SG10201913275QA - Anti-cd154 antibodies and methods of using them - Google Patents
Anti-cd154 antibodies and methods of using themInfo
- Publication number
- SG10201913275QA SG10201913275QA SG10201913275QA SG10201913275QA SG10201913275QA SG 10201913275Q A SG10201913275Q A SG 10201913275QA SG 10201913275Q A SG10201913275Q A SG 10201913275QA SG 10201913275Q A SG10201913275Q A SG 10201913275QA SG 10201913275Q A SG10201913275Q A SG 10201913275QA
- Authority
- SG
- Singapore
- Prior art keywords
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
- G01N33/686—Anti-idiotype
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Dermatology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562201150P | 2015-08-05 | 2015-08-05 | |
US201662367660P | 2016-07-28 | 2016-07-28 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201913275QA true SG10201913275QA (en) | 2020-02-27 |
Family
ID=57944010
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201913275QA SG10201913275QA (en) | 2015-08-05 | 2016-08-04 | Anti-cd154 antibodies and methods of using them |
Country Status (26)
Country | Link |
---|---|
US (2) | US10669343B2 (en) |
EP (1) | EP3331563B1 (en) |
JP (2) | JP7049988B2 (en) |
KR (1) | KR20180030917A (en) |
CN (2) | CN107921128B (en) |
AU (1) | AU2016301361B2 (en) |
BR (1) | BR112018002319A2 (en) |
CA (1) | CA2994825A1 (en) |
CL (1) | CL2018000298A1 (en) |
CO (1) | CO2018001256A2 (en) |
EA (1) | EA201890434A1 (en) |
EC (1) | ECSP18008922A (en) |
ES (1) | ES2944982T3 (en) |
GT (1) | GT201800034A (en) |
HK (1) | HK1256804A1 (en) |
IL (2) | IL293065A (en) |
MA (1) | MA45573A (en) |
MX (1) | MX2018001522A (en) |
MY (1) | MY188405A (en) |
NI (1) | NI201800017A (en) |
PE (1) | PE20180802A1 (en) |
PH (1) | PH12018500203A1 (en) |
SG (1) | SG10201913275QA (en) |
SV (1) | SV2018005624A (en) |
UA (1) | UA123398C2 (en) |
WO (1) | WO2017024146A1 (en) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20180802A1 (en) * | 2015-08-05 | 2018-05-09 | Janssen Biotech Inc | ANTI-CD154 ANTIBODIES AND METHODS OF USE OF THEM |
MX2018001557A (en) | 2015-08-05 | 2018-05-02 | Eisai R&D Man Co Ltd | Chiral reagents for preparation of homogeneous oligomers. |
CN108473561B (en) | 2015-11-27 | 2022-12-16 | 埃博灵克斯股份有限公司 | Polypeptide inhibiting CD40L |
CN112770774A (en) * | 2018-09-24 | 2021-05-07 | 詹森生物科技公司 | Methods for providing safe administration of anti-CD 154 antibodies |
EP3998282A4 (en) * | 2019-07-08 | 2023-08-09 | Progen Co., Ltd. | Novel fusion protein and use of same |
WO2021154530A1 (en) * | 2020-01-27 | 2021-08-05 | Vanderbilt University | Human anti-dengue antibodies and methods of use therefor |
US20230374127A1 (en) * | 2020-07-28 | 2023-11-23 | Lg Chem, Ltd. | Anti-lilrb1 antibody and uses thereof |
CN115586338A (en) * | 2022-09-20 | 2023-01-10 | 杭州赛基生物科技有限公司 | Kit for detecting soluble cytokine receptor and preparation method thereof |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7709A (en) | 1850-10-08 | Chas S Gaylord | Improved spring-grapple | |
US226A (en) | 1837-06-03 | Samuel goss | ||
US541606A (en) | 1895-06-25 | Sealed package | ||
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
US5869620A (en) | 1986-09-02 | 1999-02-09 | Enzon, Inc. | Multivalent antigen-binding proteins |
US5606040A (en) | 1987-10-30 | 1997-02-25 | American Cyanamid Company | Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group |
US5770701A (en) | 1987-10-30 | 1998-06-23 | American Cyanamid Company | Process for preparing targeted forms of methyltrithio antitumor agents |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
ATE255131T1 (en) | 1991-06-14 | 2003-12-15 | Genentech Inc | HUMANIZED HEREGULIN ANTIBODIES |
ES2136092T3 (en) | 1991-09-23 | 1999-11-16 | Medical Res Council | PROCEDURES FOR THE PRODUCTION OF HUMANIZED ANTIBODIES. |
