SG11201602779TA - Microfluidics sorter for cell detection and isolation - Google Patents
Microfluidics sorter for cell detection and isolationInfo
- Publication number
- SG11201602779TA SG11201602779TA SG11201602779TA SG11201602779TA SG11201602779TA SG 11201602779T A SG11201602779T A SG 11201602779TA SG 11201602779T A SG11201602779T A SG 11201602779TA SG 11201602779T A SG11201602779T A SG 11201602779TA SG 11201602779T A SG11201602779T A SG 11201602779TA
- Authority
- SG
- Singapore
- Prior art keywords
- microfluidics
- sorter
- isolation
- cell detection
- cell
- Prior art date
Links
- 238000001514 detection method Methods 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N15/0255—Investigating particle size or size distribution with mechanical, e.g. inertial, classification, and investigation of sorted collections
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0819—Microarrays; Biochips
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/02—Investigating particle size or size distribution
- G01N2015/0288—Sorting the particles
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Clinical Laboratory Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Fluid Mechanics (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Sampling And Sample Adjustment (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SG2013/000442 WO2015057159A1 (en) | 2013-10-16 | 2013-10-16 | Microfluidics sorter for cell detection and isolation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201602779TA true SG11201602779TA (en) | 2016-05-30 |
Family
ID=52828467
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201602779TA SG11201602779TA (en) | 2013-10-16 | 2013-10-16 | Microfluidics sorter for cell detection and isolation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10144009B2 (en) |
| EP (1) | EP3058365B1 (en) |
| JP (1) | JP6314220B2 (en) |
| KR (1) | KR20160075568A (en) |
| CN (1) | CN105683750B (en) |
| AU (1) | AU2013403343B2 (en) |
| RU (1) | RU2016118626A (en) |
| SG (1) | SG11201602779TA (en) |
| WO (1) | WO2015057159A1 (en) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130000396A (en) | 2010-03-04 | 2013-01-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | Microfluidics sorter for cell detection and isolation |
| SG11201501837TA (en) | 2012-09-21 | 2015-04-29 | Massachusetts Inst Technology | Micro-fluidic device and uses thereof |
| EP3107995B1 (en) | 2014-02-18 | 2019-10-30 | Massachusetts Institute Of Technology | Biophysically sorted osteoprogenitors from culture expanded bone marrow derived mesenchymal stromal cells (mscs) |
| WO2016044555A1 (en) | 2014-09-17 | 2016-03-24 | Massachusetts Institute Of Technology | System and method for inertial focusing microfiltration for intra-operative blood salvage autotransfusion |
| GB201510189D0 (en) | 2015-06-11 | 2015-07-29 | Univ Edinburgh | Microfluidic device |
| ES2977951T3 (en) * | 2015-06-23 | 2024-09-03 | Nanocellect Biomedical Inc | Systems, apparatus and methods for cell sorting and flow cytometry |
| WO2017003380A1 (en) * | 2015-07-02 | 2017-01-05 | Nanyang Technological University | Leukocyte and microparticles fractionation using microfluidics |
| US10717084B2 (en) * | 2015-11-09 | 2020-07-21 | Georgia Tech Research Corporation | Microfluidic devices for cellular sorting |
| WO2017131580A1 (en) | 2016-01-28 | 2017-08-03 | Clearbridge Biomedics Pte Ltd | Multi-stage target cell enrichment using a microfluidic device |
| US11059042B2 (en) | 2016-05-04 | 2021-07-13 | Biolidics Limited | Systems and methods for enriching target cells in a sample |
| WO2018017022A1 (en) | 2016-07-21 | 2018-01-25 | Agency For Science, Technology And Research | Apparatus for outer wall focusing for high volume fraction particle microfiltration and method for manufacture thereof |
| WO2018093475A1 (en) * | 2016-11-15 | 2018-05-24 | Massachusetts Institute Of Technology | Liquid biopsy detection of leukemia using closed-loop microfluidics |
