SG10201901863RA - Strategic dynamic range control for time-of-flight mass spectrometry - Google Patents

Strategic dynamic range control for time-of-flight mass spectrometry

Info

Publication number
SG10201901863RA
SG10201901863RA SG10201901863RA SG10201901863RA SG10201901863RA SG 10201901863R A SG10201901863R A SG 10201901863RA SG 10201901863R A SG10201901863R A SG 10201901863RA SG 10201901863R A SG10201901863R A SG 10201901863RA SG 10201901863R A SG10201901863R A SG 10201901863RA
Authority
SG
Singapore
Prior art keywords
dynamic range
strategic
time
mass spectrometry
range control
Prior art date
Application number
SG10201901863RA
Inventor
Scott Tanner
Original Assignee
Fluidigm Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fluidigm Canada Inc filed Critical Fluidigm Canada Inc
Publication of SG10201901863RA publication Critical patent/SG10201901863RA/en

Links

Classifications

    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/40—Time-of-flight spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/02—Details
    • H01J49/025—Detectors specially adapted to particle spectrometers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Abstract

STRATEGIC DYNAMIC RANGE CONTROL FOR TIME-OF-FLIGHT MASS SPECTROMETRY A mass spectrometer of the type useful in mass cytometry includes an ion detector. A digitizing system for converting analog signals from the ion detector includes two analog-to-digital converters. The analog-to-digital converters are configured to provide an increased dynamic range for a targeted period while limiting the amount of data generated. [Figure 1]
SG10201901863RA 2013-06-04 2014-05-28 Strategic dynamic range control for time-of-flight mass spectrometry SG10201901863RA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13/909,721 US9218949B2 (en) 2013-06-04 2013-06-04 Strategic dynamic range control for time-of-flight mass spectrometry

Publications (1)

Publication Number Publication Date
SG10201901863RA true SG10201901863RA (en) 2019-03-28

Family

ID=51984036

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201901863RA SG10201901863RA (en) 2013-06-04 2014-05-28 Strategic dynamic range control for time-of-flight mass spectrometry
SG11201509911TA SG11201509911TA (en) 2013-06-04 2014-05-28 Strategic dynamic range control for time-of-flight mass spectrometry

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201509911TA SG11201509911TA (en) 2013-06-04 2014-05-28 Strategic dynamic range control for time-of-flight mass spectrometry

Country Status (5)

Country Link
US (1) US9218949B2 (en)
EP (2) EP3591688A1 (en)
CA (1) CA2914099A1 (en)
SG (2) SG10201901863RA (en)
WO (1) WO2014194417A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7052688B2 (en) * 2018-11-19 2022-04-12 株式会社島津製作所 Mass spectrometer and mass spectrometry system
CN109884159A (en) * 2018-12-26 2019-06-14 宁波大学 Mass spectrometric analysis method
WO2020248757A1 (en) * 2019-06-14 2020-12-17 Shanghai Polaris Biology Co., Ltd. Systems and methods for single particle analysis

