SG10201710727UA - Antibody locker for the inactivation of protein drug - Google Patents

Antibody locker for the inactivation of protein drug

Info

Publication number
SG10201710727UA
SG10201710727UA SG10201710727UA SG10201710727UA SG10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA SG 10201710727U A SG10201710727U A SG 10201710727UA
Authority
SG
Singapore
Prior art keywords
locker
inactivation
antibody
protein drug
drug
Prior art date
Application number
SG10201710727UA
Inventor
Tian Lu Cheng
Chih Hung Chuang
Hsiu Fen Ko
yun chi Lu
Original Assignee
Dcb Usa Llc
Univ Kaohsiung Medical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dcb Usa Llc, Univ Kaohsiung Medical filed Critical Dcb Usa Llc
Publication of SG10201710727UA publication Critical patent/SG10201710727UA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/245—IL-1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
SG10201710727UA 2013-05-28 2014-05-28 Antibody locker for the inactivation of protein drug SG10201710727UA (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361827763P 2013-05-28 2013-05-28

Publications (1)

Publication Number Publication Date
SG10201710727UA true SG10201710727UA (en) 2018-02-27

Family

ID=51989521

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201710727UA SG10201710727UA (en) 2013-05-28 2014-05-28 Antibody locker for the inactivation of protein drug
SG11201509595PA SG11201509595PA (en) 2013-05-28 2014-05-28 Antibody locker for the inactivation of protein drug

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201509595PA SG11201509595PA (en) 2013-05-28 2014-05-28 Antibody locker for the inactivation of protein drug

Country Status (15)

Country Link
US (1) US10633453B2 (en)
EP (1) EP3003370B1 (en)
JP (1) JP6545666B2 (en)
KR (1) KR102182485B1 (en)
CN (1) CN105377297B (en)
AU (1) AU2014274215B2 (en)
CA (1) CA2913051C (en)
EA (1) EA035322B1 (en)
HK (1) HK1221426A1 (en)
IL (1) IL242772B (en)
MX (1) MX2015016329A (en)
SG (2) SG10201710727UA (en)
TW (1) TWI582111B (en)
WO (1) WO2014193973A2 (en)
ZA (1) ZA201508673B (en)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201710727UA (en) 2013-05-28 2018-02-27 Dcb Usa Llc Antibody locker for the inactivation of protein drug
NZ756892A (en) 2013-09-25 2022-05-27 Cytomx Therapeutics Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
RS60443B1 (en) 2013-12-17 2020-07-31 Genentech Inc Anti-cd3 antibodies and methods of use
CN106459153B (en) 2014-01-31 2021-12-21 西托姆克斯治疗公司 Substrates and other cleavable moieties for proteolytic enzymes and U-type plasminogen activators and methods of use thereof
TW201625690A (en) 2014-09-12 2016-07-16 建南德克公司 Anti-CLL-1 antibodies and immunoconjugates
MA41374A (en) 2015-01-20 2017-11-28 Cytomx Therapeutics Inc MATRIX METALLOPROTEASE CLIVABLE AND SERINE PROTEASE CLIVABLE SUBSTRATES AND METHODS OF USE THEREOF
EP4122492A1 (en) 2015-02-25 2023-01-25 Memorial Sloan Kettering Cancer Center Use of inactivated nonreplicating modified vaccinia virus ankara (mva)as monoimmunotherapy or in combination with immune checkpoint blocking agents for solid tumors
CN116173193A (en) 2015-04-17 2023-05-30 纪念斯隆凯特琳癌症中心 Use of MVA or MVA delta E3L as immunotherapeutic agent against solid tumors