| US11480567B2 (en) | 2017-02-15 | 2022-10-25 | New Jersey Institute Of Technology | Enhanced sensitivity and specificity for point-of-care (POC) micro biochip |
| WO2019004964A2 (en) * | 2017-03-17 | 2019-01-03 | Istanbul Teknik Universitesi | A microchannel having a spiral geometry structured with asymmetrical curls for continous separation of cancer cells from blood and enrichment thereof in the circulatory system |
| CN107084916B (en) * | 2017-03-29 | 2023-12-01 | 上海纳奥生物科技有限公司 | Circulating tumor cell separation micro-fluidic chip device and application method thereof |
| CN108663258A (en) * | 2017-03-29 | 2018-10-16 | 苏州含光微纳科技有限公司 | A kind of circulating tumor cell screening chip and method |
| CN107164213A (en) * | 2017-04-21 | 2017-09-15 | 华中科技大学 | One kind is based on the cellifugal chip of principle of inertia point |
| CN106955384A (en) * | 2017-05-04 | 2017-07-18 | 中国药科大学 | A kind of circulating tumor cell capturing device |
| US20180369807A1 (en) * | 2017-06-23 | 2018-12-27 | Pouya Rezai | Microfluidic centrifuge device and method for performing solution exchange and separation |
| US20180369817A1 (en) * | 2017-06-23 | 2018-12-27 | Pouya Rezai | Systems, devices and methods of performing magnetophoretic separation and solution exchange in curved fluidic channel |
| KR102184789B1 (en) | 2017-07-19 | 2020-11-30 | 윌리엄 매스턴 주니어 제임스 | Low energy dynamic water purification system and water purification method |
| CN107699478A (en) * | 2017-09-19 | 2018-02-16 | 朱嗣博 | A kind of circulating tumor cell（CTC）Detection micro flow control chip device |
| CN107746794B (en) * | 2017-09-27 | 2021-07-13 | 上海交通大学 | Cell separation device |
| US11020740B2 (en) | 2017-10-24 | 2021-06-01 | New Jersey Institute Of Technology | Microfluidic biochip with enhanced sensitivity |
| JP2019086340A (en) * | 2017-11-02 | 2019-06-06 | シスメックス株式会社 | Cell detection method and cell detection system |
| WO2019117800A1 (en) * | 2017-12-11 | 2019-06-20 | A. Menarini Biomarkers Singapore Pte Ltd | Microfluidic device and method for cell separation of a blood sample |
| SG11202005502PA (en) * | 2017-12-15 | 2020-07-29 | Univ Singapore Technology & Design | Inertial cell focusing and sorting |
| CN108132208A (en) * | 2017-12-25 | 2018-06-08 | 黄庆 | A kind of spiral shape microchannel and its application method and series and parallel installation method |
| CN112088023B (en) * | 2018-01-05 | 2024-05-14 | 帕斯艾克斯公司 | Device for capturing and removing disease substances in a fluid |
| JP7124475B2 (en) * | 2018-01-17 | 2022-08-24 | 株式会社Ihi | Cell culture system and cell culture method |
| WO2019153032A1 (en) * | 2018-02-07 | 2019-08-15 | University Of South Australia | Pre-natal cell isolation |
| CN109012775B (en) * | 2018-10-09 | 2024-01-26 | 深圳亘流科技有限公司 | Universal inertial focusing micro-fluidic chip |
| US20210395693A1 (en) | 2018-10-26 | 2021-12-23 | Guy MARTI | Method and apparatus for mesenchymal stem cells isolation and purification |
| JP2020082047A (en) | 2018-11-30 | 2020-06-04 | シスメックス株式会社 | Separation success/failure determination method, particle detection method and particle separation device |
| PL3669982T3 (en) * | 2018-12-21 | 2022-07-11 | Helmholtz-Zentrum Dresden - Rossendorf E.V. | Microfluidic device, apparatus and method for enrichment and dilution of magnetic molecular entities |
| CN109827806A (en) * | 2019-03-18 | 2019-05-31 | 中国科学院重庆绿色智能技术研究院 | A kind of acquisition device and method of circulating tumor cell |
| US11890616B2 (en) | 2019-03-26 | 2024-02-06 | The Curators Of The University Of Missouri | Microfluidic device for capture of micrometer scale objects and methods of using the device |
| CN110004059B (en) * | 2019-04-11 | 2021-10-29 | 西安电子科技大学 | Micro-fluidic chip of 3D printing river-bend-section micro-fluidic channel and design method of micro-fluidic channel |
| CN111909823B (en) * | 2019-05-08 | 2023-04-18 | 清华大学 | Inertial micro-fluidic chip for enriching circulating tumor cells |
| CN110205244B (en) * | 2019-05-22 | 2020-12-11 | 晶准生物医药集团有限公司 | High-throughput microfluidic chip and method for sorting cancer cells by using same |
