SG11201407628UA - Ribosomal polynucleotides and related expression systems - Google Patents

Ribosomal polynucleotides and related expression systems

Info

Publication number
SG11201407628UA
SG11201407628UA SG11201407628UA SG11201407628UA SG11201407628UA SG 11201407628U A SG11201407628U A SG 11201407628UA SG 11201407628U A SG11201407628U A SG 11201407628UA SG 11201407628U A SG11201407628U A SG 11201407628UA SG 11201407628U A SG11201407628U A SG 11201407628UA
Authority
SG
Singapore
Prior art keywords
international
jolla
torrey pines
pines road
california
Prior art date
Application number
SG11201407628UA
Inventor
Vincent P Mauro
Luke Burman
Gerald M Edelman
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Publication of SG11201407628UA publication Critical patent/SG11201407628UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression

Abstract

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 28 November 2013 (28.11.2013) WIPOIPCT (10) International Publication Number WO 2013/177191 A1 (51) International Patent Classification: C12N15/10 (2006.01) C12N15/11 (2006.01) (21) International Application Number: (22) International Filing Date: (25) Filing Language: (26) Publication Language: PCT/US2013/042061 21 May 2013 (21.05.2013) English English (30) Priority Data: 61/649453 61/778194 21 May 2012 (21.05.2012) US 12 March 2013 (12.03.2013) US (71) Applicant: THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10550 North Torrey Pines Road, La Jolla, Cali­ fornia 92037 (US). (72) Inventors: MAURO, Vincent P.; 10550 North Torrey Pines Road, La Jolla, California 92037 (US). BURMAN, Luke; 10550 North Torrey Pines Road, La Jolla, California 92037 (US). EDELMAN, Gerald M.; 10550 North Torrey Pines Road, La Jolla, California 92037 (US). (74) Agents: ELRIFI, Ivor R. et al.; Mintz Levin Cohnn Ferris Glovky and Popeo, P.C., One Financial Center, Boston Massachusetts 02111 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available)'. AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available)'. ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3)) — with sequence listing part of description (Rule 5.2(a)) (54) Title: RIBOSOMAL POLYNUCLEOTIDES AND RELATED EXPRESSION SYSTEMS -£8S-9-9- -eeeeg- * antibiotic -9- 98 9- 18S 5.8S 28S 252c 4b 1 2 34 5 ON - 2GS I l2b 1SS-E — 3[H 5.8S T-H o CJ O (57) Abstract: Provided herein is synthetic a or isolated polynucleotide encoding mammalian 18S rRNA a that is resistant to pacta - mycin. The pactamycin-resistance is conferred by one or more single residue substitutions in the 18S rRNA sequence; fragment a thereof harboring said substitutions; complementary sequence thereto; a or a substantially identical sequence of the foregoing. Re­ lated systems, methods and kits are also described.
SG11201407628UA 2012-05-21 2013-05-21 Ribosomal polynucleotides and related expression systems SG11201407628UA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261649453P 2012-05-21 2012-05-21
US201361778194P 2013-03-12 2013-03-12
PCT/US2013/042061 WO2013177191A1 (en) 2012-05-21 2013-05-21 Ribosomal polynucleotides and related expression systems

Publications (1)

Publication Number Publication Date
SG11201407628UA true SG11201407628UA (en) 2014-12-30

Family

ID=48577911

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407628UA SG11201407628UA (en) 2012-05-21 2013-05-21 Ribosomal polynucleotides and related expression systems

Country Status (9)

Country Link
US (1) US9359616B2 (en)
EP (1) EP2852666B1 (en)
JP (1) JP2015519899A (en)
KR (1) KR20150016336A (en)
CN (1) CN104540944A (en)
AU (1) AU2013266461A1 (en)
CA (1) CA2873447A1 (en)
SG (1) SG11201407628UA (en)
WO (1) WO2013177191A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2021106814A1 (en) * 2019-11-25 2021-06-03
CN115236245A (en) * 2022-09-21 2022-10-25 首都医科大学附属北京朝阳医院 Measurement method of serum homocysteine, candidate standard substance and preparation method

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US4469863A (en) 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US5321131A (en) 1990-03-08 1994-06-14 Hybridon, Inc. Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
DK51092D0 (en) 1991-05-24 1992-04-15 Ole Buchardt OLIGONUCLEOTIDE ANALOGUE DESCRIBED BY PEN, MONOMERIC SYNTHONES AND PROCEDURES FOR PREPARING THEREOF, AND APPLICATIONS THEREOF
US5719262A (en) 1993-11-22 1998-02-17 Buchardt, Deceased; Ole Peptide nucleic acids having amino acid side chains
US5700922A (en) 1991-12-24 1997-12-23 Isis Pharmaceuticals, Inc. PNA-DNA-PNA chimeric macromolecules
AU678769B2 (en) 1992-07-27 1997-06-12 Hybridon, Inc. Oligonucleotide alkylphosphonothioates
WO1994017091A2 (en) 1993-01-21 1994-08-04 Hybridon Inc. Foldback triplex-forming oligonucleotides
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US5962674A (en) 1995-06-01 1999-10-05 Hybridon, Inc. Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
US5614622A (en) 1995-06-01 1997-03-25 Hybridon, Inc. 5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
US6140482A (en) 1995-06-01 2000-10-31 Hybridon, Inc. Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same
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US5637683A (en) 1995-07-13 1997-06-10 Cornell Research Foundation, Inc. Nucleic acid analog with amide linkage and method of making that analog
US5652356A (en) 1995-08-17 1997-07-29 Hybridon, Inc. Inverted chimeric and hybrid oligonucleotides
US5965408A (en) 1996-07-09 1999-10-12 Diversa Corporation Method of DNA reassembly by interrupting synthesis
US6117992A (en) 1996-08-26 2000-09-12 Hybridon, Inc. Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
US5886165A (en) 1996-09-24 1999-03-23 Hybridon, Inc. Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
US5739314A (en) 1997-04-25 1998-04-14 Hybridon, Inc. Method for synthesizing 2'-O-substituted pyrimidine nucleosides
US6639059B1 (en) 1999-03-24 2003-10-28 Exiqon A/S Synthesis of [2.2.1]bicyclo nucleosides
KR20010001577A (en) 1999-06-07 2001-01-05 윤종용 Process for Preparing Oligopeptidenucleotide Probe Using Polymeric Photoacid Generator
AU6629200A (en) 1999-08-25 2001-03-19 Philip P Garner Alpha-helical peptide nucleic acid alpha-pna
IL144082A0 (en) * 2000-07-14 2002-05-23 Medical Res Council Crystal structure of antibiotics bound to the 30s ribosome and its use
US6455308B1 (en) 2001-08-01 2002-09-24 Isis Pharmaceuticals, Inc. Antisense modulation of serum amyloid A4 expression

Also Published As

Publication number Publication date
CA2873447A1 (en) 2013-11-28
KR20150016336A (en) 2015-02-11
EP2852666B1 (en) 2016-11-23
JP2015519899A (en) 2015-07-16
US9359616B2 (en) 2016-06-07
US20130309682A1 (en) 2013-11-21
AU2013266461A1 (en) 2014-12-11
CN104540944A (en) 2015-04-22
WO2013177191A1 (en) 2013-11-28
EP2852666A1 (en) 2015-04-01

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