SG11201407117TA - Composition for repairing cartilage tissue, method for producing same, and use thereof - Google Patents

Composition for repairing cartilage tissue, method for producing same, and use thereof

Info

Publication number
SG11201407117TA
SG11201407117TA SG11201407117TA SG11201407117TA SG11201407117TA SG 11201407117T A SG11201407117T A SG 11201407117TA SG 11201407117T A SG11201407117T A SG 11201407117TA SG 11201407117T A SG11201407117T A SG 11201407117TA SG 11201407117T A SG11201407117T A SG 11201407117TA
Authority
SG
Singapore
Prior art keywords
lllll
seoul
composition
cartilage tissue
llll
Prior art date
Application number
SG11201407117TA
Inventor
Ji Chul Yoo
Dong Sam Suh
Jun Keun Lee
Sang Hun Woo
Se Ken Yeo
Cheong Ho Chang
Original Assignee
Sewon Cellontech Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sewon Cellontech Co Ltd filed Critical Sewon Cellontech Co Ltd
Publication of SG11201407117TA publication Critical patent/SG11201407117TA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/26—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/02—Bones

Abstract

(43) ^n^7B Q 2013 \£ 11 ^ 21 H (21.11.2013) W1POIPCT (10) ^1^7111*1 Jl WO 2013/172504 A1 (51) ^1^^: A61L 27/24 (2006.01) A61L 27/20 (2006.01) (2i) (22) (25) A61F 2/30 (2006.01) PCT/KR2012/004524 2012 6 € 8 H (08.06.2012) ^o] (26) : (30) 10-2012-0052141 2012 5 € 16 H (16.05.2012) KR (71) #€\"?] (US -Sr(l-) *11 ^ tv S--B *1 ^cfl SH). **^(^) (SEWON CELLONTECH CO., LTD.) [KR/KR]; 150-724 A^s-ifAl 83, °1 *1 Si ^ ^ (<*| $) £^), Seoul (KR). (72) 3 (75) 1H£*}/'#$!tI (US °l] ?1-SM ): <^^5- (YEO, Se Ken) [KR/KR]; 446-740 ^7]£ -g- °1 ^ 7]^^ ^ ^ tfl 3. 2077 ^8 104-508, Gyeonggi-do (KR). % ^ Jl (CHANG, Cheong Ho) [KR/KR]; 135-841 ^ vr J r 1^1 #^3. 417 31*1 Mia. cl^l-sKS j . 02 302, Seoul (KR). -rM^i (YOO, Ji Chul) [KR/KR]; 472- 869 ^7]£ ^-7j-g_ 1530-14 — £ 5] oj- s). T= 103-301, Gyeonggi-do (KR). -M ^\"S\" (SUH, Dong Sam) [KR/KR]; 139-924 ^ A] T 1 =f TllS. 233 ^ ^ 3 ^}O]-S)-E 103-403, Seoul (KR). <>1 in\"? (LEE, Jun Keun) [KR/KR]; 131-200 ^ <•'; J r VI A l 121-19, Seoul (KR). -f#®- (WOO, Sang Hun) [KR/KR]; 420-818 ^7lJE Jf ^A] ^ *}%• 33-23 <# 201 S., Gyeonggi-do (KR). (74) ^5. (HONG, Sung-Pyo); 153-768 ^ A 1 7}^ 550-1 5-cll IT 2 202 S., Seoul (KR). (81) *13^ (l^ i A] 7} ^ ?V,7}^-?!: JSL-s- ^-14] ^ e] S] iL J:# ^ ): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) *13^ (l^ &*]7} &ir th7}^tl; JSL-s « 14] e] S] iL J:# ^ ): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), -rr A 1 o} (AM, AZ, BY, KG, KZ, RU, TJ, TM), -rr v! (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), [CFS ^ *l*f] (54) Title: COMPOSITION FOR REPAIRING CARTILAGE TISSUE, METHOD FOR PRODUCING SAME, AND USE THERE­ OF = (54) o c* i> T-H rn i-H o CJ (57) Abstract: The present invention relates to a composition for repairing cartilage tissue, to a method for producing same, and to the use thereof. The present invention provides a composition for repairing cartilage tissue, which is obtained by mixing collagen and hy­ aluronic acid using a two-way syringe or a mixer, wherein the collagen has a diluted concentration of 5-60 mg/mL excepting water or a physiological phosphate buffer solution, and the hyaluronic acid has a diluted concen­ tration of 5-20 mg/mL excepting water or a physiological phosphate buffer solution. (57) -S.SM: ^#2:21 =r4-§\" ^#-4 *11 2:^ ^ o-|o] Aj-g-Hj-tt^ °11- # a •?!#<§ ^-g-^-S: *11 ^1 & S\ ^ ^ \"cr£7} 5 ~ 60 mg / mL # iEfe ^51^ •?!#<§ ^-§-^1- *11 S] wj- s\ ^ sl ^rJE7} 5 ~ 20 mg / mL *?] \"§\"1 ^ ^71 slgfSA} -ir ^A>7l ^^-711- ol-g-e} ^S. 'agizi =r *11 4-8- WO 2013/172504 Al I lllll llllllll II llllll III lllll lllll III III III lllll lllll llll lllll lllll lllll llll lllllll llll llll OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, : MR, NE, SN, TD, TG). — Sf s^l (2;§1= x|] 21 2:(3))
SG11201407117TA 2012-05-16 2012-06-08 Composition for repairing cartilage tissue, method for producing same, and use thereof SG11201407117TA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020120052141A KR101279812B1 (en) 2012-05-16 2012-05-16 A manufacturing method of cartilage tissue repair composition
PCT/KR2012/004524 WO2013172504A1 (en) 2012-05-16 2012-06-08 Composition for repairing cartilage tissue, method for producing same, and use thereof

