SG10201806844SA - Uv associated mtdna fusion transcripts and methods and uses thereof - Google Patents
Uv associated mtdna fusion transcripts and methods and uses thereofInfo
- Publication number
- SG10201806844SA SG10201806844SA SG10201806844SA SG10201806844SA SG10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA SG 10201806844S A SG10201806844S A SG 10201806844SA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- fusion transcripts
- mtdna
- associated mtdna
- molecules
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/795—Porphyrin- or corrin-ring-containing peptides
- C07K14/80—Cytochromes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
- C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0053—Oxidoreductases (1.) acting on a heme group of donors (1.9)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/148—Screening for cosmetic compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y106/00—Oxidoreductases acting on NADH or NADPH (1.6)
- C12Y106/99—Oxidoreductases acting on NADH or NADPH (1.6) with other acceptors (1.6.99)
- C12Y106/99003—NADH dehydrogenase (1.6.99.3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y109/00—Oxidoreductases acting on a heme group of donors (1.9)
- C12Y109/03—Oxidoreductases acting on a heme group of donors (1.9) with oxygen as acceptor (1.9.3)
- C12Y109/03001—Cytochrome-c oxidase (1.9.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/10—Protein-tyrosine kinases (2.7.10)
- C12Y207/10001—Receptor protein-tyrosine kinase (2.7.10.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y306/00—Hydrolases acting on acid anhydrides (3.6)
- C12Y306/01—Hydrolases acting on acid anhydrides (3.6) in phosphorus-containing anhydrides (3.6.1)
- C12Y306/01003—Adenosine triphosphatase (3.6.1.3)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
UV ASSOCIATED MTDNA FUSION TRANSCRIPTS AND METHODS AND USES THEREOF The present invention provides novel mitochondrial fusion transcripts and related deletion molecules that are associated with UV exposure. Methods for in vivo and in vitro detection of mtDNA molecules and associated fusion transcripts is also provided, as is their use in the screening and testing of skin care products. (Figure )
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30921610P | 2010-03-01 | 2010-03-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201806844SA true SG10201806844SA (en) | 2018-09-27 |
Family
ID=44541588
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201501541QA SG10201501541QA (en) | 2010-03-01 | 2011-03-01 | Uv associated mtdna fusion transcripts and methods and uses thereof |
SG2012064937A SG183562A1 (en) | 2010-03-01 | 2011-03-01 | Uv associated mtdna fusion transcripts and methods and uses thereof |
SG10201806844SA SG10201806844SA (en) | 2010-03-01 | 2011-03-01 | Uv associated mtdna fusion transcripts and methods and uses thereof |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201501541QA SG10201501541QA (en) | 2010-03-01 | 2011-03-01 | Uv associated mtdna fusion transcripts and methods and uses thereof |
SG2012064937A SG183562A1 (en) | 2010-03-01 | 2011-03-01 | Uv associated mtdna fusion transcripts and methods and uses thereof |
Country Status (12)
Country | Link |
---|---|
US (4) | US20140024025A1 (en) |
EP (2) | EP3305902A1 (en) |
JP (1) | JP6008743B2 (en) |
KR (2) | KR102051010B1 (en) |
CN (2) | CN102791864B (en) |
AU (1) | AU2011223463B2 (en) |
CA (1) | CA2791817A1 (en) |
HK (1) | HK1253690A1 (en) |
NZ (1) | NZ602137A (en) |
RU (1) | RU2012141575A (en) |
SG (3) | SG10201501541QA (en) |
WO (1) | WO2011106892A1 (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009117811A1 (en) * | 2008-03-28 | 2009-10-01 | Genesis Genomics Inc. | Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor |
KR101705421B1 (en) * | 2015-01-05 | 2017-02-09 | 건국대학교 산학협력단 | Nucler Moelcules for detecting UV induced damage and Methods and Systems for evaluating UV induced damage and repairby using thereof |
