthesis analysis
WO2007119067A1 (en) 2006-04-19 2007-10-25 It-Is International Ltd Reaction monitoring
US8178360B2 (en) 2006-05-18 2012-05-15 Illumina Cambridge Limited Dye compounds and the use of their labelled conjugates
US7463353B2 (en) 2006-05-31 2008-12-09 Uchicago Argonne, Llc Modular, micro-scale, optical array and biodetection system
US8637436B2 (en) 2006-08-24 2014-01-28 California Institute Of Technology Integrated semiconductor bioarray
EP2489745B1 (en) 2006-06-05 2017-01-11 California Institute Of Technology Real time micro arrays
JP2009540290A (en) 2006-06-08 2009-11-19 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ Microelectronic sensor device for DNA detection
CN101467027A (en) * 2006-06-15 2009-06-24 皇家飞利浦电子股份有限公司 Integrated biosensing device having photo detector
BRPI0714970A2 (en) 2006-07-20 2013-05-07 Koninkl Philips Electronics Nv detection system for detecting luminescence of at least one sample when excited by incident excitation radiation, and method for detecting luminescence of at least one sample.
US7638182B2 (en) 2006-07-28 2009-12-29 Ut-Battelle, Llc Method for producing microchannels in drawn material
WO2008014485A2 (en) 2006-07-28 2008-01-31 California Institute Of Technology Multiplex q-pcr arrays
US8343746B2 (en) 2006-10-23 2013-01-01 Pacific Biosciences Of California, Inc. Polymerase enzymes and reagents for enhanced nucleic acid sequencing
US20080242560A1 (en) 2006-11-21 2008-10-02 Gunderson Kevin L Methods for generating amplified nucleic acid arrays
CA2672315A1 (en) * 2006-12-14 2008-06-26 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes using large scale fet arrays
US7502123B2 (en) 2007-02-05 2009-03-10 Palo Alto Research Center Incorporated Obtaining information from optical cavity output light
WO2008096296A1 (en) 2007-02-08 2008-08-14 Koninklijke Philips Electronics N.V. Biosensor with evanescent waveguide and integrated sensor
KR100825808B1 (en) 2007-02-26 2008-04-29 삼성전자주식회사 Image sensor having backside illumination structure and method of the same image sensor
CN101622552B (en) * 2007-03-05 2016-04-20 皇家飞利浦电子股份有限公司 The light improved in pixelated pet detector detects
FR2913499A1 (en) * 2007-03-09 2008-09-12 Genewave Soc Par Actions Simpl Device for reading fluorescence emitted by chromophore elements associated with biological/chemical components on object e.g. biochip surface, has unit for illuminating chromophore elements, and fluorescence collection and capture unit
ITMI20071863A1 (en) 2007-09-28 2009-03-29 Industrie De Nora Spa ELECTROCHEMICAL DEVICE FOR BIOCIDAL TREATMENT IN AGRICULTURAL APPLICATIONS
US7767441B2 (en) 2007-10-25 2010-08-03 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
US7811810B2 (en) 2007-10-25 2010-10-12 Industrial Technology Research Institute Bioassay system including optical detection apparatuses, and method for detecting biomolecules
KR100922367B1 (en) * 2008-01-18 2009-10-19 중앙대학교 산학협력단 Optical waveguide-typed surface plasmon resonance sensor
PT103998B (en) * 2008-03-20 2011-03-10 Univ Nova De Lisboa ELECTRONIC AND OPTOELECTRONIC FIELD EFFECT DEVICES UNDERSTANDING NATURAL, SYNTHETIC OR MIST FIBER LAYERS AND THEIR MANUFACTURING PROCESS
JP4544335B2 (en) 2008-04-15 2010-09-15 ソニー株式会社 Reaction processing equipment
US7782237B2 (en) 2008-06-13 2010-08-24 The Board Of Trustees Of The Leland Stanford Junior University Semiconductor sensor circuit arrangement
EP2304420A4 (en) * 2008-06-26 2013-10-30 Life Technologies Corp Methods and apparatus for detecting molecular interactions using fet arrays
