SG11201505010XA - Mg53 mutant and mutation method and use thereof - Google Patents

Mg53 mutant and mutation method and use thereof

Info

Publication number
SG11201505010XA
SG11201505010XA SG11201505010XA SG11201505010XA SG11201505010XA SG 11201505010X A SG11201505010X A SG 11201505010XA SG 11201505010X A SG11201505010X A SG 11201505010XA SG 11201505010X A SG11201505010X A SG 11201505010XA SG 11201505010X A SG11201505010X A SG 11201505010XA
Authority
SG
Singapore
Prior art keywords
mutant
mutation method
mutation
Prior art date
Application number
SG11201505010XA
Inventor
Ruiping Xiao
Chunmei Cao
Yan Zhang
fengxiang Lv
Original Assignee
Beijing Boyalife Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Boyalife Pharmaceuticals Ltd filed Critical Beijing Boyalife Pharmaceuticals Ltd
Publication of SG11201505010XA publication Critical patent/SG11201505010XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
SG11201505010XA 2013-01-25 2014-01-22 Mg53 mutant and mutation method and use thereof SG11201505010XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201310030960 2013-01-25
PCT/CN2014/000078 WO2014114184A1 (en) 2013-01-25 2014-01-22 Mg53 mutant and mutation method and use thereof

Publications (1)

Publication Number Publication Date
SG11201505010XA true SG11201505010XA (en) 2015-08-28

Family

ID=51226912

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201505010XA SG11201505010XA (en) 2013-01-25 2014-01-22 Mg53 mutant and mutation method and use thereof

Country Status (10)

Country Link
US (1) US20150361146A1 (en)
EP (1) EP2949664A4 (en)
JP (1) JP2016506919A (en)
CN (1) CN103965342B (en)
AU (1) AU2014210329A1 (en)
CA (1) CA2896688A1 (en)
HK (2) HK1200841A1 (en)
RU (1) RU2015130482A (en)
SG (1) SG11201505010XA (en)
WO (1) WO2014114184A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104877971B (en) * 2015-06-02 2018-03-30 汉恒生物科技（上海）有限公司 A kind of gland relevant viral vector for the carrying MG53 genes that can alleviate mouse symptoms of heart failure
CN112940098A (en) * 2016-04-06 2021-06-11 牡丹江友搏药业有限责任公司 MG53 mutant and preparation method and application thereof
KR102483242B1 (en) * 2016-08-01 2022-12-29 호프 메디신 (난징) 씨오., 엘티디. MG53 mutants and methods for their preparation and uses thereof
CN107987147B (en) * 2016-10-26 2024-07-05 牡丹江友搏药业有限责任公司 MG53 polymer preparation method and application thereof
CN107629123B (en) * 2017-09-07 2020-08-25 北京大学 Nano antibody for resisting MG53 protein and application

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009031842A1 (en) * 2007-09-04 2009-03-12 Korea University Industrial & Academic Collaborative Foundation Use of trim72 as a target for muscle and heart enhancer
KR101413005B1 (en) * 2007-12-04 2014-07-02 유니버시티 오브 메디신 앤드 덴티스트리 오브 뉴 저지 Compositions and methods to modulate cell membrane resealing
CN101797375B (en) * 2009-12-02 2013-01-23 北京大学 Application of MG53 protein for preventing and/or treating myocardial ischemia/reperfusion injury
CN101912617B (en) * 2010-07-29 2012-09-26 北京大学 Application of MG53 gene to treatment of insulin resistance, type II diabetes mellitus and related diseases thereof
WO2012134478A1 (en) * 2011-03-31 2012-10-04 University Of Medicine And Dentistry Of New Jersey Compositions and methods for the treatment and prevention of cardiac ischemic injury

Also Published As

Publication number Publication date
CA2896688A1 (en) 2014-07-31
EP2949664A4 (en) 2016-06-22
CN103965342A (en) 2014-08-06
HK1200841A1 (en) 2015-08-14
RU2015130482A (en) 2017-03-03
HK1217345A1 (en) 2017-01-06
JP2016506919A (en) 2016-03-07
CN103965342B (en) 2015-06-10
AU2014210329A1 (en) 2015-07-23
EP2949664A1 (en) 2015-12-02
US20150361146A1 (en) 2015-12-17
WO2014114184A1 (en) 2014-07-31

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