CA2121798C (en) | 1991-10-25 | 2007-07-24 | Richard J. Armitage | Novel cytokine |
US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
US5932448A (en) | 1991-11-29 | 1999-08-03 | Protein Design Labs., Inc. | Bispecific antibody heterodimers |
ES2227512T3 (en) | 1991-12-02 | 2005-04-01 | Medical Research Council | PRODUCTION OF ANTIBODIES AGAINST SELF-ANTIGENS FROM REPERTORIES OF ANTIBODY SEGMENTS FIXED IN A PHOTO. |
ES2198414T3 (en) | 1992-10-23 | 2004-02-01 | Immunex Corporation | PROCEDURES TO PREPARE SOLUBLE OLIGOMERIC PROTEINS. |
CA2149329C (en) | 1992-11-13 | 2008-07-15 | Darrell R. Anderson | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
US5635483A (en) | 1992-12-03 | 1997-06-03 | Arizona Board Of Regents Acting On Behalf Of Arizona State University | Tumor inhibiting tetrapeptide bearing modified phenethyl amides |
JP3720353B2 (en) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | Multivalent and multispecific binding proteins, their production and use |
US5780588A (en) | 1993-01-26 | 1998-07-14 | Arizona Board Of Regents | Elucidation and synthesis of selected pentapeptides |
HU218610B (en) | 1993-09-02 | 2000-10-28 | Trustees Of Dartmouth College | Methods for producing antygen-specific t cell tolerance inducing pharmaceutical composition |
JP2840131B2 (en) | 1993-09-02 | 1998-12-24 | トラスティーズ・オブ・ダートマス・カレッジ | Method for suppressing humoral immunity persistence |
WO1995015388A1 (en) | 1993-12-03 | 1995-06-08 | Medical Research Council | Recombinant binding proteins and peptides |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
KR100453314B1 (en) | 1995-06-07 | 2004-12-17 | 임뮤넥스 코포레이션 | CD40L Mutein |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
US5989830A (en) | 1995-10-16 | 1999-11-23 | Unilever Patent Holdings Bv | Bifunctional or bivalent antibody fragment analogue |
US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
NL1003537C2 (en) | 1996-07-08 | 1998-01-12 | Holland Railconsult B V | Method for manufacturing curved glazing. |
CA2291156A1 (en) | 1997-05-17 | 1998-11-26 | Biogen, Inc. | Use of a cd40:cd154 binding interruptor to prevent counter adaptive immune responses, particularly graft rejection |
GB2339430A (en) | 1997-05-21 | 2000-01-26 | Biovation Ltd | Method for the production of non-immunogenic proteins |
CN1173735C (en) | 1998-04-03 | 2004-11-03 | 达特茅斯学院理事 | Use of anti-gp 39 antibodies for treatment and/or reversal of lupus and associated kidney disease |
DE19819846B4 (en) | 1998-05-05 | 2016-11-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Multivalent antibody constructs |
US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
GB9915653D0 (en) | 1999-07-06 | 1999-09-01 | Bruce Terry | Hose clamp |
JP2003510371A (en) * | 1999-10-04 | 2003-03-18 | カイロン コーポレイション | CD40 antagonist for treating psoriasis |
AU767394C (en) | 1999-12-29 | 2005-04-21 | Immunogen, Inc. | Cytotoxic agents comprising modified doxorubicins and daunorubicins and their therapeutic use |
US20030103978A1 (en) * | 2000-02-23 | 2003-06-05 | Amgen Inc. | Selective binding agents of osteoprotegerin binding protein |
GB0006398D0 (en) | 2000-03-16 | 2000-05-03 | Novartis Ag | Organic compounds |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
US7041870B2 (en) | 2000-11-30 | 2006-05-09 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
MXPA05000511A (en) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Super humanized antibodies. |
US6833441B2 (en) | 2001-08-01 | 2004-12-21 | Abmaxis, Inc. | Compositions and methods for generating chimeric heteromultimers |
US7495090B2 (en) | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
US8597911B2 (en) | 2003-06-11 | 2013-12-03 | Chugai Seiyaku Kabushiki Kaisha | Process for producing antibodies |
JP4667383B2 (en) | 2003-06-13 | 2011-04-13 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | Aglycosyl anti-CD154 (CD40 ligand) antibody and use thereof |