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4490806A (en) 1982-06-04 1984-12-25 Research Corporation High repetition rate transient recorder with automatic integration
US4499052A (en) 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
US4583183A (en) 1983-02-24 1986-04-15 The United States Of America As Represented By The United States Department Of Energy Masked multichannel analyzer
US5021661A (en) * 1989-09-04 1991-06-04 Jeol Ltd. Time-resolved infrared spectrophotometer
US5367162A (en) 1993-06-23 1994-11-22 Meridian Instruments, Inc. Integrating transient recorder apparatus for time array detection in time-of-flight mass spectrometry
AUPO481097A0 (en) 1997-01-28 1997-02-20 Gbc Scientific Equipment Pty Ltd Gate for eliminating charged particles in time of flight spectrometers
US6140638A (en) 1997-06-04 2000-10-31 Mds Inc. Bandpass reactive collision cell
US6222186B1 (en) 1998-06-25 2001-04-24 Agilent Technologies, Inc. Power-modulated inductively coupled plasma spectrometry
WO2000009970A1 (en) * 1998-08-10 2000-02-24 Midac Corporation Spectrometer with dual digitizer for high-dynamic range spectroscopic data collection
EP1166085A2 (en) 1999-02-25 2002-01-02 Clemson University Research Foundation Sampling and analysis of airborne particulate matter by glow discharge atomic emission and mass spectrometries
US20040126277A1 (en) 2001-12-17 2004-07-01 Yoshitake Yamamoto Liquid chromatograph mass spectrometer
JP2001099821A (en) 1999-09-30 2001-04-13 Shimadzu Corp Liquid chromatograph mass spectroscope
US20020028434A1 (en) 2000-09-06 2002-03-07 Guava Technologies, Inc. Particle or cell analyzer and method
US7135296B2 (en) 2000-12-28 2006-11-14 Mds Inc. Elemental analysis of tagged biologically active materials
US7700295B2 (en) 2000-12-28 2010-04-20 Mds Sciex Elemental analysis of tagged biologically active materials
WO2002097403A1 (en) * 2001-05-25 2002-12-05 Analytica Of Branford, Inc. Multiple detection systems
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US7260483B2 (en) 2001-10-25 2007-08-21 The Regents Of The University Of California Real-time detection method and system for identifying individual aerosol particles
DE10152821B4 (en) 2001-10-25 2006-11-16 Bruker Daltonik Gmbh Mass spectra without electronic noise
US6747271B2 (en) 2001-12-19 2004-06-08 Ionwerks Multi-anode detector with increased dynamic range for time-of-flight mass spectrometers with counting data acquisition
US7198900B2 (en) 2003-08-29 2007-04-03 Applera Corporation Multiplex detection compositions, methods, and kits
JP2006032207A (en) 2004-07-20 2006-02-02 Shimadzu Corp Time-of-flight analyzer
CA2609802A1 (en) 2005-05-27 2006-12-07 Ionwerks, Inc. Multi-beam ion mobility time-of-flight mass spectrometer with bipolar ion extraction and zwitterion detection
US20070046934A1 (en) 2005-08-26 2007-03-01 New Wave Research, Inc. Multi-function laser induced breakdown spectroscopy and laser ablation material analysis system and method
US7375569B2 (en) 2005-09-21 2008-05-20 Leco Corporation Last stage synchronizer system
US8093014B2 (en) 2006-02-13 2012-01-10 Dvs Sciences Inc. Kit for detecting and measuring element tagged kinases and phosphatases by inductively coupled plasma mass spectrometry
US20070190560A1 (en) 2006-02-13 2007-08-16 Olga Ornatsky Element-tagged olignucleotide gene expression analysis
WO2007140571A1 (en) 2006-02-13 2007-12-13 Olga Ornatsky Quantitation of cellular dna and cell numbers using element labeling
US8101368B2 (en) 2006-02-13 2012-01-24 Dvs Sciences Inc. Quantitation of cellular DNA and cell numbers using element labeling
US7321847B1 (en) * 2006-05-05 2008-01-22 Analytica Of Branford, Inc. Apparatus and methods for reduction of coherent noise in a digital signal averager
EP2960263B1 (en) 2006-05-27 2017-07-12 Fluidigm Canada Inc. Polymer backbone element tags
US7501621B2 (en) * 2006-07-12 2009-03-10 Leco Corporation Data acquisition system for a spectrometer using an adaptive threshold
WO2008019492A1 (en) 2006-08-15 2008-02-21 Alexei Antonov Apparatus and method for elemental analysis of particles by mass spectrometry
WO2008080224A1 (en) 2006-12-29 2008-07-10 Tanner Scott D Cell injector for flow cytometer having mass spectrometer detector and method for using same
US7595487B2 (en) 2007-08-24 2009-09-29 Georgia Tech Research Corporation Confining/focusing vortex flow transmission structure, mass spectrometry systems, and methods of transmitting particles, droplets, and ions
GB0815397D0 (en) * 2008-08-22 2008-10-01 Micromass Ltd Mass spectrometer
JP5645829B2 (en) * 2009-09-14 2014-12-24 株式会社日立ハイテクノロジーズ Signal processing apparatus, mass spectrometer, and photometer
IT1395787B1 (en) * 2009-09-16 2012-10-19 Dani Instr Spa MASS SPECTROMETER WITH WIDE RANGE OF DYNAMICS.
CA2852043C (en) 2011-10-26 2020-08-25 Fluidigm Canada Inc. Sample transferring apparatus for mass cytometry

Also Published As

Publication number Publication date
EP3005404A4 (en) 2017-05-24
EP3591688A1 (en) 2020-01-08
EP3005404B1 (en) 2019-08-28
CA2914099A1 (en) 2014-12-11
SG11201509911TA (en) 2016-01-28
EP3005404A1 (en) 2016-04-13
WO2014194417A1 (en) 2014-12-11
US9218949B2 (en) 2015-12-22
US20140353484A1 (en) 2014-12-04

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