Publications (1)

Publication Number Publication Date
SG11201407117TA true SG11201407117TA (en) 2014-12-30

Family

ID=48867838

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201407117TA SG11201407117TA (en) 2012-05-16 2012-06-08 Composition for repairing cartilage tissue, method for producing same, and use thereof

Country Status (20)

Country Link
US (1) US20150141344A1 (en)
EP (1) EP2851096B1 (en)
JP (1) JP2015514752A (en)
KR (1) KR101279812B1 (en)
CN (1) CN104254350A (en)
AU (3) AU2012380001A1 (en)
BR (1) BR112014028193B1 (en)
CA (1) CA2873167C (en)
CY (1) CY1121278T1 (en)
DK (1) DK2851096T3 (en)
ES (1) ES2711528T3 (en)
HR (1) HRP20190222T1 (en)
HU (1) HUE041782T2 (en)
LT (1) LT2851096T (en)
PL (1) PL2851096T3 (en)
PT (1) PT2851096T (en)
SG (1) SG11201407117TA (en)
SI (1) SI2851096T1 (en)
TR (1) TR201901635T4 (en)
WO (1) WO2013172504A1 (en)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150053606A (en) * 2013-11-08 2015-05-18 세원셀론텍(주) A gum-type materials with the enforced physical and biological properties through naturally crosslinking of collagen and hyaluronic acid, its manufacture and its usage method
RU2750695C2 (en) 2014-11-07 2021-07-01 Экзостемтех Ко., Лтд. Composition including exosome produced from stem cells for inducing adipogenous differentiation, regeneration of fatty tissue, skin whitening or wrinkle correction
KR101706642B1 (en) 2015-02-04 2017-02-17 주식회사 엑소스템텍 Composition comprising exosomes extracted from stem cells which differentiate into chondrocytes for inducing chondrogenic differentiation or regenerating cartilage tissue
TWI649086B (en) * 2015-05-22 2019-02-01 方策科技股份有限公司 Composition for repairing cartilage defects
KR20180092348A (en) 2017-02-09 2018-08-20 주식회사 엑소코바이오 Composition for inducing chondrogenic differentiation or regenerating cartilage tissue comprising exosomes derived from umbilical cord stem cells and cord blood stem cells which differentiate into chondrocytes
KR101863532B1 (en) 2017-06-15 2018-06-01 세원셀론텍(주) Manufacturing and use method of cartilage tissue repair composition
KR102350526B1 (en) * 2018-08-16 2022-01-17 (주)메디제이 Method of preparing wound dressing composition for treating skin wounds having improved aggregation
KR20210044168A (en) * 2019-10-14 2021-04-22 손진경 Filler compositions
CN111481659A (en) * 2020-04-30 2020-08-04 广州市红十字会医院（暨南大学医学院附属广州红十字会医院） Collagen type II and hyaluronic acid composite gel liquid, preparation method and application
KR102430642B1 (en) * 2020-07-03 2022-08-16 주식회사 메피온 Dermal filler composition and method for manufacturing thr same
CN112089885A (en) * 2020-11-07 2020-12-18 单县华宇缝合制品有限公司 Absorbable collagen suture line and forming preparation method thereof
KR102229597B1 (en) * 2020-11-11 2021-03-18 주식회사 이노브바이오 Method for producing medical polymer material
CN116999619B (en) * 2023-08-03 2024-03-19 浙江崇山生物制品有限公司 Collagen gel for cartilage and preparation method thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01265970A (en) * 1988-04-19 1989-10-24 Shiseido Co Ltd Collagen water solution or water dispersion solution including hyaluronic acid