CN110312506A (en) * | 2016-11-14 | 2019-10-08 | 密歇根大学董事会 | Composition and method for shielding of ultraviolet radiation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2002311903A1 (en) * | 2001-05-09 | 2002-11-18 | University Hospitals Of Cleveland | Evaluation of ultraviolet radiation damage to skin using new genemarkers, methods and compositions related thereto |
EP1291640A1 (en) * | 2001-09-05 | 2003-03-12 | Beiersdorf AG | In vitro test method to assess the UVA protection performance of sun care products |
CA2480184C (en) | 2004-10-14 | 2011-12-20 | Mark Birch-Machin | The use of a 3895 bp mitochondrial dna deletion as a marker for sunlight exposure in human skin |
KR101363032B1 (en) * | 2005-04-18 | 2014-02-13 | 미토믹스 인크. | Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers |
JP2009502962A (en) * | 2005-07-29 | 2009-01-29 | ザ ジェネラル ホスピタル コーポレイション | Methods and compositions for reducing skin damage |
ES2396440T3 (en) * | 2006-01-18 | 2013-02-21 | The General Hospital Corporation | Methods of increasing lymphatic function |
US20110082218A1 (en) * | 2006-06-15 | 2011-04-07 | Karin Wertz | Treatment and modulation of gene expression and skin aging |
EP2217730B1 (en) * | 2007-10-11 | 2014-08-20 | Mitomics Inc. | Methods for assaying mc1r variants and mitochondrial markers in skin samples |
CA2702212C (en) * | 2007-10-11 | 2019-01-15 | Genesis Genomics Inc. | Methods for assaying mc1r variants and mitochondrial markers in skin samples |
JP6309184B2 (en) * | 2007-11-15 | 2018-04-11 | ザ ジェネラル ホスピタル コーポレイション | Methods and compositions for reduction of skin damage |
WO2009117811A1 (en) * | 2008-03-28 | 2009-10-01 | Genesis Genomics Inc. | Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor |
-
2011
- 2011-03-01 WO PCT/CA2011/050120 patent/WO2011106892A1/en active Application Filing
- 2011-03-01 SG SG10201501541QA patent/SG10201501541QA/en unknown
- 2011-03-01 KR KR1020127022982A patent/KR102051010B1/en active IP Right Grant
- 2011-03-01 CA CA2791817A patent/CA2791817A1/en not_active Abandoned
- 2011-03-01 CN CN201180011806.5A patent/CN102791864B/en not_active Expired - Fee Related
- 2011-03-01 CN CN201510253175.8A patent/CN104946676A/en active Pending
- 2011-03-01 AU AU2011223463A patent/AU2011223463B2/en not_active Ceased
- 2011-03-01 US US13/582,049 patent/US20140024025A1/en not_active Abandoned
- 2011-03-01 KR KR1020197034952A patent/KR20190136107A/en active IP Right Grant
- 2011-03-01 EP EP17192852.6A patent/EP3305902A1/en not_active Withdrawn
- 2011-03-01 SG SG2012064937A patent/SG183562A1/en unknown
- 2011-03-01 SG SG10201806844SA patent/SG10201806844SA/en unknown
- 2011-03-01 JP JP2012555266A patent/JP6008743B2/en not_active Expired - Fee Related
- 2011-03-01 RU RU2012141575/10A patent/RU2012141575A/en not_active Application Discontinuation
- 2011-03-01 EP EP11750131.2A patent/EP2542680B1/en not_active Not-in-force
- 2011-03-01 NZ NZ602137A patent/NZ602137A/en not_active IP Right Cessation
-
2014
- 2014-12-12 US US14/569,147 patent/US20150322516A1/en not_active Abandoned
-
2016
- 2016-11-09 US US15/347,601 patent/US20170175194A1/en not_active Abandoned
-
2018
- 2018-08-07 US US16/057,052 patent/US20180346985A1/en not_active Abandoned
- 2018-10-09 HK HK18112834.5A patent/HK1253690A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2011223463A1 (en) | 2012-09-06 |
KR20190136107A (en) | 2019-12-09 |
CA2791817A1 (en) | 2011-09-09 |
EP3305902A1 (en) | 2018-04-11 |
SG10201501541QA (en) | 2015-04-29 |
EP2542680A4 (en) | 2013-08-21 |
HK1253690A1 (en) | 2019-06-28 |
SG183562A1 (en) | 2012-10-30 |
JP6008743B2 (en) | 2016-10-19 |
EP2542680A1 (en) | 2013-01-09 |
US20170175194A1 (en) | 2017-06-22 |
EP2542680B1 (en) | 2017-09-27 |
AU2011223463B2 (en) | 2015-07-30 |
KR102051010B1 (en) | 2019-12-02 |
CN104946676A (en) | 2015-09-30 |
US20180346985A1 (en) | 2018-12-06 |
US20140024025A1 (en) | 2014-01-23 |
US20150322516A1 (en) | 2015-11-12 |
WO2011106892A1 (en) | 2011-09-09 |
RU2012141575A (en) | 2014-04-10 |
JP2013520965A (en) | 2013-06-10 |
CN102791864B (en) | 2015-06-17 |
CN102791864A (en) | 2012-11-21 |
NZ602137A (en) | 2015-05-29 |
KR20120128658A (en) | 2012-11-27 |
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