EP3778640A1 (en) * 2015-05-01 2021-02-17 Genentech, Inc. Masked anti-cd3 antibodies and methods of use
US10501545B2 (en) 2015-06-16 2019-12-10 Genentech, Inc. Anti-CLL-1 antibodies and methods of use
IL307276A (en) 2015-08-28 2023-11-01 Amunix Operating Inc Chimeric polypeptide assembly and methods of making and using the same
WO2017117218A1 (en) * 2015-12-30 2017-07-06 Momenta Pharmaceuticals, Inc. Methods related to biologics
MX2018010204A (en) 2016-02-25 2019-05-06 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human flt3l or gm-csf for cancer immunotherapy.
WO2017147554A2 (en) 2016-02-25 2017-08-31 Memorial Sloan-Kettering Cancer Center Recombinant mva or mvadele3l expressing human flt3l and use thereof as immuno-therapeutic agents against solid tumors
US10851400B2 (en) 2016-03-20 2020-12-01 Kevin L. Bicker Assay for high-throughput identification of therapeutic compounds
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
SG11201809699XA (en) * 2016-05-18 2018-12-28 Voyager Therapeutics Inc Modulatory polynucleotides
CN107446016A (en) * 2016-05-30 2017-12-08 上海交通大学 A kind of cell-penetrating peptide of Stearate Modified and its preparation and application
CN109312367B (en) 2016-06-06 2023-04-11 艾斯克立必恩股份有限公司 Antibody fusion proteins for drug delivery
JP7039582B2 (en) * 2016-11-03 2022-03-22 ブリストル－マイヤーズ スクイブ カンパニー Activateable anti-CTLA-4 antibody and its use
WO2018093821A1 (en) 2016-11-15 2018-05-24 Genentech, Inc. Dosing for treatment with anti-cd20/anti-cd3 bispecific antibodies
NZ753324A (en) * 2016-12-09 2022-02-25 Seagen Inc Bivalent antibodies masked by coiled coils
CN110636856A (en) * 2016-12-29 2019-12-31 财团法人生物技术开发中心 KLK 6-mediated CNS-specific antibody prodrug activation
US11242509B2 (en) 2017-05-12 2022-02-08 Memorial Sloan Kettering Cancer Center Vaccinia virus mutants useful for cancer immunotherapy
WO2018213335A1 (en) * 2017-05-16 2018-11-22 Scalmibio, Inc. Activatable antibodies and methods of use thereof
AR113862A1 (en) 2017-12-01 2020-06-17 Seattle Genetics Inc ANTI-CD47 ANTIBODIES AND THEIR USES TO TREAT CANCER
AU2019218959A1 (en) 2018-02-08 2020-09-03 Genentech, Inc. Bispecific antigen-binding molecules and methods of use
KR102245552B1 (en) * 2018-02-28 2021-04-29 부산대학교 산학협력단 Nanodrug Composites, preparation method therof, and use for the same
AU2019234642A1 (en) * 2018-03-13 2020-09-24 Memorial Sloan Kettering Cancer Center Oncolytic vaccinia virus expressing immune checkpoint blockade for cancer immunotherapy
JP7425049B2 (en) 2018-09-25 2024-01-30 ハープーン セラピューティクス，インク． DLL3 binding protein and method of use
US20220306727A1 (en) 2019-06-05 2022-09-29 Seagen Inc. Methods of Purifying Masked Antibodies
TW202112354A (en) 2019-06-05 2021-04-01 美商西雅圖遺傳學公司 Masked antibody formulations
WO2023288236A1 (en) 2021-07-14 2023-01-19 Seagen Inc. Antibody masking domains
WO2023049825A1 (en) 2021-09-24 2023-03-30 Seagen Inc. Improved antibody masking domains
WO2023064945A2 (en) * 2021-10-15 2023-04-20 Harpoon Therapeutics, Inc. Conditional activation of immunoglobulin molecules
WO2023222580A1 (en) 2022-05-16 2023-11-23 Byondis B.V. Novel masked antibodies