US5866165A (en) * 1997-01-15 1999-02-02 Orquest, Inc. Collagen-polysaccharide matrix for bone and cartilage repair
JP4187917B2 (en) * 2000-09-08 2008-11-26 独立行政法人科学技術振興機構 Method for producing glycosaminoglycan-collagen complex for tissue regeneration matrix
EP1337266A4 (en) * 2000-10-31 2006-11-02 Depuy Spine Inc Mineralized collagen-polysaccharide matrix for bone and cartilage repair
CA2435767A1 (en) 2001-01-30 2002-08-08 Orthogene, Inc. Compositions and methods for the treatment and repair of defects or lesions in articular cartilage using synovial-derived tissue or cells
US20070077236A1 (en) * 2003-06-12 2007-04-05 Interface Biotech A/S Method for cell implantation
KR100531922B1 (en) * 2003-12-23 2005-11-29 주식회사 셀론텍 a composition for cartilage therapeutics and a using method thereof
US7371399B2 (en) * 2004-07-23 2008-05-13 Prescott Albert G Polymer gel containing hyaluronic acid and collagen, and its use in joints
KR100684932B1 (en) 2005-04-13 2007-02-20 (주)필미아젠 Method For Cartilage Regeneration Using Mesenchymal Stem Cells and Ultrasound Stimulation
WO2006135843A2 (en) * 2005-06-10 2006-12-21 Celgene Corporation Human placental collagen compositions, processes for their preparation, methods of their use and kits comprising the compositions
KR100774089B1 (en) * 2005-07-20 2007-11-06 세원셀론텍(주) Simple Method of Autologous Chondrocyte Transplantation ? Injectable Chondrocyte Transplantation
KR100846311B1 (en) * 2006-02-28 2008-07-15 박정극 Porous collagen-hyaluronic acid complex material and method for the preparation thereof
DK2097116T3 (en) * 2006-12-22 2013-01-02 Medidom Lab In situ system for intra-articular cartilage and bone tissue healing
KR101027630B1 (en) * 2008-06-18 2011-04-07 주식회사 제네웰 Preparation method of porous scaffold by hyaluronic acid - collagen natural polymer for cartilage resuscitation
KR101073050B1 (en) * 2009-03-17 2011-10-12 주식회사 제네웰 Method For Preparing Porous Scaffold By Cartilage-bone Complex For Cartilage Regeneration
US20120122791A1 (en) * 2009-05-01 2012-05-17 Jnc Corporation Substrate for cartilage cultivation using artificial collagen, and method for cartilage regeneration treatment using the substrate
US8968785B2 (en) * 2009-10-02 2015-03-03 Covidien Lp Surgical compositions
KR101114773B1 (en) 2009-10-23 2012-03-05 세원셀론텍(주) A cartilage repair constituent manufacturing method thereof
KR101340458B1 (en) * 2010-11-02 2013-12-11 서울대학교산학협력단 Composition Comprising Hydrogel for Transplant to Cartilage
JP2013544593A (en) * 2010-11-23 2013-12-19 エラスタジェン ピーティーワイ リミテッド Preparation and / or formulation of proteins cross-linked by polysaccharides
US20140227235A1 (en) * 2011-07-13 2014-08-14 Cha Bio & Diostech Co., Ltd. Cartilage cell treatment comprising collagen, hyaluronic acid derivative, and stem cell derived from mammal umbilical cord
US20130116411A1 (en) * 2011-09-06 2013-05-09 Allergan, Inc. Methods of making hyaluronic acid/collagen compositions
EP2802308A1 (en) * 2012-01-13 2014-11-19 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation

