SG10201811185YA - Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii - Google Patents
Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viiiInfo
- Publication number
- SG10201811185YA SG10201811185YA SG10201811185YA SG10201811185YA SG10201811185YA SG 10201811185Y A SG10201811185Y A SG 10201811185YA SG 10201811185Y A SG10201811185Y A SG 10201811185YA SG 10201811185Y A SG10201811185Y A SG 10201811185YA SG 10201811185Y A SG10201811185Y A SG 10201811185YA
- Authority
- SG
- Singapore
- Prior art keywords
- blood coagulation
- coagulation factor
- factor viii
- decrease
- activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
9 PHARMACEUTICAL COMPOSITION FOR USE IN PREVENTION AND/OR TREATMENT OF DISEASE THAT DEVELOPS OR PROGRESSES AS A RESULT OF DECREASE OR LOSS OF ACTIVITY OF BLOOD COAGULATION FACTOR VIII AND/OR ACTIVATED BLOOD COAGULATION FACTOR VIII The inventors discovered that by administering a pharmaceutical composition comprising a bispecific antigen-binding molecule that recognizes blood coagulation factor IX and/or 5 activated blood coagulation factor IX and blood coagulation factor X and/or activated blood coagulation factor X according to a given dosage regimen, diseases that develop and/or progress due to a decrease or deficiency in the activity of blood coagulation factor VIII and/or activated blood coagulation factor VIII can be prevented and/or treated more effectively. Figure 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2014127240 | 2014-06-20 | ||
| JP2014226988 | 2014-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201811185YA true SG10201811185YA (en) | 2019-01-30 |
Family
ID=54935230
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201811185YA SG10201811185YA (en) | 2014-06-20 | 2015-03-31 | Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii |
| SG11201610581RA SG11201610581RA (en) | 2014-06-20 | 2015-03-31 | Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201610581RA SG11201610581RA (en) | 2014-06-20 | 2015-03-31 | Pharmaceutical composition for use in prevention and/or treatment of disease that develops or progresses as a result of decrease or loss of activity of blood coagulation factor viii and/or activated blood coagulation factor viii |
Country Status (16)
| Country | Link |
|---|---|
| US (9) | US20170253663A1 (en) |
| EP (2) | EP4218816A3 (en) |
| JP (2) | JP6663846B2 (en) |
| KR (2) | KR20170015517A (en) |
| CN (1) | CN106559987A (en) |
| AU (1) | AU2015275440B2 (en) |
| BR (1) | BR112016029316A2 (en) |
| CA (1) | CA2951622C (en) |
| IL (1) | IL249330B (en) |
| MX (1) | MX2016016380A (en) |
| MY (1) | MY189333A (en) |
| RU (1) | RU2721910C2 (en) |
| SG (2) | SG10201811185YA (en) |
| TW (2) | TWI831106B (en) |
| WO (1) | WO2015194233A1 (en) |
| ZA (1) | ZA201700459B (en) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| EP3345616A1 (en) | 2006-03-31 | 2018-07-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| JP5624276B2 (en) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | Methods for controlling blood kinetics of antibodies |
| JP5334319B2 (en) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Method for modifying isoelectric point of antibody by amino acid substitution of CDR |
| TWI505838B (en) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody |
| TWI452136B (en) | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
| WO2015046467A1 (en) | 2013-09-27 | 2015-04-02 | 中外製薬株式会社 | Method for producing polypeptide heteromultimer |
| TWI700300B (en) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | Antibodies that neutralize substances with the function of FVIII coagulation factor (FVIII) |
| TWI701435B (en) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | Method to determine the reactivity of FVIII |
| JP7082484B2 (en) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | Method for Producing Polypeptide Heterogeneous Multimer |
| BR112018009312A8 (en) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | method for promoting purification efficiency of fc region-containing polypeptide |
| RU2748046C2 (en) * | 2016-04-28 | 2021-05-19 | Чугаи Сейяку Кабусики Кайся | Antibody containing preparation |
| CN109415444B (en) * | 2016-07-29 | 2024-03-01 | 中外制药株式会社 | Bispecific antibodies exhibiting increased functional activity of alternative FVIII cofactors |
| CR20190162A (en) * | 2016-09-06 | 2019-05-13 | Hoffmann La Roche | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| AU2017331739A1 (en) * | 2016-09-23 | 2019-03-07 | Csl Limited | Coagulation factor binding proteins and uses thereof |
| KR20190133230A (en) * | 2017-03-31 | 2019-12-02 | 고리츠다이가쿠호징 나라켕리츠 이카다이가쿠 | Pharmaceutical composition for use in the prophylaxis and / or treatment of blood coagulation factor IX abnormalities containing multispecific antigen binding molecules that replace the function of blood coagulation factor VIII |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| EA202090641A1 (en) | 2017-09-29 | 2020-08-07 | Чугаи Сейяку Кабусики Кайся | MULTISPECIFIC ANTIGEN-BINDING MOLECULE WITH A SUBSTITUTE FUNCTIONAL ACTIVITY OF BLOOD COGULATING FACTOR VIII, AND PHARMACEUTICAL COMPOSITION, COMPOSITION |
| MA50893A (en) * | 2017-11-15 | 2020-09-23 | Novo Nordisk As | X-FACTOR BINDERS REINFORCING FX ACTIVATION |
| KR20210118085A (en) | 2018-12-21 | 2021-09-29 | 키맵 리미티드 | FIFY Bispecific Antibodies with a Common Light Chain |
| TWI745114B (en) * | 2019-10-11 | 2021-11-01 | 日商中外製藥股份有限公司 | Pharmaceutical composition for the prevention and/or treatment of acquired hemophilia A, and products containing the pharmaceutical composition |
