SG11201506054XA - Immuno imaging agent for use with antibody-drug conjugate therapy - Google Patents

Immuno imaging agent for use with antibody-drug conjugate therapy

Info

Publication number
SG11201506054XA
SG11201506054XA SG11201506054XA SG11201506054XA SG11201506054XA SG 11201506054X A SG11201506054X A SG 11201506054XA SG 11201506054X A SG11201506054X A SG 11201506054XA SG 11201506054X A SG11201506054X A SG 11201506054XA SG 11201506054X A SG11201506054X A SG 11201506054XA
Authority
SG
Singapore
Prior art keywords
antibody
drug conjugate
imaging agent
conjugate therapy
immuno
Prior art date
Application number
SG11201506054XA
Inventor
Jochen Kruip
Susanta K Sarkar
Mathias Gebauer
Christian Lange
Ingo Focken
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of SG11201506054XA publication Critical patent/SG11201506054XA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/35Valency
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626Diabody or triabody
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/60Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/64Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/20Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optics & Photonics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
SG11201506054XA 2013-02-05 2014-02-05 Immuno imaging agent for use with antibody-drug conjugate therapy SG11201506054XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361761190P 2013-02-05 2013-02-05
EP14305082 2014-01-21
PCT/IB2014/000279 WO2014122529A1 (en) 2013-02-05 2014-02-05 Immuno imaging agent for use with antibody-drug conjugate therapy

Publications (1)

Publication Number Publication Date
SG11201506054XA true SG11201506054XA (en) 2015-08-28

Family

ID=50031282

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201506054XA SG11201506054XA (en) 2013-02-05 2014-02-05 Immuno imaging agent for use with antibody-drug conjugate therapy
SG10201707391QA SG10201707391QA (en) 2013-02-05 2014-02-05 Immuno imaging agent for use with antibody-drug conjugate therapy

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201707391QA SG10201707391QA (en) 2013-02-05 2014-02-05 Immuno imaging agent for use with antibody-drug conjugate therapy

Country Status (17)

Country Link
EP (1) EP2953977B1 (en)
JP (1) JP6605331B2 (en)
KR (1) KR20150113197A (en)
CN (1) CN105229034B (en)
AU (1) AU2014213687B2 (en)
CA (1) CA2900154A1 (en)
DK (1) DK2953977T3 (en)
ES (1) ES2657053T3 (en)
HU (1) HUE037909T2 (en)
LT (1) LT2953977T (en)
MX (1) MX2015010145A (en)
PL (1) PL2953977T3 (en)
PT (1) PT2953977T (en)
RU (1) RU2015137858A (en)
SG (2) SG11201506054XA (en)
SI (1) SI2953977T1 (en)
WO (1) WO2014122529A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016202457A1 (en) * 2015-06-15 2016-12-22 Numab Ag Hetero-dimeric multi-specific antibody format
CN110124057B (en) * 2019-06-06 2022-04-19 天津医科大学总医院 An antitumor drug or drug carrier containing glutamine modified cyclodextrin

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2410551A1 (en) * 2000-06-30 2002-01-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw (Vib) Heterodimeric fusion proteins
JP2007503202A (en) 2003-07-21 2007-02-22 イミュノジェン・インコーポレーテッド CA6 antigen-specific cytotoxic conjugates and methods of use thereof
EP1917034A4 (en) * 2005-08-22 2009-04-29 Immunogen Inc A ca6 antigen-specific cytotoxic conjugate and methods of using the same
GB0822001D0 (en) * 2008-12-02 2009-01-07 Glaxosmithkline Biolog Sa Vaccine
BR112012004710A2 (en) * 2009-09-01 2016-08-16 Abbott Lab double variable domain immunoglobulins and their use
GB201005063D0 (en) * 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
UY32979A (en) * 2009-10-28 2011-02-28 Abbott Lab IMMUNOGLOBULINS WITH DUAL VARIABLE DOMAIN AND USES OF THE SAME

Also Published As

Publication number Publication date
CN105229034B (en) 2019-12-10
SI2953977T1 (en) 2018-02-28
JP2016509606A (en) 2016-03-31
ES2657053T3 (en) 2018-03-01
CN105229034A (en) 2016-01-06
DK2953977T3 (en) 2018-01-22
AU2014213687A1 (en) 2015-08-20
LT2953977T (en) 2018-02-12
EP2953977A1 (en) 2015-12-16
SG10201707391QA (en) 2017-10-30
AU2014213687B2 (en) 2018-12-06
MX2015010145A (en) 2016-05-31
CA2900154A1 (en) 2014-08-14
RU2015137858A (en) 2017-03-13
PL2953977T3 (en) 2018-04-30
HUE037909T2 (en) 2018-09-28
PT2953977T (en) 2018-01-29
EP2953977B1 (en) 2017-10-25
WO2014122529A1 (en) 2014-08-14
JP6605331B2 (en) 2019-11-13
KR20150113197A (en) 2015-10-07

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