SG10201805800XA - Methods for rapid and sensitive detection of hotspot mutations - Google Patents

Methods for rapid and sensitive detection of hotspot mutations

Info

Publication number
SG10201805800XA
SG10201805800XA SG10201805800XA SG10201805800XA SG10201805800XA SG 10201805800X A SG10201805800X A SG 10201805800XA SG 10201805800X A SG10201805800X A SG 10201805800XA SG 10201805800X A SG10201805800X A SG 10201805800XA SG 10201805800X A SG10201805800X A SG 10201805800XA
Authority
SG
Singapore
Prior art keywords
rapid
methods
mutations
sensitive detection
hotspot mutations
Prior art date
Application number
SG10201805800XA
Other languages
English (en)
Inventor
Hai Yan
Yiping He
Rui Yang
Bill H Diplas
Landon Hansen
Darell Bigner
Original Assignee
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=55400402&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201805800X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Univ Duke filed Critical Univ Duke
Publication of SG10201805800XA publication Critical patent/SG10201805800XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/101—DNA polymerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/117—Modifications characterised by incorporating modified base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2531/00—Reactions of nucleic acids characterised by
    • C12Q2531/10—Reactions of nucleic acids characterised by the purpose being amplify/increase the copy number of target nucleic acid
    • C12Q2531/113—PCR
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/166—Oligonucleotides used as internal standards, controls or normalisation probes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SG10201805800XA 2014-08-25 2015-08-24 Methods for rapid and sensitive detection of hotspot mutations SG10201805800XA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462041197P 2014-08-25 2014-08-25

Publications (1)

Publication Number Publication Date
SG10201805800XA true SG10201805800XA (en) 2018-08-30

Family

ID=55400402

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201701220PA SG11201701220PA (en) 2014-08-25 2015-08-24 Methods for rapid and sensitive detection of hotspot mutations
SG10201805800XA SG10201805800XA (en) 2014-08-25 2015-08-24 Methods for rapid and sensitive detection of hotspot mutations

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SG11201701220PA SG11201701220PA (en) 2014-08-25 2015-08-24 Methods for rapid and sensitive detection of hotspot mutations

Country Status (9)

Country Link
US (1) US10633711B2 (ja)
EP (1) EP3186399B1 (ja)
JP (1) JP6438119B2 (ja)
KR (2) KR102278401B1 (ja)
CN (1) CN106795563B (ja)
AU (1) AU2015306907C9 (ja)
BR (1) BR112017003559A2 (ja)
SG (2) SG11201701220PA (ja)
WO (1) WO2016032947A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107541557A (zh) * 2017-09-27 2018-01-05 迈基诺（重庆）基因科技有限责任公司 一种检测人类tert基因启动子热点突变的荧光定量pcr方法及其用途
WO2019173712A1 (en) * 2018-03-09 2019-09-12 Duke University Addressing treatments for glioblastoma
CN110724742A (zh) * 2019-10-18 2020-01-24 航天中心医院 一种检测人tert基因启动子热点突变的试剂盒
CN111424094A (zh) * 2019-10-18 2020-07-17 航天中心医院 一种检测人tert基因启动子热点突变的方法
CN114381518A (zh) * 2020-10-05 2022-04-22 复旦大学附属华山医院 一种用于快速检测胶质瘤突变位点及分型的引物和试剂盒
CN114182003A (zh) * 2022-01-11 2022-03-15 杭州百迈生物股份有限公司 用于cyp3a5多态性位点基因分型检测的试剂盒及其检测方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5422120B2 (ja) * 2004-05-27 2014-02-19 ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイト 癌患者による上皮成長因子受容体阻害薬に対する臨床転帰の予測方法
CA2684570A1 (en) * 2007-04-19 2008-10-30 Molecular Detection Inc. Methods, compositions and kits for detection and analysis of antibiotic-resistant bacteria
AU2009288004B2 (en) 2008-09-03 2015-02-05 Duke University Genetic alterations in isocitrate dehydrogenase and other genes in malignant glioma
SG183029A1 (en) 2009-01-13 2012-08-30 Fluidigm Corp Single-cell nucleic acid analysis
CA2764315A1 (en) 2009-06-02 2010-12-09 Monoquant Pty Ltd A method of nucleic acid amplification
US20130143747A1 (en) * 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
GB201004339D0 (en) * 2010-03-16 2010-04-28 Enigma Diagnostics Ltd Sequence detection assay
EP2569637B1 (en) * 2010-05-14 2015-04-08 Deutsches Krebsforschungszentrum Methods for the diagnosis and prognosis of a tumor using bcat1 protein
CN103571953A (zh) 2013-10-28 2014-02-12 深圳市第二人民医院 Tert启动子的单核苷酸多态性序列的检测方法
CN103923976A (zh) 2014-01-28 2014-07-16 吴松 一种检测tert单核苷酸多态性的方法

Also Published As

Publication number Publication date
AU2015306907C9 (en) 2019-11-21
WO2016032947A1 (en) 2016-03-03
SG11201701220PA (en) 2017-03-30
AU2015306907A1 (en) 2017-03-09
KR102278401B1 (ko) 2021-07-19
CN106795563B (zh) 2021-08-06
CN106795563A (zh) 2017-05-31
AU2015306907C1 (en) 2019-11-07
JP6438119B2 (ja) 2018-12-12
BR112017003559A2 (pt) 2017-12-19
EP3186399B1 (en) 2022-06-22
KR20190065479A (ko) 2019-06-11
EP3186399A4 (en) 2018-07-18
AU2015306907B2 (en) 2018-07-19
US20170247765A1 (en) 2017-08-31
EP3186399A1 (en) 2017-07-05
US10633711B2 (en) 2020-04-28
JP2017525375A (ja) 2017-09-07
KR20170042725A (ko) 2017-04-19

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