EP4325209A2 (en) 2008-09-16 2024-02-21 Pacific Biosciences Of California, Inc. Integrated optical device
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
KR101045206B1 (en) 2008-10-31 2011-06-30 삼성전자주식회사 Integrated bio-chip and method of fabricating the same
KR101065077B1 (en) 2008-11-05 2011-09-15 삼성전자주식회사 Substrate for detecting samples, Bio-chip employ the same, method of fabricating the substrate for detecting samples, and apparatus for detecting bio-material
KR101065078B1 (en) 2008-11-05 2011-09-15 삼성전자주식회사 A substate for bio-chip and manufacturing method of the same
US20100122904A1 (en) 2008-11-17 2010-05-20 Board Of Regents, The University Of Texas System Incorporating cmos integrated circuits in the design of affinity-based biosensor systems
IT1392168B1 (en) 2008-12-02 2012-02-22 Industrie De Nora Spa ELECTRODE SUITABLE FOR USE AS CATHODE FOR HYDROGEN EVOLUTION
WO2010088761A1 (en) 2009-02-06 2010-08-12 Maziyar Khorasani Method and apparatus for manipulating and detecting analytes
KR101563688B1 (en) * 2009-02-11 2015-10-28 삼성전자주식회사 Integrated bio-chip and method of fabricating the integrated bio-chip
KR101059565B1 (en) 2009-02-11 2011-08-26 어플라이드 프레시젼, 인코포레이티드 Microarrays with bright reference point labels and methods of collecting optical data therefrom
EP2221606A3 (en) * 2009-02-11 2012-06-06 Samsung Electronics Co., Ltd. Integrated bio-chip and method of fabricating the integrated bio-chip
US8673627B2 (en) * 2009-05-29 2014-03-18 Life Technologies Corporation Apparatus and methods for performing electrochemical reactions
IT1395113B1 (en) 2009-07-28 2012-09-05 Industrie De Nora Spa ELECTRODE FOR EVOLUTION OF OXYGEN IN INDUSTRIAL ELECTROCHEMICAL PROCESSES
US8041221B2 (en) * 2009-11-11 2011-10-18 Elbex Video Ltd. Method and apparatus for coupling optical signal with packaged circuits via optical cables and lightguide couplers
AU2011217862B9 (en) 2010-02-19 2014-07-10 Pacific Biosciences Of California, Inc. Integrated analytical system and method
US8962252B2 (en) * 2010-08-31 2015-02-24 Canon U.S. Life Sciences, Inc. Optical system for high resolution thermal melt detection
JP2012073701A (en) * 2010-09-28 2012-04-12 Hitachi Displays Ltd Optical sensor
EP2632593B1 (en) * 2010-10-27 2021-09-29 Illumina, Inc. Flow cells for biological or chemical analysis
CN202548048U (en) * 2011-01-10 2012-11-21 伊鲁米那股份有限公司 Flow cell and jet device for analyzing samples
US8466437B2 (en) * 2011-04-28 2013-06-18 Aptina Imaging Corporation High resolution fluorescence detection system
JP2013045857A (en) * 2011-08-24 2013-03-04 Sony Corp Image sensor, manufacturing method of the same, and inspection device
JP2013092393A (en) 2011-10-24 2013-05-16 Sony Corp Chemical sensor, biomolecule detection device, and biomolecule detection method
US9373732B2 (en) 2012-02-07 2016-06-21 Semiconductor Components Industries, Llc Image sensors with reflective optical cavity pixels
CN102706954B (en) * 2012-06-05 2016-06-29 清华大学 Spin Valve GMR membrane structure, the biosensor with it and manufacture method
US9193998B2 (en) * 2013-03-15 2015-11-24 Illumina, Inc. Super resolution imaging
SG10201804913YA (en) 2013-12-10 2018-07-30 Illumina Inc Biosensors for biological or chemical analysis and methods of manufacturing the same
US9799697B2 (en) 2014-04-25 2017-10-24 Taiwan Semiconductor Manufacturing Company, Ltd. Back side illuminated image sensor with deep trench isolation structures and self-aligned color filters

Also Published As

Publication number Publication date
CN105980832A (en) 2016-09-28
SG10202010045QA (en) 2020-11-27
AU2014364006B2 (en) 2019-07-11