Also Published As

Publication number Publication date
JP2015514752A (en) 2015-05-21
CA2873167C (en) 2016-12-20
PL2851096T3 (en) 2019-06-28
HRP20190222T1 (en) 2019-04-05
SI2851096T1 (en) 2019-04-30
WO2013172504A1 (en) 2013-11-21
AU2018201871B2 (en) 2020-04-02
AU2012380001A1 (en) 2014-12-18
AU2016202877A1 (en) 2016-05-26
BR112014028193B1 (en) 2019-12-17
BR112014028193A2 (en) 2017-06-27
KR101279812B1 (en) 2013-06-28
AU2018201871A1 (en) 2018-04-12
EP2851096A4 (en) 2015-11-18
PT2851096T (en) 2019-02-21
ES2711528T3 (en) 2019-05-06
LT2851096T (en) 2019-04-25
EP2851096A1 (en) 2015-03-25
TR201901635T4 (en) 2019-02-21
US20150141344A1 (en) 2015-05-21
CN104254350A (en) 2014-12-31
CY1121278T1 (en) 2020-05-29
DK2851096T3 (en) 2019-03-11
CA2873167A1 (en) 2013-11-21
EP2851096B1 (en) 2018-11-28
HUE041782T2 (en) 2019-05-28

Similar Documents

Publication Publication Date Title
SG11201407117TA (en) Composition for repairing cartilage tissue, method for producing same, and use thereof
SG11201811431VA (en) Multispecific antibodies against cd40 and cd137
SG11201900163PA (en) Macrocycle kinase inhibitors
SG11201804373VA (en) Compositions and methods for immunooncology
SG11201808622SA (en) Chimeric receptors to flt3 and methods of use thereof
SG11201804510PA (en) Biparatopic polypeptides antagonizing wnt signaling in tumor cells
SG11201810117WA (en) Human platelet lysate derived extracellular vesicles for use in medicine
SG11201807252QA (en) Anti-lag-3 antibodies
SG11201805044WA (en) Compounds useful as kinase inhibitors
SG11201805451TA (en) Immune effector cell therapies with enhanced efficacy
SG11201809344QA (en) Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde
SG11201809132RA (en) Novel compounds as autotaxin inhibitors and pharmaceutical compositions comprising the same
SG11201808222RA (en) Methods of treatment of cholestatic diseases
SG11201903287PA (en) Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201808108XA (en) Synthesis of indazoles
SG11201810430WA (en) Heater assembly for an aerosol-generating system
SG11201407917PA (en) Highly efficient method for establishing artificial pluripotent stem cell
SG11201407655TA (en) Therapeutic uses of fibroblast growth factor 21 proteins
SG11201811149TA (en) METABOLIC DRUG LOADING OF EVs
SG11201810965YA (en) 1h-pyrazolo[4,3-b]pyridines as pde1 inhibitors
SG11201807523PA (en) Ilt7 binding molecules and methods of using the same
SG11201805001UA (en) Method of treating influenza a
SG11201809172WA (en) Crystalline forms of n-[2-(3-hydroxy-3-methylbutyl)-6-(2-hydroxypropan-2-yl)-2h-indazol-5-yl]-6-(trifluoromethyl)pyridine-2-carboxamide
SG11201805755SA (en) Methods of administering hepcidin
SG11201805149XA (en) Compositions comprising 15-hepe and methods of using the same