NZ583292A (en) | 2003-11-06 | 2012-03-30 | Seattle Genetics Inc | Monomethylvaline compounds capable of conjugation to ligands |
EA014226B1 (en) | 2004-07-26 | 2010-10-29 | Байоджен Айдек Ма Инк. | Anti-cd154 antibodies, fragments thereof and methods for using antibodies and fragments |
US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
EP2361933A3 (en) | 2005-01-26 | 2012-05-02 | Amgen Fremont Inc. | Antibodies against interleukin-1 beta |
DK3050963T3 (en) | 2005-03-31 | 2019-12-09 | Chugai Pharmaceutical Co Ltd | Process for producing polypeptide by arrangement control |
WO2006125201A2 (en) | 2005-05-19 | 2006-11-23 | Centocor, Inc. | Anti-biotin-pegylated-mcp-1 mutein antibodies, compositions, methods and uses |
US8114964B2 (en) | 2005-05-19 | 2012-02-14 | Centocor, Inc. | Anti-MCP-1 antibodies, compositions, methods and uses |
EP1999154B1 (en) | 2006-03-24 | 2012-10-24 | Merck Patent GmbH | Engineered heterodimeric protein domains |
JP2009541275A (en) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー/エス | Production of bispecific antibodies |
CL2007002567A1 (en) * | 2006-09-08 | 2008-02-01 | Amgen Inc | ISOLATED PROTEINS FROM LINK TO ACTIVINE TO HUMAN. |
WO2008064152A2 (en) | 2006-11-20 | 2008-05-29 | Nanostellar, Inc. | Method for producing heterogeneous catalysts containing metal nanoparticles |
BRPI0809042B1 (en) | 2007-03-22 | 2021-08-31 | Biogen Ma Inc. | ISOLATED CD154-BINDING PROTEIN, ITS USE, AND COMPOSITION |
CN101802015B (en) | 2007-03-29 | 2015-05-06 | 根马布股份公司 | Bispecific antibodies and methods for production thereof |
US8748356B2 (en) | 2007-10-19 | 2014-06-10 | Janssen Biotech, Inc. | Methods for use in human-adapting monoclonal antibodies |
ES2564523T3 (en) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Design and generation of phage de novo human presentation libraries by fusion with pIX or pVII, vectors, antibodies and methods |
EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
MX2010011955A (en) | 2008-04-29 | 2011-01-21 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof. |
EP2347038A4 (en) | 2008-10-14 | 2013-06-12 | Janssen Biotech Inc | Methods of humanizing and affinity-maturing antibodies |
EP2424567B1 (en) | 2009-04-27 | 2018-11-21 | OncoMed Pharmaceuticals, Inc. | Method for making heteromultimeric molecules |
GB201005063D0 (en) | 2010-03-25 | 2010-05-12 | Ucb Pharma Sa | Biological products |
EA030792B1 (en) | 2009-11-30 | 2018-09-28 | Янссен Байотек, Инк | ANTIBODY Fc MUTANTS WITH ABLATED EFFECTOR FUNCTIONS |
US20110206672A1 (en) | 2010-02-25 | 2011-08-25 | Melvyn Little | Antigen-Binding Molecule And Uses Thereof |
SG10201800757TA (en) | 2010-04-20 | 2018-02-27 | Genmab As | Heterodimeric antibody fc-containing proteins and methods for production thereof |
CA2797981C (en) | 2010-05-14 | 2019-04-23 | Rinat Neuroscience Corporation | Heterodimeric proteins and methods for producing and purifying them |
US8795950B2 (en) | 2010-06-30 | 2014-08-05 | Jonghan Choi | Method of improving print performance in flexographic printing plates |
EP2420253A1 (en) | 2010-08-20 | 2012-02-22 | Leadartis, S.L. | Engineering multifunctional and multivalent molecules with collagen XV trimerization domain |
EP2444101A1 (en) | 2010-10-21 | 2012-04-25 | Universitätsklinikum Freiburg | Selective targeting of the CD40L/Mac-1 interaction by small peptide inhibitors and its use for the treatment of inflammation and atherogenesis |
WO2012058137A2 (en) | 2010-10-29 | 2012-05-03 | Merck Sharp & Dohme Corp. | Methods for diversifying antibodies, antibodies derived therefrom and uses thereof |
PL2635607T3 (en) | 2010-11-05 | 2020-05-18 | Zymeworks Inc. | Stable heterodimeric antibody design with mutations in the fc domain |
MY162489A (en) | 2010-12-23 | 2017-06-15 | Janssen Biotech Inc | ACTIVE PROTEASE-RESISTANT ANTIBODY Fc MUTANTS |