KR20200042023A (en) 2020-04-22
IL246060A0 (en) 2016-07-31
BR112016013353B1 (en) 2020-11-24
CA2932916C (en) 2021-12-07
CA2932916A1 (en) 2015-06-18
CA3133543A1 (en) 2015-06-18
JP2022062076A (en) 2022-04-19
SG10201804913YA (en) 2018-07-30
WO2015089092A1 (en) 2015-06-18
KR20160096644A (en) 2016-08-16
EP3080585B1 (en) 2023-12-06
KR102102934B1 (en) 2020-04-21
IL246060B (en) 2020-05-31
CL2016001389A1 (en) 2017-04-28
US20210381977A1 (en) 2021-12-09
CN110411998B (en) 2022-06-07
JP7355864B2 (en) 2023-10-03
US11181478B2 (en) 2021-11-23
DK3080585T3 (en) 2024-02-05
KR20210080628A (en) 2021-06-30
AU2014364006A1 (en) 2016-06-23
MX360883B (en) 2018-11-21
JP7013503B2 (en) 2022-01-31
CN110411998A (en) 2019-11-05
EP4220137A1 (en) 2023-08-02
US20230358678A1 (en) 2023-11-09
US20190204225A1 (en) 2019-07-04
AU2019246860B2 (en) 2021-04-08
NZ720871A (en) 2020-03-27
NZ759805A (en) 2021-08-27
JP2020112560A (en) 2020-07-27
JP6672149B2 (en) 2020-03-25
CA3133543C (en) 2023-05-02
KR102271774B1 (en) 2021-06-30
ZA202206081B (en) 2023-11-29
US10254225B2 (en) 2019-04-09
KR102374536B1 (en) 2022-03-14
CN105980832B (en) 2019-08-16
EP3080585A1 (en) 2016-10-19
SA516371289B1 (en) 2020-06-15
US11719637B2 (en) 2023-08-08
AU2019246860A1 (en) 2019-10-31
ZA201603872B (en) 2019-11-27
BR122020010030B1 (en) 2022-02-01
EP3080585A4 (en) 2017-08-23
ZA201903597B (en) 2022-12-21
BR112016013353A2 (en) 2017-08-08
US20160356715A1 (en) 2016-12-08
RU2016122443A (en) 2018-01-23
JP2017504789A (en) 2017-02-09
RU2675775C1 (en) 2018-12-24
MX2016007382A (en) 2016-12-20

Similar Documents

Publication Publication Date Title
ZA201903597B (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
EP3535566A4 (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
HK1209184A1 (en) Methods and systems for measuring and using the oxidation-reduction potential of a biological sample
EP2971141A4 (en) Systems and methods for biological analysis
SG11201510001RA (en) Ion complex material having function of inhibiting adhesion of biological substance and method for manufacturing the same
EP3602629A4 (en) Biosensors for biological or chemical analysis and methods of manufacturing the same
HK1213989A1 (en) Automated specimen processing systems and methods of using the same
EP3027775A4 (en) Dna sequencing and epigenome analysis
EP2807479A4 (en) Devices and methods for the rapid and accurate detection of analytes
PT3272874T (en) Reagent composition for biosensor and biosensor having the same
EP2967509A4 (en) Biological sample collection and preservation
EP3017302A4 (en) Methods for predicting responses to chemical or biologic substances
SG11201507949YA (en) Biological sample processing
SG11201510642UA (en) Case and case holder for biological samples and corresponding method of use
GB201315748D0 (en) Biological methods and materials for use therein
SG11201406040SA (en) Systems and methods for assessing of biological samples
GB201323015D0 (en) Kits and methods for analysis of DNA
SG11201503592TA (en) Case for containing biological samples and corresponding method of use
GB201412156D0 (en) Analyte concentration measurement
SG11201509866TA (en) Protease-responsive peptide biosensors and methods for analyte detection
HK1224011A1 (en) Methods and systems for obtaining clinical samples
EP2990784A4 (en) Liquid sample measurement device, liquid sample measurement method, and biosensor
HK1220769A1 (en) Progressive approximation of sample analyte concentration
DK2943580T3 (en) Biological sample analytical instrument
EP2970962A4 (en) Methods and devices for biological sample preparation