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932448A (en) 1991-11-29 1999-08-03 Protein Design Labs., Inc. Bispecific antibody heterodimers
GB9322156D0 (en) 1993-10-27 1993-12-15 Univ Newcastel Upon Tyne Activation of molecules
EP0871673B1 (en) 1995-05-03 2006-04-05 Bioenhancementsments Ltd. Bispecific antibodies in which the binding capability is reversibly inhibited by a photocleavable moiety
US20040014652A1 (en) 2000-06-01 2004-01-22 Andre Trouet Tumor activated prodrug compounds and methods of making and using the same
US7238505B2 (en) 2000-10-04 2007-07-03 Ahram Biosystems Inc. Immobilized DNA polymerase
HUP0402333A3 (en) * 2001-11-12 2007-05-02 Merck Patent Gmbh Modified anti-tnf alpha antibody
AU2003217415B2 (en) 2002-02-14 2009-01-08 William J Rutter Chimeric molecules for cleavage in a treated host
US20040109855A1 (en) 2002-07-23 2004-06-10 Herman Waldmann Therapeutic antibodies with reduced side effect
AU2004248155B2 (en) 2003-06-09 2008-10-23 Redox-Reactive Reagents L.L.C. Method of altering the binding specificity of plasma proteins by oxidation-reduction reactions
GB0404187D0 (en) 2004-02-25 2004-03-31 Biotransformations Ltd Binding agents
MX2007004374A (en) * 2004-10-12 2008-01-29 Amprotein Corp Chimeric protein.
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
GB0605702D0 (en) 2006-03-21 2006-05-03 Biotransformations Ltd Materials and methods for immune cell stimulation
AT503902B1 (en) * 2006-07-05 2008-06-15 F Star Biotech Forsch & Entw METHOD FOR MANIPULATING IMMUNE LOBULINS
EP2178914A2 (en) 2007-08-15 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Monospecific and multispecific antibodies and method of use
GB0716160D0 (en) 2007-08-17 2007-09-26 Biotransformations Ltd Materials and methods for treating cancers which express folate receptors
JP6035009B2 (en) * 2007-08-22 2016-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Activable binding polypeptides and methods for identification and use thereof
JP5448397B2 (en) * 2007-09-07 2014-03-19 キヤノン株式会社 Substrate probe, detection method of enzyme activity by multiple nuclear magnetic resonance method, and imaging method of enzyme activity
EP2356131A4 (en) 2008-12-08 2012-09-12 Tegopharm Corp Masking ligands for reversible inhibition of multivalent compounds
JP5851842B2 (en) * 2009-01-12 2016-02-03 サイトムエックス セラピューティクス, インク.CytomX Therapeutics, Inc. Modified antibody composition and methods of making and using the same
WO2010096838A2 (en) * 2009-02-23 2010-08-26 Cytomx Therapeutics, Llc Proproteins and methods of use thereof
RU2573915C2 (en) 2009-09-16 2016-01-27 Дженентек, Инк. Protein complexes containing superhelix and/or banding, and their use
MX346731B (en) * 2010-04-23 2017-03-30 Genentech Inc * Production of heteromultimeric proteins.
EP2609112B1 (en) 2010-08-24 2017-11-22 Roche Glycart AG Activatable bispecific antibodies
WO2012025530A1 (en) 2010-08-24 2012-03-01 F. Hoffmann-La Roche Ag Bispecific antibodies comprising a disulfide stabilized - fv fragment
AU2011312106B8 (en) 2010-10-08 2017-09-14 City Of Hope A monoclonal antibody framework binding interface for meditopes, meditope delivery systems and methods for their use
CN110229235A (en) * 2011-06-22 2019-09-13 霍夫曼-拉罗奇有限公司 Target cell is removed by the HIV-specific cytotoxic T lymphocytes in circulation using the compound comprising MHC I class
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
BR112014024373A2 (en) 2012-03-30 2017-08-08 Bayer Healthcare Llc protease-regulated antibodies
IN2014MN02164A (en) 2012-04-27 2015-08-28 Cytomx Therapeutics Inc
WO2013192546A1 (en) 2012-06-22 2013-12-27 Cytomx Therapeutics, Inc. Activatable antibodies having non-binding steric moieties and mehtods of using the same
KR20150037857A (en) 2012-06-22 2015-04-08 싸이톰스 테라퓨틱스, 인크. Anti-jagged 1/jagged 2 cross-reactive antibodies, activatable anti-jagged antibodies and methods of use thereof
US9487590B2 (en) 2012-09-25 2016-11-08 Cytomx Therapeutics, Inc. Activatable antibodies that bind interleukin-6 receptor and methods of use thereof
TW201522368A (en) 2013-03-15 2015-06-16 Bayer Healthcare Llc Pro-drug antibodies against tissue factor pathway inhibitor
SG10201710727UA (en) 2013-05-28 2018-02-27 Dcb Usa Llc Antibody locker for the inactivation of protein drug
ES2683268T3 (en) 2013-07-25 2018-09-25 Cytomx Therapeutics, Inc. Multispecific antibodies, multispecific activatable antibodies and methods for using them
NZ756892A (en) 2013-09-25 2022-05-27 Cytomx Therapeutics Inc Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
WO2015066279A2 (en) 2013-10-30 2015-05-07 Cytomx Therapeutics, Inc. Activatable antibodies that bind epidermal growth factor receptor and methods of use thereof
DE102014201538A1 (en) 2014-01-29 2015-07-30 Robert Bosch Gmbh A method for driving a parking lot management system for at least one parking lot and parking lot management system for at least one parking lot

Also Published As

Publication number Publication date
EA035322B1 (en) 2020-05-28
KR20160032041A (en) 2016-03-23
US20160185875A1 (en) 2016-06-30
WO2014193973A3 (en) 2015-02-19
AU2014274215B2 (en) 2019-02-28
SG11201509595PA (en) 2015-12-30
KR102182485B1 (en) 2020-11-25
EP3003370A4 (en) 2017-01-25
CN105377297B (en) 2019-09-17
HK1221426A1 (en) 2017-06-02
JP2016520614A (en) 2016-07-14
US10633453B2 (en) 2020-04-28
CA2913051C (en) 2023-09-05
MX2015016329A (en) 2016-07-20
ZA201508673B (en) 2017-05-31
EA201592049A1 (en) 2016-04-29
TWI582111B (en) 2017-05-11
WO2014193973A2 (en) 2014-12-04
IL242772B (en) 2020-04-30
TW201520230A (en) 2015-06-01
JP6545666B2 (en) 2019-07-17
EP3003370B1 (en) 2020-01-22
CN105377297A (en) 2016-03-02
EP3003370A2 (en) 2016-04-13
AU2014274215A1 (en) 2015-12-03
CA2913051A1 (en) 2014-12-04

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