| CN110106069A (en) * | 2019-05-30 | 2019-08-09 | 合肥工业大学 | A kind of biochip based on fluid dynamic label-free separation cancer cell |
| JP2021013333A (en) * | 2019-07-12 | 2021-02-12 | 株式会社Ihi | Microorganism sorting system and microorganism sorting method |
| US20220395831A1 (en) * | 2019-10-21 | 2022-12-15 | Nanyang Technological University | Direct and scalable isolation of circulating extracellular vesicles from whole blood using centrifugal forces |
| CN111763606B (en) * | 2020-06-18 | 2022-11-04 | 上海交通大学 | Inertial focusing micro-fluidic chip for separating circulating tumor cells from blood without labels |
| TWI769507B (en) * | 2020-08-26 | 2022-07-01 | 國立陽明交通大學 | Cascaded design microfluidic structure with step difference |
| JP2024500269A (en) * | 2020-10-22 | 2024-01-09 | ザ ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ テキサス システム | High-throughput cell migration assay plates and manufacturing methods |
| CN112358958B (en) * | 2020-11-23 | 2023-10-27 | 浙江省人民医院 | Separation and filtration device for tumor cell mass for oncology department |
| US20220258160A1 (en) * | 2021-02-18 | 2022-08-18 | City University Of Hong Kong | Microfluidic device and method for detecting an infected cell in a fluid sample |
| CN115069134B (en) * | 2022-07-07 | 2023-09-05 | 山东省科学院能源研究所 | Micro-fluid high-efficiency mixer based on Dien vortex |
| CN117903906A (en) * | 2022-10-18 | 2024-04-19 | 北京大学 | Micro-channel structure and micro-channel chip |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999037488A1 (en) * | 1998-01-21 | 1999-07-29 | Securency Pty. Ltd. | Method of verifying the authenticity of a security document and document for use in such a method |
| JP2007268490A (en) | 2006-03-31 | 2007-10-18 | Fujifilm Corp | Micro device and catalytic reaction method using the same |
| JP5172946B2 (en) | 2007-04-16 | 2013-03-27 | ザ ジェネラル ホスピタル コーポレーション ドゥーイング ビジネス アズ マサチューセッツ ジェネラル ホスピタル | Systems and methods for particle focusing in microchannels |
| SG184592A1 (en) * | 2011-03-18 | 2012-10-30 | Univ Singapore | Isolating target cells from a biological fluid |
| US8208138B2 (en) * | 2009-09-24 | 2012-06-26 | University Of Cincinnati | Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems |
| KR20130000396A (en) * | 2010-03-04 | 2013-01-02 | 메사추세츠 인스티튜트 오브 테크놀로지 | Microfluidics sorter for cell detection and isolation |
| US8361415B2 (en) * | 2010-09-13 | 2013-01-29 | The Regents Of The University Of California | Inertial particle focusing system |
| CN104741157B (en) * | 2010-09-14 | 2017-04-12 | 加利福尼亚大学董事会 | Device for isolating cells from heterogeneous solution using microfluidic trapping vortices |
| CN202786220U (en) * | 2012-08-10 | 2013-03-13 | 中国科学院深圳先进技术研究院 | Microfluidic biochip |
-
2013
- 2013-10-16 AU AU2013403343A patent/AU2013403343B2/en active Active
- 2013-10-16 KR KR1020167012576A patent/KR20160075568A/en not_active Application Discontinuation
- 2013-10-16 WO PCT/SG2013/000442 patent/WO2015057159A1/en active Application Filing
- 2013-10-16 EP EP13895623.0A patent/EP3058365B1/en active Active
- 2013-10-16 CN CN201380080249.1A patent/CN105683750B/en active Active
- 2013-10-16 SG SG11201602779TA patent/SG11201602779TA/en unknown
- 2013-10-16 RU RU2016118626A patent/RU2016118626A/en not_active Application Discontinuation
- 2013-10-16 US US15/029,627 patent/US10144009B2/en active Active
- 2013-10-16 JP JP2016524521A patent/JP6314220B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013403343B2 (en) | 2021-01-07 |
| JP6314220B2 (en) | 2018-04-18 |
| AU2013403343A1 (en) | 2016-05-19 |
| EP3058365B1 (en) | 2020-04-01 |
| RU2016118626A (en) | 2017-11-21 |
| KR20160075568A (en) | 2016-06-29 |
| JP2017500006A (en) | 2017-01-05 |
| CN105683750A (en) | 2016-06-15 |
| US20160303565A1 (en) | 2016-10-20 |
| EP3058365A4 (en) | 2017-11-15 |
| WO2015057159A1 (en) | 2015-04-23 |
| EP3058365A1 (en) | 2016-08-24 |
| CN105683750B (en) | 2020-02-28 |
| US10144009B2 (en) | 2018-12-04 |
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