| MX2022003912A (en) | 2019-10-11 | 2022-04-20 | Chugai Pharmaceutical Co Ltd | Pharmaceutical composition which can be used for prevention and/or treatment of acquired hemophilia a, and product comprising said pharmaceutical composition. |
| KR20230130558A (en) | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Methods of administering fviii mimetic bispecidic antibodies once monthly |
| KR20230130560A (en) | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Methods of administering fviii mimetic bispecidic antibodies once weekly |
| KR20230130561A (en) | 2022-03-02 | 2023-09-12 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | Methods of administering fviii mimetic bispecidic antibodies every second week |
Family Cites Families (23)
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| EP0546073B1 (en) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production and use of transgenic non-human animals capable of producing heterologous antibodies |
| AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| AU675661B2 (en) | 1992-07-24 | 1997-02-13 | Abgenix, Inc. | Generation of xenogeneic antibodies |
| JPH08509612A (en) | 1993-04-26 | 1996-10-15 | ジェンファーム インターナショナル インコーポレイテッド | Transgenic non-human animal capable of producing heterologous antibody |
| FR2707189B1 (en) | 1993-07-09 | 1995-10-13 | Gradient Ass | Method for treating combustion residues and installation for implementing said method. |
| WO1996002576A1 (en) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Reconstituted human antibody against human interleukin-8 |
| EP1978033A3 (en) | 1995-04-27 | 2008-12-24 | Amgen Fremont Inc. | Human antibodies derived from immunized xenomice |
| CA2219486A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US6677436B1 (en) | 1998-04-03 | 2004-01-13 | Chugai Seiyaku Kabushiki Kaisha | Humanized antibody against human tissue factor (TF) and process of production of the humanized antibody |
| DE60140474D1 (en) | 2000-09-08 | 2009-12-24 | Univ Zuerich | COLLECTION OF PROTEINS WITH REPEATED SEQUENCES (REPEAT PROTEINS) CONTAINING REPETITIVE SEQUENCE MODULES |
| JP2004526419A (en) | 2000-10-16 | 2004-09-02 | フィロス インク． | Protein scaffolds for antibody mimics and other binding proteins |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| WO2005035753A1 (en) * | 2003-10-10 | 2005-04-21 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| AU2003271186A1 (en) | 2003-10-14 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
| US20050164301A1 (en) | 2003-10-24 | 2005-07-28 | Avidia Research Institute | LDL receptor class A and EGF domain monomers and multimers |
| EP2824183B1 (en) | 2005-04-08 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing bispecific antibodies |
| TWI505838B (en) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody |
| JP2013531651A (en) * | 2010-06-14 | 2013-08-08 | パイオン ドイチュラント ゲーエムベーハー | Treatment of coagulopathy with increased fibrinolysis |
| TWI452136B (en) * | 2010-11-17 | 2014-09-11 | 中外製藥股份有限公司 | A multiple specific antigen-binding molecule that replaces the function of Factor VIII in blood coagulation |
-
2015
- 2015-03-27 TW TW110149549A patent/TWI831106B/en active
- 2015-03-27 TW TW104109925A patent/TW201625299A/en unknown
- 2015-03-31 SG SG10201811185YA patent/SG10201811185YA/en unknown
- 2015-03-31 AU AU2015275440A patent/AU2015275440B2/en active Active
- 2015-03-31 EP EP23157462.5A patent/EP4218816A3/en active Pending
- 2015-03-31 CA CA2951622A patent/CA2951622C/en active Active
- 2015-03-31 EP EP15809216.3A patent/EP3159006A4/en not_active Withdrawn
- 2015-03-31 MY MYPI2016704659A patent/MY189333A/en unknown
- 2015-03-31 MX MX2016016380A patent/MX2016016380A/en unknown
- 2015-03-31 RU RU2017101705A patent/RU2721910C2/en active
- 2015-03-31 KR KR1020177001413A patent/KR20170015517A/en not_active IP Right Cessation
- 2015-03-31 BR BR112016029316-9A patent/BR112016029316A2/en active Search and Examination
- 2015-03-31 JP JP2016529118A patent/JP6663846B2/en active Active
- 2015-03-31 US US15/319,016 patent/US20170253663A1/en not_active Abandoned
- 2015-03-31 KR KR1020247013296A patent/KR20240063162A/en active Search and Examination
- 2015-03-31 WO PCT/JP2015/060171 patent/WO2015194233A1/en active Application Filing
- 2015-03-31 CN CN201580039806.4A patent/CN106559987A/en active Pending
- 2015-03-31 SG SG11201610581RA patent/SG11201610581RA/en unknown
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2016
- 2016-12-01 IL IL249330A patent/IL249330B/en unknown
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2017
- 2017-01-19 ZA ZA2017/00459A patent/ZA201700459B/en unknown
-
2019
- 2019-06-05 US US16/432,790 patent/US20190309090A1/en not_active Abandoned
- 2019-12-16 JP JP2019226196A patent/JP2020055864A/en active Pending
-
2020
- 2020-02-04 US US16/780,977 patent/US20200157243A1/en not_active Abandoned
- 2020-09-11 US US17/017,971 patent/US20200407463A1/en not_active Abandoned
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2021
- 2021-04-20 US US17/235,445 patent/US20210238307A1/en not_active Abandoned
- 2021-11-24 US US17/534,566 patent/US20220073645A1/en not_active Abandoned
-
2022
- 2022-06-27 US US17/849,879 patent/US20220324999A1/en not_active Abandoned
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2023
- 2023-02-06 US US18/164,709 patent/US20230174673A1/en not_active Abandoned
- 2023-10-02 US US18/479,149 patent/US20240052060A1/en active Pending
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