EP2681242B1 (en) * | 2011-03-01 | 2018-01-24 | Amgen Inc. | Sclerostin and dkk-1 bispecific binding agents |
WO2012138768A2 (en) | 2011-04-04 | 2012-10-11 | Trustees Of Dartmouth College | Anti-cd154 antibodies having impaired fcr binding and/or complement binding properties and the use thereof in immune therapies |
SI2771022T1 (en) | 2011-10-11 | 2020-12-31 | Viela Bio, Inc. | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
EP2766395B1 (en) | 2011-10-13 | 2019-11-20 | Bristol-Myers Squibb Company | Antibody polypeptides that antagonize cd40l |
AU2013267161A1 (en) | 2012-05-31 | 2014-11-20 | Sorrento Therapeutics, Inc. | Antigen binding proteins that bind PD-L1 |
LT2931030T (en) | 2012-12-14 | 2020-11-10 | Open Monoclonal Technology, Inc. | Polynucleotides encoding rodent antibodies with human idiotypes and animals comprising same |
PE20180802A1 (en) * | 2015-08-05 | 2018-05-09 | Janssen Biotech Inc | ANTI-CD154 ANTIBODIES AND METHODS OF USE OF THEM |
US10651781B2 (en) | 2017-08-24 | 2020-05-12 | Corning Incorporated | Glass roof shingle |
-
2016
- 2016-08-04 PE PE2018000170A patent/PE20180802A1/en unknown
- 2016-08-04 MX MX2018001522A patent/MX2018001522A/en unknown
- 2016-08-04 MA MA045573A patent/MA45573A/en unknown
- 2016-08-04 EP EP16833880.4A patent/EP3331563B1/en active Active
- 2016-08-04 JP JP2018505712A patent/JP7049988B2/en active Active
- 2016-08-04 CA CA2994825A patent/CA2994825A1/en active Pending
- 2016-08-04 AU AU2016301361A patent/AU2016301361B2/en not_active Ceased
- 2016-08-04 ES ES16833880T patent/ES2944982T3/en active Active
- 2016-08-04 WO PCT/US2016/045574 patent/WO2017024146A1/en active Application Filing
- 2016-08-04 UA UAA201802170A patent/UA123398C2/en unknown
- 2016-08-04 CN CN201680046010.6A patent/CN107921128B/en active Active
- 2016-08-04 US US15/228,582 patent/US10669343B2/en not_active Expired - Fee Related
- 2016-08-04 EA EA201890434A patent/EA201890434A1/en unknown
- 2016-08-04 SG SG10201913275QA patent/SG10201913275QA/en unknown
- 2016-08-04 CN CN202210426273.7A patent/CN114605549A/en active Pending
- 2016-08-04 KR KR1020187005880A patent/KR20180030917A/en not_active Application Discontinuation
- 2016-08-04 IL IL293065A patent/IL293065A/en unknown
- 2016-08-04 BR BR112018002319-1A patent/BR112018002319A2/en active Search and Examination
- 2016-08-04 MY MYPI2018700407A patent/MY188405A/en unknown
-
2018
- 2018-01-18 IL IL256997A patent/IL256997B/en unknown
- 2018-01-25 PH PH12018500203A patent/PH12018500203A1/en unknown
- 2018-02-01 CL CL2018000298A patent/CL2018000298A1/en unknown
- 2018-02-02 GT GT201800034A patent/GT201800034A/en unknown
- 2018-02-02 NI NI201800017A patent/NI201800017A/en unknown
- 2018-02-05 SV SV2018005624A patent/SV2018005624A/en unknown
- 2018-02-07 CO CONC2018/0001256A patent/CO2018001256A2/en unknown
- 2018-02-07 EC ECIEPI20188922A patent/ECSP18008922A/en unknown
- 2018-12-11 HK HK18115888.3A patent/HK1256804A1/en unknown
-
2020
- 2020-04-21 US US16/853,786 patent/US11421037B2/en active Active
-
2021
- 2021-12-24 JP JP2021211010A patent/JP2022058414A/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL304117A (en) | Anti-pvrig antibodies and methods of use | |
IL282962A (en) | Anti-pd-1 antibodies and methods of use thereof | |
HK1258058A1 (en) | Anti-tigit antibodies and methods of use | |
HK1252858A1 (en) | Anti-cll-1 antibodies and methods of use | |
HK1249445A1 (en) | Anti-sortilin antibodies and methods of use thereof | |
HK1252698A1 (en) | Anti-siglec-9 antibodies and methods of use thereof | |
HK1252696A1 (en) | Anti-siglec-7 antibodies and methods of use thereof | |
IL270793A (en) | Anti-htra1 antibodies and methods of use thereof | |
HK1256804A1 (en) | Anti-cd154 antibodies and methods of using them | |
HK1258850A1 (en) | Anti-tpbg antibodies and methods of use |